NO922949L - Forbindelser og fremgangsmaater for inhibering av hiv- og beslektede virus - Google Patents
Forbindelser og fremgangsmaater for inhibering av hiv- og beslektede virusInfo
- Publication number
- NO922949L NO922949L NO92922949A NO922949A NO922949L NO 922949 L NO922949 L NO 922949L NO 92922949 A NO92922949 A NO 92922949A NO 922949 A NO922949 A NO 922949A NO 922949 L NO922949 L NO 922949L
- Authority
- NO
- Norway
- Prior art keywords
- relationships
- procedures
- related viruses
- inhibiting hiv
- hiv
- Prior art date
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- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61K31/415—1,2-Diazoles
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- C07D241/20—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
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- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
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- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
- C07D257/06—Five-membered rings with nitrogen atoms directly attached to the ring carbon atom
-
- C—CHEMISTRY; METALLURGY
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- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
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- C07D263/48—Nitrogen atoms not forming part of a nitro radical
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- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
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- C07D275/03—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
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- C07D277/18—Nitrogen atoms
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- C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
-
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- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
- C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
- C07D285/135—Nitrogen atoms
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- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- AIDS & HIV (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
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NO931339A NO931339D0 (no) | 1991-08-02 | 1993-04-07 | Forbindelser og fremgangsmaater for inhibering av hiv og beslektede virus |
NO931337A NO931337D0 (no) | 1991-08-02 | 1993-04-07 | Forbindelser og fremgangsmaater for inhibering av hiv og beslektede virus |
NO931340A NO931340D0 (no) | 1991-08-02 | 1993-04-07 | Forbindelser og fremgangsmaater for inhibering av hiv og beslektede virus |
NO931338A NO931338D0 (no) | 1991-08-02 | 1993-04-07 | Forbindelser og fremgangsmaater for inhibering av hiv og beslektede virus |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US73992791A | 1991-08-02 | 1991-08-02 |
Publications (2)
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NO922949D0 NO922949D0 (no) | 1992-07-24 |
NO922949L true NO922949L (no) | 1993-02-03 |
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Family Applications (1)
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NO92922949A NO922949L (no) | 1991-08-02 | 1992-07-24 | Forbindelser og fremgangsmaater for inhibering av hiv- og beslektede virus |
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EP (1) | EP0540143B1 (he) |
JP (1) | JP3383328B2 (he) |
KR (1) | KR100252453B1 (he) |
CN (1) | CN1069882A (he) |
AP (2) | AP388A (he) |
AT (1) | ATE232095T1 (he) |
AU (2) | AU657978B2 (he) |
BG (1) | BG98623A (he) |
CA (1) | CA2075173C (he) |
CZ (1) | CZ282900B6 (he) |
DE (1) | DE69232919T2 (he) |
ES (1) | ES2051641B1 (he) |
FI (1) | FI923443A (he) |
HU (2) | HU9202477D0 (he) |
IL (1) | IL102548A (he) |
MX (1) | MX9204454A (he) |
NO (1) | NO922949L (he) |
OA (1) | OA09914A (he) |
RU (1) | RU2106341C1 (he) |
TW (1) | TW252110B (he) |
WO (1) | WO1993003022A1 (he) |
YU (1) | YU74292A (he) |
ZA (1) | ZA925663B (he) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
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US5593993A (en) * | 1991-08-02 | 1997-01-14 | Medivir Ab | Method for inhibition of HIV related viruses |
AU687440B2 (en) * | 1993-08-24 | 1998-02-26 | Medivir Ab | Compounds and methods for inhibition of HIV and related viruses |
US6156924A (en) * | 1996-05-06 | 2000-12-05 | Eli Lilly And Company | Anti-viral compounds |
CA2253405A1 (en) * | 1996-05-06 | 1997-11-13 | William Joseph Hornback | Anti-viral compounds |
WO1997042155A1 (en) * | 1996-05-06 | 1997-11-13 | Eli Lilly And Company | Anti-viral compounds |
US6127422A (en) * | 1996-05-06 | 2000-10-03 | Eli Lilly And Company | Anti-viral method |
US6103923A (en) * | 1996-05-06 | 2000-08-15 | Eli Lilly And Company | Anti-viral compounds |
DE69704180T2 (de) | 1996-05-06 | 2001-08-30 | Eli Lilly And Co., Indianapolis | Antivirusverbindungen |
EP0806205A3 (en) * | 1996-05-06 | 1997-11-19 | Eli Lilly And Company | Urea, thiourea and guanidine compounds and their use as anti-viral agents |
US6096917A (en) * | 1997-05-02 | 2000-08-01 | Eli Lilly And Company | Anti-viral compounds |
US5998411A (en) | 1998-03-17 | 1999-12-07 | Hughes Institute | Heterocyclic nonnucleoside inhibitors of reverse transcriptase |
US6136335A (en) | 1998-12-31 | 2000-10-24 | Hughes Institute | Phenethyl-5-bromopyridylthiourea (PBT) and dihydroalkoxybenzyloxopyrimidine (DABO) derivatives exhibiting spermicidal activity |
US7186736B1 (en) * | 1999-03-20 | 2007-03-06 | Parker Hughes Institute | NNI for treatment of multi-drug resistant HIV |
US6340696B1 (en) | 1999-03-31 | 2002-01-22 | The Procter & Gamble Company | Viral treatment |
US6258831B1 (en) | 1999-03-31 | 2001-07-10 | The Procter & Gamble Company | Viral treatment |
US6245788B1 (en) | 1999-03-31 | 2001-06-12 | The Procter & Gamble Company | Viral treatment |
US6124324A (en) * | 1999-06-23 | 2000-09-26 | Hughes Institute | Thiophene-ethyl thiourea compounds and use |
US6469034B1 (en) * | 1999-06-23 | 2002-10-22 | Parker Hughes Institute | Cyclohexenyl-ethyl-thiourea compounds for inhibiting HIV reverse transcriptase |
US6207688B1 (en) | 1999-06-23 | 2001-03-27 | Parker Hughes Institute | Phenethyl-thiourea compounds and use |
GB2361473C (en) * | 2000-03-08 | 2005-06-28 | Microgenics Corp | Ecstasy-class analogs and use of same in detection of ecstasy-class compounds |
US6175034B1 (en) | 2000-04-10 | 2001-01-16 | Eli Lilly And Company | Anti-viral compounds |
US6774139B1 (en) | 2000-06-30 | 2004-08-10 | Parker Hughes Institute | Dual function microbicides |
US6545152B1 (en) | 2000-07-18 | 2003-04-08 | Parker Hughes Institute | R-isomers of nonnucleoside inhibitors |
CA2426148A1 (en) * | 2000-10-19 | 2002-04-25 | Taracad K. Venkatachalam | Aromatic and heterocyclic thiazolyl thiourea compounds and use |
US6689793B2 (en) | 2000-12-06 | 2004-02-10 | Parker Hughes Institute | Piperidinylethyl-, phenoxyethyl-, and β-fluorophenethyl-substituted thiourea compounds with potent anti-HIV activity |
SE0100733D0 (sv) | 2001-03-05 | 2001-03-05 | Medivir Ab | Non-nucleoside reverse transcriptase inhibitors |
SE0102867D0 (sv) | 2001-08-28 | 2001-08-28 | Medivir Ab | Non-nucleoside reverse transcriptase inhibitors |
US20050096319A1 (en) * | 2003-02-21 | 2005-05-05 | Balzarini Jan M.R. | Identification of compounds that inhibit replication of human immunodeficiency virus |
CA2720552C (en) * | 2008-04-10 | 2016-06-14 | Taiho Pharmaceutical Co., Ltd. | Acylthiourea compound or salt thereof, and use thereof |
KR101064258B1 (ko) * | 2008-12-29 | 2011-09-14 | 한국과학기술연구원 | 벤조아릴우레이도 화합물, 및 이를 함유하는 퇴행성 뇌질환예방 또는 치료용 조성물 |
LT3019476T (lt) | 2013-07-08 | 2018-04-10 | Syngenta Participations Ag | 4 narių žiedo karboksamidai, naudojami kaip nematicidai |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
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CA689412A (en) * | 1964-06-23 | Berger Arthur | Preparation of 3-allyl-5-isobutyl-2-thiohydantoin | |
US3061640A (en) * | 1959-03-30 | 1962-10-30 | Monsanto Chemicals | 3, 4-dichlorophenyl dialkylaminoalkyl ureas and thioureas |
CH1631464A4 (he) * | 1964-12-17 | 1966-10-15 | ||
FR1471681A (he) * | 1965-03-25 | 1967-05-25 | ||
GB1310224A (en) * | 1969-07-22 | 1973-03-14 | Lilly Industries Ltd | Oxazole thioureas |
NL7108189A (he) * | 1970-07-24 | 1972-01-26 | ||
CH543535A (de) * | 1970-07-24 | 1973-10-31 | Hoffmann La Roche | Verfahren zur Herstellung von Thiazolderivaten |
DE2132431A1 (de) * | 1971-06-30 | 1973-01-11 | Riedel De Haen Ag | 4-phenyl-thiazolderivate enthaltende pharmazeutische praeparate |
DE2136233A1 (de) * | 1971-07-20 | 1973-02-01 | Riedel De Haen Ag | Tetrahydrobenzthiazolderivate enthaltende pharmazeutische praeparate |
SU517587A1 (ru) * | 1971-08-23 | 1976-06-15 | Медицинска Академие (Инопредприятие) | Способ получени производных 2оксфенилмочевины |
US4048333A (en) * | 1971-08-23 | 1977-09-13 | Medizinska Akademia | Method for treating a picorna virus infection |
GB1354830A (en) * | 1972-08-31 | 1974-06-05 | Dainippon Pharmaceutical Co | 1,3-disubstituted thiourea compounds their preparation and use |
US3950537A (en) | 1973-06-29 | 1976-04-13 | Rohm And Haas Company | Gastrointestinally active thioureas |
HU168393B (he) * | 1973-11-09 | 1976-04-28 | ||
US3891769A (en) | 1974-02-01 | 1975-06-24 | Dow Chemical Co | Psychotherapeutic methods employing thioureas |
US3950538A (en) * | 1974-03-18 | 1976-04-13 | The Dow Chemical Company | Anti-inflammatory methods utilizing certain thioureas |
BE819436A (fr) * | 1974-08-30 | 1975-02-28 | Composition pharmaceutique renfermant des pyridylthiourees. | |
GB1489879A (en) * | 1974-12-20 | 1977-10-26 | Leo Pharm Prod Ltd | N'-cyano-n'-3-pyridylguanidines |
DD123466A1 (he) * | 1975-12-01 | 1976-12-20 | ||
US4096276A (en) * | 1976-04-15 | 1978-06-20 | Hoffmann-La Roche Inc. | Thiourea derivatives for treating hypertension |
DK543178A (da) * | 1977-12-01 | 1979-06-02 | Wellcome Found | Thiodydantoinderivater |
JPS604830B2 (ja) * | 1979-04-24 | 1985-02-06 | 株式会社 大塚製薬工場 | フエニル酢酸誘導体 |
PL137012B1 (en) * | 1982-05-27 | 1986-04-30 | Politechnika Gdanska | Process for preparing 3,5-substituted derivatives of 2-thiohydantoin |
US4724232A (en) * | 1985-03-16 | 1988-02-09 | Burroughs Wellcome Co. | Treatment of human viral infections |
ATE44464T1 (de) * | 1985-03-16 | 1989-07-15 | Wellcome Found | Antivirale nukleoside. |
DE3607381A1 (de) * | 1986-03-06 | 1987-09-10 | Pascal Zimmer | Verwendung von diphenylhydantoin und seinen derivaten zur behandlung von immunerkrankungen |
US4880836A (en) * | 1988-03-11 | 1989-11-14 | Danek Elbaum | Antiviral amphiphilics |
DE3815046A1 (de) * | 1988-05-04 | 1989-11-16 | Basf Ag | 3-chlor-2-methylphenethylaminoderivate |
IL93136A (he) * | 1989-02-23 | 1995-01-24 | Janssen Pharmaceutica Nv | תולדות טטראהידרואימידאזו ]1,4[ בנזודיאזפין-2-תיון, הכנתן ותכשירי רוקחות המכילים אותן |
GB8908063D0 (en) * | 1989-04-11 | 1989-05-24 | Beecham Group Plc | Novel compounds |
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1992
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- 1992-07-30 YU YU74292A patent/YU74292A/sh unknown
- 1992-07-30 RU SU5052783A patent/RU2106341C1/ru active
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- 1992-07-30 FI FI923443A patent/FI923443A/fi unknown
- 1992-07-31 CA CA002075173A patent/CA2075173C/en not_active Expired - Fee Related
- 1992-07-31 KR KR1019920013801A patent/KR100252453B1/ko not_active IP Right Cessation
- 1992-07-31 JP JP22521892A patent/JP3383328B2/ja not_active Expired - Fee Related
- 1992-08-03 AT AT92307092T patent/ATE232095T1/de not_active IP Right Cessation
- 1992-08-03 EP EP92307092A patent/EP0540143B1/en not_active Expired - Lifetime
- 1992-08-03 AU AU24074/92A patent/AU2407492A/en not_active Abandoned
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1994
- 1994-01-28 OA OA60464A patent/OA09914A/en unknown
- 1994-02-28 BG BG98623A patent/BG98623A/bg unknown
-
1995
- 1995-06-22 HU HU95P/P00395P patent/HU211164A9/hu unknown
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