HU195727B - Cosmetics based on medical, mineral or thermal water and process for production of the active substance - Google Patents

Abstract

The invention further relates to a process for the preparation of an active ingredient. 195727 -1-

Description

The present invention relates to cosmetic preparations based on medicinal water, mineral water, thermal water, preferably cream, lotion, shampoo, mouthwash or toothpaste. The formulations contain from 0.1 to 10% by weight of an 80-95% by weight dry animal protein or from 5 to 9% by weight of an animal hemoglobin solution or a vegetable hemoglobin solution obtained from animal blood. from 80-95% by weight of protein of dry matter and 15-90% by weight of trace elements, preferably potassium, sodium, calcium, magnesium, manganese salts and optionally salts of trace elements in medicinal water, mineral water, thermal water or mixtures of these waters. , preferably a protein trace adduct of iron (II), copper, nickel, potassium, zinc, cobalt, manganese, tin, magnesium, 'vanadate, molybdenum or precious metal salts - in which ΙΟ' - contains ¹ part by weight of trace element - contains, with the known additives necessary for 100% by weight.

The active ingredient of the present invention is prepared by administering 0.1 to 10% by weight of animal protein from 80 to 95% by weight of animal protein, or from 5 to 9% by weight of animal blood plasma or 15 to 35% by weight of animal blood. a solids-containing hemoglobin solution or a vegetable-derived 80-95% by weight solids-containing protein in 15-90% by weight of medicinal water, mineral water, thermal water or a mixture of these waters and optionally 0.001-0.1% by weight of iron (XI). , copper, nickel, potassium, zinc, cobalt, manganese, ion, magnesium, vanadate, molybdenate or precious metal salt, and the resulting mixture is kept at a temperature of 30-150 ° C. -80 minutes.

An article by Am. Perfumer Aromat (67, 3, 43, 1956) recommends 5-hydroxytryptamine from blood tryptophan for the treatment of aging, dehydrated skin, Kosmetik Perfume Drug Rundschau [12/7/8, 106-7, 114 (1965) describes the use of a protein derived from blood in anti-wrinkle formulations.

British Patent No. 1038,415 discloses the use of animal blood albumin and Polish Patent No. 51,007 disclose the use of animal derived protein in cosmetic compositions.

Known cosmetic formulations have a very good moisturizing effect but are not suitable for biological regeneration of the skin.

It has now been found that by attaching trace elements essential to the body to blood, its elements or a hydrophilic protein molecule derived therefrom, an active ingredient is obtained which has a bioregenerative effect in cosmetic compositions.

Trace elements play a very small role in the functioning of the living organism.

Trace elements are usually co-enzymes of various enzymatic reactions and are essential for the proper functioning of hormones, enzymes and the nervous system.

The lack of trace elements leads to a damaging effect on the body and, in a narrower sense, on the skin surface.

However, trace elements cannot work without intermediary molecules, no, they cannot reach the proper points in the body.

For example, zinc deficiency results in a deleterious appearance of the skin as it is a constituent of at least thirty enzymes and plays an important role in skin protein synthesis.

Zinc metalloenzymes are involved in DNA and RNA synthesis. Their absence inhibits skin regeneration. ·

In the case of copper deficiency, the collagen structure of the skin is damaged.

Essential trace elements include: iron, copper, zinc, manganese, cobalt, fluorine, selenium, molybdenum, barium, strontium, magnesium, boron, vanadium, tin, precious metals, etc.

We have found that the addition of trace elements alone cannot make up for the deficiency in the body. Trace elements are only absorbed in the body by attaching them to a special protein molecule, which is the only way they can exert their regenerative effect.

Trace elements with protein molecules form an adduct that is easily absorbed through the skin. The trace elements thus introduced into the body primarily promote enzymatic reactions by enhancing the enzyme's life function. Thus, it has a cell rejuvenating, anti-wrinkling, anti-inflammatory, etc. they can make an impact.

Mineral, medicinal and thermal waters contain trace elements in very favorable composition.

The amount of dissolved ions in 1 liter of Hajdúszoboszló's medicinal water is as follows:

mg mg equivalent

potassium, K * 20:58 0:53 Sodium So* 1759.0 76.47 ammonium NH 4 * 0.C1 0:03 Calcium Ca ² * 6:18 0:31 Magnesium Mg 2+ 3:57 0:29 Iron Fe ² * 0:09 0:03 Alumir ium ΛΡ * 1.77 0:20 Cations oaazu o ¹ · '· 1791.81 77.86 nitrate NOj- cannot be detected i Niti'it NO r cannot be detected í

Chloride Cl 1815.5 51.20 bromide Br 12:51 0:16 iodide J- 7:49 0:16 Fluoride F- 1:40 0:07 Sulfate SO4 ² - 4.76 0:10 Hydrogen- carbonate HCO3- 1575.0 25.81 carbonate CO ^J 3- 16:40 0:47 Sum of anions: 3433.06 77.79 metaboric HBO2 97.37 silicic acid H2SÍO3 47.81 - Free carbonated CO2 does not can be detected - dissolved oxygen O2 no can be detected - Altogether: 5370.05 155.83 The water of Hévíz composition the following:

mg mg equivalent

Potassium sodium

in sodium expressed So* 42.63 1.81 ammonium NH 4 * 0.2 0:01 Calcium Ca ² * 77.18 3.85 Magnesium Mg ² * 34.10 2.81 Iron Fe ² * 0:01 - Manganese Mn ² * trace - Aluminum Al ³ * no can be detected - Arsenic AS ³ * no can be detected Sum of cations: 154.12 8:48 nitrate NO3- no can be detected Nitrite NO2 no can be detected Chloride Cl 28.0 9.73 bromide Br 0:15 0002 iodide J- 0:02 - Fluoride F- 1:32 0:56 Sulfate SO4 ² - 61.91 1:28 Hydrogen- • carbonate HCO3- 380.1 6:23 Sulphide s ² - 3.0 0:18 Sum of anions: 474.50 8982 metaboric HBO2 5:10 - silicic acid H2S1O3 22.84 - Free carbonated CO2 119.24 - Dissolved oxygen O2 no can be detected - Altogether: 755.80 17 462

The spring water of the Lukács Bath Budapest has the following composition:

mg mg equivalent

Potassium Sodium ammonium Calcium Magnesium Iron Manganese K * Na * NH * 4 Ca ² * Mg ² * Fe ² * Mii ² * no no 13:50 143.1 0:50 155.8 31.0 detected detected Who Who 0:34 6:22 0:03 7.79 2:55 Sum of cations: 343.9 16.93 nitrate NO3- no detected Who Nitrite NO2 no detected Who - Chloride Cl 140.0 3.95 bromide bi- 0:13 0001 iodide J- 0069 - Fluoride F- 2:40 0:12 Sulfate SO4 ² - 182.1 3.79 Hydrogen- carbonate HCO3- 555.1 9:10 Sulphide s ² - 0:14 0008 Sum of anions: 879.93 16.97 silicic acid H2SÍO3 40.1 - Free carbonated CO2 404.6 - Dissolved oxygen 02 no can be detected -

Total: 1668.53 33.90

Surprisingly, it has been found that medicinal waters, mineral waters, thermal waters, mixtures thereof, and optionally enriched in metal salts, are reacted with animal blood proteins or plant proteins to form a protein trace adduct and formulate the adduct as an active ingredient. cosmetics are obtained which have a bioregenerative effect. Protein adducts can be used to produce highly effective anti-wrinkle agents which can also optimize the fat content of the skin.

The compositions of the present invention are also useful for treating pressure, impact sensitive skin, body parts, and muscles and joints.

The composition of the present invention may be used for any personal care such as the medicinal water, mineral water or thermal water contained therein. In the form of a protein adduct, the trace elements present in medicinal, thermal or mineral water, and optionally added to these waters, are very well absorbed into the skin.

The cosmetic composition may be a cream, lotion, foam bath, shampoo, mouthwash or toothpaste.

-3ö

The trace elements are introduced in the form of inorganic nickel, copper, zinc, cobalt, iron, magnesium, tin, manganese, vanadate, molybdenate or alkali fluoride, boric acid or alkali borate or mixtures thereof. the protein trace element adduct.

The adduct is prepared by administering 5 to 9% by weight of plasma solids from animal blood or a 15 to 35% by weight solution of animal hemoglobin in animal blood or from 80 to 95% by weight of animal protein from 80 to 95% by weight of dry matter. The solids-containing vegetable protein is reacted with water containing the trace element at 30-150 ° C for 10-80 minutes. The composition contains from 0.1 to 10% by weight of protein and 15 to 90% by weight of medicinal water.

The resulting mixture is optionally diluted with fermented or unfermented vegetable juices. Preferably, the fermented vegetable juice is wine, and the non-fermented vegetable solution is preferably fruit or vegetable or vegetable juice, such as cucumber juice, carrot juice, apple or tomato juice, or an aqueous extract of herbs.

The latter is preferably an aqueous extract or a mixture of extracts of catanza, tansy burr, walnut leaf, canine bark, thistle or chamomile flower.

Physiological saline can also be used as a diluent, and such a composition is preferably used for iontophoretic treatment.

Fats, vegetable oils, glycols, alcohols, preservatives, boron wetting additives, emulsifiers, antioxidants, vitamins, flavors and fragrances may be used as additives.

Preferred preservatives are nipagine (10% alcohol solution of benzoic acid ester) or phenonip solution (solutions of NIPA esters) or cathonium CG (isothiazolin-3-one derivative). Preferred emulsifiers are amphisol (phosphoric acid ester), tween-60 Ipoli (oxyethylene glycerol fatty acid ester) and cremophor nonionic emulsifier (ethylene glycol polymer).

Fats and vegetable oils may be used as follows: stearin monoglyceride, edible sunflower oil, edible corn oil, petroleum jelly, synthetic duckweed extract, brand name Cetiol V, which is a skin related oil. Alfol RDS 16 (cetyl alcohol) may be used as the alcohol.

Preferably, the antioxidant is butylhydroxytoluene.

In addition, allantoin (5-ureido-hydantoin) cell stimulant may be used in the cosmetic composition, as well as Hygroplex HHG, a mixture of mono- and disaccharides and amino acids, as a moisturizing additive.

Additionally, silicone oil antifoam agents, flavoring agents, essential oils and fillers may be used.

After the addition of the additives, the mixture is kept at a temperature of 30-150 ° C for 10-80 minutes, then, in the case of a cream preparation, it is mixed with the gaseous phase and maintained at 65-80 ° C with constant stirring.

In the manufacture of a foam bath, shampoo, mouthwash or toothpaste, additives specific to the particular formulation may be used.

The following examples illustrate the composition of the invention and the process for its preparation.

Example 1

Preparation of Skin Care Cream Bleached beeswax, 10 g cetyl alcohol, 5 g white petrolatum, 8 g sunflower oil and 5 g tween 60 were melted in a water bath at 90 ° C and homogenized. To 48 g of Hajdúszoboszló curative water is added 20 ml of 7.5% w / w porcine blood fluid, the mixture is kept at 121 ° C for 30 minutes, cooled to 90 ° C and homogenized with the above fat phase. The mixture was stirred under constant stirring until cooled. To the cold mixture was added 2 nd of a 10 wt% alcoholic solution of Nipagin M. After repeated homogenization, the product is filled into tubes. Highly moisturizing lotion is obtained which is suitable for the treatment of inflamed, acne-prone skin.

Example 2

Production of skin care cream

9.5 g of protein derived from swine blood (dry weight content: 88% by weight), 2 g of edible gelatin in a mixture of 40 ml of Harkány and 16 ml of Hajdúszoboszló healing waters, 5 mg of ferric sulphate, 1 mg of copper sulphate, 2 mg of manganese; chloride, 2 mg zinc chloride, 1.5 mg cobalt (II) chloride and 10 mg magnesium sulfate were treated at 121 ° C for 30 minutes and then made up to 100 ml with the fat phase of Example 1, instead of the medicinal water of Hajdúszoboszló, the resulting mixture is incorporated into the ointment base as a water phase.

Example 3

Preparation of Skincare Cream To ml of plasma liquid containing 7.5% by weight of dry matter, prepared by centrifugation of swine blood, add 48 ml of Hajdúszoboszló healing water, 5 mg of ferric sulphate, 1 mg of manganese (II) chloride, 0.5 mg of zinc chloride, 0.5 mg of copper sulfate, 5 mg of potassium chloride, 0.5 mg of cobalt (III) chloride and Ί0 mg of magnesium sulfate. The mixture was treated for 30 minutes at 121 ° C and then treated according to Example 1. make up to 100 ml with the lipase. The product obtained is an excellent moisturizing, skin regenerating cream.

#. example

Preparation of skincare cream To 1 ml of sponge bath water, add 1 mg of copper sulfate, 2 mg of ferric sulfate, 0.5 mg of zinc chloride, 1 mg of gold trichloride, then add 2 g of pig blood (dry weight content: 5% by weight). %) hemoglobin powder (dry weight content: 90% by weight). The mixture was treated for 40 minutes at 121 ° C and the adduct thus obtained was mixed with the ointment base. It is prepared by melting 3 g of bleached beeswax, 10 g of cetyl alcohol, 5 g of white petrolatum, 8 g of sunflower oil and 5 g of Tween 60. The two mixtures were homogenized and stirred until cooled. To the cold mixture was added 1 mL of a 10 wt% solution of Nipagin M. After repeated homogenization, the cream is removed. An easily absorbed regenerating cream with excellent hydration capacity is obtained.

Example 5

Preparation of skin care cream

In each case, the same procedure as in Example 4 was followed, except that 10 ml of an extract of 2 g of chamomile and 2 g of chamomile and 2 g of calendula grass in 100 ml of hot water were added to the mixture of pig blood hemoglobin, medicinal water and inorganic salts.

A cream suitable for the treatment of inflamed acne skin is obtained.

Example 6

Preparation of skin care cream

All proceed as in Example 4, but replacing half of the curative water with Isaac's Sari White wine.

Example 7 Preparation of a mixture for treatment of lontophoresis from g bovine blood (dry matter content:

7.5 ml of Hydrophilic Plasma Protein Powder (dry weight: 88 wt.%) Was added to 250 ml of Hajdúszoboszló healing water. Add 30 ml of squeezed filtered tomato juice. The homogenized solution was filled into 2 ml ampoules and treated at 121 ° C for 30 minutes. a solution suitable for lontophoresis treatment is obtained.

Example 8

Manufacture of toothpaste

Plasma powder prepared from 9.5 g bovine plasma (dry matter content: 8.5% by weight), 5 ml of 0.001% iron (II) sulphate solution in dry matter (90% by weight) and 50 ml of paraffin water 120 ° C at 60 ° C for 60 minutes to prepare a protein trace element adduct. The amount of trace element contained in 1 g of adduct per solids content is 10 ^{4 5} g.

g of dicalcium phosphate, 250 g of sodium silicoaluminate, 30 g of sodium lauryl sulfate, 15 g of hydroxyethyl cellulose, 10 g of colloidal silica, 8 g of sodium monofluorophosphate, 250 g of sorbitol (70% sorbitol content) ), 3 g of chamomile extract (dry weight content 25%), 10 g of titanium dioxide, 1 g of prenylamine lactate and 15 g of strawberry flavor, and 0.5 g of saccharin sodium.

To the mixture is added 50 g of a protein trace element adduct with a dry weight content of 20%. The material is homogenized and 25.7 g of distilled water are added.

Toothpaste containing iron and other trace element protein adducts is added to make up for the body's lack of local trace element and prevent tooth decay.

Example 9

Preparation of Mouthwash from g Bovine Plasma Powder (dry weight: 88% by weight) and 50 ml of Paradise Mineral Water at 40 ° C for 60 minutes gives a protein trace adduct of 10 g to ³ g of solids.

300 g of ethanol by weight are mixed with 25 g of sodium lauryl sulfate, 1 g of sodium monofluorophosphate, 0.3 g of saccharin sodium, 10 g of chamomile alcoholic extract (2.5% by weight dry matter) and 2 g with menthol. To the resulting mixture was added 5 g of iron-containing protein trace element adduct with 20 wt.% Solids and 640 g of distilled water.

The mouthwash containing the trace element protein adduct inhibits the body's lack of local trace element and prevents tooth decay.

Example 10

Preparation of bath composition

Add to -510 g of bovine plasma powder (dry matter content: 92% by weight)

1000 ml of thermal water of Hévíz 10 mg iron (II) sulphate, 0.2 mg nickel sulphate, 1 mg zinc sulphate, 1 mg manganese (II) sulphate, 10 mg potassium chloride, 0.5 mg cobalt chloride, 10 mg of magnesium chloride, 0.2 mg of tin chloride, 1 mg of ammonium molybdenate, 0.1 mg of ammonium vanadate, 1 mg of gold trichloride, 1 mg of copper sulphate, 2 mg of boric acid and the mixture is heated for 30 minutes at 121 ° C. temperature. To this solution was added 2 g of Nipagin M preservative and 2 g of lemon oil. The obtained product is suitable for the supply of trace elements in bath waters, for the reduction and replacement of the trace element loss of the skin.

Example 11

Preparation of bath salt composition

All of the procedures described in Example 10 are followed, but using Margaret Island thermal water instead of Heviz Lake.

Example 12

Preparation of skin care cream

All proceed as in Example 4 but using yeast protein (dry weight: 90% by weight) instead of hemoglobin powder.

An excellent moisturizing cream is obtained which is particularly suitable for the treatment of inflamed sensitive skin.

Example 13

Preparation of skin care cream

All proceed as in Example 4, but using 2 g of alfalfa protein (dry weight: 85% by weight) instead of the hemoglobin powder. The amount of alfalfa protein was calculated on a dry matter basis. The protein content of the alfalfa press juice used in the composition is 3% by weight.

The cream thus obtained has an excellent moisturizing and regenerating effect.

Example 14

Preparation of Shaving Cream Stearic acid (g) is heated to 75 ° C and then mixed with 0.5 g of sodium citrate, 1 g of cetyl alcohol, 2 g of isopropylamine, 5 g of glycerol at 70 ° C.

Adduct (66 ml) of Hemoglobin solution (dry weight: 25% by weight) from Zalakaros medicinal water and 10 g of pig blood at 120 ° C for CO min. The mixture was homogenized and 0.3 g of p-hydroxybenzoic acid propyl esters were added.

After cooling, we smell the stuff.

We obtain a shaving cream that contains the bioactive substances of the Zalakaros medicinal water, its trace elements in the form of an adduct and provides a hydrating treatment of the face when shaving.

Example 15

Preparation of foam bath composition

68.5 g of sodium lauryl ether sulphate, 2 g of coconut fatty acid diethanolamide, 0.2 g of p-hydroxybenzoic acid propyl ester and 26.5 g of harkany water and 3 g of swine blood (dry matter content: 7) (9% by weight) of the adduct prepared at 120 ° C for 30 minutes at 40 ° C. A foam bath composition containing bioactive substances of the Harkány thermal water is obtained, thus promoting skin care during bathing.

Example 16

Preparation of shampoo g 27% by weight of sodium lauryl ether sulphate, 1 g of coconut fatty acid diethanolamide, 5 g of polyglycol ether (Ms: 200), 4 g of concentrated fatty alcohol ether sulphate, 1 g of perfume, 0.3 g of Nipagin at 50 ° C. and a filtrate of 12 ml of bovine plasma (solids content: 7% by weight), 0.1 g of sodium citrate and 15 ml of a solution of Budapest Embryo's Bath water at 121 ° C for 30 minutes is added. The mixture was homogenized at 40 ° C and cooled to room temperature. We obtain a shampoo that prevents dandruff from the scalp, loss of trace elements in the hair during washing, and fragility of the hair.

Example 17

Production of skin care cream

All proceed as in Example 1, except that 96 ml of Hajdúszoboszló's healing water is diluted to 48 ml and the cream is treated with this mineral-rich mineral water.

-612

Example 18 (Functional)

Example 4 was tested in a living group of 22 subjects. The subjects' skin was dry and the skin had wrinkles.

The cream was applied twice daily for 2 months.

after daily use, the subjects' skin dryness decreased, skin elasticity increased, and surface wrinkles smoothed. No adverse reactions were observed. After 2 months of treatment, the skin was dry and the skin was firm and wrinkle-free.

Example 19 (Activity) The effect of the cream of Example 5 was investigated in 30 subjects, 22 of whom had seborrheic skin and 8 had acne. All subjects had a greasy, radiant skin on their face. Of the subjects, 23 were female and 7 were male. The subjects received the preparation twice daily for 2 months. The beneficial effect was apparent after 5 days. The oily skin, the formation of the scab, ceased. The preparation was found to be good in 24 cases and satisfactory in 5 cases. Lipid tartrate of the forehead surface was measured in 15 subjects. In 11 cases a decrease in lipid content was observed.

After 2 months of treatment, the subjects' skin fat mass was significantly reduced, acne formation was reduced, and seborrheic complaints practically resolved.

Example 20

Comparative studies

Comparative studies are performed with the same fat-based creams. In a blind experiment, the cream contains only distilled water; for comparison, creams are prepared which contain only medicinal water or only protein, or only the known protein adduct (prepared according to Example 1 of EP-A-190723) or the protein-medicinal water mixture according to the invention.

Changes in red cell membrane ion transport were measured during the experiments. The results are summarized in the table below.

Spreadsheet

preparations contain active transport inhibition% % increase in passive transport outflow cream containing only medicinal water 1.0 0.0 only protein containing cream 5.0 0.0 cream containing protein trace elements (according to Example 1 of 190 1903) 18.0 98.0 protein-water cream (according to the invention) 68.7 533 protein-water cream (according to the invention) 73.2 545 protein-water cream (according to the invention) 78.2 560 only distilled water containing cream 0.0 0.0

PATENT CLAIMS

Claims (2)

1) Cosmetic preparations based on medicinal water, mineral water, thermal water, preferably cream, lotion, foam bath, shampoo, mouthwash, toothpaste, preferably containing fermented or unfermented herbal juices, herbal extracts, fats, vegetable oils, emulsifiers, preservatives and antioxidants; The metal salts are characterized in that the preparation contains from 0.1 to 10% by weight of animal blood, 80 to 95% by weight of dry matter, of protein or animal blood, 5 to 9% by weight of dry matter. , 80-95% by weight of hemoglobin or 15-35% by weight of dry matter derived from plasma fluids or animal blood; containing from 15 to 90% by weight of protein and 15 to 90% by weight of trace elements, preferably potassium, sodium, calcium, magnesium, manganese salts and optionally ferric salts (preferably iron salts), II) consisting of copper, nickel, potassium, zinc, cobalt, manganese, tin, magnesium, vanadate, molybdenate or precious metal salts -714 protein trace element adducts, containing IO '' - ¹ mass fraction trace element by weight, in addition to known additives for 100% by weight. 2) A process for the production of protein trace element adduct, characterized in that it contains from 0.1 to 10% by weight of animal protein, 80 to 95% by weight of dry matter, or 5 to 9% by weight of animal fluid from plasma or animal blood. 15% to 35% by weight of a dry solution of hemoglobin or of plant origin, 80-95% by weight of protein in dry matter with 15-90% by weight of medicinal water, mineral water, thermal water or a mixture thereof, and optionally 5 to 0.001 to 0.1% by weight of iron (II), copper, nickel, potassium, cobalt, zinc, manganese, tin, magnesium, varietal, molybdenate or precious metal salts are added. obtained between 30 and 150 ^U Keep at 10 for 10-80 minutes.