NO338769B1 - Piperazindioner som oksytocinreseptorantagonister - Google Patents
Piperazindioner som oksytocinreseptorantagonister Download PDFInfo
- Publication number
- NO338769B1 NO338769B1 NO20070173A NO20070173A NO338769B1 NO 338769 B1 NO338769 B1 NO 338769B1 NO 20070173 A NO20070173 A NO 20070173A NO 20070173 A NO20070173 A NO 20070173A NO 338769 B1 NO338769 B1 NO 338769B1
- Authority
- NO
- Norway
- Prior art keywords
- acid
- compound
- formula
- dimethyl
- pharmaceutically acceptable
- Prior art date
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- -1 2-indanyl Chemical group 0.000 claims description 32
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Classifications
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Gynecology & Obstetrics (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pregnancy & Childbirth (AREA)
- Ophthalmology & Optometry (AREA)
- Hematology (AREA)
- Nutrition Science (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Anesthesiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0414093.5A GB0414093D0 (en) | 2004-06-23 | 2004-06-23 | Novel compounds |
| PCT/EP2005/006760 WO2006000399A1 (en) | 2004-06-23 | 2005-06-21 | Novel compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20070173L NO20070173L (no) | 2007-01-22 |
| NO338769B1 true NO338769B1 (no) | 2016-10-17 |
Family
ID=32800053
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20070173A NO338769B1 (no) | 2004-06-23 | 2007-01-10 | Piperazindioner som oksytocinreseptorantagonister |
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|---|---|
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| EP (2) | EP1758886B1 (enExample) |
| JP (2) | JP5405019B2 (enExample) |
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| CN (1) | CN1972924B (enExample) |
| AR (1) | AR049405A1 (enExample) |
| AU (1) | AU2005256470B2 (enExample) |
| BR (1) | BRPI0512376A (enExample) |
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| HU (1) | HUE025869T2 (enExample) |
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| MX (1) | MXPA06014545A (enExample) |
| MY (1) | MY143578A (enExample) |
| NO (1) | NO338769B1 (enExample) |
| NZ (1) | NZ551733A (enExample) |
| PE (1) | PE20060477A1 (enExample) |
| PL (1) | PL1758886T3 (enExample) |
| PT (1) | PT1758886E (enExample) |
| RU (1) | RU2382038C2 (enExample) |
| SI (1) | SI1758886T1 (enExample) |
| TW (1) | TWI348466B (enExample) |
| WO (1) | WO2006000399A1 (enExample) |
| ZA (1) | ZA200610022B (enExample) |
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| GB0130677D0 (en) * | 2001-12-21 | 2002-02-06 | Glaxo Group Ltd | Medicaments and novel compounds |
| EP2392659B1 (en) | 2002-06-17 | 2015-01-14 | Thrasos Innovation, Inc. | Single domain TDF-related compounds and analogs thereof |
| GB0314738D0 (en) | 2003-06-24 | 2003-07-30 | Glaxo Group Ltd | Novel compounds |
| JP4971149B2 (ja) | 2004-06-17 | 2012-07-11 | スラソス セラピューティックス インコーポレーテッド | Ｔｄｆ関連化合物およびその類似体 |
| GB0414100D0 (en) * | 2004-06-23 | 2004-07-28 | Glaxo Group Ltd | Novel compounds |
| GB0414093D0 (en) * | 2004-06-23 | 2004-07-28 | Glaxo Group Ltd | Novel compounds |
| JP2009508532A (ja) | 2005-09-20 | 2009-03-05 | スラソス セラピューティックス インコーポレーテッド | Ｔｄｆ関連化合物およびその類似体 |
| EP2493874A1 (en) | 2009-10-30 | 2012-09-05 | Glaxo Group Limited | Novel crystalline forms of (3r,6r) -3- (2, 3 -dihydro- 1h- inden- 2 -yl) - 1 - [ (1r) - 1 - (2, 6 - dimethyl - 3 - pyridinyl) - 2 - (4 -morpholinyl) -2-oxoethyl]-6- [(1s) - 1 -methylpropyl]-2,5- piperazinedione |
| EP4144351A1 (en) | 2016-01-04 | 2023-03-08 | ObsEva S.A. | Hydroxypropylthiazolidine carboxamide derivatives as inhibitors of the prostaglandin f receptor |
| WO2017203012A1 (en) * | 2016-05-27 | 2017-11-30 | Glaxosmithkline Intellectual Property (No.2) Limited | Epelsiban for use in the treatment of adenomyosis |
| BR112019001047A2 (pt) | 2016-07-21 | 2019-04-30 | ObsEva S.A. | método para tratar um indivíduo submetido à terapia de transferência de embriões e kit |
| WO2019230647A1 (ja) * | 2018-05-29 | 2019-12-05 | 花王株式会社 | シートの快感情喚起性能の評価方法及び快感情喚起シート |
| CA3117323A1 (en) | 2018-10-22 | 2020-04-30 | William D. Carlson | Therapeutic combinations of tdfrps and additional agents and methods of use |
| EP4025207A1 (en) | 2019-09-03 | 2022-07-13 | ObsEva S.A. | Oxytocin antagonist dosing regimens for promoting embryo implantation and preventing miscarriage |
| EP4103750A1 (en) | 2020-02-10 | 2022-12-21 | ObsEva S.A. | Biomarkers for oxytocin receptor antagonist therapy |
Citations (1)
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| WO2003053443A1 (en) * | 2001-12-21 | 2003-07-03 | Glaxo Group Limited | Substituted diketopiperazines as oxytocin antagonists |
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| US4596819A (en) * | 1984-01-23 | 1986-06-24 | Warner-Lambert Company | Modified tripeptides |
| DE3830096A1 (de) | 1988-09-03 | 1990-03-15 | Hoechst Ag | Piperazindione mit psychotroper wirkung |
| US5464788A (en) * | 1994-03-24 | 1995-11-07 | Merck & Co., Inc. | Tocolytic oxytocin receptor antagonists |
| US5817751A (en) * | 1994-06-23 | 1998-10-06 | Affymax Technologies N.V. | Method for synthesis of diketopiperazine and diketomorpholine derivatives |
| GB2326639A (en) | 1997-06-18 | 1998-12-30 | Merck & Co Inc | Piperazine Oxytocin Receptor Antagonists |
| WO1999037304A1 (en) | 1998-01-27 | 1999-07-29 | Aventis Pharmaceuticals Products Inc. | SUBSTITUTED OXOAZAHETEROCYCLYL FACTOR Xa INHIBITORS |
| CN1173946C (zh) | 1998-01-29 | 2004-11-03 | 阿温蒂斯药物公司 | 制备n-[(脂族或芳族)羰基]-2-氨基乙酰胺化合物和环化化合物的方法 |
| CA2289621A1 (en) * | 1998-03-16 | 1999-09-23 | Ontogen Corporation | Piperazines as inhibitors of fructose-1,6-bisphosphatase (fbpase) |
| GB0314738D0 (en) * | 2003-06-24 | 2003-07-30 | Glaxo Group Ltd | Novel compounds |
| GB0314733D0 (en) * | 2003-06-24 | 2003-07-30 | Glaxo Group Ltd | Medicaments |
| GB0414100D0 (en) * | 2004-06-23 | 2004-07-28 | Glaxo Group Ltd | Novel compounds |
| GB0414093D0 (en) * | 2004-06-23 | 2004-07-28 | Glaxo Group Ltd | Novel compounds |
| GB0414092D0 (en) * | 2004-06-23 | 2004-07-28 | Glaxo Group Ltd | Novel compounds |
| GB0428235D0 (en) | 2004-12-23 | 2005-01-26 | Glaxo Group Ltd | Novel compounds |
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2004
- 2004-06-23 GB GBGB0414093.5A patent/GB0414093D0/en not_active Ceased
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2005
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- 2005-06-21 ES ES05755563.3T patent/ES2537801T3/es not_active Expired - Lifetime
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- 2005-06-21 EP EP15157368.0A patent/EP2918580A1/en not_active Withdrawn
- 2005-06-21 JP JP2007517197A patent/JP5405019B2/ja not_active Expired - Fee Related
- 2005-06-21 CN CN2005800210140A patent/CN1972924B/zh not_active Expired - Fee Related
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003053443A1 (en) * | 2001-12-21 | 2003-07-03 | Glaxo Group Limited | Substituted diketopiperazines as oxytocin antagonists |
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| US20070208031A1 (en) | Substituted Diketopiperazines as Oxytocin Antagonists | |
| US20070185162A1 (en) | Substituted diketopiperazines as oxytocin receptor antagonists | |
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Owner name: GLAXO GROUP LTD, GB |
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| MM1K | Lapsed by not paying the annual fees |