DK135380A - Fremgangsmaade til fremstilling af imidazobenzodiazepiner eller syreadditionssalte deraf samt ved fremgangsmaaden anvendelige mellemprodukter og udgangsmaterialer - Google Patents

Fremgangsmaade til fremstilling af imidazobenzodiazepiner eller syreadditionssalte deraf samt ved fremgangsmaaden anvendelige mellemprodukter og udgangsmaterialer

Info

Publication number
DK135380A
DK135380A DK135380A DK135380A DK135380A DK 135380 A DK135380 A DK 135380A DK 135380 A DK135380 A DK 135380A DK 135380 A DK135380 A DK 135380A DK 135380 A DK135380 A DK 135380A
Authority
DK
Denmark
Prior art keywords
procedure
imidazobenzodiazepines
preparation
materials used
initial materials
Prior art date
Application number
DK135380A
Other languages
Danish (da)
English (en)
Inventor
G F Field
W J Zally
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of DK135380A publication Critical patent/DK135380A/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/511Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
    • C07C45/515Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups the singly bound functional group being an acetalised, ketalised hemi-acetalised, or hemi-ketalised hydroxyl group
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00Compounds having —CHO groups
    • C07C47/02Saturated compounds having —CHO groups bound to acyclic carbon atoms or to hydrogen
    • C07C47/14Saturated compounds having —CHO groups bound to acyclic carbon atoms or to hydrogen containing halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Agronomy & Crop Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK135380A 1979-03-29 1980-03-28 Fremgangsmaade til fremstilling af imidazobenzodiazepiner eller syreadditionssalte deraf samt ved fremgangsmaaden anvendelige mellemprodukter og udgangsmaterialer DK135380A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/025,219 US4194049A (en) 1979-03-29 1979-03-29 2-[[2-Methyl-1-[2-benzoyl(or benzyl)phenyl]-1H-imidazol-5-yl]methyl]-1H-isoindole-1,3(2H)-diones
US8690979A 1979-10-22 1979-10-22

Publications (1)

Publication Number Publication Date
DK135380A true DK135380A (da) 1980-09-30

Family

ID=26699457

Family Applications (1)

Application Number Title Priority Date Filing Date
DK135380A DK135380A (da) 1979-03-29 1980-03-28 Fremgangsmaade til fremstilling af imidazobenzodiazepiner eller syreadditionssalte deraf samt ved fremgangsmaaden anvendelige mellemprodukter og udgangsmaterialer

Country Status (11)

Country Link
US (1) US4194049A (ko)
EP (1) EP0017181A1 (ko)
JP (1) JPS55147285A (ko)
KR (1) KR830001967B1 (ko)
CA (1) CA1126269A (ko)
DK (1) DK135380A (ko)
ES (1) ES490022A0 (ko)
FI (1) FI800943A (ko)
GR (1) GR67758B (ko)
NO (1) NO800899L (ko)
PT (1) PT71031B (ko)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4250095A (en) * 1979-07-25 1981-02-10 Hoffmann-La Roche Inc. Imidazobenzodiazepines
FR2617478B1 (fr) * 1987-07-01 1990-01-05 Esteve Labor Dr Nouveaux derives d'aryl-heteroaryl cetones, leur procede de preparation ainsi que leur application a titre de medicament
ES2004809A6 (es) * 1987-07-29 1989-02-01 Ferrer Int Procedimiento de obtencion de nuevas 1-(2-(fenilmetil)fenil)piperazinas
US5565577A (en) * 1992-09-23 1996-10-15 Smithkline Beecham Corporation Process for preparing 1-alkyaryl-2-alkyl-5-formylimidazole
IN184976B (ko) * 1996-06-13 2000-10-14 Ranbaxy Lab Ltd
CA2206219A1 (en) * 1996-06-13 1997-12-13 Ranbaxy Laboratories Limited A novel process for the manufacture of 8-chloro-6-(2-fluorophenyl)-1-methyl-4h-imidazo [1,5a] [1,4] benzodiazepine (midazolam)
ZA974769B (en) * 1996-10-09 1997-12-30 Ranbaxy Lab Ltd A novel process for the manufacture of 8-chloro-6-(2-flourophenyl)-1-methyl-4H-imidazo (1,5A) (1,4) benzodiazepine (midazolam).
CN115894192A (zh) * 2022-12-05 2023-04-04 苏州诚和医药化学有限公司 一种2-溴丙二醛的合成方法、应用及2-溴丙二醛

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1055490A (en) * 1974-06-19 1979-05-29 Upjohn Company (The) Process for preparing triazolobenzodiazepines
US3941803A (en) * 1975-03-28 1976-03-02 The Upjohn Company 2-(Imidazol-1-yl)benzophenones
US4169150A (en) * 1975-11-12 1979-09-25 Teijin Limited Benzodiazepine derivatives and pharmaceutical compositions containing said derivatives
US4005099A (en) * 1975-11-21 1977-01-25 The Upjohn Company 1-[(Dimethylamino)-methyl]-6-aryl-4H-imidazo[1,5-a][1,4]benzodiazepines

Also Published As

Publication number Publication date
FI800943A (fi) 1980-09-30
PT71031A (en) 1980-04-01
KR830001967B1 (ko) 1983-09-29
NO800899L (no) 1980-09-30
ES8104291A1 (es) 1981-04-16
GR67758B (ko) 1981-09-22
PT71031B (en) 1981-06-25
US4194049A (en) 1980-03-18
JPS55147285A (en) 1980-11-17
EP0017181A1 (de) 1980-10-15
KR830001936A (ko) 1983-05-19
ES490022A0 (es) 1981-04-16
CA1126269A (en) 1982-06-22

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Legal Events

Date Code Title Description
AHS Application shelved for other reasons than non-payment
PBP Patent lapsed