NO864206L - Derivat av interleukin-2, dets fremstilling og anvendelse. - Google Patents
Derivat av interleukin-2, dets fremstilling og anvendelse.Info
- Publication number
- NO864206L NO864206L NO864206A NO864206A NO864206L NO 864206 L NO864206 L NO 864206L NO 864206 A NO864206 A NO 864206A NO 864206 A NO864206 A NO 864206A NO 864206 L NO864206 L NO 864206L
- Authority
- NO
- Norway
- Prior art keywords
- protein
- derivatives
- production
- amino acid
- dna
- Prior art date
Links
- 108010002350 Interleukin-2 Proteins 0.000 title claims description 23
- 102000000588 Interleukin-2 Human genes 0.000 title claims description 22
- 238000004519 manufacturing process Methods 0.000 title claims description 5
- 108090000623 proteins and genes Proteins 0.000 claims description 12
- 102000004169 proteins and genes Human genes 0.000 claims description 11
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 7
- 150000001413 amino acids Chemical class 0.000 claims description 6
- 230000004071 biological effect Effects 0.000 claims description 4
- 230000000694 effects Effects 0.000 claims description 3
- 101001002657 Homo sapiens Interleukin-2 Proteins 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 102000055277 human IL2 Human genes 0.000 claims description 2
- 229940126601 medicinal product Drugs 0.000 claims description 2
- 241000588724 Escherichia coli Species 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 description 6
- 239000013612 plasmid Substances 0.000 description 5
- 229920001184 polypeptide Polymers 0.000 description 3
- 102000004196 processed proteins & peptides Human genes 0.000 description 3
- 108090000765 processed proteins & peptides Proteins 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 2
- 239000013613 expression plasmid Substances 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 238000010353 genetic engineering Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 102000012410 DNA Ligases Human genes 0.000 description 1
- 108010061982 DNA Ligases Proteins 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 241001302584 Escherichia coli str. K-12 substr. W3110 Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 101000702488 Rattus norvegicus High affinity cationic amino acid transporter 1 Proteins 0.000 description 1
- 108700005078 Synthetic Genes Proteins 0.000 description 1
- 239000007983 Tris buffer Substances 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 239000011543 agarose gel Substances 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- NKLPQNGYXWVELD-UHFFFAOYSA-M coomassie brilliant blue Chemical compound [Na+].C1=CC(OCC)=CC=C1NC1=CC=C(C(=C2C=CC(C=C2)=[N+](CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=2C=CC(=CC=2)N(CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=C1 NKLPQNGYXWVELD-UHFFFAOYSA-M 0.000 description 1
- DNJIEGIFACGWOD-UHFFFAOYSA-N ethyl mercaptane Natural products CCS DNJIEGIFACGWOD-UHFFFAOYSA-N 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- -1 indolyl-acrylacetic acid Chemical compound 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 238000004153 renaturation Methods 0.000 description 1
- 108091008146 restriction endonucleases Proteins 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Toxicology (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19853537461 DE3537461A1 (de) | 1985-10-22 | 1985-10-22 | Derivat des interleukin-2, seine herstellung und verwendung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO864206D0 NO864206D0 (no) | 1986-10-21 |
| NO864206L true NO864206L (no) | 1987-04-23 |
Family
ID=6284108
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO864206A NO864206L (no) | 1985-10-22 | 1986-10-21 | Derivat av interleukin-2, dets fremstilling og anvendelse. |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0219839A3 (fi) |
| JP (1) | JPS62100299A (fi) |
| KR (1) | KR870004142A (fi) |
| AU (1) | AU6422986A (fi) |
| DE (1) | DE3537461A1 (fi) |
| DK (1) | DK504286A (fi) |
| FI (1) | FI864235A (fi) |
| HU (1) | HUT43109A (fi) |
| IL (1) | IL80366A0 (fi) |
| NO (1) | NO864206L (fi) |
| NZ (1) | NZ217994A (fi) |
| PT (1) | PT83591B (fi) |
| ZA (1) | ZA867968B (fi) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5359035A (en) * | 1985-12-21 | 1994-10-25 | Hoechst Aktiengesellschaft | Bifunctional proteins including interleukin-2 (IL-2) and granuloctyte macrophage colony stimulating factor (GM-CSF) |
| JPS62185098A (ja) * | 1986-02-10 | 1987-08-13 | Otsuka Pharmaceut Co Ltd | インタ−ロイキン−２活性を有するポリペプチド |
| ZA898139B (en) * | 1988-11-17 | 1990-08-29 | Hoffmann La Roche | Recombinant interleukin-2 hybrid proteins |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2559782B1 (fr) * | 1984-02-16 | 1986-07-18 | Transgene Sa | Vecteur d'expression dans les levures de l'interleukine-2, levures transformees et procede de preparation de l'interleukine-2 |
| DE3575072D1 (de) * | 1984-03-28 | 1990-02-08 | Cetus Corp | Pharmazeutische zusammensetzungen von mikrobenerzeugtem interleukin-2. |
| DE3419995A1 (de) * | 1984-05-29 | 1985-12-05 | Hoechst Ag, 6230 Frankfurt | Gentechnologisches verfahren zur herstellung von human-interleukin-2 und mittel zur durchfuehrung dieses verfahrens |
-
1985
- 1985-10-22 DE DE19853537461 patent/DE3537461A1/de not_active Withdrawn
-
1986
- 1986-10-18 EP EP86114468A patent/EP0219839A3/de not_active Withdrawn
- 1986-10-20 NZ NZ217994A patent/NZ217994A/xx unknown
- 1986-10-20 IL IL80366A patent/IL80366A0/xx unknown
- 1986-10-20 FI FI864235A patent/FI864235A/fi not_active Application Discontinuation
- 1986-10-21 AU AU64229/86A patent/AU6422986A/en not_active Abandoned
- 1986-10-21 DK DK504286A patent/DK504286A/da not_active Application Discontinuation
- 1986-10-21 PT PT83591A patent/PT83591B/pt unknown
- 1986-10-21 ZA ZA867968A patent/ZA867968B/xx unknown
- 1986-10-21 HU HU864371A patent/HUT43109A/hu unknown
- 1986-10-21 NO NO864206A patent/NO864206L/no unknown
- 1986-10-22 KR KR1019860008846A patent/KR870004142A/ko not_active Application Discontinuation
- 1986-10-22 JP JP61249806A patent/JPS62100299A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| PT83591A (de) | 1986-11-01 |
| ZA867968B (en) | 1987-06-24 |
| EP0219839A3 (de) | 1988-05-04 |
| DK504286A (da) | 1987-04-23 |
| DE3537461A1 (de) | 1987-04-23 |
| NZ217994A (en) | 1988-09-29 |
| NO864206D0 (no) | 1986-10-21 |
| FI864235A0 (fi) | 1986-10-20 |
| AU6422986A (en) | 1987-04-30 |
| DK504286D0 (da) | 1986-10-21 |
| FI864235A (fi) | 1987-04-23 |
| EP0219839A2 (de) | 1987-04-29 |
| IL80366A0 (en) | 1987-01-30 |
| KR870004142A (ko) | 1987-05-07 |
| HUT43109A (en) | 1987-09-28 |
| PT83591B (de) | 1988-11-10 |
| JPS62100299A (ja) | 1987-05-09 |
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