CS252816B2 - Cosmetic agent for epidermis care - Google Patents

Abstract

This invention relates to cosmetic, health- and bodypreserving compositions of high biological value, promoting the restoration of the cells and of that the skin, optimizing the biological processes occurring in the skin cells and providing the most preferable function of the enzyme system of the cells connected with the age of the organism. The compositions of the invention contain in addition to the commonly used carrier and additive and/or filling materials and active ingredients, native mineral waters, medicinal waters and/or the mixtures thereof and/or the mixtures thereof with fermented or non-fermented plant juices and/or optionally inorganic materials playing the role of trace elements in the living organism as well as proteins.

Description

The invention relates to a process for the production of biologically high-value, effective skin care cosmetic compositions. The compositions of the invention promote cell and skin regeneration, optimize biological processes occurring in skin cells and ensure optimal functioning of the enzyme system in cells related to the age of the organism.

It is an object of the invention to achieve skin regeneration and skin care and skin cells using natural substances. According to the invention, this object is achieved by treating proteins, in particular blood proteins or proteins prepared from the blood fraction with substances having a trace element function in the body, natural waters, river, lake or sea water, mineral waters, medicinal waters or with inorganic substances obtained from these waters and finally processed into cosmetic products.

It is known that the trace elements involved in active transfer processes - as the proportions of various numerous enzymes - have a decisive influence on the function of the body. If these elements, such as copper or zinc, are missing, cell function degeneration occurs. Impairment of functions due to lack of trace elements is most noticeable in the condition of the skin. The skin is a highly differentiated organ and its condition is crucial for the aesthetic effect of man.

Eliminating trace-element impairments is not an easy task in many cases since trace-element salts, such as iron sulfate, are not accepted by the body to the extent that it would be desirable for incorporation into biological processes satisfactorily.

According to current knowledge, trace elements can perform their function in the body and thus also in cells when they are linked to a carrier molecule, and then incorporated into the corresponding enzyme. In general, protein molecules, especially blood proteins, act as carrier molecules. The mechanism of this process is not yet fully understood, but it is certain that the protein and trace element compound is a decisive condition for the multi-step process.

Of the trace elements known to function, zinc, copper, iron, cobalt, manganese, silicon and zinc are irreplaceable for the skin. 20% of the zinc content of the human body is contained in the skin. Zinc plays an important role in skin protein synthesis. In addition to the general effect on blood count, currency is of great importance for the structural formation of collagen and elastin. In the absence of swab, the solubility of collagen and elastin increases and their function is not satisfactory. Manganese is also involved in collagen synthesis. Silicon is also important for the formation of the collagen structure. The importance of inorganic elements for the optimal functioning of living cells and hence for the appearance of the skin is not astonishing if it is considered that these substances were already present in prehistoric oceans at the origin of life itself.

It is known that an inorganic substance, a trace element, an ion only enters active transport if it contacts one side of the cell membrane with the carrier molecule, the protein molecule, and forms a carrier-substrate complex. This complex then passes through the cell membrane, releasing and leaving an inorganic atom in the cell, and the carrier molecule returns to the outside of the cell. Carrier molecules include plasma proteins, transferrin, alpha-macroglobulin, transmagine, nickloplasmin and the like. Their number and structure are not yet known precisely, but their existence and functions are already clear.

Cosmetic compositions containing trace elements are known, and cosmetic compositions containing various proteins are known to support a function, for example, a hydrating ability. Nevertheless, the optimal supply of trace elements that act as biocatalysts cannot be considered to be resolved, since trace elements as such are not sufficiently absorbed by the body and skin from the aqueous phase; also the absorption of generally known organic complexes of trace elements is not sufficient.

Mineral waters, which contain important trace elements for the skin, have been consistent in composition for centuries, yet the effects on the skin of individual people vary widely; therefore, the individual skin characteristics of an individual must be the cause of extraordinary differences in the results of its action. It is believed that there are not always available carrier molecules that inhibit the uptake of trace elements. As mentioned above, the trace elements, the inorganic ions as such, cannot diffuse into the cells and associate there with. enzymes but needed.

for this purpose, the carrier melatula. Such carriers are specific, i.e. each is suitable for transporting a particular trace element to its site of action. Suitable carrier molecules are believed to be contained in the blood.

For this reason, according to the invention, plasma proteins are processed along with trace elements, mineral waters, or various natural waters. optionally with inorganic substances derived therefrom for cosmetic skin care and hydration compositions.

It has been found that cosmic compositions can be produced when a protein, such as a plasma protein, is prepared from blood or blood components with appropriate trace elements, optionally heating and processing the cosmic composition. The formulations prepared in this manner have an extremely beneficial effect in the growth of the skin and also improve the quality of the hair.

The skin care composition according to the invention thus contains in 100 g of 0.1 to g of protein, 0.1 to 100 mg of trace elements, 0.5 to 50 g of adjuvants, for example dispersing agents, the remainder being up to 100 g they form mineral water or curative water and / or mixtures thereof with fermented or unfermented vegetable juices.

Practical tests of ^the tvvdily that kosmeeické compositions according to the invention surprisingly maai PUJ ^ t ^ J ^ e ^ r ^ her. They are suitable for the treatment and regeneration of the skin as well as for the reduction of hair properties. They are also suitable for sun-tanning products, as they provide ^{for the} regeneration of sun-burned skin.

The advantageous action of the compositions according to the invention can be further increased if, together with or instead of natural waters, they are used as aqueous phases of routine extracts, plant juices, mixtures thereof or solutions thereof enriched with the necessary trace elements. The invention is illustrated in more detail by the following non-limiting examples.

In the following cases, the adjuvants referred to by the trade name are used. Jet ^ r ^ nH-i ^ v ^ s trade names MAI meanings: Tween 60 is of ^the Lyt ^{χ У et} УLLrnlorbiSanmtnottearát, Alfozid KT-25 is mixed sarcosinates, fatty kyseein, Alfdd-D-11 dύrthsntlsmid fatty kyseein and Nipagin M is benzoic acid meevate.

Pi-IIS

A mixture of white petrolatum (137.5 g), 82.5 g of cetyl- 27.5 g of paraffin oil and

27, ⁵ g of Tween 60 are heated to a temperature of ⁸⁰ ° C. This mixture formed ^ fatty aci ^ ^f ^ u sharply. Plasma proteins, prepared jakýmk-IV as napříklsa precipitation with acid or lyofilzzací from 10 g bovine plasma, prepared for example by centrifuging the blood is allowed to swell in 200 ml of l ^{EC IV.E} water of Harkany and the mixture ^{of p} and ud ^ U is te ^ OTE ¹¹² ° ^{C when} about ⁹⁰ minutes at ^b. The active water from ^the raclvsn ^{and beat} ^ ^k ^ ⁱ ^ to the TV is cooled to ⁶⁰ ° C and ^H and SMIC with AZI ^f fat heated to a temperature of ⁸⁰ ° C. After ^{the H} omo er ⁿ is sewn at a more ^ ^d te ^r l ^E mixture ⁶⁰⁰ ml of water ^{IV.E treatment of tumors} of the Harkány te ^ Oto ⁷⁰ ° C and MICs ^hook and ^{from D-Gln-by} cooling it. The cream thus obtained is ^{characterized} in it ^for moisturizing skin ající regenneruící action.

The cream contains the following trace elements:

95µg of iron, 8µg of tin, 10µg of zinc, 3µg of manganese, 1µg of chromium, 10µg of nickel, 5µg of cobblt, 33µg of molybdenum and 494µg of fluorine.

Example 2

The procedure of Example 1 is followed except that 1 mg of gold chloride is added to the weighed plasma protein before or after heat treatment. The obtained cream again has excellent moisturizing and skin regenerating effect.

Peak d 3

The process described in Example 1 or 2 with the only difference that as the aqueous ^and that it uses f ^s l ^t rq u ^t a ^dy from Haaťluszotbs ^. The ^y yy ^b Lea Maat ZTE ^to determines the blanking at 70 ° C and has vyněkaaící skin Regen ^^ ICI effect.

The ointment contains the following trace elements:

yug iron, 22 µg copper, 20 µg zinc, 4 µg manganese, 2 µg chromium, 45 µg nickel, 35 µg cobbat, 30 µg molybdenum and 684 yug fluorine.

Example 4

The procedure of Case 1 or 2 is followed except that the water of the parade is used as the aqueous phase.

Example 5

Following the procedure of Examples 1-4, the plasma protein is treated with mineral water to which 1 mg of gold chloride, 0.5 mg of silver nitrate, 0.1 mg of chromium chloride, 2 mg of sulfate are added per 200 ml prior to heat treatment. iron (III), 1 mg of mannannium chloride, 0.5 mg of cobbltitt chloride, 0.2 mg of boric acid and 0.2 mg of low-sulphate. Made cream soothes and regenerates the skin.

Example 6 ’

The procedure of Example 1 is followed, except that the plasma protein is treated with 200 ml of medicinal water from the Luke / Budapest spa, to which 1 mg of ferrous sulfate, 1 mg of copper sulfate, 0.5 mg of potassium sulfate was previously added, 1 mg of zinc sulfate and 0.5 mg of magnesium chloride. The prepared cream has a regenerating effect on the skin.

The prepared cream contains the following trace elements:

110 µg of iron, 47 µg of copper, 590 µg of zinc, 27 µg of manganese, 4 µg of chromium, 48 µg of nickel, 25 µg of cobsat, 35 µg of molybdenum and 760 µg of fluorine.

Example 7

The procedure of Cases 1 to 6 is followed except that water from the Carlsbad thermal spring is used as the aqueous phase. *

EXAMPLE 8

The procedure of Cases 1 to 7 is followed except that the water from Blatno Lake in its natural state is used as the aqueous phase. ’

Example 9

The procedure of Example 1 is followed except that the Plasma protein is heat-treated with distilled water (200 ml) and 600 ml of sea water, such as Aegean water, is used to prepare the cream.

Example 10

The procedure of Examples 1 to 6 is followed except that plasma proteins and 200 ml of natural water from the Danube are used for heat treatment.

Example 11

The procedure of Example 1 was followed except that the plasma protein was treated with mineral water in the presence of 2 mg of zinc sulfate.

Example 12

The procedure of Example 1 is followed except that water containing 5 micrograms of copper, 5 micrograms of iron, 10 micrograms of zinc, 2 micrograms of cobalt, 1 micrograms of nickel, 20 micrograms of magnesium and 20 micrograms of calcium is used instead of mineral water.

Example 13

The procedure of Example 1 was followed except that carrot juice was used as the phase.

Example 14 '

The procedure of Examples 1 to 6 is followed except that wine from grapes is used as the aqueous phase.

Example 15

The procedure of Examples 1 to 6 is followed, except that the aqueous phase used is cider that is neutralized with carbonate-containing hydrogen carbonate.

Example 16

The procedure of Example 1 is followed using fruit juices such as apple juice as the aqueous phase.

Example 17

Mix 20 ml of pork blood with 80 ml of water and 2 g of sodium hydrogengeilicate. The mixture is maintained for one. hours at 120 ° C. After filtering, 700 ml of Harkana water was added to the filtrate. The solution obtained is processed into a cream in a manner known per se. An exhilarating, moisturizing, skin-regulating cosmetic composition is obtained.

Example 18

To 100 ml of sheep blood plasma is added 2 g of sodium lydrogeenilicate, 50 ml of aqueous chamomile extract and 600 ml of HHViz mental water. The mixture is stirred at 20 ° C for one hour and then processed in a manner known per se to form a skin care cream.

Example 19

The procedure of Example 1 is followed, but water from Harkány, Hajduszoboszio and HHviz is used instead of Harkány · smmsi in a 1: 1: 1 ratio. J

Example 20

The plasma protein obtained from 10 g of pork blood is heat-treated at 120 DEG C. for one hour with 200 ml of Heviz mineral water. 300 ml of Hévíz natural water was added to the obtained solution. The solution is filled into 2 ml ampoules and the sealed ampoules are sterilized. The composition is suitable for skin care in rubbing hands or iontophoretic treatment.

Example 21

To 100 ml of native bovine blood plasma were added 2 mg of ferric sulfate, 1 mg of manganese chloride, 1 mg of copper sulfate, 1 mg of zinc sulfate, and 20 ml of extract prepared from boiling water and 1 g of chamomile. The mixture was heated to 80 ° C with vigorous stirring. The obtained gel-like substance has an excellent moisturizing effect on the skin.

Example 22

The procedure of Example 20 or 21 is followed except that a 1: 1 mixture of Harkány and Hajduszoboszo mineral water is used instead of Heviz or Heviz mineral water.

Example 23

To prepare a foaming bath, 200 ml of Harkana mineral water at 70 ° C is added to the powdered plasma protein from 10 g of bovine blood. The mixture was maintained at 112 ° C for 90 minutes. After cooling, 70 ml of Harkana natural mineral water, 30 g of Alfozide KT-12, 80 g of Zala betaine, 570 g of sodium lauryl ether sulfate, 20 g of Alf-D-11, 2 g of preservative Alfasept, 10 g of polyethylene glycol are added to the solution. 200% and 10 ml of 9% ethyl alcohol. The resulting foaming bath refreshes and regenerates the skin.

Example 24

For the preparation of the sun-tanning composition and for the treatment of burnt skin, the plasma protein of 10 g of pork blood is treated at 120 ° C for one hour with 200 ml of Harkana water. A further 125 ml of Harkány mineral water and 125 ml of mineral water from the Lukács Spa (Budapest) are added to the solution obtained. The solution obtained is mixed with a suitable preservative and can be used in the form of a spray.

Example 25

For the production of hair shampoo, the plasma protein obtained from 10 g of rabbit blood is heat treated with 200 ml of Hajduszoboszlo mineral water at 112 ° C for 90 minutes. To the still warm solution was added 300 ml of Balfer mineral water and 50 ml of sea water. 92 g of Alfozide KT-25, 75 g of betaine Zala, 190 g of sodium lauryl ether sulfate, 10 g of Alf-D-11 and 2 g of Alfasept are added to the solution. An excellent hair shampoo is obtained which promotes hair root regeneration and affects even hair growth.

Example 26

For the production of anti-dandruff and anti-dandruff products, the pulverulent plasma protein obtained from 10 g of bovine blood is swelled while stirring in 20 ml of Harkana mineral water and the mixture is then held at 112 ° C for one hour. 300 ml of Harkana mineral water containing dissolved 0.2 mg of ferrous sulphate, 0.2 mg of zinc sulphate, 0.3 mg of copper sulphate, 0.1 mg of nickel sulphate and 0.1 mg of chloride are added to the obtained solution. cobalt. The solution is filled into 2 ml glass ampoules and sterilized. The solution is rubbed into the scalp and hair. It inhibits hair lubrication and promotes hair root regeneration.

Example 27

For the manufacture of hand balm, the plasma protein obtained from 10 g of pork blood is dissolved in 100 ml of Harkana mineral water and 100 ml of Hajduszoboszlo mineral water at ¹²⁰ ° C. ^The organic solution were mixed, ^{and 100 g} of taven.nou ^{cetylalkohols,} 101 g of isopropyl myristate, 220 g of 70% soobits, 60 'g kosmeeického stearin, 140 g kosmeeického vaseline oil, 2 g of glutaraldehyde, 39.2 g kosmeeického 2 0 g propylene glycol and 3 ^g Nipagin zfedí N. the mixture was 1100 ^ml in mineral ^d yo ^60C of Ha jčszoboszló and 5 g of potassium hydroxide and the mixture is stirred until vychladnnuí. The balm is an excellent way to treat the skin, for example after it has been exposed to detergents.

P Píkl a d 28

It was roasted with 800 g of powdered soap at 80 ° C in two liters of distilled water. To the solution was added 200 g natrismlausylrthersulfátu solution / 5% / prepared from 200 ml mineeální water ^{characterized} Har ^ka n ^yp s tejo-TE ¹²⁰ DEG-ReMOTe ^ plasma ^y beef Jcm ⁵⁰⁰ mL of glycerol, 8 g Nipagin and a little fragrance - The mixture is stirred while cooling, The soap obtained has a creaminess and regenerates the skin.

P Píkl a d 29

Zmýýlení 14 ^{2 g} weld tysel ^ in ⁵⁰⁰ ml ^of hedged six ^d in ^{dy p} s at ⁸⁰ ° C

28.5 g of potassium hydroxide. Soap with 200 ml of a solution připaaveného Yi ^ ε ^ ríá.mí water ^{characterized} Héviz ^ ^{10 g} ^ ReMOTe from beaches ^rp s te ^p Lot ^{E 16} 0 C ^{gives 100 g} le ^y iatrisýljur lrthrrsulfátu, 100 g of glycerol 3 g of Nipagin M as a preservative and stirred until cooled. The resulting product cleans the skin and prevents it from drying out.

He said 30

25 g of cetyl alcohol, 12 g of petroleum jelly, 2.5 g of Tween 60 and 5 g of glycerine are ^melted at 72 ° C. ^ In the melt are added ^and 6 ml of ^p s at ¹²⁰ ° ^C with a false VOFO from ^H ESee připaaveného 1% solution of protein from plasma and 5 ml of ethane-lu. Optionally, a baking agent and a fragrance are added with stirring. The product is suitable for lip care and prevents the lips from drying out.

Example 31

At 80 ° C ^even play in ^g 197.5 ^g lo ^ é vaseline ^82.5 g ^27.5 rafňr gp ^ ^ C ^ ^^^ s him oils and 27.5 g of Tween 60. The mixture was added to 700 ml ýini ^ cal water of Harkany rpm ^EP ture of 60 ° C. Then stirred ^and Ar in chladnnu ^ !. ZIS ^{Ka h} ydrata ^No. There are three different her.

Example 32

The procedure was as in Example 31 except that a mixture of 350 ml of Harkana water and 350 ml of extract prepared from 350 ml of boiling water and 5 g of chamomile was used as the aqueous phase.

Example 33

The procedure is as described in Examples 31 and 32, except that 1 mg of ferrous sulfate, 1 mg of zinc sulphate, 1 mg of copper sulphate, 0.5 mg of low-sulfate sulfate, 0.5 mg of manganese sulphate and 0.2 mg are dissolved in the aqueous phase prior to mixing. mg ammonium orthophosphate.

Example 34.

To a mixture of 0.5 g of salt obtained by evaporating mineral water from Harkana is added 200 ml of distilled and 10 g of protein plasma prepared from 10 g of bovine blood plasma. The mixture is maintained at 121 ° C for two hours and then processed to a cream as described in Example 1.

Claims (16)

SUBJECT OF THE INVENTION Coomeric skin care composition, characterized in that it contains, in 100 g, 0.1 to 90 g of protein, 0.1 to 100 g of trace elements, 0.5 to 50 g of auxiliary substances, for example dispersing agents, wherein: the remainder up to 100 g consists of mental or therapeutic water and / or mixtures of these waters with slaked or non-slaked vegetable sores. 2. A composition according to claim 1, characterized in that it contains 0.1 to 90 g of protein, 0.1 to 100 mg of trace elements, 0.5 to 50 g of auxiliary substances, e.g. fermented or unfermented vegetable juices. ₍ · 3. A composition according to claim 1, characterized in that it contains 0.1 to 90 g of protein, 0.1 to 10 mg of trace elements, 0.5 to 50 g of auxiliary substances, for example dispersants, per 100 g. with the remainder up to 100 g being eineral or curative water. 4. A composition according to claim 3, characterized in that it contains protein from animal blood or its constituents, blood or its constituents and / or forms obtained by processing animal blood or its constituents, or proteins prepared therefrom, substances which function as trace elements in the body. substances having a trace element function, metallic salt and / or water, natural, river, weir, moose, mineral or medicinal substances in the living organism and / or substances derived from the processing of blood or its components and / or substances obtained from the processing of protein from blood or its components natural, river, lake, sea, mental, medicinal or hot spring waters. 5. A composition according to claim 3 or 4, characterized in that it contains natural, river, lake, sea, mineral, medicinal and hot spring water as the aqueous phase. 6. Cosrneeic composition according to claim 2, characterized in that it contains plant extracts, plant juices and / or fermented plant juices as the aqueous phase. 7. A cosmetic composition according to Claims 2 and 6, characterized in that it comprises products obtained by treating the blood or its components or proteins from the blood or its components with routine extracts or quenched or quenched with sera. 8. A cosmetic composition according to Claims 3, 4 and 5, characterized in that it contains products obtained by treating the blood or its constituents or protein from the blood or its constituents with natural, river, lake, metric, mineral and / or medicinal waters and / or inorganic substances. 9. A composition according to Claims 3,4,5 and 8, characterized in that it contains natural hot spring water as the aqueous phase. 10. A composition according to Claims 3,4,5,8 and 9, characterized in that it comprises products of blood or blood components thereof or of blood protein or components thereof obtained by treatment with hot spring water. 11. A composition according to claim 1, characterized in that it comprises as an aqueous phase a mixture of natural, river, lakes, lakes, other medicinal waters and / or mixtures of these waters with or without fermentation. Cosmetic composition according to Claims 1 and 11, characterized in that it contains products obtained by treating the blood or its constituents or the blood protein with natural, mineral, medicinal, hot spring and / or fermented and / or unfermented vegetable juices or mixtures thereof. Cosmetic composition according to Claims 3,4,5,8,9 and 10, characterized in that it contains products obtained by processing of blood or its components or protein obtained from blood by concentrates obtained by evaporation or otherwise from natural, river, lake, marine waters , thermal, mineral or medicinal, or containing mineral substances. 14. Cosmetic composition according to Claims 3,4,5,8,9,10 and 13, characterized in that it contains products obtained from blood or blood components and / or blood protein or blood components obtained by treatment with precious metals, in particular gold, silver, platinum and / or hot metal salts and ions. Cosmetic composition according to Claims 3,4,5,8,9,10,13 and 14, characterized in that it contains products of blood or its components obtained by treatment and / or heat treatment with inorganic substances and / or natural, river, lake, marine, mineral or medicinal, which have a trace element function in the body. 16. A cosmetic composition according to claim 15 which is filled into ampoules.