NO912864L - Stedsspesifikk in vivo-aktivering av terapeutiske forbindelser - Google Patents
Stedsspesifikk in vivo-aktivering av terapeutiske forbindelserInfo
- Publication number
- NO912864L NO912864L NO91912864A NO912864A NO912864L NO 912864 L NO912864 L NO 912864L NO 91912864 A NO91912864 A NO 91912864A NO 912864 A NO912864 A NO 912864A NO 912864 L NO912864 L NO 912864L
- Authority
- NO
- Norway
- Prior art keywords
- activator
- prodrug
- target tissue
- targeting moiety
- vivo activation
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6891—Pre-targeting systems involving an antibody for targeting specific cells
- A61K47/6899—Antibody-Directed Enzyme Prodrug Therapy [ADEPT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Nanotechnology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
1. Aktivator-målsøkingsdel-konjugat, karakterisert ved at det omfatter lysozym som aktivator og et humant monoklonalt antistoff eller et fragment av dette som målsøkingsdel. 2. Prodroge, karakterisert ved at den omfatter et anti- kreftmiddel som bærer et spaltbart molekyl som hindrer celle- opptak. 3. Prodroge ifølge krav 2, karakterisert ved at den omfatter et anti- kreftmiddel som er derivatisert med et kitinoligomer-avstands- materiale. 4. Prodroge ifølge krav 3, karakterisert ved at antikreftmidlet er et antracyklin. 5. Prodroge ifølge krav 4, karakterisert ved at kitinoligomer-avstands- materialet er festet via en aminogruppe på et sted valgt fra gruppen som består av C13-karbonylstedet på antracyklinet og sukkerdelen av antracyklinet. 6. Prodroge ifølge krav 5, karakterisert ved at kitinoligomer-derivatet inneholder (GlcNAc)n, hvor n er 1-10, som bærer negativt ladede grupper og en reaktiv gruppe som gir mulighet for kovalent festing til antracyklinet. 7. Prodroge ifølge krav 6, karakterisert ved at de negativt ladede grupper representerer sulfonater, fosfater, karboksylater eller fosfonater. 8. Prodroge ifølge krav 6, karakterisert ved at antallet negativt ladede grupper er fra l til 10. 9. Prodroge ifølge krav 3, karakterisert ved at kitinoligoroer-avstands- materialet er bundet kovalent til drogen via en aktiv gruppe valgt blant disulfid-, tioester-, imid-, halogen-, amin-, karboksyl-, ester-, tiol- og alkoholgrupper. 10. Prodroge ifølge krav 6, karakterisert ved at den reaktive gruppe er valgt blant disulfid-, tioester-, imid-, halogen-, amin-, karboksyl-, ester-, tiol- og alkoholgrupper.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30099989A | 1989-01-23 | 1989-01-23 | |
PCT/US1990/000503 WO1990007929A1 (en) | 1989-01-23 | 1990-01-23 | Site specific in-vivo activation of therapeutic drugs |
Publications (2)
Publication Number | Publication Date |
---|---|
NO912864D0 NO912864D0 (no) | 1991-07-22 |
NO912864L true NO912864L (no) | 1991-09-19 |
Family
ID=23161497
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO91912864A NO912864L (no) | 1989-01-23 | 1991-07-22 | Stedsspesifikk in vivo-aktivering av terapeutiske forbindelser |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0454783B1 (no) |
JP (1) | JP3273608B2 (no) |
KR (1) | KR0185967B1 (no) |
AT (1) | ATE123414T1 (no) |
AU (1) | AU648015B2 (no) |
CA (1) | CA2025899A1 (no) |
DE (1) | DE69019959T2 (no) |
DK (1) | DK0454783T3 (no) |
ES (1) | ES2075893T3 (no) |
FI (1) | FI97692C (no) |
NO (1) | NO912864L (no) |
WO (1) | WO1990007929A1 (no) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5773435A (en) * | 1987-08-04 | 1998-06-30 | Bristol-Myers Squibb Company | Prodrugs for β-lactamase and uses thereof |
US5851527A (en) * | 1988-04-18 | 1998-12-22 | Immunomedics, Inc. | Method for antibody targeting of therapeutic agents |
ATE233100T1 (de) * | 1989-08-02 | 2003-03-15 | Mitra Medical Technology Ab | System zur verwendung in einem verfahren zur therapeutischen und diagnostischen behandlung |
DE4106389A1 (de) * | 1991-02-28 | 1992-09-03 | Behringwerke Ag | Fusionsproteine zur prodrug-aktivierung, ihre herstellung und verwendung |
US6610299B1 (en) | 1989-10-19 | 2003-08-26 | Aventis Pharma Deutschland Gmbh | Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates |
US6475486B1 (en) | 1990-10-18 | 2002-11-05 | Aventis Pharma Deutschland Gmbh | Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates |
US7241595B2 (en) | 1989-10-20 | 2007-07-10 | Sanofi-Aventis Pharma Deutschland Gmbh | Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates |
ATE177321T1 (de) * | 1989-12-11 | 1999-03-15 | Immunomedics Inc | Verfahren zum aufspüren von diagnostischen oder therapeutischen mitteln durch antikörper |
SE9100142L (sv) | 1991-01-17 | 1992-07-18 | Bengt Sandberg | En metod och ett system foer foerbaettrad in vivo reducering av diagnostiska och/eller terapeutiska substanser medelst extrakorporeal borttagning, och anvaendandet av naemnda substanser foer detta aendamaal |
FR2676058B1 (fr) * | 1991-04-30 | 1994-02-25 | Hoechst Lab | Prodrogues glycosylees, leur procede de preparation et leur utilisation dans le traitement des cancers. |
AU4663493A (en) * | 1992-07-06 | 1994-01-31 | Hybritech Incorporated | Method for delivery of cytotoxic agents and components thereof |
GB9323429D0 (en) * | 1993-11-12 | 1994-01-05 | Wellcome Found | Therapy |
BR9510490B1 (pt) * | 1994-12-23 | 2010-10-05 | composição farmacêutica combinada de dois componentes estruturada para uso em um hospedeiro. | |
BR9610050A (pt) | 1995-08-16 | 1999-10-13 | Zeneca Ltd | Conjugado,sitemas de dois componentes combinados destinados a uso em um hospedeiro, compostos ou um sal destes famaceuticamente aceitavel,enzima,sequencia de polinucleotìdeos e de02 nucleotìdeos,vetor, célula hospedeira,processos de producão de uma enzima e de um conjugado e de tratamento de célulasneoplásticas em um hospedeiro,composicão farmaceutica e plasmìdeo |
ATE316799T1 (de) * | 1996-03-12 | 2006-02-15 | Sanofi Aventis Deutschland | Neuartige prodrugs für die therapie von tumoren und entzündlichen erkrankungen |
PL229108B1 (pl) * | 2014-08-22 | 2018-06-29 | Celther Polska Spolka Z Ograniczona Odpowiedzialnoscia | Sposób wydzielania i oczyszczania estrów chityny (mono-, di‑podstawionych) oraz kopoliestrów chityny z mieszanin poreakcyjnych |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4067774A (en) * | 1971-05-14 | 1978-01-10 | Syva Company | Compounds for enzyme amplification assay |
LU85581A1 (fr) * | 1984-10-10 | 1986-06-11 | Smb Lab | Ensembles d'anticorps monoclonaux diriges contre la lactoferrine humaine et le lysozyme humain |
JPS62138496A (ja) * | 1985-12-11 | 1987-06-22 | Ihara Chem Ind Co Ltd | キチンオリゴマ−の製造方法 |
ATE137674T1 (de) * | 1987-07-02 | 1996-05-15 | Akzo Nobel Nv | Von mca 16-88 erkanntes antigen |
NZ225599A (en) * | 1987-08-04 | 1991-09-25 | Bristol Myers Co | Antibody-enzyme conjugates and combinations with prodrugs for the treatment of tumour cells |
ZA893284B (en) * | 1988-05-04 | 1990-03-28 | Igen Inc | Peptide analogs and their use as haptens to elicit catalytic antibodies |
-
1990
- 1990-01-23 KR KR1019900702129A patent/KR0185967B1/ko not_active IP Right Cessation
- 1990-01-23 DE DE69019959T patent/DE69019959T2/de not_active Expired - Fee Related
- 1990-01-23 CA CA002025899A patent/CA2025899A1/en not_active Abandoned
- 1990-01-23 DK DK90902934.0T patent/DK0454783T3/da active
- 1990-01-23 AU AU50397/90A patent/AU648015B2/en not_active Ceased
- 1990-01-23 EP EP90902934A patent/EP0454783B1/en not_active Revoked
- 1990-01-23 WO PCT/US1990/000503 patent/WO1990007929A1/en not_active Application Discontinuation
- 1990-01-23 AT AT90902934T patent/ATE123414T1/de not_active IP Right Cessation
- 1990-01-23 JP JP50311690A patent/JP3273608B2/ja not_active Expired - Fee Related
- 1990-01-23 ES ES90902934T patent/ES2075893T3/es not_active Expired - Lifetime
-
1991
- 1991-07-22 FI FI913511A patent/FI97692C/fi active
- 1991-07-22 NO NO91912864A patent/NO912864L/no unknown
Also Published As
Publication number | Publication date |
---|---|
FI97692B (fi) | 1996-10-31 |
DE69019959T2 (de) | 1995-10-05 |
AU648015B2 (en) | 1994-04-14 |
JP3273608B2 (ja) | 2002-04-08 |
DK0454783T3 (da) | 1995-10-16 |
AU5039790A (en) | 1990-08-13 |
EP0454783B1 (en) | 1995-06-07 |
KR0185967B1 (ko) | 1999-05-01 |
JPH04503068A (ja) | 1992-06-04 |
EP0454783A1 (en) | 1991-11-06 |
WO1990007929A1 (en) | 1990-07-26 |
CA2025899A1 (en) | 1990-07-24 |
NO912864D0 (no) | 1991-07-22 |
KR910700072A (ko) | 1991-03-13 |
ATE123414T1 (de) | 1995-06-15 |
FI97692C (fi) | 1997-02-10 |
DE69019959D1 (de) | 1995-07-13 |
FI913511A0 (fi) | 1991-07-22 |
ES2075893T3 (es) | 1995-10-16 |
EP0454783A4 (en) | 1992-01-15 |
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