NO893021L - Fremgangsmaate for fremstilling av en biologisk aktiv forbindelse, fr 901228. - Google Patents
Fremgangsmaate for fremstilling av en biologisk aktiv forbindelse, fr 901228.Info
- Publication number
- NO893021L NO893021L NO89893021A NO893021A NO893021L NO 893021 L NO893021 L NO 893021L NO 89893021 A NO89893021 A NO 89893021A NO 893021 A NO893021 A NO 893021A NO 893021 L NO893021 L NO 893021L
- Authority
- NO
- Norway
- Prior art keywords
- substance
- preparing
- procedure
- active compound
- biological active
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Reinforced Plastic Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
FR901228-stoff med fsigende formel:. fremstilles ved at en stamme som tilhører slekten Kromobacteriuro. og som er i stand til å produsere FR901228-stoff, dyrkes i et vandig næringsmedium under aerobe betingelser, hvorefter F901228-stoff isoleres. F012-stoff har anti-mikrobiell aktivitet og antitumoraktivitet.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB888817743A GB8817743D0 (en) | 1988-07-26 | 1988-07-26 | Fr901228 substance & preparation thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
NO893021D0 NO893021D0 (no) | 1989-07-25 |
NO893021L true NO893021L (no) | 1990-01-29 |
Family
ID=10641100
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO89893021A NO893021L (no) | 1988-07-26 | 1989-07-25 | Fremgangsmaate for fremstilling av en biologisk aktiv forbindelse, fr 901228. |
Country Status (16)
Country | Link |
---|---|
US (1) | US4977138A (no) |
EP (1) | EP0352646B1 (no) |
JP (1) | JPH0764872B2 (no) |
CN (1) | CN1040054A (no) |
AT (1) | ATE94561T1 (no) |
AU (1) | AU3829089A (no) |
CA (1) | CA1335083C (no) |
DE (1) | DE68909139T2 (no) |
DK (1) | DK366889A (no) |
ES (1) | ES2058411T3 (no) |
FI (1) | FI893359A (no) |
GB (1) | GB8817743D0 (no) |
HU (1) | HU211514A9 (no) |
IL (1) | IL90949A0 (no) |
NO (1) | NO893021L (no) |
ZA (1) | ZA895121B (no) |
Families Citing this family (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5130414A (en) * | 1989-11-30 | 1992-07-14 | Arizona Board Of Regents, A Body Corporate Of Arizona State University | Isolation and structural elucidation of the cyclic peptide hymenistatin 1 |
JPH06247964A (ja) * | 1993-02-22 | 1994-09-06 | Snow Brand Milk Prod Co Ltd | 新規生理活性物質hs−1及びその製造方法 |
WO1998022572A1 (en) * | 1996-11-22 | 1998-05-28 | Pioneer Hi-Bred International, Inc. | Moniliformin detoxification compositions and methods |
AU2002700A (en) | 1999-01-13 | 2000-08-01 | Yamanouchi Pharmaceutical Co., Ltd. | Novel depsipeptide compound |
PT1438966E (pt) * | 1999-12-08 | 2007-05-31 | Cyclacel Pharmaceuticals Inc | Uso de depsipéptidos e seus congéneres como imunosupressores para tratamento de doenças infecciosas, como uma doença autoimune, reacções alérgicas ou doença hiperproliferativa da pele. |
US6828302B1 (en) * | 1999-12-08 | 2004-12-07 | Xcyte Therapies, Inc. | Therapeutic uses of depsipeptides and congeners thereof |
JP4810784B2 (ja) * | 2000-07-17 | 2011-11-09 | アステラス製薬株式会社 | 還元型fk228およびその用途 |
JP2004508049A (ja) * | 2000-09-01 | 2004-03-18 | 藤沢薬品工業株式会社 | Fr901228物質の製造法 |
MXPA04001612A (es) * | 2001-08-21 | 2004-07-08 | Fujisawa Pharmaceutical Co | Uso medicinal de inhibidor de la histona desacetilasa y metodo para evaluar el efecto antitumoral del mismo. |
US20040132643A1 (en) * | 2002-01-09 | 2004-07-08 | Fojo Antonio Tito | Histone deacelylase inhibitors in diagnosis and treatment of thyroid neoplasms |
JP2005521737A (ja) * | 2002-04-05 | 2005-07-21 | 藤沢薬品工業株式会社 | 腎臓癌の治療のためのデプシペプチド |
US20080233562A1 (en) * | 2003-02-19 | 2008-09-25 | Astellas Pharma Inc. | Method of Estimating Antitumor Effect of Histone Deacetylase Inhibitor |
EP2238982B8 (en) * | 2003-06-27 | 2013-01-16 | Astellas Pharma Inc. | Therapeutic agent for soft tissue sarcoma |
MXPA06003222A (es) | 2003-09-25 | 2006-05-22 | Astellas Pharma Inc | Agente antitumoral que comprende un inhibidor de histona desacetilasa y un inhibidor de topoisomerasa ii. |
WO2005058298A2 (en) * | 2003-12-10 | 2005-06-30 | Wisconsin Alumni Research Foundation | Fk228 analogs and their use as hdac-inhibitors |
US20050187148A1 (en) * | 2004-02-25 | 2005-08-25 | Yoshinori Naoe | Antitumor agent |
US7951780B2 (en) * | 2004-02-25 | 2011-05-31 | Astellas Pharma Inc. | Antitumor agent |
WO2005115149A2 (en) * | 2004-05-20 | 2005-12-08 | Dow Agrosciences Llc | Insectidal activity of a cyclic peptide |
AU2005307814A1 (en) * | 2004-11-17 | 2006-05-26 | The University Of Chicago | Histone deacetylase inhibitors and methods of use |
GB0511266D0 (en) * | 2005-06-02 | 2005-07-13 | Trust | Chemical compounds |
CA2630216A1 (en) * | 2005-11-18 | 2007-05-31 | Gloucester Pharmaceuticals, Inc. | Metabolite derivatives of the hdac inhibitor fk228 |
CA2649877A1 (en) * | 2006-04-24 | 2007-12-21 | Gloucester Pharmaceuticals | Gemcitabine combination therapy |
WO2007146730A2 (en) * | 2006-06-08 | 2007-12-21 | Gloucester Pharmaceuticals | Deacetylase inhibitor therapy |
AU2007342030B2 (en) * | 2006-12-29 | 2013-08-15 | Celgene Corporation | Romidepsin-based treatments for cancer |
AU2007342028B2 (en) * | 2006-12-29 | 2013-06-13 | Celgene Corporation | Purifiction of romidepsin |
US8148102B2 (en) * | 2007-02-08 | 2012-04-03 | Uwm Research Foundation, Inc. | Sequences for FK228 biosynthesis and methods of synthesizing FK228 and FK228 analogs |
US20110060021A1 (en) * | 2009-08-19 | 2011-03-10 | Yiqiang Cheng | Histone deacetylase inhibitors and uses thereof |
AR080234A1 (es) * | 2010-02-25 | 2012-03-21 | Marrone Bio Innovations Inc | Cepa bacteriana aislada del genero burkholderia y metabolitos pesticidas del mismo |
CA2804795A1 (en) | 2010-07-12 | 2012-01-19 | Nicholas Vrolijk | Romidepsin solid forms and uses thereof |
US8859502B2 (en) | 2010-09-13 | 2014-10-14 | Celgene Corporation | Therapy for MLL-rearranged leukemia |
JP5961693B2 (ja) * | 2011-08-27 | 2016-08-02 | マローネ バイオ イノベーションズ,インコーポレイテッド | ブルクホルデリア(Burkholderia)属の単離細菌株及びそれに由来する殺有害生物性代謝物の製剤及び使用 |
CA2849708A1 (en) | 2011-09-23 | 2013-03-28 | Celgene Corporation | Romidepsin and 5 - azacitidine for use in treating lymphoma |
AU2012316266B2 (en) | 2011-09-26 | 2015-07-30 | Celgene Corporation | Combination therapy for chemoresistant cancers |
JP6214397B2 (ja) | 2011-09-30 | 2017-10-18 | 国立大学法人東北大学 | 新規ホスファチジルイノシトール3キナーゼ阻害剤及び医薬組成物 |
WO2013085902A1 (en) | 2011-12-05 | 2013-06-13 | The University Of Texas M.D. | Combination therapy methods for treating an inflammatory breast cancer |
CA2863291A1 (en) | 2012-01-12 | 2013-07-18 | Celgene Corporation | Romidepsin formulations and uses thereof |
AU2013202506B2 (en) | 2012-09-07 | 2015-06-18 | Celgene Corporation | Resistance biomarkers for hdac inhibitors |
AU2013202507B9 (en) | 2012-11-14 | 2015-08-13 | Celgene Corporation | Inhibition of drug resistant cancer cells |
CN103877010B (zh) * | 2012-12-21 | 2018-06-01 | 正大天晴药业集团股份有限公司 | 一种罗米地辛溶液的制备方法 |
US9006462B2 (en) | 2013-02-28 | 2015-04-14 | Dermira, Inc. | Glycopyrrolate salts |
EP2961734B1 (en) | 2013-02-28 | 2018-09-26 | Dermira, Inc. | Glycopyrrolate salts |
US8558008B2 (en) | 2013-02-28 | 2013-10-15 | Dermira, Inc. | Crystalline glycopyrrolate tosylate |
CN103173390B (zh) * | 2013-03-16 | 2014-09-10 | 浙江海正药业股份有限公司 | 一种紫色杆菌菌株及其应用 |
CN104072589B (zh) * | 2013-03-29 | 2017-09-22 | 浙江海正药业股份有限公司 | 抗肿瘤三硫化合物及其制备方法与应用 |
CN104447950A (zh) * | 2013-09-18 | 2015-03-25 | 上海医药工业研究院 | 一种罗米地辛的分离纯化方法 |
CN104450837B (zh) * | 2013-09-18 | 2019-01-01 | 上海医药工业研究院 | 一种用于生产罗米地辛的方法及发酵培养基 |
NZ630311A (en) | 2013-12-27 | 2016-03-31 | Celgene Corp | Romidepsin formulations and uses thereof |
US10294276B2 (en) * | 2014-03-04 | 2019-05-21 | Concord Biotech Limited | Process for isolation of romidepsin from fermentation broth and preparation of crystals of romidepsin |
CN104894195B (zh) * | 2014-03-07 | 2018-11-13 | 上海医药工业研究院 | 一种提高fk228产量的发酵培养基 |
CN104262456B (zh) * | 2014-09-11 | 2018-01-09 | 浙江海正药业股份有限公司 | 一种罗米地辛的新晶型及其制备方法和用途 |
WO2016210292A1 (en) | 2015-06-25 | 2016-12-29 | Children's Medical Center Corporation | Methods and compositions relating to hematopoietic stem cell expansion, enrichment, and maintenance |
US10562931B2 (en) * | 2015-10-20 | 2020-02-18 | Msn Laboratories Private Limited | Process for the preparation of (1S, 4S, 7Z, 10S, 16E, 21R)-7-ethyldene-4,21-bis(1-methyl-ethyl)-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8.7.6]tricos-16-ene-3, 6, 9, 19, 22-pentone |
US20190119642A1 (en) | 2016-03-15 | 2019-04-25 | Children's Medical Center Corporation | Methods and compositions relating to hematopoietic stem cell expansion |
BR112021011370A2 (pt) | 2018-12-14 | 2021-08-31 | Pioneer Hi-Bred International, Inc. | Produtos biológicos e seu uso em plantas |
US20220049213A1 (en) * | 2018-12-24 | 2022-02-17 | Marrone Bio Innovations, Inc. | A method for increasing romidepsin production from fermentation broth |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61101501A (ja) * | 1984-10-24 | 1986-05-20 | Yamanouchi Pharmaceut Co Ltd | 制癌作用を有する多糖及びその製法 |
US4785078A (en) * | 1985-04-18 | 1988-11-15 | Pfizer Inc. | Transformation product of thiosporamicin |
DE3782199T2 (de) * | 1986-07-08 | 1993-02-25 | Takeda Chemical Industries Ltd | Biologisch aktive peptide tan-866. |
US4777160A (en) * | 1986-09-18 | 1988-10-11 | Bristol-Myers | BU-2867T peptide antibiotics |
-
1988
- 1988-07-26 GB GB888817743A patent/GB8817743D0/en active Pending
-
1989
- 1989-07-05 ZA ZA895121A patent/ZA895121B/xx unknown
- 1989-07-06 US US07/375,998 patent/US4977138A/en not_active Expired - Lifetime
- 1989-07-11 FI FI893359A patent/FI893359A/fi not_active Application Discontinuation
- 1989-07-12 IL IL90949A patent/IL90949A0/xx unknown
- 1989-07-19 JP JP1186760A patent/JPH0764872B2/ja not_active Expired - Lifetime
- 1989-07-20 AU AU38290/89A patent/AU3829089A/en not_active Abandoned
- 1989-07-21 DE DE89113394T patent/DE68909139T2/de not_active Expired - Lifetime
- 1989-07-21 AT AT89113394T patent/ATE94561T1/de not_active IP Right Cessation
- 1989-07-21 ES ES89113394T patent/ES2058411T3/es not_active Expired - Lifetime
- 1989-07-21 EP EP89113394A patent/EP0352646B1/en not_active Expired - Lifetime
- 1989-07-25 CA CA000606621A patent/CA1335083C/en not_active Expired - Lifetime
- 1989-07-25 CN CN89106081A patent/CN1040054A/zh active Pending
- 1989-07-25 NO NO89893021A patent/NO893021L/no unknown
- 1989-07-25 DK DK366889A patent/DK366889A/da not_active Application Discontinuation
-
1995
- 1995-06-22 HU HU95P/P00343P patent/HU211514A9/hu unknown
Also Published As
Publication number | Publication date |
---|---|
JPH0764872B2 (ja) | 1995-07-12 |
ZA895121B (en) | 1990-08-29 |
DK366889A (da) | 1990-01-27 |
DE68909139T2 (de) | 1994-02-10 |
FI893359A (fi) | 1990-01-27 |
JPH0285296A (ja) | 1990-03-26 |
ES2058411T3 (es) | 1994-11-01 |
AU3829089A (en) | 1990-02-01 |
HU211514A9 (en) | 1995-11-28 |
ATE94561T1 (de) | 1993-10-15 |
GB8817743D0 (en) | 1988-09-01 |
DE68909139D1 (de) | 1993-10-21 |
EP0352646B1 (en) | 1993-09-15 |
DK366889D0 (da) | 1989-07-25 |
NO893021D0 (no) | 1989-07-25 |
IL90949A0 (en) | 1990-02-09 |
EP0352646A3 (en) | 1990-10-31 |
US4977138A (en) | 1990-12-11 |
EP0352646A2 (en) | 1990-01-31 |
CA1335083C (en) | 1995-04-04 |
FI893359A0 (fi) | 1989-07-11 |
CN1040054A (zh) | 1990-02-28 |
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