NO875461L - Fremgangsmaate for fremstilling av et terapeutisk aktivt peptid. - Google Patents
Fremgangsmaate for fremstilling av et terapeutisk aktivt peptid.Info
- Publication number
- NO875461L NO875461L NO875461A NO875461A NO875461L NO 875461 L NO875461 L NO 875461L NO 875461 A NO875461 A NO 875461A NO 875461 A NO875461 A NO 875461A NO 875461 L NO875461 L NO 875461L
- Authority
- NO
- Norway
- Prior art keywords
- rer
- tyr
- ala
- asp
- ser
- Prior art date
Links
- 230000001225 therapeutic effect Effects 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 241000251468 Actinopterygii Species 0.000 abstract 1
- QNAYBMKLOCPYGJ-UWTATZPHSA-N D-alanine Chemical compound C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 abstract 1
- HNDVDQJCIGZPNO-RXMQYKEDSA-N D-histidine Chemical compound OC(=O)[C@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-RXMQYKEDSA-N 0.000 abstract 1
- OUYCCCASQSFEME-MRVPVSSYSA-N D-tyrosine Chemical compound OC(=O)[C@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-MRVPVSSYSA-N 0.000 abstract 1
- BMPPMAOOKQJYIP-WMZOPIPTSA-N Tyr-Trp Chemical compound C([C@H]([NH3+])C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C([O-])=O)C1=CC=C(O)C=C1 BMPPMAOOKQJYIP-WMZOPIPTSA-N 0.000 abstract 1
- 238000009360 aquaculture Methods 0.000 abstract 1
- 244000144974 aquaculture Species 0.000 abstract 1
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 230000001817 pituitary effect Effects 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000000638 stimulation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Feed For Specific Animals (AREA)
- Fodder In General (AREA)
Abstract
Oppfinnelsen vedrører peptider som er potente i stimuleringen av frigjøringen av hypofyse-CH i fisk og amfibier og har en vesentlig del eller alle de følgende sekvenser: RRRRRPh----Tyr-Arg-R-Leu-J»-Gln-Leu-R8la-ArgLys^eu-R-R^^jjjj^"33~34~35"36"37"38"39"~~42". RRServcri Ri NMe Tyr, Tyr. desNH-Tyr, D-Tyr, N-Et Tyr, N-Ip Tyr, N-Me His, His, desNH-His, D-His, N-Et Hie, oq N-Ip Hist Rer Ala, D-AlaellerD-NMAj Rj er AspellcrD-Asp; Rer Gly. eller Ala; Rj og Rer valgt fra gruppen bestående av. Het, Leu, Val, Nva, Gin, Thr, Ile, Ala,. Arg, Asn, iAsp, Cys, Glu, Gly, His, Nie, Lys, Phe, Pro,. Ser, TyrTrp; R7er • AsnellerThr; Rg er Lys, Asn. «-Heiser; R? er AlaellerSer; Rer LysellerArg; R. er Ala, Valelle; Rer GlyellerAla; Rer Seripr. Tyr; Rer TyrellerLeu; "er HisllerGln; Rer. Thr, Asp, ellerClu; Rg er Leuellerlle; Rer Ala, Ser. elleiAsn;er.ysellerArg; Rjn er ArgellerGln; R. er ValeUerGlns Rer GlyellcrGlu; Rer Gly, Arg elkar. Ser; R,, er Ser eUerAsn; R,, «r Met, Leu, Val, Nva,. JD JO. Gin, Thr, Ile ellerNle; Rer IlerGlu; Rer Glu, GleUerrg;er Asp, ArgellerGly; Rer Asp, Ser. pllfrftla;er Asn, ArgeUerLys; Rer Glu, Phe, Ala ellerVal; Rer ProAsnellerArg; "er LeuellerAla;. med det forbehold at imidlertid minst et av de følgende er tilstede: R? ersn, Rfl er Lys, Rer Ala, Rer Tyr og Rer Thr; og ytterligere med det forbehold at noen eller, alle restene etter Rkan vare utelatt. Et 29-restpeptid som begynner ved den N-terminale enden kan være foretrukket. Disse peptider, såvel som deres ikke-giftige salter, bestraktes å vsre spesielt anvendbare i akva-dyrking.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US272387A | 1987-01-13 | 1987-01-13 | |
| US07/060,149 US4784987A (en) | 1987-01-13 | 1987-06-10 | GRF analogs VI |
| US07/096,513 US4843064A (en) | 1987-01-13 | 1987-09-11 | GRF analogs V |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO875461D0 NO875461D0 (no) | 1987-12-29 |
| NO875461L true NO875461L (no) | 1988-07-14 |
Family
ID=27357223
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO875461A NO875461L (no) | 1987-01-13 | 1987-12-29 | Fremgangsmaate for fremstilling av et terapeutisk aktivt peptid. |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0274916A3 (no) |
| JP (1) | JP2685195B2 (no) |
| KR (1) | KR970001510B1 (no) |
| AU (1) | AU593973B2 (no) |
| DK (1) | DK14488A (no) |
| IL (1) | IL84758A (no) |
| NO (1) | NO875461L (no) |
| NZ (1) | NZ222951A (no) |
| PH (1) | PH26896A (no) |
| PT (1) | PT86544B (no) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5565606A (en) * | 1986-10-21 | 1996-10-15 | Hoechst Aktiengesellschaft | Synthesis of peptide aminoalkylamides and peptide hydrazides by the solid-phase method |
| DE3742633A1 (de) * | 1987-12-16 | 1989-06-29 | Hoechst Ag | Peptide mit beeinflussender wirkung auf die hypophyse von saeugern |
| IL86102A (en) * | 1987-05-11 | 1994-04-12 | Univ Tulane | Alkylated peptides that release growth hormone and their use |
| US5043322A (en) * | 1988-07-22 | 1991-08-27 | The Salk Institute For Biological Studies | Cyclic GRF analogs |
| CA2026776A1 (en) * | 1989-01-27 | 1990-07-28 | Alan R. Friedman | Stabilized, potent grf analogs |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4563352A (en) * | 1982-10-04 | 1986-01-07 | The Salk Institute For Biological Studies | Human pancreatic GRF |
| US4518586A (en) * | 1983-01-13 | 1985-05-21 | The Salk Institute For Biological Studies | GRF Analogs III |
| US4528190A (en) * | 1983-10-25 | 1985-07-09 | The Salk Institute For Biological Studies | GRF Analogs IV |
| US4689318A (en) * | 1985-08-29 | 1987-08-25 | The Salk Institute For Biological Studies | GRF analogs |
-
1987
- 1987-12-08 IL IL84758A patent/IL84758A/xx not_active IP Right Cessation
- 1987-12-16 NZ NZ222951A patent/NZ222951A/xx unknown
- 1987-12-29 NO NO875461A patent/NO875461L/no unknown
- 1987-12-31 EP EP87311543A patent/EP0274916A3/en not_active Withdrawn
-
1988
- 1988-01-11 AU AU10166/88A patent/AU593973B2/en not_active Ceased
- 1988-01-12 KR KR1019880000231A patent/KR970001510B1/ko not_active IP Right Cessation
- 1988-01-13 DK DK014488A patent/DK14488A/da not_active Application Discontinuation
- 1988-01-13 JP JP63005694A patent/JP2685195B2/ja not_active Expired - Lifetime
- 1988-01-13 PH PH36355A patent/PH26896A/en unknown
- 1988-01-13 PT PT86544A patent/PT86544B/pt not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU593973B2 (en) | 1990-02-22 |
| DK14488A (da) | 1988-07-14 |
| KR890005149A (ko) | 1989-05-13 |
| PT86544A (en) | 1988-02-01 |
| PT86544B (pt) | 1991-12-31 |
| DK14488D0 (da) | 1988-01-13 |
| KR970001510B1 (ko) | 1997-02-11 |
| NO875461D0 (no) | 1987-12-29 |
| EP0274916A2 (en) | 1988-07-20 |
| EP0274916A3 (en) | 1989-11-15 |
| PH26896A (en) | 1992-12-03 |
| IL84758A (en) | 1992-03-29 |
| JP2685195B2 (ja) | 1997-12-03 |
| NZ222951A (en) | 1990-09-26 |
| IL84758A0 (en) | 1988-05-31 |
| JPS63174999A (ja) | 1988-07-19 |
| AU1016688A (en) | 1988-07-14 |
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