NO784407L - 2-metyltio-6-fluor-9-(1-metyl-4-piperidyliden)-tioxanten og syreaddisjonssalter derav - Google Patents
2-metyltio-6-fluor-9-(1-metyl-4-piperidyliden)-tioxanten og syreaddisjonssalter deravInfo
- Publication number
- NO784407L NO784407L NO784407A NO784407A NO784407L NO 784407 L NO784407 L NO 784407L NO 784407 A NO784407 A NO 784407A NO 784407 A NO784407 A NO 784407A NO 784407 L NO784407 L NO 784407L
- Authority
- NO
- Norway
- Prior art keywords
- fluoro
- methyl
- piperidylidene
- methylthio
- thioxanthene
- Prior art date
Links
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- CCIVGXIOQKPBKL-UHFFFAOYSA-M ethanesulfonate Chemical compound CCS([O-])(=O)=O CCIVGXIOQKPBKL-UHFFFAOYSA-M 0.000 description 1
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- 230000002349 favourable effect Effects 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 125000001153 fluoro group Chemical group F* 0.000 description 1
- 229960002690 fluphenazine Drugs 0.000 description 1
- 235000019253 formic acid Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000004508 fractional distillation Methods 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000003365 glass fiber Substances 0.000 description 1
- 125000000404 glutamine group Chemical group N[C@@H](CCC(N)=O)C(=O)* 0.000 description 1
- 125000003827 glycol group Chemical group 0.000 description 1
- LEQAOMBKQFMDFZ-UHFFFAOYSA-N glyoxal Chemical compound O=CC=O LEQAOMBKQFMDFZ-UHFFFAOYSA-N 0.000 description 1
- 230000035929 gnawing Effects 0.000 description 1
- 229940093915 gynecological organic acid Drugs 0.000 description 1
- 229910000042 hydrogen bromide Inorganic materials 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 239000002050 international nonproprietary name Substances 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000005567 liquid scintillation counting Methods 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000003551 muscarinic effect Effects 0.000 description 1
- 235000010460 mustard Nutrition 0.000 description 1
- 239000003176 neuroleptic agent Substances 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 229960002516 physostigmine salicylate Drugs 0.000 description 1
- HZOTZTANVBDFOF-PBCQUBLHSA-N physostigmine salicylate Chemical compound OC(=O)C1=CC=CC=C1O.C12=CC(OC(=O)NC)=CC=C2N(C)[C@@H]2[C@@]1(C)CCN2C HZOTZTANVBDFOF-PBCQUBLHSA-N 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 239000004926 polymethyl methacrylate Substances 0.000 description 1
- 229920000137 polyphosphoric acid Polymers 0.000 description 1
- CHKVPAROMQMJNQ-UHFFFAOYSA-M potassium bisulfate Chemical compound [K+].OS([O-])(=O)=O CHKVPAROMQMJNQ-UHFFFAOYSA-M 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 229920001592 potato starch Polymers 0.000 description 1
- 239000013558 reference substance Substances 0.000 description 1
- 208000026451 salivation Diseases 0.000 description 1
- 239000011833 salt mixture Substances 0.000 description 1
- 230000000698 schizophrenic effect Effects 0.000 description 1
- 229940022808 scopolamine 0.4 mg Drugs 0.000 description 1
- WTGQALLALWYDJH-MOUKNHLCSA-N scopolamine hydrobromide (anhydrous) Chemical compound Br.C1([C@@H](CO)C(=O)O[C@H]2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 WTGQALLALWYDJH-MOUKNHLCSA-N 0.000 description 1
- 229940125723 sedative agent Drugs 0.000 description 1
- 239000000932 sedative agent Substances 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 239000012064 sodium phosphate buffer Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000008174 sterile solution Substances 0.000 description 1
- IIACRCGMVDHOTQ-UHFFFAOYSA-N sulfamic acid group Chemical class S(N)(O)(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-N 0.000 description 1
- XTHPWXDJESJLNJ-UHFFFAOYSA-N sulfurochloridic acid Chemical compound OS(Cl)(=O)=O XTHPWXDJESJLNJ-UHFFFAOYSA-N 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 210000003568 synaptosome Anatomy 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 235000013616 tea Nutrition 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 229960000278 theophylline Drugs 0.000 description 1
- 238000011287 therapeutic dose Methods 0.000 description 1
- 231100001274 therapeutic index Toxicity 0.000 description 1
- 230000001519 thymoleptic effect Effects 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 210000004916 vomit Anatomy 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 239000011592 zinc chloride Substances 0.000 description 1
- 235000005074 zinc chloride Nutrition 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB5417577 | 1977-12-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO784407L true NO784407L (no) | 1979-07-02 |
Family
ID=10470168
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO784407A NO784407L (no) | 1977-12-29 | 1978-12-28 | 2-metyltio-6-fluor-9-(1-metyl-4-piperidyliden)-tioxanten og syreaddisjonssalter derav |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US4235916A (es) |
| EP (1) | EP0002902A1 (es) |
| JP (1) | JPS5498778A (es) |
| AT (1) | AT366042B (es) |
| AU (1) | AU519403B2 (es) |
| CA (1) | CA1112245A (es) |
| ES (1) | ES476405A1 (es) |
| FI (1) | FI784010A (es) |
| NO (1) | NO784407L (es) |
| NZ (1) | NZ189108A (es) |
| ZA (1) | ZA786879B (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4777177A (en) * | 1984-10-19 | 1988-10-11 | Ciba-Geigy Corporation | Pesticidal thioxanthen-9-ylidenepiperidines |
| US20040037760A1 (en) * | 2002-08-21 | 2004-02-26 | Abb Lummus Heat Transfer | Steam reforming catalytic reaction apparatus |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE585338A (es) * | 1958-12-04 | |||
| NL260070A (es) * | 1960-02-25 | |||
| NL111765C (es) * | 1961-05-06 | |||
| GB1453828A (en) * | 1972-12-08 | 1976-10-27 | Kefalas As | Fluoro-substituted thiaxanthene derivatives |
| US4086350A (en) * | 1974-11-06 | 1978-04-25 | Smithkline Corporation | Pharmaceutical compositions and method of producing anti-psychotic activity without extrapyramidal symptoms |
| ZA756550B (en) * | 1974-11-06 | 1976-09-29 | Smithkline Corp | Pharmaceutical compositions and method of producing antipsychotic activity without extrapyramidal symptoms |
-
1978
- 1978-12-06 NZ NZ189108A patent/NZ189108A/xx unknown
- 1978-12-07 ZA ZA00786879A patent/ZA786879B/xx unknown
- 1978-12-08 EP EP78300779A patent/EP0002902A1/en not_active Withdrawn
- 1978-12-19 AT AT0906178A patent/AT366042B/de not_active IP Right Cessation
- 1978-12-20 US US05/971,509 patent/US4235916A/en not_active Expired - Lifetime
- 1978-12-22 AU AU42851/78A patent/AU519403B2/en not_active Expired
- 1978-12-27 JP JP16019678A patent/JPS5498778A/ja active Pending
- 1978-12-28 CA CA318,765A patent/CA1112245A/en not_active Expired
- 1978-12-28 FI FI784010A patent/FI784010A/fi unknown
- 1978-12-28 NO NO784407A patent/NO784407L/no unknown
- 1978-12-28 ES ES476405A patent/ES476405A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| EP0002902A1 (en) | 1979-07-11 |
| ES476405A1 (es) | 1980-03-01 |
| FI784010A (fi) | 1979-06-30 |
| ATA906178A (de) | 1981-07-15 |
| AU4285178A (en) | 1979-07-05 |
| JPS5498778A (en) | 1979-08-03 |
| US4235916A (en) | 1980-11-25 |
| CA1112245A (en) | 1981-11-10 |
| AT366042B (de) | 1982-03-10 |
| NZ189108A (en) | 1982-02-23 |
| ZA786879B (en) | 1979-12-27 |
| AU519403B2 (en) | 1981-12-03 |
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