FI913511A0 - Menetelmä terapeuttisesti käyttökelpoisen aktivaattori-kohdistusosa -konjugaatin ja esilääkkeen valmistamiseksi - Google Patents
Menetelmä terapeuttisesti käyttökelpoisen aktivaattori-kohdistusosa -konjugaatin ja esilääkkeen valmistamiseksiInfo
- Publication number
- FI913511A0 FI913511A0 FI913511A FI913511A FI913511A0 FI 913511 A0 FI913511 A0 FI 913511A0 FI 913511 A FI913511 A FI 913511A FI 913511 A FI913511 A FI 913511A FI 913511 A0 FI913511 A0 FI 913511A0
- Authority
- FI
- Finland
- Prior art keywords
- activator
- targeting moiety
- prodrug
- target tissue
- preparing
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6891—Pre-targeting systems involving an antibody for targeting specific cells
- A61K47/6899—Antibody-Directed Enzyme Prodrug Therapy [ADEPT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Nanotechnology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Cardiology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30099989A | 1989-01-23 | 1989-01-23 | |
US30099989 | 1989-01-23 | ||
US9000503 | 1990-01-23 | ||
PCT/US1990/000503 WO1990007929A1 (en) | 1989-01-23 | 1990-01-23 | Site specific in-vivo activation of therapeutic drugs |
Publications (3)
Publication Number | Publication Date |
---|---|
FI913511A0 true FI913511A0 (fi) | 1991-07-22 |
FI97692B FI97692B (fi) | 1996-10-31 |
FI97692C FI97692C (fi) | 1997-02-10 |
Family
ID=23161497
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI913511A FI97692C (fi) | 1989-01-23 | 1991-07-22 | Menetelmä terapeuttisesti käyttökelpoisen aktivaattori-kohdistusosa -konjugaatin ja esilääkkeen valmistamiseksi |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0454783B1 (fi) |
JP (1) | JP3273608B2 (fi) |
KR (1) | KR0185967B1 (fi) |
AT (1) | ATE123414T1 (fi) |
AU (1) | AU648015B2 (fi) |
CA (1) | CA2025899A1 (fi) |
DE (1) | DE69019959T2 (fi) |
DK (1) | DK0454783T3 (fi) |
ES (1) | ES2075893T3 (fi) |
FI (1) | FI97692C (fi) |
NO (1) | NO912864L (fi) |
WO (1) | WO1990007929A1 (fi) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5773435A (en) * | 1987-08-04 | 1998-06-30 | Bristol-Myers Squibb Company | Prodrugs for β-lactamase and uses thereof |
US5851527A (en) * | 1988-04-18 | 1998-12-22 | Immunomedics, Inc. | Method for antibody targeting of therapeutic agents |
DE69034042T2 (de) * | 1989-08-02 | 2003-07-17 | Mitra Medical Technology Ab Lu | System zur verwendung in einem verfahren zur therapeutischen und diagnostischen behandlung |
DE4106389A1 (de) * | 1991-02-28 | 1992-09-03 | Behringwerke Ag | Fusionsproteine zur prodrug-aktivierung, ihre herstellung und verwendung |
US6610299B1 (en) | 1989-10-19 | 2003-08-26 | Aventis Pharma Deutschland Gmbh | Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates |
US6475486B1 (en) | 1990-10-18 | 2002-11-05 | Aventis Pharma Deutschland Gmbh | Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates |
US7241595B2 (en) | 1989-10-20 | 2007-07-10 | Sanofi-Aventis Pharma Deutschland Gmbh | Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates |
EP0505357B1 (en) * | 1989-12-11 | 1999-03-10 | Immunomedics, Inc. | Method for antibody targeting of diagnostic or therapeutic agents |
SE9100142L (sv) * | 1991-01-17 | 1992-07-18 | Bengt Sandberg | En metod och ett system foer foerbaettrad in vivo reducering av diagnostiska och/eller terapeutiska substanser medelst extrakorporeal borttagning, och anvaendandet av naemnda substanser foer detta aendamaal |
FR2676058B1 (fr) * | 1991-04-30 | 1994-02-25 | Hoechst Lab | Prodrogues glycosylees, leur procede de preparation et leur utilisation dans le traitement des cancers. |
AU4663493A (en) * | 1992-07-06 | 1994-01-31 | Hybritech Incorporated | Method for delivery of cytotoxic agents and components thereof |
GB9323429D0 (en) * | 1993-11-12 | 1994-01-05 | Wellcome Found | Therapy |
EP0806964B1 (en) * | 1994-12-23 | 2002-08-14 | AstraZeneca AB | Chemical compounds |
KR19990036383A (ko) | 1995-08-16 | 1999-05-25 | 크로우 캐씨 엘 | 화학적 화합물 |
ATE316799T1 (de) * | 1996-03-12 | 2006-02-15 | Sanofi Aventis Deutschland | Neuartige prodrugs für die therapie von tumoren und entzündlichen erkrankungen |
PL229108B1 (pl) * | 2014-08-22 | 2018-06-29 | Celther Polska Spolka Z Ograniczona Odpowiedzialnoscia | Sposób wydzielania i oczyszczania estrów chityny (mono-, di‑podstawionych) oraz kopoliestrów chityny z mieszanin poreakcyjnych |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4067774A (en) * | 1971-05-14 | 1978-01-10 | Syva Company | Compounds for enzyme amplification assay |
LU85581A1 (fr) * | 1984-10-10 | 1986-06-11 | Smb Lab | Ensembles d'anticorps monoclonaux diriges contre la lactoferrine humaine et le lysozyme humain |
JPS62138496A (ja) * | 1985-12-11 | 1987-06-22 | Ihara Chem Ind Co Ltd | キチンオリゴマ−の製造方法 |
WO1989000050A1 (en) * | 1987-07-02 | 1989-01-12 | Akzo N.V. | Antigen recognized by mca 16-88 |
NZ225599A (en) * | 1987-08-04 | 1991-09-25 | Bristol Myers Co | Antibody-enzyme conjugates and combinations with prodrugs for the treatment of tumour cells |
ZA893284B (en) * | 1988-05-04 | 1990-03-28 | Igen Inc | Peptide analogs and their use as haptens to elicit catalytic antibodies |
-
1990
- 1990-01-23 KR KR1019900702129A patent/KR0185967B1/ko not_active IP Right Cessation
- 1990-01-23 AT AT90902934T patent/ATE123414T1/de not_active IP Right Cessation
- 1990-01-23 CA CA002025899A patent/CA2025899A1/en not_active Abandoned
- 1990-01-23 ES ES90902934T patent/ES2075893T3/es not_active Expired - Lifetime
- 1990-01-23 AU AU50397/90A patent/AU648015B2/en not_active Ceased
- 1990-01-23 EP EP90902934A patent/EP0454783B1/en not_active Revoked
- 1990-01-23 JP JP50311690A patent/JP3273608B2/ja not_active Expired - Fee Related
- 1990-01-23 DE DE69019959T patent/DE69019959T2/de not_active Expired - Fee Related
- 1990-01-23 DK DK90902934.0T patent/DK0454783T3/da active
- 1990-01-23 WO PCT/US1990/000503 patent/WO1990007929A1/en not_active Application Discontinuation
-
1991
- 1991-07-22 FI FI913511A patent/FI97692C/fi active
- 1991-07-22 NO NO91912864A patent/NO912864L/no unknown
Also Published As
Publication number | Publication date |
---|---|
ES2075893T3 (es) | 1995-10-16 |
EP0454783B1 (en) | 1995-06-07 |
JPH04503068A (ja) | 1992-06-04 |
AU648015B2 (en) | 1994-04-14 |
DK0454783T3 (da) | 1995-10-16 |
KR910700072A (ko) | 1991-03-13 |
AU5039790A (en) | 1990-08-13 |
EP0454783A1 (en) | 1991-11-06 |
EP0454783A4 (en) | 1992-01-15 |
DE69019959T2 (de) | 1995-10-05 |
FI97692B (fi) | 1996-10-31 |
NO912864L (no) | 1991-09-19 |
KR0185967B1 (ko) | 1999-05-01 |
WO1990007929A1 (en) | 1990-07-26 |
JP3273608B2 (ja) | 2002-04-08 |
CA2025899A1 (en) | 1990-07-24 |
DE69019959D1 (de) | 1995-07-13 |
NO912864D0 (no) | 1991-07-22 |
FI97692C (fi) | 1997-02-10 |
ATE123414T1 (de) | 1995-06-15 |
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Legal Events
Date | Code | Title | Description |
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BB | Publication of examined application |