NO933581L - "Crosstalk"-inhibitorer og deres anvendelse - Google Patents

"Crosstalk"-inhibitorer og deres anvendelse

Info

Publication number
NO933581L
NO933581L NO933581A NO933581A NO933581L NO 933581 L NO933581 L NO 933581L NO 933581 A NO933581 A NO 933581A NO 933581 A NO933581 A NO 933581A NO 933581 L NO933581 L NO 933581L
Authority
NO
Norway
Prior art keywords
ligand
crosstalk
binding
assay
analogue conjugate
Prior art date
Application number
NO933581A
Other languages
English (en)
Other versions
NO933581D0 (no
Inventor
Kenneth Francis Buechler
Richard Ray Anderson
Theodore Tsan-Tsung Lee
Gunars Edwin Valkirs
Original Assignee
Biosite Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biosite Diagnostics Inc filed Critical Biosite Diagnostics Inc
Publication of NO933581D0 publication Critical patent/NO933581D0/no
Publication of NO933581L publication Critical patent/NO933581L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/416—2,5-Pyrrolidine-diones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5306—Improving reaction conditions, e.g. reduction of non-specific binding, promotion of specific binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/962—Prevention or removal of interfering materials or reactants or other treatment to enhance results, e.g. determining or preventing nonspecific binding
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/815—Test for named compound or class of compounds
    • Y10S436/816—Alkaloids, amphetamines, and barbiturates
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/815—Test for named compound or class of compounds
    • Y10S436/817—Steroids or hormones
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/822—Identified hapten

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Communication Cables (AREA)
  • Stereophonic System (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Materials For Photolithography (AREA)

Abstract

Analyse for å bestemme mengde eller tilstedeværelse av targetligand i en prøve. Analysen inkluderer et ligand-analogkonjugat med et koblingssete og et bindingssete, en ligandreseptor, og en prøve. Analysen inkluderer trinnet med tilveiebringelse av minst encrosstalk"-inhibitor. Denne inhibitor vil, under analysebetingelser, konkurrere med koblingssetet i ligand-analogkonjugatet for binding til ligandreseptoren, og vil ikke konkurrere med bindingssetet i ligand-analogkonjugatet for binding til ligandreseptoren. Analysen gjennomføres for targetliganden i nærvær av en til-strekkelig mengde avcrosstalk-inhibitor for å redusere omfanget av binding av koblingssetet i ligand-analogkonjugatet til ligandreseptoren. En fremgangsmåte for å identifisere "crosstalk"-inhibitorer og selvecrosstalk"-inhibitorene er også beskrevet.
NO933581A 1991-04-10 1993-10-07 "Crosstalk"-inhibitorer og deres anvendelse NO933581L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68345691A 1991-04-10 1991-04-10
PCT/US1992/002837 WO1992018868A1 (en) 1991-04-10 1992-04-07 Crosstalk inhibitors and their uses

Publications (2)

Publication Number Publication Date
NO933581D0 NO933581D0 (no) 1993-10-07
NO933581L true NO933581L (no) 1993-12-10

Family

ID=24744132

Family Applications (1)

Application Number Title Priority Date Filing Date
NO933581A NO933581L (no) 1991-04-10 1993-10-07 "Crosstalk"-inhibitorer og deres anvendelse

Country Status (10)

Country Link
US (1) US5525524A (no)
EP (1) EP0585310B1 (no)
JP (1) JPH06506688A (no)
AT (1) ATE177841T1 (no)
AU (1) AU1772992A (no)
CA (1) CA2107894C (no)
DE (1) DE69228682T2 (no)
FI (1) FI934437A (no)
NO (1) NO933581L (no)
WO (1) WO1992018868A1 (no)

Families Citing this family (174)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5994103A (en) 1995-06-02 1999-11-30 Human Genome Science, Inc. Human stanniocalcin-alpha
FR2751989B1 (fr) * 1996-08-01 1998-10-30 Soc D Rech Et De Dev En Activa Methode d'identification de cellules eucaryotes par fixation desdites cellules sur un support et support pour mettre en oeuvre ladite methode
US6544797B1 (en) * 1997-04-09 2003-04-08 Biosite Diagnostics, Inc. Compositions and methods for inhibiting light-induced inactivation of biological reagents
US6830731B1 (en) * 1998-01-05 2004-12-14 Biosite, Inc. Immunoassay fluorometer
US6392894B1 (en) 1998-01-05 2002-05-21 Biosite Incorporated Media carrier for an assay device
US6096726A (en) * 1998-03-11 2000-08-01 Surface Solutions Laboratories Incorporated Multicomponent complex for use with substrate
ES2390425T3 (es) 2000-12-22 2012-11-12 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Uso de moléculas de orientación repulsivas (RGM) y sus moduladores
US20040203083A1 (en) * 2001-04-13 2004-10-14 Biosite, Inc. Use of thrombus precursor protein and monocyte chemoattractant protein as diagnostic and prognostic indicators in vascular diseases
US20040253637A1 (en) * 2001-04-13 2004-12-16 Biosite Incorporated Markers for differential diagnosis and methods of use thereof
US7713705B2 (en) * 2002-12-24 2010-05-11 Biosite, Inc. Markers for differential diagnosis and methods of use thereof
US7524635B2 (en) * 2003-04-17 2009-04-28 Biosite Incorporated Methods and compositions for measuring natriuretic peptides and uses thereof
US20030219734A1 (en) * 2001-04-13 2003-11-27 Biosite Incorporated Polypeptides related to natriuretic peptides and methods of their identification and use
US20040121350A1 (en) * 2002-12-24 2004-06-24 Biosite Incorporated System and method for identifying a panel of indicators
US20030199000A1 (en) * 2001-08-20 2003-10-23 Valkirs Gunars E. Diagnostic markers of stroke and cerebral injury and methods of use thereof
US20040126767A1 (en) * 2002-12-27 2004-07-01 Biosite Incorporated Method and system for disease detection using marker combinations
US7632647B2 (en) 2001-04-13 2009-12-15 Biosite Incorporated Use of B-type natriuretic peptide as a prognostic indicator in acute coronary syndromes
CA2414073A1 (en) 2001-05-04 2002-11-14 Gunars E. Valkirs Diagnostic markers of acute coronary syndromes and methods of use thereof
US20040219509A1 (en) * 2001-08-20 2004-11-04 Biosite, Inc. Diagnostic markers of stroke and cerebral injury and methods of use thereof
JP2005522669A (ja) * 2001-08-20 2005-07-28 バイオサイト インコーポレイテッド 卒中および脳損傷の診断マーカーおよびその使用方法
WO2004094460A2 (en) 2003-04-17 2004-11-04 Ciphergen Biosystems, Inc. Polypeptides related to natriuretic peptides and methods of their identification and use
WO2005033327A2 (en) * 2003-09-29 2005-04-14 Biosite Incorporated Methods and compositions for the diagnosis of sepsis
ATE449337T1 (de) 2003-12-12 2009-12-15 Inverness Medical Switzerland Assay
US6991911B2 (en) * 2003-12-15 2006-01-31 Dade Behring Inc. Assay for entactogens
US7022492B2 (en) * 2003-12-15 2006-04-04 Dade Behring Inc. Ecstasy haptens and immunogens
US20050130243A1 (en) * 2003-12-15 2005-06-16 Zheng Yi F. Assay for entactogens
US7037669B2 (en) * 2004-03-22 2006-05-02 Dade Behring Inc. Assays for amphetamine and methamphetamine using stereospecific reagents
US7115383B2 (en) * 2004-03-22 2006-10-03 Dade Behring Inc. Assays for amphetamine and methamphetamine
US20060105419A1 (en) * 2004-08-16 2006-05-18 Biosite, Inc. Use of a glutathione peroxidase 1 as a marker in cardiovascular conditions
JP4581571B2 (ja) * 2004-09-06 2010-11-17 富士ゼロックス株式会社 粒子のマレイミジル基量を測定する定量方法
US20060051825A1 (en) * 2004-09-09 2006-03-09 Buechler Kenneth F Methods and compositions for measuring canine BNP and uses thereof
US20060084184A1 (en) * 2004-10-19 2006-04-20 Renovar Incorporated Reagents for urine-based immunological assays
US20080050832A1 (en) * 2004-12-23 2008-02-28 Buechler Kenneth F Methods and compositions for diagnosis and/or prognosis in systemic inflammatory response syndromes
WO2006078813A2 (en) * 2005-01-21 2006-07-27 Biosite Incorporated Arginine analogs, and methods for their synthesis and use
WO2006135781A2 (en) * 2005-06-09 2006-12-21 Biosite, Inc. Methods and compositions for the diagnosis of venous thromboembolic disease
WO2007028070A2 (en) * 2005-08-30 2007-03-08 Biosite, Inc. Use of soluble flt-1 and its fragments in cardiovascular conditions
EP1928905B1 (de) 2005-09-30 2015-04-15 AbbVie Deutschland GmbH & Co KG Bindungsdomänen von proteinen der repulsive guidance molecule (rgm) proteinfamilie und funktionale fragmente davon sowie deren verwendung
US20070224643A1 (en) * 2006-03-09 2007-09-27 Mcpherson Paul H Methods and compositions for the diagnosis of diseases of the aorta
US20080118924A1 (en) * 2006-05-26 2008-05-22 Buechler Kenneth F Use of natriuretic peptides as diagnostic and prognostic indicators in vascular diseases
GB0611116D0 (en) 2006-06-06 2006-07-19 Oxford Genome Sciences Uk Ltd Proteins
ATE528411T1 (de) 2006-06-07 2011-10-15 Otago Innovation Ltd Diagnoseverfahren und -marker
US20100311186A1 (en) * 2006-07-28 2010-12-09 Biosite Incorporated Devices and methods for performing receptor binding assays using magnetic particles
CA2662629C (en) 2006-09-07 2019-08-13 University Of Otago Bnp signal peptide fragments for acute cardiac disorders
WO2008060607A2 (en) * 2006-11-14 2008-05-22 Biosite Incorporated Methods and compositions for monitoring and risk prediction in cardiorenal syndrome
EP2095106B1 (en) * 2006-11-14 2013-03-20 Alere San Diego, Inc. Methods and compositions for diagnosis and prognosis of renal artery stenosis
US8221995B2 (en) * 2007-03-23 2012-07-17 Seok-Won Lee Methods and compositions for diagnosis and/or prognosis in systemic inflammatory response syndromes
US20090004755A1 (en) * 2007-03-23 2009-01-01 Biosite, Incorporated Methods and compositions for diagnosis and/or prognosis in systemic inflammatory response syndromes
US7903970B2 (en) * 2007-03-30 2011-03-08 Georgia Tech Research Corporation Optical network evaluation systems and methods
US20090053832A1 (en) * 2007-08-20 2009-02-26 Link William F Simultaneous assay for determining drugs
US7947465B2 (en) * 2007-08-20 2011-05-24 Bio-Rad Laboratories, Inc. Simultaneous assay for determining drugs
US8962803B2 (en) 2008-02-29 2015-02-24 AbbVie Deutschland GmbH & Co. KG Antibodies against the RGM A protein and uses thereof
CN101977933A (zh) 2008-03-12 2011-02-16 奥塔哥创新有限公司 生物标记物
WO2009113879A1 (en) 2008-03-12 2009-09-17 Christopher Joseph Pemberton Biomarkers
US11150250B2 (en) 2008-08-28 2021-10-19 Astute Medical, Inc. Methods for diagnosing acute kidney injury or renal failure
EP2813848A3 (en) 2008-08-29 2015-03-11 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
US20110207161A1 (en) 2008-10-21 2011-08-25 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
EP2364444A4 (en) 2008-10-21 2012-08-08 Astute Medical Inc METHOD AND COMPOSITIONS FOR THE DIAGNOSIS AND FORECASTING KIDNEY INJURY AND KIDNEY FAILURES
AU2009313189B2 (en) 2008-11-10 2014-10-23 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
BRPI0921921A2 (pt) 2008-11-22 2019-09-24 Astute Medical Inc método para avaliar a condição renal em um indivíduo, e, uso de um ou mais marcadores de lesão renal.
US20100204055A1 (en) * 2008-12-05 2010-08-12 Bonner-Ferraby Phoebe W Autoantibody detection systems and methods
US20120053072A1 (en) 2009-02-06 2012-03-01 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
US20120052512A1 (en) 2009-02-06 2012-03-01 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
CA2767616A1 (en) 2009-07-09 2011-01-13 The Scripps Research Institute Gene expression profiles associated with chronic allograft nephropathy
US8871459B2 (en) 2009-08-07 2014-10-28 Astute Medical, Inc. Method for evaluating renal status by determining beta-2-glycoprotein 1
NZ598035A (en) 2009-08-07 2014-06-27 Astute Medical Inc Methods and compositions for diagnosis and prognosis of renal injury and renal failure
CN102792161B (zh) 2009-08-28 2014-11-12 阿斯图特医药公司 肾损伤和肾衰竭的诊断及预后的方法及组合物
US20130045494A1 (en) 2009-09-18 2013-02-21 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
CA2774223A1 (en) 2009-09-21 2011-03-24 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
CA2779902A1 (en) 2009-11-07 2011-05-12 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
CA2779905A1 (en) 2009-11-07 2011-05-12 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
JP5951498B2 (ja) * 2009-12-08 2016-07-13 アッヴィ・ドイチュラント・ゲー・エム・ベー・ハー・ウント・コー・カー・ゲー 網膜神経線維層変性の治療に使用するためのｒｇｍａタンパク質に対するモノクローナル抗体
EP2513649B1 (en) 2009-12-20 2016-04-20 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
EA201290627A1 (ru) 2010-02-05 2013-05-30 Астьют Медикал, Инк. Способы и композиции для диагностики и прогнозирования повреждений почек и почечной недостаточности
EP2531621A4 (en) 2010-02-05 2013-07-31 Astute Medical Inc METHOD AND COMPOSITIONS FOR DIAGNOSIS AND FORECASTING kidney injury and kidney insufficiency
WO2011097539A1 (en) 2010-02-05 2011-08-11 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
WO2011162820A1 (en) 2010-06-23 2011-12-29 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
WO2011106746A1 (en) 2010-02-26 2011-09-01 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
JP5786020B2 (ja) 2010-04-16 2015-09-30 アボットジャパン株式会社 関節リウマチを診断する方法および試薬
CA2804297A1 (en) 2010-06-23 2011-12-29 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
EP3339859A1 (en) 2010-06-23 2018-06-27 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
EP2596010B1 (en) 2010-07-19 2017-04-12 Otago Innovation Limited Signal biomarkers
US10557856B2 (en) 2010-09-24 2020-02-11 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Biomarkers of renal injury
CA2813011A1 (en) 2010-09-24 2012-03-29 Astute Medical, Inc. Methods and compositions for the evaluation of renal injury using hyaluronic acid
CA2811438A1 (en) 2010-10-07 2012-04-12 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
US8795975B2 (en) 2010-11-29 2014-08-05 Alere San Diego, Inc. Methods and compositions for diagnosis and risk prediction in heart failure
WO2012094658A2 (en) 2011-01-08 2012-07-12 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
WO2012102963A1 (en) 2011-01-26 2012-08-02 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Urine biomarkers for prediction of recovery after acute kidney injury : proteomics
US20130330752A1 (en) 2011-01-29 2013-12-12 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
KR101988600B1 (ko) * 2011-06-29 2019-06-12 가부시키가이샤 엘에스아이 메디엔스 비특이 반응 억제제, 비특이 반응 억제 방법 및 키트
JP2014529073A (ja) 2011-08-26 2014-10-30 アスチュート メディカル，インコーポレイテッド 腎損傷および腎不全の診断および予後診断のための方法ならびに組成物
AU2012340748A1 (en) 2011-11-22 2014-06-26 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
US10935548B2 (en) 2011-12-08 2021-03-02 Astute Medical, Inc. Methods for diagnosis and prognosis of renal injury and renal failure using insulin-like growth factor-binding protein 7 and metalloproteinase inhibitor 2
EP3800200A1 (en) 2011-12-14 2021-04-07 AbbVie Deutschland GmbH & Co. KG Composition and method for the diagnosis and treatment of iron-related disorders
EP2791175A2 (en) 2011-12-14 2014-10-22 Abbvie Deutschland GmbH & Co. KG Composition and method for the diagnosis and treatment of iron-related disorders
PE20142168A1 (es) 2012-01-27 2015-01-17 AbbVie Deutschland GmbH and Co KG Composicion y metodo para el diagnostico y el tratamiento de las enfermedades asociadas a la degeneracion de las neuritas
IN2014MN01760A (no) 2012-02-27 2015-07-03 Astute Medical Inc
US20130245038A1 (en) 2012-03-13 2013-09-19 Abbvie Inc. Method For Selecting Or Identifying A Subject For V1B Antagonist Therapy
ES2661516T3 (es) 2012-03-20 2018-04-02 Otago Innovation Limited Biomarcadores
ES2794448T3 (es) 2012-04-02 2020-11-18 Astute Medical Inc Procedimientos para el diagnóstico y pronóstico de sepsis
WO2013163345A1 (en) 2012-04-24 2013-10-31 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of stroke or other cerebral injury
EP3572809A1 (en) 2012-07-23 2019-11-27 Astute Medical, Inc. Methods for diagnosis of sepsis
WO2014028339A1 (en) 2012-08-11 2014-02-20 Astute Medical, Inc. Evaluating renal injury using hyaluronic acid
CN105074466B (zh) 2013-01-17 2018-01-09 阿斯图特医药公司 用于肾损伤和肾衰竭的诊断及预后的方法和组合物
EP2970319A4 (en) 2013-03-14 2016-11-09 Alere San Diego Inc 6-ACETYLMORPHINE ANALOGUE AND METHOD FOR THE SYNTHESIS AND USE
US9469686B2 (en) 2013-03-15 2016-10-18 Abbott Laboratories Anti-GP73 monoclonal antibodies and methods of obtaining the same
WO2014197729A1 (en) 2013-06-05 2014-12-11 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
EP3632467B1 (en) 2013-06-07 2023-09-27 Duke University Inhibitors of complement factor h
JP2016528236A (ja) 2013-08-07 2016-09-15 アスチュート メディカル，インコーポレイテッド 生物学的試料において改善された性能を有するｔｉｍｐ２のためのアッセイ
KR102322057B1 (ko) 2013-08-23 2021-11-05 리아타 파마슈티컬즈, 아이엔씨. 바독솔론 메틸 또는 이의 유사체를 이용한 내피 기능장애의 치료 및 예방 방법
WO2015031626A1 (en) 2013-08-28 2015-03-05 Abbvie Inc. Soluble cmet assay
CN105556308B (zh) 2013-09-20 2018-05-29 阿斯图特医药公司 用于阑尾炎的诊断和预后及腹痛病因的区分的方法和组合物
JP2017501211A (ja) 2013-11-06 2017-01-12 アスチュート メディカル，インコーポレイテッド 生体試料中で改善された性能を有するｉｇｆｂｐ７のためのアッセイ
CN110007084B (zh) 2013-12-03 2022-11-18 阿斯图特医药公司 用于肾损伤和肾衰竭的诊断和预后的方法和组合物
EP3090067B1 (en) 2013-12-30 2020-07-22 The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. Genomic rearrangements associated with prostate cancer and methods of using the same
EP3825418A3 (en) 2014-05-22 2021-09-15 The Scripps Research Institute Molecular signatures for distinguishing liver transplant rejections or injuries
EP3825416A3 (en) 2014-05-22 2021-09-15 The Scripps Research Institute Gene expression profiles associated with sub-clinical kidney transplant rejection
US10443100B2 (en) 2014-05-22 2019-10-15 The Scripps Research Institute Gene expression profiles associated with sub-clinical kidney transplant rejection
EP3146077A4 (en) 2014-05-22 2018-05-02 The Scripps Research Institute Tissue molecular signatures of kidney transplant rejections
US11104951B2 (en) 2014-05-22 2021-08-31 The Scripps Research Institute Molecular signatures for distinguishing liver transplant rejections or injuries
US11333671B2 (en) 2014-10-20 2022-05-17 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
WO2016100912A1 (en) 2014-12-18 2016-06-23 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
WO2016164854A1 (en) 2015-04-09 2016-10-13 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
JP2018521307A (ja) 2015-05-12 2018-08-02 アスチュート メディカル，インコーポレイテッド 腎障害および腎不全の診断および予後のための方法および組成物
CA2988980A1 (en) 2015-06-11 2016-12-15 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
WO2016205740A1 (en) 2015-06-17 2016-12-22 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of appendicitis and differentiation of causes of abdominal pain
CN108291330A (zh) 2015-07-10 2018-07-17 西弗吉尼亚大学 卒中和卒中严重性的标志物
US11192857B2 (en) 2016-05-18 2021-12-07 Alere San Diego, Inc. 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine analogs and methods for their synthesis and use
US11243217B2 (en) 2016-06-06 2022-02-08 Astute Medical, Inc. Management of acute kidney injury using insulin-like growth factor-binding protein 7 and tissue inhibitor of metalloproteinase 2
NL2017267B1 (en) 2016-07-29 2018-02-01 Aduro Biotech Holdings Europe B V Anti-pd-1 antibodies
BR112019006706A2 (pt) 2016-10-03 2019-06-25 Abbott Lab métodos melhorados para avaliar o estado de gfap em amostras de paciente
US11633411B2 (en) 2016-10-04 2023-04-25 University Of Maryland, Baltimore Methods of treating sepsis using anti-sepsis lipid A (ASLA) based therapeutics
NZ753546A (en) 2016-11-08 2022-10-28 Reata Pharmaceuticals Holdings Llc Methods of treating alport syndrome using bardoxolone methyl or analogs thereof
AU2018207151B2 (en) 2017-01-12 2024-02-29 Astute Medical, Inc. Methods and compositions for evaluation and treatment of renal injury and renal failure based on C-C motif chemokine ligand 14 measurement
EP3593134A1 (en) 2017-03-09 2020-01-15 Cleara Biotech B.V. Biomarkers for cellular senescence
CA3052513A1 (en) 2017-03-23 2018-09-27 Abbott Laboratories Methods for aiding in the diagnosis and determination of the extent of traumatic brain injury in a human subject using the early biomarker ubiquitin carboxy-terminal hydrolase l1
CN110546513A (zh) 2017-04-15 2019-12-06 雅培实验室 使用早期生物标记物帮助超急性诊断和确定人类受试者中的创伤性脑损伤的方法
EP3635407A1 (en) 2017-04-28 2020-04-15 Abbott Laboratories Methods for aiding in the hyperacute diagnosis and determination of traumatic brain injury using early biomarkers on at least two samples from the same human subject
US10865238B1 (en) 2017-05-05 2020-12-15 Duke University Complement factor H antibodies
WO2018208684A1 (en) 2017-05-07 2018-11-15 Astute Medical, Inc. Use of insulin-like growth factor-binding protein 7 and tissue inhibitor of metalloproteinase 2 in the management of renal replacement therapy
US10866251B2 (en) 2017-05-25 2020-12-15 Abbott Laboratories Methods for aiding in the determination of whether to perform imaging on a human subject who has sustained or may have sustained an injury to the head using early biomarkers
BR112019025387A2 (pt) 2017-05-30 2020-07-07 Abbott Laboratories métodos para auxiliar no diagnóstico e avaliação de uma lesão traumática cerebral branda em um indivíduo humano com o uso de troponina cardíaca i e biomarcadores precoces
WO2019010131A1 (en) 2017-07-03 2019-01-10 Abbott Laboratories IMPROVED METHODS FOR MEASURING CARBOXY TERMINATION HYDROLASE LEVELS OF UBIQUITIN L1 IN BLOOD
JP7379165B2 (ja) 2017-12-09 2023-11-14 アボット・ラボラトリーズ Ｇｆａｐとｕｃｈ－ｌ１との組合せを使用する、ヒト対象における外傷性脳損傷を診断及び査定する一助となるための方法
JP7344801B2 (ja) 2017-12-09 2023-09-14 アボット・ラボラトリーズ グリア原線維性酸性タンパク質（ｇｆａｐ）及び／又はユビキチンカルボキシ末端ヒドロラーゼｌ１（ｕｃｈ－ｌ１）を使用する、整形外科損傷を負っており、軽度外傷性脳損傷（ｔｂｉ）などの頭部への損傷を負ったか又は負った可能性がある対象についての診断及び査定の一助となるための方法
CN112041341B (zh) 2017-12-28 2024-05-24 机敏医药股份有限公司 Ccl14的抗体和检测
CA3084064A1 (en) 2017-12-29 2019-07-04 Abbott Laboratories Novel biomarkers and methods for diagnosing and evaluating traumatic brain injury
US20210239700A1 (en) 2018-05-04 2021-08-05 Abbott Laboratories Hbv diagnostic, prognostic, and therapeutic methods and products
WO2020051231A1 (en) 2018-09-04 2020-03-12 H. Lee Moffitt Cancer Center & Research Institute Inc. Use of delta-tocotrienol for treating cancer
EP4375669A2 (en) 2018-12-28 2024-05-29 Abbott Laboratories Direct detection of single molecules on microparticles
WO2020144535A1 (en) 2019-01-08 2020-07-16 Aduro Biotech Holdings, Europe B.V. Methods and compositions for treatment of multiple myeloma
EP3931573A1 (en) 2019-03-01 2022-01-05 Abbott Laboratories Methods for predicting major adverse cardiovascular events in subjects with coronary artery disease
CA3175523A1 (en) 2020-04-13 2021-10-21 Antti Virtanen Methods, complexes and kits for detecting or determining an amount of a .beta.-coronavirus antibody in a sample
US20230255982A1 (en) 2020-05-09 2023-08-17 Reata Pharmaceuticals Holdings, LLC Methods of treating covid-19 using bardoxolone methyl or analogs thereof
MX2022015287A (es) 2020-06-01 2023-02-22 Loop Diagnostics S L Metodo y kit para la deteccion temprana de septicemia.
EP4193151A1 (en) 2020-08-04 2023-06-14 Abbott Rapid Diagnostics International Unlimited Company Assays for detecting sars-cov-2
EP4193149A1 (en) 2020-08-04 2023-06-14 Abbott Laboratories Improved methods and kits for detecting sars-cov-2 protein in a sample
WO2022099216A1 (en) * 2020-11-09 2022-05-12 Children's Medical Center Corporation Systems and methods for high throughput screening of molecular interactions
WO2022119841A1 (en) 2020-12-01 2022-06-09 Abbott Laboratories Use of one or more biomarkers to determine traumatic brain injury (tbi) in a subject having received a head computerized tomography scan that is negative for a tbi
WO2023102384A1 (en) 2021-11-30 2023-06-08 Abbott Laboratories Use of one or more biomarkers to determine traumatic brain injury (tbi) in a subject having received a head computerized tomography scan that is negative for a tbi
AU2021397631A1 (en) 2020-12-11 2023-07-20 Reata Pharmaceuticals Holdings, LLC Synthetic triterpenoids for use in therapy
EP4271998A1 (en) 2020-12-30 2023-11-08 Abbott Laboratories Methods for determining sars-cov-2 antigen and anti-sars-cov-2 antibody in a sample
WO2022245920A1 (en) 2021-05-18 2022-11-24 Abbott Laboratories Methods of evaluating brain injury in a pediatric subject
BR112023026199A2 (pt) 2021-06-14 2024-03-05 Abbott Lab Métodos para diagnosticar ou auxiliar no diagnóstico de lesão cerebral causada por energia acústica, energia eletromagnética, onda de sobrepressurização e/ou rajada de vento
WO2023028186A1 (en) 2021-08-27 2023-03-02 Abbott Laboratories Methods for detecting immunoglobulin g, subclass 4 (igg4) in a biological sample
WO2023034777A1 (en) 2021-08-31 2023-03-09 Abbott Laboratories Methods and systems of diagnosing brain injury
CA3232176A1 (en) 2021-09-30 2023-04-06 Beth MCQUISTON Methods and systems of diagnosing brain injury
CA3240822A1 (en) 2021-12-17 2023-06-22 Tony Lee Systems and methods for determining uch-l1, gfap, and other biomarkers in blood samples
WO2023129942A1 (en) 2021-12-28 2023-07-06 Abbott Laboratories Use of biomarkers to determine sub-acute traumatic brain injury (tbi) in a subject having received a head computerized tomography (ct) scan that is negative for a tbi or no head ct scan
WO2023144206A1 (en) 2022-01-27 2023-08-03 Sanofi Pasteur Modified vero cells and methods of using the same for virus production
WO2023150652A1 (en) 2022-02-04 2023-08-10 Abbott Laboratories Lateral flow methods, assays, and devices for detecting the presence or measuring the amount of ubiquitin carboxy-terminal hydrolase l1 and/or glial fibrillary acidic protein in a sample
WO2023212298A1 (en) 2022-04-29 2023-11-02 Broadwing Bio Llc Bispecific antibodies and methods of treating ocular disease
WO2023212293A1 (en) 2022-04-29 2023-11-02 Broadwing Bio Llc Complement factor h related 4-specific antibodies and uses thereof
WO2023212294A1 (en) 2022-04-29 2023-11-02 Broadwing Bio Llc Angiopoietin-related protein 7-specific antibodies and uses thereof
WO2024059692A1 (en) 2022-09-15 2024-03-21 Abbott Laboratories Hbv diagnostic, prognostic, and therapeutic methods and products
WO2024059708A1 (en) 2022-09-15 2024-03-21 Abbott Laboratories Biomarkers and methods for differentiating between mild and supermild traumatic brain injury

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL171930C (nl) * 1972-05-11 1983-06-01 Akzo Nv Werkwijze voor het aantonen en bepalen van haptenen, alsmede testverpakkingen.
US4456716A (en) * 1982-12-29 1984-06-26 Ciba-Geigy Corporation 4-(Hydroxyphenylthio)imide stabilizers
FR2566271B1 (fr) * 1984-06-20 1986-11-07 Sanofi Sa Nouveaux conjugues cytotoxiques utilisables en therapeutique et procede d'obtention
US4981979A (en) * 1987-09-10 1991-01-01 Neorx Corporation Immunoconjugates joined by thioether bonds having reduced toxicity and improved selectivity
US5068227A (en) * 1989-01-18 1991-11-26 Cyclex, Inc. Cyclodextrins as carriers
US5068277A (en) * 1989-05-03 1991-11-26 Rhone-Poulenc Inc. Hydrolyzable silicone polymers

Also Published As

Publication number Publication date
CA2107894C (en) 2003-10-14
CA2107894A1 (en) 1992-10-11
AU1772992A (en) 1992-11-17
JPH06506688A (ja) 1994-07-28
WO1992018868A1 (en) 1992-10-29
ATE177841T1 (de) 1999-04-15
US5525524A (en) 1996-06-11
EP0585310B1 (en) 1999-03-17
DE69228682T2 (de) 1999-07-01
DE69228682D1 (de) 1999-04-22
EP0585310A1 (en) 1994-03-09
EP0585310A4 (en) 1995-06-14
NO933581D0 (no) 1993-10-07
FI934437A (fi) 1993-11-22
FI934437A0 (fi) 1993-10-08

Similar Documents

Publication Publication Date Title
NO933581L (no) "Crosstalk"-inhibitorer og deres anvendelse
DE3885220T2 (de) Toilette mit Vorrichtung zum Feststellen der Zusammensetzung von Urin.
DE68908293T2 (de) Verfahren zur Bestimmung von Bohrbedingungen während des Bohrens.
DK0507831T3 (da) Fremgangsmåde til detektion af knogle- og bindevævssygdomme hos mennesker og dyr
CA2207505A1 (en) Neurological drug screens
GB2233463B (en) Method for determining the relative heat affected zone("haz")toughness of steel
DE69225794T2 (de) Test zur bestimmung von estersubstraten
FI901397A0 (fi) Odlingsunderlag foer vattenodling.
DE69214843D1 (de) Verfahren zum nachweis von beschädigungen des magenepithels
DE68915437D1 (de) Verfahren zur bestimmung des typs und des schweregrades von krankheitszuständen des zahnfleisches.
PL322209A1 (en) Detection of antibody production
DE68906167T2 (de) Zusammensetzung zur erkennung von paradontalen krankheiten.
OA08334A (fr) Protéines de différentiation acino-foetales associées au cancer du pancréas, antisérum et anticorps monoclonaux contre ces protéines, procédés de préparation.
KR890019688U (ko) 자동샤르피 충격시험기
DE68910084T2 (de) Vorrichtung zur Ermittlung der Bespannungshärte von Ballschlägern.
DE69421619T2 (de) Phosphattest
IT1242173B (it) Metodo di analisi quantitativa altamente sensibile di acidi biliari e composizione per la analisi quantitativa.
MA21068A1 (fr) Procede de preparation d'une composition a base d'inhibiteur de l'enzyme de conversion de l'angiotensine .
ATE171545T1 (de) Verfahren zur bestimmung des lysingehaltes von samen
IT8819063A0 (it) Dispositivo per anastomosi vascolari e simili mediante punti metallici.
ATE208901T1 (de) Verfahren zum nachweis einer hormon- bzw. antihormonresistenz bei tumoren
IT8985508A0 (it) Dispositivo per allargare pelli o simili.
KR910009525U (ko) 강판의 온라인(on-line)경도 측정장치
IT8920805A0 (it) Reattivo per la determinazione analitica dell'enzima gamma glutamiltransferasi.
KR890019687U (ko) 로크웰 경도 시험기의 게이지