NO922949L - Forbindelser og fremgangsmaater for inhibering av hiv- og beslektede virus - Google Patents

Forbindelser og fremgangsmaater for inhibering av hiv- og beslektede virus

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Publication number
NO922949L
NO922949L NO92922949A NO922949A NO922949L NO 922949 L NO922949 L NO 922949L NO 92922949 A NO92922949 A NO 92922949A NO 922949 A NO922949 A NO 922949A NO 922949 L NO922949 L NO 922949L
Authority
NO
Norway
Prior art keywords
relationships
procedures
related viruses
inhibiting hiv
hiv
Prior art date
Application number
NO92922949A
Other languages
English (en)
Norwegian (no)
Other versions
NO922949D0 (no
Inventor
Peter Thomas Lind
Jr John Michael Morin
Rolf Noreen
Original Assignee
Medivir Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medivir Ab filed Critical Medivir Ab
Publication of NO922949D0 publication Critical patent/NO922949D0/no
Publication of NO922949L publication Critical patent/NO922949L/no
Priority to NO931339A priority Critical patent/NO931339D0/no
Priority to NO931337A priority patent/NO931337D0/no
Priority to NO931340A priority patent/NO931340D0/no
Priority to NO931338A priority patent/NO931338D0/no

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    • A61K31/17Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
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NO92922949A 1991-08-02 1992-07-24 Forbindelser og fremgangsmaater for inhibering av hiv- og beslektede virus NO922949L (no)

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NO931339A NO931339D0 (no) 1991-08-02 1993-04-07 Forbindelser og fremgangsmaater for inhibering av hiv og beslektede virus
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NO931340A NO931340D0 (no) 1991-08-02 1993-04-07 Forbindelser og fremgangsmaater for inhibering av hiv og beslektede virus
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Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5593993A (en) * 1991-08-02 1997-01-14 Medivir Ab Method for inhibition of HIV related viruses
AU687440B2 (en) * 1993-08-24 1998-02-26 Medivir Ab Compounds and methods for inhibition of HIV and related viruses
US6156924A (en) * 1996-05-06 2000-12-05 Eli Lilly And Company Anti-viral compounds
CA2253405A1 (en) * 1996-05-06 1997-11-13 William Joseph Hornback Anti-viral compounds
WO1997042155A1 (en) * 1996-05-06 1997-11-13 Eli Lilly And Company Anti-viral compounds
US6127422A (en) * 1996-05-06 2000-10-03 Eli Lilly And Company Anti-viral method
US6103923A (en) * 1996-05-06 2000-08-15 Eli Lilly And Company Anti-viral compounds
DE69704180T2 (de) 1996-05-06 2001-08-30 Eli Lilly And Co., Indianapolis Antivirusverbindungen
EP0806205A3 (en) * 1996-05-06 1997-11-19 Eli Lilly And Company Urea, thiourea and guanidine compounds and their use as anti-viral agents
US6096917A (en) * 1997-05-02 2000-08-01 Eli Lilly And Company Anti-viral compounds
US5998411A (en) 1998-03-17 1999-12-07 Hughes Institute Heterocyclic nonnucleoside inhibitors of reverse transcriptase
US6136335A (en) 1998-12-31 2000-10-24 Hughes Institute Phenethyl-5-bromopyridylthiourea (PBT) and dihydroalkoxybenzyloxopyrimidine (DABO) derivatives exhibiting spermicidal activity
US7186736B1 (en) * 1999-03-20 2007-03-06 Parker Hughes Institute NNI for treatment of multi-drug resistant HIV
US6340696B1 (en) 1999-03-31 2002-01-22 The Procter & Gamble Company Viral treatment
US6258831B1 (en) 1999-03-31 2001-07-10 The Procter & Gamble Company Viral treatment
US6245788B1 (en) 1999-03-31 2001-06-12 The Procter & Gamble Company Viral treatment
US6124324A (en) * 1999-06-23 2000-09-26 Hughes Institute Thiophene-ethyl thiourea compounds and use
US6469034B1 (en) * 1999-06-23 2002-10-22 Parker Hughes Institute Cyclohexenyl-ethyl-thiourea compounds for inhibiting HIV reverse transcriptase
US6207688B1 (en) 1999-06-23 2001-03-27 Parker Hughes Institute Phenethyl-thiourea compounds and use
GB2361473C (en) * 2000-03-08 2005-06-28 Microgenics Corp Ecstasy-class analogs and use of same in detection of ecstasy-class compounds
US6175034B1 (en) 2000-04-10 2001-01-16 Eli Lilly And Company Anti-viral compounds
US6774139B1 (en) 2000-06-30 2004-08-10 Parker Hughes Institute Dual function microbicides
US6545152B1 (en) 2000-07-18 2003-04-08 Parker Hughes Institute R-isomers of nonnucleoside inhibitors
CA2426148A1 (en) * 2000-10-19 2002-04-25 Taracad K. Venkatachalam Aromatic and heterocyclic thiazolyl thiourea compounds and use
US6689793B2 (en) 2000-12-06 2004-02-10 Parker Hughes Institute Piperidinylethyl-, phenoxyethyl-, and β-fluorophenethyl-substituted thiourea compounds with potent anti-HIV activity
SE0100733D0 (sv) 2001-03-05 2001-03-05 Medivir Ab Non-nucleoside reverse transcriptase inhibitors
SE0102867D0 (sv) 2001-08-28 2001-08-28 Medivir Ab Non-nucleoside reverse transcriptase inhibitors
US20050096319A1 (en) * 2003-02-21 2005-05-05 Balzarini Jan M.R. Identification of compounds that inhibit replication of human immunodeficiency virus
CA2720552C (en) * 2008-04-10 2016-06-14 Taiho Pharmaceutical Co., Ltd. Acylthiourea compound or salt thereof, and use thereof
KR101064258B1 (ko) * 2008-12-29 2011-09-14 한국과학기술연구원 벤조아릴우레이도 화합물, 및 이를 함유하는 퇴행성 뇌질환예방 또는 치료용 조성물
LT3019476T (lt) 2013-07-08 2018-04-10 Syngenta Participations Ag 4 narių žiedo karboksamidai, naudojami kaip nematicidai

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA689412A (en) * 1964-06-23 Berger Arthur Preparation of 3-allyl-5-isobutyl-2-thiohydantoin
US3061640A (en) * 1959-03-30 1962-10-30 Monsanto Chemicals 3, 4-dichlorophenyl dialkylaminoalkyl ureas and thioureas
CH1631464A4 (he) * 1964-12-17 1966-10-15
FR1471681A (he) * 1965-03-25 1967-05-25
GB1310224A (en) * 1969-07-22 1973-03-14 Lilly Industries Ltd Oxazole thioureas
NL7108189A (he) * 1970-07-24 1972-01-26
CH543535A (de) * 1970-07-24 1973-10-31 Hoffmann La Roche Verfahren zur Herstellung von Thiazolderivaten
DE2132431A1 (de) * 1971-06-30 1973-01-11 Riedel De Haen Ag 4-phenyl-thiazolderivate enthaltende pharmazeutische praeparate
DE2136233A1 (de) * 1971-07-20 1973-02-01 Riedel De Haen Ag Tetrahydrobenzthiazolderivate enthaltende pharmazeutische praeparate
SU517587A1 (ru) * 1971-08-23 1976-06-15 Медицинска Академие (Инопредприятие) Способ получени производных 2оксфенилмочевины
US4048333A (en) * 1971-08-23 1977-09-13 Medizinska Akademia Method for treating a picorna virus infection
GB1354830A (en) * 1972-08-31 1974-06-05 Dainippon Pharmaceutical Co 1,3-disubstituted thiourea compounds their preparation and use
US3950537A (en) 1973-06-29 1976-04-13 Rohm And Haas Company Gastrointestinally active thioureas
HU168393B (he) * 1973-11-09 1976-04-28
US3891769A (en) 1974-02-01 1975-06-24 Dow Chemical Co Psychotherapeutic methods employing thioureas
US3950538A (en) * 1974-03-18 1976-04-13 The Dow Chemical Company Anti-inflammatory methods utilizing certain thioureas
BE819436A (fr) * 1974-08-30 1975-02-28 Composition pharmaceutique renfermant des pyridylthiourees.
GB1489879A (en) * 1974-12-20 1977-10-26 Leo Pharm Prod Ltd N'-cyano-n'-3-pyridylguanidines
DD123466A1 (he) * 1975-12-01 1976-12-20
US4096276A (en) * 1976-04-15 1978-06-20 Hoffmann-La Roche Inc. Thiourea derivatives for treating hypertension
DK543178A (da) * 1977-12-01 1979-06-02 Wellcome Found Thiodydantoinderivater
JPS604830B2 (ja) * 1979-04-24 1985-02-06 株式会社 大塚製薬工場 フエニル酢酸誘導体
PL137012B1 (en) * 1982-05-27 1986-04-30 Politechnika Gdanska Process for preparing 3,5-substituted derivatives of 2-thiohydantoin
US4724232A (en) * 1985-03-16 1988-02-09 Burroughs Wellcome Co. Treatment of human viral infections
ATE44464T1 (de) * 1985-03-16 1989-07-15 Wellcome Found Antivirale nukleoside.
DE3607381A1 (de) * 1986-03-06 1987-09-10 Pascal Zimmer Verwendung von diphenylhydantoin und seinen derivaten zur behandlung von immunerkrankungen
US4880836A (en) * 1988-03-11 1989-11-14 Danek Elbaum Antiviral amphiphilics
DE3815046A1 (de) * 1988-05-04 1989-11-16 Basf Ag 3-chlor-2-methylphenethylaminoderivate
IL93136A (he) * 1989-02-23 1995-01-24 Janssen Pharmaceutica Nv תולדות טטראהידרואימידאזו ]1,4[ בנזודיאזפין-2-תיון, הכנתן ותכשירי רוקחות המכילים אותן
GB8908063D0 (en) * 1989-04-11 1989-05-24 Beecham Group Plc Novel compounds

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EP0540143B1 (en) 2003-02-05
AU2407492A (en) 1993-03-02
ATE232095T1 (de) 2003-02-15
HU9202477D0 (en) 1992-10-28
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AP384A (en) 1995-05-15
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ZA925663B (en) 1994-01-28
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CA2075173C (en) 2007-04-24
ES2051641B1 (es) 1995-10-01
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NO922949D0 (no) 1992-07-24
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CZ228892A3 (en) 1993-05-12
RU2106341C1 (ru) 1998-03-10
KR100252453B1 (ko) 2000-07-01
FI923443A (fi) 1993-02-03
AP9500723A0 (en) 1995-04-30
CA2075173A1 (en) 1993-02-03
AP9200412A0 (en) 1992-07-31
EP0540143A2 (en) 1993-05-05
AU657978B2 (en) 1995-03-30
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