NO800899L - Fremgangsmaate ved fremstilling av benzodiazepinderivater - Google Patents

Fremgangsmaate ved fremstilling av benzodiazepinderivater

Info

Publication number
NO800899L
NO800899L NO800899A NO800899A NO800899L NO 800899 L NO800899 L NO 800899L NO 800899 A NO800899 A NO 800899A NO 800899 A NO800899 A NO 800899A NO 800899 L NO800899 L NO 800899L
Authority
NO
Norway
Prior art keywords
compound
general formula
halogen
trifluoromethyl
acid
Prior art date
Application number
NO800899A
Other languages
English (en)
Norwegian (no)
Inventor
George Francis Field
William J Zally
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO800899L publication Critical patent/NO800899L/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/511Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
    • C07C45/515Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups the singly bound functional group being an acetalised, ketalised hemi-acetalised, or hemi-ketalised hydroxyl group
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00Compounds having —CHO groups
    • C07C47/02Saturated compounds having —CHO groups bound to acyclic carbon atoms or to hydrogen
    • C07C47/14Saturated compounds having —CHO groups bound to acyclic carbon atoms or to hydrogen containing halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Agronomy & Crop Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
NO800899A 1979-03-29 1980-03-27 Fremgangsmaate ved fremstilling av benzodiazepinderivater NO800899L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/025,219 US4194049A (en) 1979-03-29 1979-03-29 2-[[2-Methyl-1-[2-benzoyl(or benzyl)phenyl]-1H-imidazol-5-yl]methyl]-1H-isoindole-1,3(2H)-diones
US8690979A 1979-10-22 1979-10-22

Publications (1)

Publication Number Publication Date
NO800899L true NO800899L (no) 1980-09-30

Family

ID=26699457

Family Applications (1)

Application Number Title Priority Date Filing Date
NO800899A NO800899L (no) 1979-03-29 1980-03-27 Fremgangsmaate ved fremstilling av benzodiazepinderivater

Country Status (11)

Country Link
US (1) US4194049A (ko)
EP (1) EP0017181A1 (ko)
JP (1) JPS55147285A (ko)
KR (1) KR830001967B1 (ko)
CA (1) CA1126269A (ko)
DK (1) DK135380A (ko)
ES (1) ES8104291A1 (ko)
FI (1) FI800943A (ko)
GR (1) GR67758B (ko)
NO (1) NO800899L (ko)
PT (1) PT71031B (ko)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4250095A (en) * 1979-07-25 1981-02-10 Hoffmann-La Roche Inc. Imidazobenzodiazepines
FR2617478B1 (fr) * 1987-07-01 1990-01-05 Esteve Labor Dr Nouveaux derives d'aryl-heteroaryl cetones, leur procede de preparation ainsi que leur application a titre de medicament
ES2004809A6 (es) * 1987-07-29 1989-02-01 Ferrer Int Procedimiento de obtencion de nuevas 1-(2-(fenilmetil)fenil)piperazinas
US5565577A (en) * 1992-09-23 1996-10-15 Smithkline Beecham Corporation Process for preparing 1-alkyaryl-2-alkyl-5-formylimidazole
CA2206219A1 (en) * 1996-06-13 1997-12-13 Ranbaxy Laboratories Limited A novel process for the manufacture of 8-chloro-6-(2-fluorophenyl)-1-methyl-4h-imidazo [1,5a] [1,4] benzodiazepine (midazolam)
IN184976B (ko) * 1996-06-13 2000-10-14 Ranbaxy Lab Ltd
ZA974769B (en) * 1996-10-09 1997-12-30 Ranbaxy Lab Ltd A novel process for the manufacture of 8-chloro-6-(2-flourophenyl)-1-methyl-4H-imidazo (1,5A) (1,4) benzodiazepine (midazolam).
CN115894192A (zh) * 2022-12-05 2023-04-04 苏州诚和医药化学有限公司 一种2-溴丙二醛的合成方法、应用及2-溴丙二醛

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1055490A (en) * 1974-06-19 1979-05-29 Upjohn Company (The) Process for preparing triazolobenzodiazepines
US3941803A (en) * 1975-03-28 1976-03-02 The Upjohn Company 2-(Imidazol-1-yl)benzophenones
US4169150A (en) * 1975-11-12 1979-09-25 Teijin Limited Benzodiazepine derivatives and pharmaceutical compositions containing said derivatives
US4005099A (en) * 1975-11-21 1977-01-25 The Upjohn Company 1-[(Dimethylamino)-methyl]-6-aryl-4H-imidazo[1,5-a][1,4]benzodiazepines

Also Published As

Publication number Publication date
CA1126269A (en) 1982-06-22
PT71031A (en) 1980-04-01
ES490022A0 (es) 1981-04-16
ES8104291A1 (es) 1981-04-16
PT71031B (en) 1981-06-25
JPS55147285A (en) 1980-11-17
EP0017181A1 (de) 1980-10-15
KR830001967B1 (ko) 1983-09-29
DK135380A (da) 1980-09-30
US4194049A (en) 1980-03-18
FI800943A (fi) 1980-09-30
GR67758B (ko) 1981-09-22
KR830001936A (ko) 1983-05-19

Similar Documents

Publication Publication Date Title
CA2562216C (en) Process for producing a trifluoro-3-buten-2-one compound
NO156328B (no) Konstruksjon med keramisk overflatebelegg samt fremgangsmaate til fremstilling av samme.
NO800899L (no) Fremgangsmaate ved fremstilling av benzodiazepinderivater
US4118386A (en) Synthesis of imidazo[1,5-a]diazepine-3-carboxylates
RU2014333C1 (ru) Производные 4-оксо-3н-фталазин-1-уксусной кислоты, способ получения производных сложных алкиловых эфиров 4-оксо-3н-фталазин-1-уксусной кислоты
US4469633A (en) N-oxides of 5-oxo-1-phenyl-2-benzazepines
KR100249594B1 (ko) 5-알콕시(1,2,4)트리아졸로(1,5-c)피리미딘-2(3h)-티온화합물, 및 2,2'-디티오비스(5-알콕시(1,2,4)트리아졸로(1,5-c)-피리미딘) 및 2-클로로설포닐-5-알콕시(1,2,4)트리아졸로(1,5-c)피리미딘 화합물의 제조에 있어서의 이의 용도
CA1128937A (en) Intermediates in the production of 2-benzazepines
US4318854A (en) Intermediates in the production of 2-benzazepines
RU2117007C1 (ru) Способ получения 2-замещенных 4,6-диалкоксипиримидинов,2-n-бутиламино-4,6-диметоксипиримидин и способ получения галогенпроизводных пиримидина
JP2524491B2 (ja) 新規なアミノカルボン酸エステル及びその製法
US5461153A (en) 2-alkoxy-4-hydrazinopyrimidine compounds
Wang et al. A novel method for the synthesis of pyrazolo [5, 1-b] thiazole
US4281142A (en) Imidazolecarboxaldehydes
US4388239A (en) Production of 1-halophenyl and 1-phenyl-3,4-dihydro-5H-2-benzazepine-5-ones
SU419034A3 (ru) СПОСОБ ПОЛУЧЕНИЯ ПРОИЗВОДНЫХ ХИНАЗОЛИНА1Изобретение относитс к способу получени новых производных хиназолина, которые обладают улучшенными лекарственными свойствами и могут найти нрименение в фармацевтической промышленности.Предлагаетс основанный на известной реакции алкилировани хиназолннов способ получени производных хиназолина общей формулы ICnH,n--R.Примером галоида в формуле I могут служить атомы хлора, брома, фтора и йода; Ci—С4-алкилов — метил, этил, н-пропил, изо- пропил, н-бутил, изобутил и т/?ет-бутил; 5 Ci—С4-алкоксильных групп — метокси-, эток- СИ-, н-пропокси-, изопронокси-, н-бутокси-, изо- бутокси- и грег-бутоксигруппы; Сз—Се-цикло- алкилов — циклопропил, циклобутил, цикло- пентил, циклогексил, метилциклопропил, ди- 10 метилциклопронил и т. п. группы. Когда СпН2п группа — алкилен с 1—3 атомами углерода, она может быть представлена такими группами, как метиленова , этиленова , 1-метилэти- ленова , 2-метилэтиленова и триметиленова .где D — группаСпособ получени соединений формулы 1 заключаетс в том, что 1-незамеш,енное производное хиназолина общей формулы П15Нг; , :- ;-О "^ О ."^ -'.RI, R2 и Rs каждый — водород, галоид, нит- рогруппа, Ci—С4-алкил, Ci—Сгалкоксил, С\—С4-алкилтиогруП'Па, Ci—С^алкилсульфо- группа, Ci—С4-алкилсульфинильна группа, грифторметил;R4 — Сз—Сб-циклоалг-'ил;W — кислород или сера;п — О или целое число от 1 до 3.2025где RI, Ra, D и W имеют вышеуказанные зна- 30 чени .
US4394311A (en) Production of 2-benzazepines
US4379090A (en) Process for the preparation of 1-(phenyl and halophenyl)-3,4-dihydro-4-[(dimethylamino)methylene]5H-2-benzazepin-5-one-2-oxides
US4402876A (en) Production of 2-benzazepines
GB1563578A (en) Preparation of benzodiazepines
NO115019B (ko)
Eldin 2-Amino-1, 1, 3-tricyanopropene in heterocyclic synthesis: novel synthesis of thiopyran pyridinethiones and nicotinonitrile derivatives
SU276829A1 (ko)
SU662014A3 (ru) Способ получени производных триазолобензтиазола
US4267325A (en) Bleaching agents