TWI348466B - Novel diketopiperazine derivatives as oxytocin receptor antagonists - Google Patents
Novel diketopiperazine derivatives as oxytocin receptor antagonistsInfo
- Publication number
- TWI348466B TWI348466B TW094120517A TW94120517A TWI348466B TW I348466 B TWI348466 B TW I348466B TW 094120517 A TW094120517 A TW 094120517A TW 94120517 A TW94120517 A TW 94120517A TW I348466 B TWI348466 B TW I348466B
- Authority
- TW
- Taiwan
- Prior art keywords
- receptor antagonists
- oxytocin receptor
- diketopiperazine derivatives
- novel
- novel diketopiperazine
- Prior art date
Links
- 229940122828 Oxytocin receptor antagonist Drugs 0.000 title 1
- BXRNXXXXHLBUKK-UHFFFAOYSA-N piperazine-2,5-dione Chemical class O=C1CNC(=O)CN1 BXRNXXXXHLBUKK-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Gynecology & Obstetrics (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pregnancy & Childbirth (AREA)
- Ophthalmology & Optometry (AREA)
- Hematology (AREA)
- Nutrition Science (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Anesthesiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0414093.5A GB0414093D0 (en) | 2004-06-23 | 2004-06-23 | Novel compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW200616636A TW200616636A (en) | 2006-06-01 |
| TWI348466B true TWI348466B (en) | 2011-09-11 |
Family
ID=32800053
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW094120517A TWI348466B (en) | 2004-06-23 | 2005-06-21 | Novel diketopiperazine derivatives as oxytocin receptor antagonists |
Country Status (30)
| Country | Link |
|---|---|
| US (9) | US7550462B2 (enExample) |
| EP (2) | EP1758886B1 (enExample) |
| JP (2) | JP5405019B2 (enExample) |
| KR (1) | KR101186447B1 (enExample) |
| CN (1) | CN1972924B (enExample) |
| AR (1) | AR049405A1 (enExample) |
| AU (1) | AU2005256470B2 (enExample) |
| BR (1) | BRPI0512376A (enExample) |
| CA (1) | CA2571527C (enExample) |
| CY (1) | CY1116183T1 (enExample) |
| DK (1) | DK1758886T3 (enExample) |
| ES (1) | ES2537801T3 (enExample) |
| GB (1) | GB0414093D0 (enExample) |
| HK (1) | HK1208669A1 (enExample) |
| HR (1) | HRP20150401T1 (enExample) |
| HU (1) | HUE025869T2 (enExample) |
| IL (2) | IL179905A0 (enExample) |
| MA (1) | MA28675B1 (enExample) |
| MX (1) | MXPA06014545A (enExample) |
| MY (1) | MY143578A (enExample) |
| NO (1) | NO338769B1 (enExample) |
| NZ (1) | NZ551733A (enExample) |
| PE (1) | PE20060477A1 (enExample) |
| PL (1) | PL1758886T3 (enExample) |
| PT (1) | PT1758886E (enExample) |
| RU (1) | RU2382038C2 (enExample) |
| SI (1) | SI1758886T1 (enExample) |
| TW (1) | TWI348466B (enExample) |
| WO (1) | WO2006000399A1 (enExample) |
| ZA (1) | ZA200610022B (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0130677D0 (en) * | 2001-12-21 | 2002-02-06 | Glaxo Group Ltd | Medicaments and novel compounds |
| EP2392659B1 (en) | 2002-06-17 | 2015-01-14 | Thrasos Innovation, Inc. | Single domain TDF-related compounds and analogs thereof |
| GB0314738D0 (en) | 2003-06-24 | 2003-07-30 | Glaxo Group Ltd | Novel compounds |
| JP4971149B2 (ja) | 2004-06-17 | 2012-07-11 | スラソス セラピューティックス インコーポレーテッド | Ｔｄｆ関連化合物およびその類似体 |
| GB0414100D0 (en) * | 2004-06-23 | 2004-07-28 | Glaxo Group Ltd | Novel compounds |
| GB0414093D0 (en) * | 2004-06-23 | 2004-07-28 | Glaxo Group Ltd | Novel compounds |
| JP2009508532A (ja) | 2005-09-20 | 2009-03-05 | スラソス セラピューティックス インコーポレーテッド | Ｔｄｆ関連化合物およびその類似体 |
| EP2493874A1 (en) | 2009-10-30 | 2012-09-05 | Glaxo Group Limited | Novel crystalline forms of (3r,6r) -3- (2, 3 -dihydro- 1h- inden- 2 -yl) - 1 - [ (1r) - 1 - (2, 6 - dimethyl - 3 - pyridinyl) - 2 - (4 -morpholinyl) -2-oxoethyl]-6- [(1s) - 1 -methylpropyl]-2,5- piperazinedione |
| EP4144351A1 (en) | 2016-01-04 | 2023-03-08 | ObsEva S.A. | Hydroxypropylthiazolidine carboxamide derivatives as inhibitors of the prostaglandin f receptor |
| WO2017203012A1 (en) * | 2016-05-27 | 2017-11-30 | Glaxosmithkline Intellectual Property (No.2) Limited | Epelsiban for use in the treatment of adenomyosis |
| BR112019001047A2 (pt) | 2016-07-21 | 2019-04-30 | ObsEva S.A. | método para tratar um indivíduo submetido à terapia de transferência de embriões e kit |
| WO2019230647A1 (ja) * | 2018-05-29 | 2019-12-05 | 花王株式会社 | シートの快感情喚起性能の評価方法及び快感情喚起シート |
| CA3117323A1 (en) | 2018-10-22 | 2020-04-30 | William D. Carlson | Therapeutic combinations of tdfrps and additional agents and methods of use |
| EP4025207A1 (en) | 2019-09-03 | 2022-07-13 | ObsEva S.A. | Oxytocin antagonist dosing regimens for promoting embryo implantation and preventing miscarriage |
| EP4103750A1 (en) | 2020-02-10 | 2022-12-21 | ObsEva S.A. | Biomarkers for oxytocin receptor antagonist therapy |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4596819A (en) * | 1984-01-23 | 1986-06-24 | Warner-Lambert Company | Modified tripeptides |
| DE3830096A1 (de) | 1988-09-03 | 1990-03-15 | Hoechst Ag | Piperazindione mit psychotroper wirkung |
| US5464788A (en) * | 1994-03-24 | 1995-11-07 | Merck & Co., Inc. | Tocolytic oxytocin receptor antagonists |
| US5817751A (en) * | 1994-06-23 | 1998-10-06 | Affymax Technologies N.V. | Method for synthesis of diketopiperazine and diketomorpholine derivatives |
| GB2326639A (en) | 1997-06-18 | 1998-12-30 | Merck & Co Inc | Piperazine Oxytocin Receptor Antagonists |
| WO1999037304A1 (en) | 1998-01-27 | 1999-07-29 | Aventis Pharmaceuticals Products Inc. | SUBSTITUTED OXOAZAHETEROCYCLYL FACTOR Xa INHIBITORS |
| CN1173946C (zh) | 1998-01-29 | 2004-11-03 | 阿温蒂斯药物公司 | 制备n-[(脂族或芳族)羰基]-2-氨基乙酰胺化合物和环化化合物的方法 |
| CA2289621A1 (en) * | 1998-03-16 | 1999-09-23 | Ontogen Corporation | Piperazines as inhibitors of fructose-1,6-bisphosphatase (fbpase) |
| GB0130677D0 (en) * | 2001-12-21 | 2002-02-06 | Glaxo Group Ltd | Medicaments and novel compounds |
| GB0314738D0 (en) * | 2003-06-24 | 2003-07-30 | Glaxo Group Ltd | Novel compounds |
| GB0314733D0 (en) * | 2003-06-24 | 2003-07-30 | Glaxo Group Ltd | Medicaments |
| GB0414100D0 (en) * | 2004-06-23 | 2004-07-28 | Glaxo Group Ltd | Novel compounds |
| GB0414093D0 (en) * | 2004-06-23 | 2004-07-28 | Glaxo Group Ltd | Novel compounds |
| GB0414092D0 (en) * | 2004-06-23 | 2004-07-28 | Glaxo Group Ltd | Novel compounds |
| GB0428235D0 (en) | 2004-12-23 | 2005-01-26 | Glaxo Group Ltd | Novel compounds |
-
2004
- 2004-06-23 GB GBGB0414093.5A patent/GB0414093D0/en not_active Ceased
-
2005
- 2005-06-21 MY MYPI20052837A patent/MY143578A/en unknown
- 2005-06-21 EP EP05755563.3A patent/EP1758886B1/en not_active Expired - Lifetime
- 2005-06-21 WO PCT/EP2005/006760 patent/WO2006000399A1/en not_active Ceased
- 2005-06-21 ES ES05755563.3T patent/ES2537801T3/es not_active Expired - Lifetime
- 2005-06-21 TW TW094120517A patent/TWI348466B/zh not_active IP Right Cessation
- 2005-06-21 EP EP15157368.0A patent/EP2918580A1/en not_active Withdrawn
- 2005-06-21 JP JP2007517197A patent/JP5405019B2/ja not_active Expired - Fee Related
- 2005-06-21 CN CN2005800210140A patent/CN1972924B/zh not_active Expired - Fee Related
- 2005-06-21 US US11/630,179 patent/US7550462B2/en not_active Expired - Fee Related
- 2005-06-21 PT PT57555633T patent/PT1758886E/pt unknown
- 2005-06-21 AU AU2005256470A patent/AU2005256470B2/en not_active Ceased
- 2005-06-21 RU RU2007102274/04A patent/RU2382038C2/ru not_active IP Right Cessation
- 2005-06-21 SI SI200531963T patent/SI1758886T1/sl unknown
- 2005-06-21 MX MXPA06014545A patent/MXPA06014545A/es active IP Right Grant
- 2005-06-21 CA CA2571527A patent/CA2571527C/en not_active Expired - Fee Related
- 2005-06-21 BR BRPI0512376-3A patent/BRPI0512376A/pt not_active Application Discontinuation
- 2005-06-21 NZ NZ551733A patent/NZ551733A/en not_active IP Right Cessation
- 2005-06-21 HR HRP20150401TT patent/HRP20150401T1/hr unknown
- 2005-06-21 KR KR1020067027107A patent/KR101186447B1/ko not_active Expired - Fee Related
- 2005-06-21 PL PL05755563T patent/PL1758886T3/pl unknown
- 2005-06-21 DK DK05755563T patent/DK1758886T3/da active
- 2005-06-21 AR ARP050102539A patent/AR049405A1/es not_active Application Discontinuation
- 2005-06-21 HU HUE05755563A patent/HUE025869T2/en unknown
- 2005-06-22 PE PE2005000714A patent/PE20060477A1/es active IP Right Grant
-
2006
- 2006-11-30 ZA ZA200610022A patent/ZA200610022B/en unknown
- 2006-12-07 IL IL179905A patent/IL179905A0/en not_active IP Right Cessation
- 2006-12-21 MA MA29549A patent/MA28675B1/fr unknown
-
2007
- 2007-01-10 NO NO20070173A patent/NO338769B1/no not_active IP Right Cessation
- 2007-07-23 HK HK15109142.1A patent/HK1208669A1/en unknown
-
2009
- 2009-06-08 US US12/480,182 patent/US20090247541A1/en not_active Abandoned
-
2010
- 2010-08-04 US US12/850,386 patent/US7919492B2/en not_active Expired - Fee Related
-
2011
- 2011-02-25 US US13/035,366 patent/US8202864B2/en not_active Expired - Fee Related
-
2012
- 2012-04-19 US US13/451,196 patent/US20120202811A1/en not_active Abandoned
- 2012-10-05 JP JP2012223526A patent/JP5503709B2/ja not_active Expired - Fee Related
-
2013
- 2013-05-20 US US13/897,853 patent/US8742099B2/en not_active Expired - Fee Related
-
2014
- 2014-04-25 US US14/261,994 patent/US20140235639A1/en not_active Abandoned
-
2015
- 2015-02-16 US US14/623,098 patent/US20150157640A1/en not_active Abandoned
- 2015-03-02 IL IL237513A patent/IL237513A0/en unknown
- 2015-04-08 CY CY20151100339T patent/CY1116183T1/el unknown
- 2015-10-13 US US14/881,322 patent/US9408851B2/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Annulment or lapse of patent due to non-payment of fees |