NO852427L - PROCEDURE FOR THE MANUFACTURE OF MEDICAL, COSMETIC PREPARATIONS - Google Patents

Description

The present invention relates to the production of health-preserving and regenerating preparations, to which human blood characteristics for the species, the type of the donor living organism, e.g. associated blood type A, B, AB, 0, Rh-positive, Rh-negative or elements thereof and/or proteins obtained therefrom and/or tissues derived from animal organisms of given species or types and/or the elements thereof and/or proteins obtained therefrom applied per se, and/or reacted with inorganic substances, e.g. with elements that have a trace element function in the organism, possibly together with known additives, auxiliaries, fillers, which can be used in the production of health, body and skin preserving preparations, and/or in the form of internally administered preparations.

The greatest distinctive feature of the present invention

lies in the use of the elements and plasma proteins of human blood, by reacting these with inorganic ions and by using the obtained product for body preservative use externally and/or internally, e.g. orally.

It is known that mineral substances, the trace elements, play a significant role in the functioning of living organisms even in very small concentrations, primarily because they are components of several enzymes, enzyme activators or inhibitors as parts of larger molecules or by interaction with these molecules such that they thus play a regulatory role in the organism's functioning. As is known, the trace elements have a specific activity in the living organism despite the fact that they are inactive in vitro. The trace elements exhibit their specific and necessary effect by binding to the so-called carrier molecules and thereby enter into biologically active transport. Such large molecules are plasma proteins. The connection between the trace elements and the proteins will be established in the organism when the conditions for this are ensured.

However, this connection is not always suitable and does not respond to the necessary degree so that the effect of the trace elements does not appear, the enzymes with suitable activity are not formed so that skin diseases and deficiency diseases will develop. According to literature data, a lack of trace elements can induce cancerous transformation in the organism, in which cases the introduction of suitable protein/trace element adducts into the organism can be beneficial - Thus, the trace elements cannot get to the necessary places in the organism and will not get into a biologically active condition without a transmitter and will thus not participate in the vital processes so that the state of health will be reduced. This appears, for example, when it comes to a lack of zinc, also when it comes to the external change of the skin. Zinc is a component of at least 30 enzymes and plays a crucial role in the skin's protein synthesis. Lack of copper, for example, causes the quality of wool from sheep to deteriorate as it leads to insufficient protein synthesis. The zinc metalloenzymes participate in the synthesis of DNS and RNS and a lack of these inhibits the transfer of genetic information necessary for the formation of proteins, induces dwarfism and inhibits skin regeneration. When it comes to copper deficiency, the skin's collagen structure will be damaged.

According to experiments, the above-mentioned disadvantages cannot be eliminated using mineral substances per se, which can be proven by the simple addition of iron salts will not lead to the healing of diseases caused by iron deficiency. The details of the activation processes for the trace elements are not known, but it has already been proven that they need a carrier molecule so that they can play their important biological role.

The aim of the present invention is to eliminate the above-mentioned disadvantages. The main feature of the present invention is that by using proteins and trace elements that are species- or type-specific, an adduct is obtained from which the active absorption of trace elements is ensured, whereby health-preserving and skin-regenerating preparations can be prepared. Use of the above-mentioned components eliminates the unwanted antigenic effect, does not cause allergic reactions and ensures a rapid regeneration of the damaged cells in the skin and the adequate functioning of the metallo-enzymes. It has been found that the skin-regenerating cream produced according to the invention has healed, for example, a pumice-sized wound on the nose which had been oozing for 15 years and which was considered incurable, by applying it twice a week. day for 8 days so that the skin on the nose was completely regenerated and the wound left no trace. In other cases, the cream produced according to the invention has regenerated peeled skin on a rat within 6 days to such an extent that even hair has grown on the peeled skin surface, while the skin of the control animal was completely damaged. The cream according to the invention can be applied with advantage, for example, to skin with psoriasis.

The health-preserving and regenerating preparation

according to the invention can also be applied internally. The adduct of the trace elements and the species-specific proteins ensures the absorbable trace elements also for the enzyme system which is necessary for the functioning of the entire organism. This enables optimal functioning of the organism, taking into account a specific status of the organism.

Accordingly, the invention relates to a species-specific, type-specific health-preserving preparation which can be applied both internally and externally, and which is characterized by the fact that it is produced from trace elements and proteins, proteinaceous substances which are characteristic of the given species and types on which the obtained preparation is used for health - conservation of a living organism of the same species and type.

Production of the health-preserving and regenerating preparations according to the invention is illustrated in the following

- not examples.

Example 1

100 ml of human blood belonging to group A was separated

for plasma and blood elements. 1 g of sodium bicarbonate was added to the plasma fluid obtained and the reaction mixture was heated to 80°C. The protein precipitate was separated, and after drying or to the still wet plasma protein with a dry matter content of 3.5 g, 70 ml of an aqueous solution containing 35 µg iron(II), 35 µg zinc(II), 10 µg copper(II),

10 ug silver(I), 1 ug chromium(III), 2 ug manganese(XI), 1 ug gold(III) ions as well as 1 ug boron and 1 ug molybdenum ions added. The reaction mixture was treated in a bath at 100°C for 60 minutes, and after cooling, 100 g of cream was prepared from the

held substance in a manner known in the field of cosmetics. The product thus obtained is an excellent skin agent which is suitable for the treatment of damaged skin surfaces.

Example 2

The procedure of Example 1 was followed but the plasma proteins and inorganic substances were treated at 121°C for 35 minutes.

Example 3

The procedure according to example 1 or 2 was followed, but pig blood was used, and the product obtained after heat treatment was used for supplying trace element deficiencies to pigs per se by application as an ointment to the skin or by oral administration.

Example 4

The procedure according to example 1 was followed but human blood belonging to group B was used.

Example 5

The procedure according to Example 1 was followed but 70 ml of Héviz medicinal water was used instead of the aqueous solution containing inorganic substances.

Example 6

The procedure according to examples 1 to 4 was followed but the protein was reacted with medicinal water from Csåszårbath, Budapest.

Example 7

The procedure according to examples 1 to 4 was followed but a mineral water, e.g. Purified water was used instead of the aqueous solution prepared in example 1.

Example 8

To 10 liters of blood plasma from an ox, 25 ml of water, 100 mg of copper sulfate and 100 mg of zinc sulfate were added, and the reaction mixture was kept at 121°C for 60 minutes. The product obtained was applied by spraying to the skin or hair of animals or by irrigation for the treatment of diseases due to a lack of trace elements.

Example

To the dry plasma powder obtained from human blood from group 0 according to example 1, 400 ml of water and 0.5 ml of commercial "Béres-csepp" containing trace elements were added. The reaction mixture was treated at 121°C for 35 minutes and was then processed to a cream in a known manner. The cream is suitable for the regeneration of skin with heat damage.

Example 10

The procedure according to examples 1 to 9 was followed but the protein containing substances was heat treated in a medium free of oxygen or the presence of an inert gas.

Example 11

The procedure according to example 1 or 9 was followed, but the preparation was prepared from the tissue of the organism of the person concerned.

Example 12

100 ml of human blood was separated for plasma fluid and blood elements. To the plasma was added 80 µg iron (III) sulfate, 8 µg manganese (II) chloride, 40 µg zinc chloride, 40 µg copper sulfate, 80 µg potassium chloride, 4 µg each of boric acid, silver nitrate and gold (III) chloride, and the reaction mixture was stirred at 36°C for 30 minutes. The obtained solution was applied parenterally.

Example 13

To 8 g of dry, hydrophilic human blood plasma was added 400 ml of physiological sodium chloride in which 160 ug of iron (II) sulfate, 16 ug of manganese (II) chloride, 80 ug of zinc chloride, 80 pg of copper sulfate,

60 µg of potassium chloride and 8 µg each of silver nitrate, boric acid and gold(III) chloride had previously been dissolved. The reaction mixture was sterilized in a sealed container at 121°C

for 30 minutes. The obtained solution was applied parenterally.

Claims (7)

1. Procedure for the production of medical cosmetic preparations, characterized in that human blood characteristics are used for the preparation of the preparation for species, type of the donor living organism, e.g. associated blood type A, B, AB, 0, Rh-positive, Rh-negative or the elements thereof and/or proteins obtained from them per se and/or by reacting these with trace elements, possibly together with known substances that are generally used for the production of cosmetic preparations. 2. Method according to claim 1, characterized in that the blood and/or its elements derived from the given species of animals are used in preparations administered to animals. 3. Method according to claim 1 or 2, characterized in that the protein containing the substance is reacted with natural water and/or mineral water, medical water and the original substances contained therein. • 4. Method according to claims 1, 2 and 3, characterized in that the protein-containing substances are reacted in a medium free of oxygen and/or an inert gas atmosphere. 5. Method according to claims 1, 3 and 4, characterized in that the preparation is prepared for a given person by using the blood or tissue from the given person. 6. Procedure for turnover of "human blood plasma with trace elements, inorganic substances and for use of the obtained product, characterized in that blood plasma is reacted with inorganic salts at a temperature of 70°C and that the resulting solution is applied parenterally. 7. Procedure for reacting the protein obtained from human blood plasma with inorganic substances and use of the obtained product, characterized in that the protein obtained from the blood plasma is reacted with inorganic substances in an aqueous medium at a temperature of 90 to 140°C, after which the obtained solution is sterilized and applied for the regeneration of internal wounds on the organism, e.g. intravenously.