ES2537801T3 - Piperazinodionas como antagonistas del receptor de la oxitocina - Google Patents
Piperazinodionas como antagonistas del receptor de la oxitocina Download PDFInfo
- Publication number
- ES2537801T3 ES2537801T3 ES05755563.3T ES05755563T ES2537801T3 ES 2537801 T3 ES2537801 T3 ES 2537801T3 ES 05755563 T ES05755563 T ES 05755563T ES 2537801 T3 ES2537801 T3 ES 2537801T3
- Authority
- ES
- Spain
- Prior art keywords
- piperazinodiones
- receptor antagonists
- oxytocin receptor
- formula
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 229940122828 Oxytocin receptor antagonist Drugs 0.000 title 1
- -1 2-indanyl Chemical group 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Gynecology & Obstetrics (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Pregnancy & Childbirth (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Ophthalmology & Optometry (AREA)
- Diabetes (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Nutrition Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
Un compuesto de fórmula (I)**Fórmula** en la que R1 es 2-indanilo, R2 es 1-metipropilo, R3 es 2,6-dimetil-3-piridilo, R4 y R5 conjuntamente con el átomo de nitrógeno al cual están unidos representan morfolino, o una sal de adición de ácido farmacéuticamente aceptable del mismo, en el cual el ácido está seleccionado entre: ácido clorhídrico, bromhídrico, nítrico, fosfórico, sulfúrico, meta-nosulfónico, etanosulfónico, bencenosulfónico, p-toluenosulfónico, cítrico, tartárico, láctico, pirúvico, acético, succíni-co, fumárico y maléico.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0414093.5A GB0414093D0 (en) | 2004-06-23 | 2004-06-23 | Novel compounds |
| GB0414093 | 2004-06-23 | ||
| PCT/EP2005/006760 WO2006000399A1 (en) | 2004-06-23 | 2005-06-21 | Novel compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2537801T3 true ES2537801T3 (es) | 2015-06-12 |
Family
ID=32800053
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES05755563.3T Active ES2537801T3 (es) | 2004-06-23 | 2005-06-21 | Piperazinodionas como antagonistas del receptor de la oxitocina |
Country Status (30)
| Country | Link |
|---|---|
| US (9) | US7550462B2 (es) |
| EP (2) | EP2918580A1 (es) |
| JP (2) | JP5405019B2 (es) |
| KR (1) | KR101186447B1 (es) |
| CN (1) | CN1972924B (es) |
| AR (1) | AR049405A1 (es) |
| AU (1) | AU2005256470B2 (es) |
| BR (1) | BRPI0512376A (es) |
| CA (1) | CA2571527C (es) |
| CY (1) | CY1116183T1 (es) |
| DK (1) | DK1758886T3 (es) |
| ES (1) | ES2537801T3 (es) |
| GB (1) | GB0414093D0 (es) |
| HK (2) | HK1106499A1 (es) |
| HR (1) | HRP20150401T1 (es) |
| HU (1) | HUE025869T2 (es) |
| IL (2) | IL179905A0 (es) |
| MA (1) | MA28675B1 (es) |
| MX (1) | MXPA06014545A (es) |
| MY (1) | MY143578A (es) |
| NO (1) | NO338769B1 (es) |
| NZ (1) | NZ551733A (es) |
| PE (1) | PE20060477A1 (es) |
| PL (1) | PL1758886T3 (es) |
| PT (1) | PT1758886E (es) |
| RU (1) | RU2382038C2 (es) |
| SI (1) | SI1758886T1 (es) |
| TW (1) | TWI348466B (es) |
| WO (1) | WO2006000399A1 (es) |
| ZA (1) | ZA200610022B (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0130677D0 (en) * | 2001-12-21 | 2002-02-06 | Glaxo Group Ltd | Medicaments and novel compounds |
| EP1572950B1 (en) | 2002-06-17 | 2012-10-10 | Thrasos, Inc. | Single domain tdf-related compounds and analogs thereof |
| GB0314738D0 (en) | 2003-06-24 | 2003-07-30 | Glaxo Group Ltd | Novel compounds |
| EP2789342A1 (en) | 2004-06-17 | 2014-10-15 | Thrasos Innovation, Inc. | TDF-related compounds and analogs thereof |
| GB0414093D0 (en) * | 2004-06-23 | 2004-07-28 | Glaxo Group Ltd | Novel compounds |
| GB0414100D0 (en) * | 2004-06-23 | 2004-07-28 | Glaxo Group Ltd | Novel compounds |
| CA2863125A1 (en) | 2005-09-20 | 2007-03-29 | Thrasos Innovation, Inc. | Tdf-related compounds and analogs thereof |
| US8716286B2 (en) | 2009-10-30 | 2014-05-06 | Glaxo Group Limited | Crystalline forms of (3R, 6R)-3-(2,3-dihydro-1H-inden-2-yl)-1-[(1R)-1-(2,6-dimethyl-3-pyridinyl)-2-(4-morpholinyl)-2-oxoethyl]-6-[(1S)-1-methylpropyl]-2,5-piperazinedione |
| KR20180100120A (ko) | 2016-01-04 | 2018-09-07 | 옵스에파 에스에이 | 하이드록시프로필티아졸리딘 카르복사미드 유도체의 알파-아미노 에스테르 및 이의 염 형태, 결정 다형체 |
| WO2017203012A1 (en) * | 2016-05-27 | 2017-11-30 | Glaxosmithkline Intellectual Property (No.2) Limited | Epelsiban for use in the treatment of adenomyosis |
| US20190247361A1 (en) | 2016-07-21 | 2019-08-15 | ObsEva S.A. | Oxytocin antagonist dosing regimens for promoting embryo implantation and preventing miscarriage |
| EP3805763A4 (en) * | 2018-05-29 | 2022-03-09 | Kao Corporation | SHEET COMFORT EVOCATION PERFORMANCE EVALUATION METHOD AND COMFORT EVOCATION SHEET |
| WO2021043726A1 (en) | 2019-09-03 | 2021-03-11 | ObsEva S.A. | Oxytocin antagonist dosing regimens for promoting embryo implantation and preventing miscarriage |
| WO2021160597A1 (en) | 2020-02-10 | 2021-08-19 | ObsEva S.A. | Biomarkers for oxytocin receptor antagonist therapy |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4596819A (en) * | 1984-01-23 | 1986-06-24 | Warner-Lambert Company | Modified tripeptides |
| DE3830096A1 (de) | 1988-09-03 | 1990-03-15 | Hoechst Ag | Piperazindione mit psychotroper wirkung |
| US5464788A (en) * | 1994-03-24 | 1995-11-07 | Merck & Co., Inc. | Tocolytic oxytocin receptor antagonists |
| US5817751A (en) * | 1994-06-23 | 1998-10-06 | Affymax Technologies N.V. | Method for synthesis of diketopiperazine and diketomorpholine derivatives |
| GB2326639A (en) | 1997-06-18 | 1998-12-30 | Merck & Co Inc | Piperazine Oxytocin Receptor Antagonists |
| BR9907300A (pt) | 1998-01-27 | 2000-10-24 | Aventis Pharm Prod Inc | Inibidores do fator xa oxoaza-heterociclila substituìdos |
| EP1051397B1 (en) | 1998-01-29 | 2008-12-31 | Aventis Pharmaceuticals Inc. | Method for preparing an n- (aliphatic or aromatic)carbonyl -2-aminoacetamide compound and a cyclyzed compound |
| EP1070084A4 (en) | 1998-03-16 | 2001-09-12 | Ontogen Corp | PIPERAZINE AS INHIBITORS OF FRUKTOSE-1,6-BISPHOSPHATASE (FBPASE) |
| GB0130677D0 (en) * | 2001-12-21 | 2002-02-06 | Glaxo Group Ltd | Medicaments and novel compounds |
| GB0314738D0 (en) * | 2003-06-24 | 2003-07-30 | Glaxo Group Ltd | Novel compounds |
| GB0314733D0 (en) | 2003-06-24 | 2003-07-30 | Glaxo Group Ltd | Medicaments |
| GB0414100D0 (en) | 2004-06-23 | 2004-07-28 | Glaxo Group Ltd | Novel compounds |
| GB0414092D0 (en) | 2004-06-23 | 2004-07-28 | Glaxo Group Ltd | Novel compounds |
| GB0414093D0 (en) * | 2004-06-23 | 2004-07-28 | Glaxo Group Ltd | Novel compounds |
| GB0428235D0 (en) | 2004-12-23 | 2005-01-26 | Glaxo Group Ltd | Novel compounds |
-
2004
- 2004-06-23 GB GBGB0414093.5A patent/GB0414093D0/en not_active Ceased
-
2005
- 2005-06-21 US US11/630,179 patent/US7550462B2/en not_active Expired - Fee Related
- 2005-06-21 TW TW094120517A patent/TWI348466B/zh not_active IP Right Cessation
- 2005-06-21 DK DK05755563T patent/DK1758886T3/da active
- 2005-06-21 EP EP15157368.0A patent/EP2918580A1/en not_active Withdrawn
- 2005-06-21 MX MXPA06014545A patent/MXPA06014545A/es active IP Right Grant
- 2005-06-21 RU RU2007102274/04A patent/RU2382038C2/ru not_active IP Right Cessation
- 2005-06-21 PL PL05755563T patent/PL1758886T3/pl unknown
- 2005-06-21 SI SI200531963T patent/SI1758886T1/sl unknown
- 2005-06-21 CN CN2005800210140A patent/CN1972924B/zh not_active Expired - Fee Related
- 2005-06-21 NZ NZ551733A patent/NZ551733A/en not_active IP Right Cessation
- 2005-06-21 CA CA2571527A patent/CA2571527C/en not_active Expired - Fee Related
- 2005-06-21 HU HUE05755563A patent/HUE025869T2/en unknown
- 2005-06-21 AU AU2005256470A patent/AU2005256470B2/en not_active Ceased
- 2005-06-21 AR ARP050102539A patent/AR049405A1/es not_active Application Discontinuation
- 2005-06-21 MY MYPI20052837A patent/MY143578A/en unknown
- 2005-06-21 ES ES05755563.3T patent/ES2537801T3/es active Active
- 2005-06-21 WO PCT/EP2005/006760 patent/WO2006000399A1/en active Application Filing
- 2005-06-21 EP EP05755563.3A patent/EP1758886B1/en active Active
- 2005-06-21 PT PT57555633T patent/PT1758886E/pt unknown
- 2005-06-21 BR BRPI0512376-3A patent/BRPI0512376A/pt not_active Application Discontinuation
- 2005-06-21 KR KR1020067027107A patent/KR101186447B1/ko active IP Right Grant
- 2005-06-21 JP JP2007517197A patent/JP5405019B2/ja not_active Expired - Fee Related
- 2005-06-22 PE PE2005000714A patent/PE20060477A1/es active IP Right Grant
-
2006
- 2006-11-30 ZA ZA200610022A patent/ZA200610022B/en unknown
- 2006-12-07 IL IL179905A patent/IL179905A0/en not_active IP Right Cessation
- 2006-12-21 MA MA29549A patent/MA28675B1/fr unknown
-
2007
- 2007-01-10 NO NO20070173A patent/NO338769B1/no not_active IP Right Cessation
- 2007-07-23 HK HK07107960.4A patent/HK1106499A1/xx not_active IP Right Cessation
- 2007-07-23 HK HK15109142.1A patent/HK1208669A1/xx unknown
-
2009
- 2009-06-08 US US12/480,182 patent/US20090247541A1/en not_active Abandoned
-
2010
- 2010-08-04 US US12/850,386 patent/US7919492B2/en not_active Expired - Fee Related
-
2011
- 2011-02-25 US US13/035,366 patent/US8202864B2/en not_active Expired - Fee Related
-
2012
- 2012-04-19 US US13/451,196 patent/US20120202811A1/en not_active Abandoned
- 2012-10-05 JP JP2012223526A patent/JP5503709B2/ja not_active Expired - Fee Related
-
2013
- 2013-05-20 US US13/897,853 patent/US8742099B2/en not_active Expired - Fee Related
-
2014
- 2014-04-25 US US14/261,994 patent/US20140235639A1/en not_active Abandoned
-
2015
- 2015-02-16 US US14/623,098 patent/US20150157640A1/en not_active Abandoned
- 2015-03-02 IL IL237513A patent/IL237513A0/en unknown
- 2015-04-08 CY CY20151100339T patent/CY1116183T1/el unknown
- 2015-04-10 HR HRP20150401TT patent/HRP20150401T1/hr unknown
- 2015-10-13 US US14/881,322 patent/US9408851B2/en not_active Expired - Fee Related
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