NO885812L - Fremgangsmaate for fremstilling av nye sulfhydrylholdige tricykliske lactamer. - Google Patents
Fremgangsmaate for fremstilling av nye sulfhydrylholdige tricykliske lactamer.Info
- Publication number
- NO885812L NO885812L NO88885812A NO885812A NO885812L NO 885812 L NO885812 L NO 885812L NO 88885812 A NO88885812 A NO 88885812A NO 885812 A NO885812 A NO 885812A NO 885812 L NO885812 L NO 885812L
- Authority
- NO
- Norway
- Prior art keywords
- formula
- compound
- compounds
- lower alkyl
- hydrogen
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 20
- 238000000034 method Methods 0.000 title claims abstract description 18
- 150000003951 lactams Chemical class 0.000 title abstract description 8
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 16
- 239000001257 hydrogen Substances 0.000 claims abstract description 15
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 15
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract 3
- 150000001875 compounds Chemical class 0.000 claims description 78
- -1 alkyl nitrite Chemical compound 0.000 claims description 38
- 239000000203 mixture Substances 0.000 claims description 24
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- 150000002431 hydrogen Chemical group 0.000 claims description 8
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 8
- 239000007858 starting material Substances 0.000 claims description 7
- XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Chemical compound P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 claims description 6
- 125000003118 aryl group Chemical group 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 6
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- 239000012442 inert solvent Substances 0.000 claims description 2
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pyrrole Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/139,485 US4824832A (en) | 1987-12-30 | 1987-12-30 | Sulfhydryl containing tricyclic lactams and their pharmacological methods of use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO885812D0 NO885812D0 (no) | 1988-12-29 |
| NO885812L true NO885812L (no) | 1989-07-03 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO88885812A NO885812L (no) | 1987-12-30 | 1988-12-29 | Fremgangsmaate for fremstilling av nye sulfhydrylholdige tricykliske lactamer. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4824832A (ja) |
| EP (1) | EP0322914B1 (ja) |
| JP (1) | JP2681291B2 (ja) |
| KR (1) | KR0128158B1 (ja) |
| CN (1) | CN1034721A (ja) |
| AT (1) | ATE100453T1 (ja) |
| AU (1) | AU611984B2 (ja) |
| CA (1) | CA1336191C (ja) |
| DE (1) | DE3887307T2 (ja) |
| DK (1) | DK725988A (ja) |
| ES (1) | ES2061621T3 (ja) |
| FI (1) | FI886005A (ja) |
| HU (2) | HU204050B (ja) |
| IL (1) | IL88810A (ja) |
| NO (1) | NO885812L (ja) |
| NZ (1) | NZ227432A (ja) |
| PT (1) | PT89346B (ja) |
| ZA (1) | ZA889542B (ja) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CA2053340C (en) * | 1990-10-18 | 2002-04-02 | Timothy P. Burkholder | Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace |
| US5208230A (en) * | 1990-12-21 | 1993-05-04 | Merrell Dow Pharmaceuticals | Amino and nitro containing tricyclic compounds useful as inhibitors of ACE |
| CA2057786C (en) * | 1990-12-21 | 2002-06-18 | Gary A. Flynn | Amino and nitro containing tricyclic compounds useful as inhibitors or ace |
| US5308841A (en) * | 1990-12-21 | 1994-05-03 | Merrell Dow Pharmaceuticals Inc. | Amino and nitro containing tricyclic compounds useful as inhibitors of ACE |
| ZA927211B (en) * | 1991-09-27 | 1993-03-24 | Merrell Dow Pharma | Novel carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE. |
| EP0534363B1 (en) * | 1991-09-27 | 1997-07-09 | Merrell Pharmaceuticals Inc. | Novel 2-substituted indane-2-mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace |
| US5455242A (en) * | 1991-09-27 | 1995-10-03 | Merrell Dow Pharmaceuticals Inc. | Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace |
| US5457196A (en) * | 1991-09-27 | 1995-10-10 | Merrell Dow Pharmaceuticals Inc. | 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE |
| DE69317764T2 (de) * | 1992-02-14 | 1998-07-30 | Merrell Pharmaceuticals Inc., Cincinnati, Ohio | Aminoacetylmercaptoacetylamid derivate mit enkephalinase- und ace-hemmwirkung |
| US5552397A (en) * | 1992-05-18 | 1996-09-03 | E. R. Squibb & Sons, Inc. | Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase |
| EP0640086B1 (en) * | 1992-05-15 | 1999-08-04 | Merrell Pharmaceuticals Inc. | MERCAPTOACETYLAMIDO PYRIDAZO[ 1,2-a][1,2]DIAZEPINE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE |
| US5238932A (en) * | 1992-05-20 | 1993-08-24 | Merrell Dow Pharmaceuticals Inc. | Mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase |
| US5420271A (en) * | 1992-08-24 | 1995-05-30 | Merrell Dow Pharmaceuticals, Inc. | 2-substituted indane-2-mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase |
| JP3420766B2 (ja) * | 1992-10-30 | 2003-06-30 | メレルダウファーマス−ティカルズ インコーポレイテッド | エンケファリナーゼ及びａｃｅの阻害剤として有用な新規なメルカプトアセチルアミド二環式ラクタム誘導体類 |
| US5654294A (en) * | 1993-05-13 | 1997-08-05 | Bristol-Myers Squibb | Spiro lactam dual action inhibitors |
| US5362727A (en) * | 1993-07-26 | 1994-11-08 | Bristol-Myers Squibb | Substituted azepino[2,1-a]isoquinoline compounds |
| US5525723A (en) * | 1993-11-18 | 1996-06-11 | Bristol-Myers Squibb Co. | Compounds containing a fused multiple ring lactam |
| HU220895B1 (en) * | 1993-11-19 | 2002-06-29 | Merrell Pharma Inc | Process for preparing (s)-1-[2(s)-(1,3-dihydro-1,3-dioxo-isoindol-2-yl)-1-oxo-3-phenylpropyl]-1,2,3,4-tetrahydro-2-pyridine-carboxylic acid methyl ester and intermediates thereof |
| US5530013A (en) * | 1994-02-14 | 1996-06-25 | American Home Products Corporation | Venlafaxine in the inducement of cognition enhancement |
| WO1995021854A1 (en) * | 1994-02-14 | 1995-08-17 | Merrell Pharmaceuticals Inc. | Novel mercaptoacetylamido 1,3,4,5-tetrahydro-benzo[c]azepin-3-one disulfide derivatives useful as inhibitors of enkephalinase and ace |
| DK0745081T3 (da) * | 1994-02-14 | 2002-05-21 | Merrell Pharma Inc | Indan-2-mercaptoacetylamiddisulfidderivater, der er anvendelige som enkephalinase-inhibitorer |
| CA2183314C (en) * | 1994-02-14 | 1999-08-31 | Gary A. Flynn | Novel 2-substituted indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ace |
| ATE177098T1 (de) * | 1994-02-14 | 1999-03-15 | Merrell Pharma Inc | Mercaptoacetylamid disulfidderivate als enkephalinase und ace inhibitoren |
| US5484783A (en) * | 1994-03-24 | 1996-01-16 | Merrell Dow Pharmaceuticals Inc. | Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives |
| EP0751783B1 (en) * | 1994-03-24 | 2000-02-02 | Merrell Pharmaceuticals Inc. | Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic use of aminoacetylmercapto derivatives |
| DE69531489T2 (de) * | 1994-03-24 | 2004-04-08 | Merrell Pharmaceuticals Inc., Cincinnati | Cholesterin senkende mercaptoacetylamiddisulfidderivate |
| US5641880A (en) * | 1994-12-21 | 1997-06-24 | Hoechst Marion Roussel, Inc. | Processes for preparing intermediates of inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof |
| SI0800527T1 (en) * | 1994-12-21 | 2000-08-31 | Hoechst Marion Roussel, Inc. | Novel processes for preparing intermediates of inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof |
| US5587375A (en) * | 1995-02-17 | 1996-12-24 | Bristol-Myers Squibb Company | Azepinone compounds useful in the inhibition of ACE and NEP |
| US5877313A (en) | 1995-05-17 | 1999-03-02 | Bristol-Myers Squibb | Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP |
| US5650408A (en) * | 1995-06-07 | 1997-07-22 | Karanewsky; Donald S. | Thiazolo benzazepine containing dual action inhibitors |
| US5635504A (en) * | 1995-06-07 | 1997-06-03 | Bristol-Myers Squibb Co. | Diazepine containing dual action inhibitors |
| GB0119305D0 (en) | 2001-04-12 | 2001-10-03 | Aventis Pharma Gmbh | Mercaptoacetylamide derivatives,a process for their preparation and their use |
| US20030229007A1 (en) * | 2002-05-30 | 2003-12-11 | Roberto Levi | Form of human renin and its use as a target in treatments for cardiac ischemia and arrhythmia |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3185680A (en) * | 1962-10-16 | 1965-05-25 | American Home Prod | Reduced benzodiazepinium compounds |
| US4584294A (en) * | 1984-11-07 | 1986-04-22 | Merck & Co., Inc. | Fused tricyclic lactams as angiotensin converting enzyme inhibitors and as antihypertensive agents |
| ZA874107B (ja) * | 1986-06-13 | 1987-12-09 |
-
1987
- 1987-12-30 US US07/139,485 patent/US4824832A/en not_active Expired - Lifetime
-
1988
- 1988-12-21 CA CA000586691A patent/CA1336191C/en not_active Expired - Lifetime
- 1988-12-21 NZ NZ227432A patent/NZ227432A/en unknown
- 1988-12-21 AU AU27368/88A patent/AU611984B2/en not_active Ceased
- 1988-12-21 ZA ZA889542A patent/ZA889542B/xx unknown
- 1988-12-22 HU HU895880A patent/HU204050B/hu not_active IP Right Cessation
- 1988-12-22 HU HU886576A patent/HU200181B/hu not_active IP Right Cessation
- 1988-12-23 JP JP63323844A patent/JP2681291B2/ja not_active Expired - Lifetime
- 1988-12-27 IL IL88810A patent/IL88810A/xx unknown
- 1988-12-27 PT PT89346A patent/PT89346B/pt not_active IP Right Cessation
- 1988-12-28 KR KR1019880017625A patent/KR0128158B1/ko not_active IP Right Cessation
- 1988-12-28 DK DK725988A patent/DK725988A/da not_active Application Discontinuation
- 1988-12-28 FI FI886005A patent/FI886005A/fi not_active Application Discontinuation
- 1988-12-29 NO NO88885812A patent/NO885812L/no unknown
- 1988-12-29 DE DE88121850T patent/DE3887307T2/de not_active Expired - Lifetime
- 1988-12-29 EP EP88121850A patent/EP0322914B1/en not_active Expired - Lifetime
- 1988-12-29 AT AT88121850T patent/ATE100453T1/de not_active IP Right Cessation
- 1988-12-29 CN CN88105629A patent/CN1034721A/zh active Pending
- 1988-12-29 ES ES88121850T patent/ES2061621T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| HU204050B (en) | 1991-11-28 |
| CN1034721A (zh) | 1989-08-16 |
| EP0322914A2 (en) | 1989-07-05 |
| FI886005A (fi) | 1989-07-01 |
| US4824832A (en) | 1989-04-25 |
| PT89346B (pt) | 1993-08-31 |
| DE3887307T2 (de) | 1994-05-05 |
| DE3887307D1 (de) | 1994-03-03 |
| IL88810A0 (en) | 1989-07-31 |
| AU2736888A (en) | 1989-07-06 |
| CA1336191C (en) | 1995-07-04 |
| ES2061621T3 (es) | 1994-12-16 |
| HU200181B (en) | 1990-04-28 |
| KR890009927A (ko) | 1989-08-04 |
| ATE100453T1 (de) | 1994-02-15 |
| IL88810A (en) | 1993-08-18 |
| DK725988D0 (da) | 1988-12-28 |
| ZA889542B (en) | 1989-09-27 |
| PT89346A (pt) | 1989-12-29 |
| HUT49137A (en) | 1989-08-28 |
| JPH01203382A (ja) | 1989-08-16 |
| JP2681291B2 (ja) | 1997-11-26 |
| KR0128158B1 (ko) | 1998-04-04 |
| DK725988A (da) | 1989-07-01 |
| AU611984B2 (en) | 1991-06-27 |
| NO885812D0 (no) | 1988-12-29 |
| NZ227432A (en) | 1990-11-27 |
| EP0322914B1 (en) | 1994-01-19 |
| EP0322914A3 (en) | 1990-12-27 |
| HU895880D0 (en) | 1990-02-28 |
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