CA1243957A

CA1243957A - Compositions for cosmetic, health- and body- preserving use

Info

Publication number: CA1243957A
Application number: CA000455540A
Authority: CA
Inventors: Laszlo Bogdany; Olga Bogdany; Laszlo Dede; Maria Dede
Original assignee: CAOLA KOZMETIKAI ES HAZTARTASVEGYIPARI VALLALAT
Current assignee: CAOLA KOZMETIKAI ES HAZTARTASVEGYIPARI VALLALAT
Priority date: 1983-06-03
Filing date: 1984-05-31
Publication date: 1988-11-01
Also published as: ES8603258A1; FR2546754B1; ES533050A0; PL248003A1; DE3490279T1; SE8500470D0; FI850354L; SU1718709A3; CH677319A5; NL8420169A; GB8502534D0; DK47885A; GB2156216A; FI82598C; FI850354A0; FI82598B; SE8500470L; FR2546754A1; YU95284A; CS414284A2

Abstract

ABSTRACT OF THE DISCLOSURE
This invention relates to cosmetic, health- and body-preserving compositions of high biological value, promoting the restoration of the cells and of that the skin, optimizing the biological processes occurring in the skin cells and providing the most preferable function of the enzyme system of the cells connected with the age of the organism. The compositions of the invention contain in addition to the commonly used carrier and additive and/or filling materials and active ingredients, native mineral waters, medicinal waters and/or the mixtures thereof and/or the mixtures thereof with fermented or non-fermented plant juices and/or optionally inorganic materials playing the role of trace elements in the living organism as well as proteins.

Description

~ 43957 his invention relates to cosmetic compositions promot ing the restoration of body cells and skin, optimizing the bio-logical processes occurring in the skin cells and particularly improving the enzyme system of cells to prevent them aging.

n one form, the present invention provides a composi-tion for the restoration and preservation of body cells and the skin by using natural substances. According to the invention, this aim is accomplished by treating proteins present in blood or blood plasma with inorganic trace elements occurring in the body that are present in natural mineral water, e.g. river-, lake-, sea-, or medicinal waters or in fruit extracts, vegetable extracts or fermented fruit juices and transforming the materials obtained to a pharmaceutical and/or cosmetic composition.
It is known that inorganic trace elements are essential components of a number of enzymes and exert a decisive influence on the function of living organisms. Their deficiency, e.g. that of copper, iron or zinc, causes the degeneration of cellular activity; thus cell respiration, hematopoiesis, brain tissues, the lungs and the nervous system can become damaged.

Although the primary role of a cosmetic is the beauty care of the skin, it can be stated that the function and health of the individual parts of a body cannot be considered alone since all parts and tissues are in mutual interaction.

Disorders arising from a deficiency of trace elements exert a general influence on the whole body and hence also on the condition of the skin which is, of course, the most visible part of the body. The skin is a highly differentiated organ and its condition has a decisive influence on the aesthetic appearance of humans.

In many cases the elimination of disorders arising from a deficiency of trace elements is not a simple task since the ~,.. .
.~ .

1~439S7 salts of trace elements, e.g. of iron sulphate, must be in a form capable of being absorbed by the body so that it can take part in the physiological processes.

From among the trace elements, the role of which is known, zinc, copper, iron, cobalts, manganese, silicon and magne-sium, etc. are essential for the skin. Thus, 20 per cent of the zinc content of the human organism is found in the skin and zinc plays an important role in the protein synthesis of the skin.
Copper is also very important in the structural development of collagen and elastin, and has a well known effect on the blood count. When these trace elements are not present in a sufficient amount, the solubility of collagen and elastin is increased and their function is impaired. Manganese and magnesium take part in a number of enzyme reactions, e.g. collagen synthesis, however their effects on the activity of the enzymes regulating the nuclei acid metabolism are also significant. Silicon plays an important role in the structural development of both the collage-nous and cartilaginous tissues. In addition to the trace ele-ments mentioned above, a number of other ones, such as seleniumas well as sulphur, sulphides, vanadium and nickel also possess important roles. Practically all inorganic materials are signif-icant for the optimum function of a living cell, which is not surprising when one considers that all these materials were pre-sent in the primary ocean, at the beginning of the evolution oflife.

There are cosmetics containing trace elements as well as other cosmetic compositions utilizing various proteins known for providing distinct types of activities, e.g. hydrating abil-ity, etc. These agents, however, do not give rise to an optimum supply of the trace elements to the skin cells or to other orga-nisms through the skin since the trace elements cannot be absorbed advantageously from an aqueous medium either alone or in a complex with one of the common organic ligands. It is for this reason that skin or rheumatic disorders (diseases) do not react ~ ~3 .

1243~57 consistently to medicinal baths and mineral water therapy or sometimes these treatments are even ineffective, although balne-ologists might expect a beneficial action on the basis of the quality and quantity of inorganic salts of these waters.' The composition of established mineral waters do not change and that of the sea-water can be considered as stable under natural condi-tions. In spite of these facts, the effect of these waters varies for patients suffering from identical skin disorders or diseases. As the composition of mineral waters containing the trace elements is stable, the reasons for these extreme results must lie in the individual characteristics of the patients. The likely reason for the divergent results is that the carrier molecules transferring the trace elements are not always avail-able. As mentioned above, trace elements in the form of simple organic salts and ions cannot freely diffuse through the skin into the body and into the cells to a sufficient extent and they cannot be bound to enzymes; this occurs only by the aid of car-rier molecules. These carriers can specifically transfer only a single, defined trace element to the site of action and it can be supposed that these carriers are present in the blood.

According to the present invention, there is provided a pharmaceutical and/or cosmetic composition for external applica-tion to the body comprising: (a) proteins obtained from animal blood or animal blood plasma treated with a liquid containing trace elements, which liquid is chosen from the group consisting of mineral waters, juices and extracts of plants and fermented plant juices; (b) an adjuvant suitable for forming compositions for external application to the body, which adjuvant is selected from the group consisting of an oily adjuvant, a soap, a deter-gent and a preservative.

It was found that the compositions of the present invention show an outstanding activity for the care of skin, for the therapy of rheumatic pains, for improvement of hair quality, restoration of hair follicles as well as for the treatment of ~2~L3~57 skin disorders and eczematous symptoms caused by detergents.

By treating blood, e.g. plasma proteins, with trace elements in mineral water or in natural plant (fruit or veg-etable) juices or extracts, cosmetics with an excellent and sur-prising effect may be prepared, such as tha-t described later e.g.
in Example 6. This composition was subjected to animal experi-ments that show that the compositions of the invention have advantageous and surprising activities. The results of these 0 experiments are summarized in Table 1 below. The study was car-ried out as described by H.C. Stoerk et al. [Am. J. Path. 30, 616 (1954)], The action of the cream describe,d in Example 6 was studied using the adjuvant arthritis test on Long-Evans rats to test the effects of the composition on arthritis in the rat. For obtaining a better comparison, the rats under test were treated with a cream containing 1 or 5 percent, respectively, of phenylbutazone known as one of the best anti-arthritic agents at present. The arthritis was induced by in;e,cting 'Ravenal' (Mycobacteria tuberculosis in a concentration of 0.2 mg/kg, in an amount of 0.1 ml/paw, in a paraffin oil suspension~ to the right posterior paw of the rat. The left posterior and both anterior paws of the animals were treated with the cream once daily for three weeks, i.e. 16 times in the course of the experiment. The evaluation was made on the basis of the volume alteration of the left posterior paw. ~A generalization of the arthritis was indicated by t,he swelling of the jolnts of the legs.) on day 21, in addition to the volume alteration of the left posterior paw, the leg use and physical state of the animals, as compared to the controls, were also evaluated. (This gave information about the mobility of the arthritic rats.) Twelve rats were used for the investigation of each cream in our experiments. The averages of the experimental results are summarized in Table 1. It is clearly demonstrated ~2g~3~3S7 from the results of Table 1 that the cream described in Example 6 had a stronger effect than the cream containing 1 percent of phenylbutazone, because it was as effective as a cream containing 5 percent of phenylbutazone. The cream described in Example 6, through used daily once only, inhibited the degenerative alter-ation of the joints and improved the walking and motion. Both the physical condition and mobility of the animals were good.
This test gives good indirect evidence of the beneficial effect of the composition of the invention in spite of the fact that its mechanism of action is clearly different from that of phenylbuta-zone. This test shows that plasma proteins treated with trace elements in mineral waters and/or with inorganic materials obtained therefrom play a role in the transfer of trace elements to skin cells; these elements are needed for the optimum func-tioning of the skin cells as well as for physiological processes.It is thought that this beneficial effect is due to the use of proteins as active ingredients prepared from blood and treated with trace elements in mineral waters, e.g. natural, and medici-nal waters and/or with inorganic materials obtained therefrom in the cosmetic compositions of the invention.

j) ~ - 5 -~2~gs7 Table 1 Comparative tests performed with the composition of the invention Cream accord- Phenylbutazone Phenylbutazone ing to Example 6 cream (1%) cream (5%) __,_____________________________________________________________________ Inhibition of increas-ing the volume of the right paw compared to 6% 5% 6%
the control ________________________________________________________________________ Inhibltion of increas-ing the volume of the left paw compared to 50% 25% 50%
the control ________________________________________________________________________ Using ths paw com-pared to the control 32% 25% 30%
______________________________________________ _________.____________ ___ Physical condition compared to the control 35% 25% 22 ________________________________________________________________________ ,~
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~243g;~7 The compositions prepared according to the invention are useful for the care and restoration of the skin, for the treatment of pustulous and inflammated skin and surprisingly, for the alleviation and abolishment of rheumatic pains.

The compositions of the invention can also be used for the treatment of psoriasis when the appropriate medicinal water is chosen as an aqueous phase and mixed with the protein compo-nent. Such medicinal water components are e.g. the waters of Harkany or ~ajduszoboszlo' as described in Examples l and 3. ~y using the medicinal water of Harka'ny and Héviz, the restoration of hair follicles is promoted and fattening of the hair follicles is diminished.

The composition described in Example 21 enhances the restoration of skin damaged by sunburn and exerts a beneficial effect on milder household burn injuries.

The beneficial effect of the compositions of the inven-tion is intensified when in addition to or instead o~ naturalmineral waters, mixtures of plant extracts and/or plant ~uices with medicinal waters, mixtures of natural waters and/or plant juices or extracts enriched with the required trace elements are used as the aqueous phase of the compositions of the lnvention.
When the compositions of the invention are to be used for alleviating rheumatic pains, then the proteins are suitably treated with noble metal salts or with the solutions thereof in water and/or in medicinal waters as illustrated by Example ~.
The compositions and embodiments of the invention are illustrated by the following non-limiting Examples.

- Exam~le 1 A mixture containing 137.5 g of white petroleum ~b ~ _ 7 _ ~Z439S7 /Vaseline*/, 82.5 g of cetyl alcohol, 27.5 g of paraffin oil and 27.5 g of Tween* 60 is heated to 80C to form the fatty phase of the composition. Meanwhile, 10 g of plasma protein prepared from cattle blood plasma are swollen in 200 ml of the medicinal water of Harkany and the mixture is heat treated at 112C for 90 min-utes. After the treatment with the medicinal water, the protein ~is cooled to 60C and mixed with the fatty phase kept at 80C.
After homogenation, a further amount of 600 ml of the medicinal water of Harkany heated to 70C are added to the hot mixture and the whole are stirred until cool. A cream is obtained which pos-sesses an excellent hydratating, skin-restoring /preserving/
effect and surprisingly, when smeared on the painful part of -the body, it alleviates or removes the rheumatic pains.

Example 2 The process described in Example 1 is followed, except that 1 mg of gold /III/-trichloride is added to the plasma pro-tein before or after the heat treatment.

Exame~_3 The process described in Example 1 or 2 is followed, except that the medicinal water of Hajduszoboszlo is used as an aqueous phase.
Example 4 The process described in Example 1 or 2 is followed, except that the medical water of Parad is used as an aqueous phase.

*Trad~ Mark *Trade Mark ~ - 8 -~Z43~3~7 I Example 5 The process described in Examples 1 to 4 is followed, except that the plasma protein is treated with a natural medici-nal water, to 200 ml of which 1 mg of gold /III/-trlchloride, 0.5 mg of silver nitrate, 0.1 mg of chromic chloride, 2 mg of ferrous 'sulphate, 1 mg of manganous chloride, 1 mg of ammonium molybdate, 0.5 mg of cupric sulphate, 1 mg zinc chloride, 0.5 mg cobaltic chloride, 0.2 mg of boric acid and 0.2 mg of nickelous sulphate were added before the heat treatment.
Example 6 ~ The process described in Example 1 is followed, except ! ï5 that the plasma protein is treated with 200 ml of the medicinal water arising from the Lukacs-bath /Budapest/ which contain 1 mg of ferrous sulphate, 1 mg of cupric sulphate, 0.5 mg of nickelous sulphate, 1 mg of zinc sulphate and 0.5 mg of colbaltic chloride added previously.

Example 7 The process described in Examples 1 to 6 is followed, except that the geyser water of Karlsbad is used as an aqueous phase of the composition.
.

Example 8 The process described in Examples 1 to 7 is followed, except that the natural water of Balaton is used as an aqueous phase.

Example g The process described in Example 1 is followed, except that the plasma protein is heat-treated with 200 ml of distllled ~3 _ 9 _ i;243~3S7 water and then 600 ml o sea-water, e.g. of the water of the Aegean Sea is used for preparing the cream.

Example 10 The process described in Examples 1 to 6 is followed, bxcept that in addition to 200 ml of medicinal water employed to treat the plasma protein, the natural water of the Danube river is used for preparing the cream.

Example 11 The process described in Example 1 is followed, except that the plasma protein is treated with the medicinal water in the presence of 2 mg of zinc sulphate.
Examp_e 12 The process described in Example 1 is followed, except that, instead of the medicinal water, water is used which con-tains in 1 ml each 5 ~ g of copper, 5 ~g of iron, 10 Jug of zinc, 2 ~g of cobalt, 1 ~ g of nickel, 20 ~ g of magnesium and 20 ~ g of calcium.

Example 13 The process described in Example 1 is followed, except that carrot juice is used as an aqueous phase.

Example 1~

The process described in Examples 1 to 6 is followed, except that a wine prepared from grape is used as an aqueous phase.

_ 3~57 Example 15 The process described in Examples 1 to 6 is followed, except that apple wine neutralized by sodium bicarbonate is used as an aqueous phase~

Example 16 The process described in Examples l to 6 is followed, except that a frui-t juice, e.g. apple juice is used as an aqueous phase.

Ex mple 17 80 ml of ~ater and 2 g of sodium bicarbonate are added to 20 ml of swine blood, then the mixture is kept at 120C for l hour. The material obtained is filtered and 700 ml of the medic-inal water of Harkany are added to the filtrate. The aqueous solution obtained is worked up to a cream in a manner known in the art to glve an excellent, hydratating and skin-restoring /skin-preserving/ cosmetic which is also useful for alleviating rheumatic pains.

Example 18

2 g of sodium bicarbonate, 50 ml of aqueous camomile extract and 600 ml of the medicinal water of Heviz are added to 100 ml of sheep blood plasma. The mixture is stirred at 20C for 1 hour, then it is worked up to a body-preserving cream in a manner known in the art.

Example 19 The process described in Example 1 is followed, except that, instead of the medicinal water of Harka'ny, an 1:1:1 mixture ~Z43957 containing the medicinal waters of Harkany, Hajduszoboszlo and Heviz is used as an aqueous phase.
Example 20 To a plasma protein powder prepared from 10 g of cattle 'blood, 200 ml of the medicinal water of Harkany kept at 70C are added and the mixture is heated at 112C for 90 minutes. After cooling, 70 ml of natural medicinal water of Harkany, 30 g of Alfozide Kt-25, 80 g of Zala betaine, 570 g of sodium lauryl ether sulphate, 20 g of Alfid-D-ll, 2 g of Alphasept (a preserva-tive), 10 g of polyethyleneglycol M-200 and 10 ml of 96% ethanol are added to the mixture to given an excellent refreshing, skin-restoring foam bath which also promotes the restoration of the rheumatic parts of the body.
EX ample 21 A plasma protein prepared from 10 g swine blood is treated with 200 ml of the medicinal water of Harkany at 120C
for 1 hour, then 125 ml of the medicinal water of Harkany and 125 ml of the medicinal water of the Luka'cs-bath / Budapest/ are added to the solution obtained. This mixture is supplemented with an appropriate preservative and used in spray form to treat the skin injuries caused by sunburn.
Example 22 A plasma protein prepared from 10 g of rabbit blood is treated with 200 ml of the medicinal water of Hajduszobosælo at 112C for 90 minutes, then 300 ml of the medicinal water of Balf and 50 ml of sea-water are added to the hot solution. Then 92 g of Alfozide KT-25, 75 g of Zala betaine, lgO g of sodium lauryl ether sulphate, 10 g of Alfid-D-ll and 2 g of Alphasept are added to the mlxture to give an outstanding hair shampoo promoting the restoration of the hair bulb,s and the steady hair growth.

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~2~357 Example 23 A plasma protein prepared from 10 g of swine blood is transformed to a solution by treating with 100 ml of the medici-nal water of ~ajduszoboszlo and 100 ml of the medicinal water ofHarkany at 120C. To this solution, a melt containing 100 g of cetyl alcohol, 101 g of isopropyl myristate, 220 g of sorbitol of 70%, 60 g of cosmetic stearin, 140 g of cosmetic Vaseline* oil, 2 g of glutaraldehyde, 39.2 g of cosmetic lanolin, 20 g of pro-pyleneglycol and 3 g of Nipagin*M is added. The mixture is sup-plemented with 1100 ml of medicinal water of Hajduszoboszlo kept at 60C and with 5 g of potassium hydroxide and stirred until cool. This composition is excellently useful as a hand-preserv-ing balsam to restore the eczematous skin disorders caused by e.g. detergents.
Example 24 800 g of a soap powder is dissolved in 2 litres of dis-tilled water at 80C, thereafter 200 g of sodium lauryl ether sulphate, a plasma protein solution prepared from a cattle blood of 5% with 200 ml of medicinal water of Harka'ny at 120C, as well as 500 ml of glycerol, 8 g of Nipagin and an odour are added and stirred until cool. An excellent cream soap is obtained which inhibits the damaging of the skin and is particularly suitable tokeep the inflammated skin in a clean state.

Example 25 142 g of stearin is saponified by 28.5 g of potassium : hydroxide in 500 ml of distilled water at aoc, then a solution : prepared from 10 g of plasma protein with 200 ml of the medicinal water of Héviz at 160C, as well as 100 g of sodium lauryl ether *Trade Mark *Trade Mark t; ~ ~

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~2~3~i7 sulphate, 100 g of glycerol, 3 g of Nipagin M preservative agent are added and stirred until cool. An outstanding cleaning agent is obtained which inhibits the damaging /in~ury/ and desiccation of the skin.

Example 26 To a rnelt prepared from 25 g of cetyl alcohol, 12 g of Vaseline*, 2.5 g of Tween* 60 and S g of glycerol at 72C, a plasma protein solution of 1% prepared with 6 ml of the medicinal water of Héviz at 120C as well as 5 ml of ethanol are added~
The mixture is coloured and aromatized as desired to give a lip-preserving agent which diminishes the desiccation of the lips.

Example_27 A salt mixture obtained by evaporating 0.5 g of the medicinal water of Harkany is mixed with 200 ml of distilled water, the plasma protein prepared from 10 g of cattle blood plasma is added and the mixture obtained is heat-treated at 121C
for 2 hours. The material obtained is worked up to a cream according to the Example 1.

*Trade Mark *Trade Mark , ~ - 14 -

Claims

THE EMBODIMENTS OF THE INVENTION IN WHICH AN EXCLUSIVE
PROPERTY OR PRIVILEGE IS CLAIMED ARE DEFINED AS FOLLOWS:

1. A cosmetic composition for external application to the body comprising: (a) proteins obtained from animal blood or animal blood plasma treated with a liquid containing trace ele-ments, which liquid is chosen from the group consisting of min-eral waters, juices and extracts of plants and fermented plant juices; and (b) an adjuvant suitable for forming compositions for external application to the body, which adjuvant is selected from the group consisting of an oily adjuvant, a soap, a detergent and a preservative.

2. A composition as claimed in claim 1, wherein the mineral water is selected from the group consisting of spa water of natural origin, river water, lake water and sea water.

3. A composition as claimed in claim 2, wherein the mineral water is water from the Hungarian Lukcs bath in Budapest or from the Hungarian Harkny bath.

4. A composition as claimed in claim 2 or 3, wherein the mineral water includes additionally dissolved trace elements.

5. A composition as claimed in any one of claims 1 to 3, wherein the composition contains blood plasma or whole blood.

6. A composition as claimed in any one of claims 1 to 3, wherein the trace elements are selected from the group con-sisting of Au, Ag, Pt, Cr, Fe, Mn, Co, Cu, Ni, Zn, Mg and Ca.

7. A composition as claimed in any one of claims 1 to 3, wherein the liquid containing trace elements is apple juice or apple wine,

8. A process of preparing a pharmaceutical and/or cos-metic composition, which process comprises treating proteins obtained from animal blood or animal blood plasma with a liquid containing trace elements, which liquid is selected from the group consisting of mineral waters, juices and extracts of plants and fermented plant juices, heating the mixture and mixing the contained aqueous solution with an adjuvant selected from the group consisting of an oily adjuvant, a soap, a detergent and a preservative.

9. A process as claimed in claim 8, wherein the trace elements are selected from the group consisting of Au, Ag, Pt, Cr, Fe, Mn, Co, Cu, Ni, Zn, Mg and Ca.

10. A process as claimed in claim 8, wherein the said protein is in the form of cattle or pig blood plasma which plasma is mixed with the said liquid.

11. A process as claimed in any one of claims 8 to 10, wherein the mineral water is water from the Hungarian Lukcs bath in Budapest or from the Hungarian Harkny bath.

12. A process as claimed in any one of claims 8 to 10, wherein the liquid containing trace elements is apple juice or apple wine.