NO332112B1 - Isolert, syntetisk eller rekombinant nukleinsyremolekyl og polypeptid, ekspresjonsvektor, fremgangsmate for a produsere nystatin eller et nystatinderivat, anvendelse av et nukleinsyremolekyl, fremgangsmate for fremstilling av et modifisert PKS-system og nystatin, modifisert PKS-system, vertscelle, nystatinderivat samt antibiotikum. - Google Patents

Isolert, syntetisk eller rekombinant nukleinsyremolekyl og polypeptid, ekspresjonsvektor, fremgangsmate for a produsere nystatin eller et nystatinderivat, anvendelse av et nukleinsyremolekyl, fremgangsmate for fremstilling av et modifisert PKS-system og nystatin, modifisert PKS-system, vertscelle, nystatinderivat samt antibiotikum. Download PDF

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Publication number
NO332112B1
NO332112B1 NO20023741A NO20023741A NO332112B1 NO 332112 B1 NO332112 B1 NO 332112B1 NO 20023741 A NO20023741 A NO 20023741A NO 20023741 A NO20023741 A NO 20023741A NO 332112 B1 NO332112 B1 NO 332112B1
Authority
NO
Norway
Prior art keywords
nystatin
seq
nucleic acid
acid molecule
pks
Prior art date
Application number
NO20023741A
Other languages
English (en)
Norwegian (no)
Other versions
NO20023741L (no
NO20023741D0 (no
Inventor
Svein Valla
Havard Sletta
Trond E Ellingsen
Sergey Borisovich Zotchev
Olga Nikolayivna Sekurova
Espen Fjaervik
Trygve Brautaset
Arne Reidar Strom
Ole-Martin Gullicksen
Original Assignee
Sinvent As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0002840A external-priority patent/GB0002840D0/en
Priority claimed from GB0008786A external-priority patent/GB0008786D0/en
Priority claimed from GB0009387A external-priority patent/GB0009387D0/en
Application filed by Sinvent As filed Critical Sinvent As
Publication of NO20023741D0 publication Critical patent/NO20023741D0/no
Publication of NO20023741L publication Critical patent/NO20023741L/no
Publication of NO332112B1 publication Critical patent/NO332112B1/no

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08Hetero rings containing eight or more ring members, e.g. erythromycins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52Genes encoding for enzymes or proenzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/44Preparation of O-glycosides, e.g. glucosides
    • C12P19/60Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Plant Pathology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
NO20023741A 2000-02-08 2002-08-07 Isolert, syntetisk eller rekombinant nukleinsyremolekyl og polypeptid, ekspresjonsvektor, fremgangsmate for a produsere nystatin eller et nystatinderivat, anvendelse av et nukleinsyremolekyl, fremgangsmate for fremstilling av et modifisert PKS-system og nystatin, modifisert PKS-system, vertscelle, nystatinderivat samt antibiotikum. NO332112B1 (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0002840A GB0002840D0 (en) 2000-02-08 2000-02-08 Novel genes and their manipulation and utility
GB0008786A GB0008786D0 (en) 2000-04-10 2000-04-10 Novel genes and their manipulation and utility
GB0009387A GB0009387D0 (en) 2000-04-14 2000-04-14 Novel genes and their manipulation and utility
PCT/GB2001/000509 WO2001059126A2 (en) 2000-02-08 2001-02-08 Gene cluster encoding a nystatin polyketide synthase and its manipulation and utility

Publications (3)

Publication Number Publication Date
NO20023741D0 NO20023741D0 (no) 2002-08-07
NO20023741L NO20023741L (no) 2002-10-07
NO332112B1 true NO332112B1 (no) 2012-06-25

Family

ID=27255517

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20023741A NO332112B1 (no) 2000-02-08 2002-08-07 Isolert, syntetisk eller rekombinant nukleinsyremolekyl og polypeptid, ekspresjonsvektor, fremgangsmate for a produsere nystatin eller et nystatinderivat, anvendelse av et nukleinsyremolekyl, fremgangsmate for fremstilling av et modifisert PKS-system og nystatin, modifisert PKS-system, vertscelle, nystatinderivat samt antibiotikum.

Country Status (7)

Country Link
US (3) US7141660B2 (https=)
EP (1) EP1255840A2 (https=)
JP (1) JP4902925B2 (https=)
AU (2) AU784995B2 (https=)
CA (1) CA2399689A1 (https=)
NO (1) NO332112B1 (https=)
WO (1) WO2001059126A2 (https=)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2360011A1 (en) 1999-01-05 2000-07-13 Trustees Of Boston University Ordered gene assembly
FR2907465A1 (fr) * 2006-10-18 2008-04-25 Commissariat Energie Atomique Polynucleotides et polypeptides codes par lesdits polynucleotides impliques dans la voie de biosynthese de la congocidine et ses derives
GB0712881D0 (en) * 2007-07-03 2007-08-15 Biosergen As Compounds
GB0805363D0 (en) 2008-03-20 2008-04-30 Sinvent As Novel NRPS-PKS gene cluster and its manipulation and utility
EP2546345A1 (en) * 2008-06-04 2013-01-16 Eisai R&D Management Co., Ltd. DNA encoding polypeptide involved in biosynthesis of herboxidiene
EP3247378B8 (en) 2015-01-09 2023-08-23 Revolution Medicines, Inc. Macrocyclic compounds that participate in cooperative binding and medical uses thereof
CN109641062A (zh) 2016-04-12 2019-04-16 华普卓威生物公司 用于产生化合物的组合物和方法
GB2553356A (en) * 2016-09-05 2018-03-07 Geomec Eng Ltd Improvements in or relating to geothermal power plants
US11479797B2 (en) * 2016-10-28 2022-10-25 Ginkgo Bioworks, Inc. Compositions and methods for the production of compounds
CN110423790B (zh) * 2019-08-16 2021-04-02 上海交通大学 一种抗真菌四霉素b定向高产的代谢工程方法
TW202132316A (zh) 2019-11-04 2021-09-01 美商銳新醫藥公司 Ras抑制劑
AU2020377925A1 (en) 2019-11-04 2022-05-05 Revolution Medicines, Inc. Ras inhibitors
IL322454A (en) 2019-11-04 2025-09-01 Revolution Medicines Inc ras inhibitors
US11049590B1 (en) 2020-02-12 2021-06-29 Peptilogics, Inc. Artificial intelligence engine architecture for generating candidate drugs
CA3194067A1 (en) 2020-09-15 2022-03-24 Revolution Medicines, Inc. Ras inhibitors
US11403316B2 (en) 2020-11-23 2022-08-02 Peptilogics, Inc. Generating enhanced graphical user interfaces for presentation of anti-infective design spaces for selecting drug candidates
KR20240017811A (ko) 2021-05-05 2024-02-08 레볼루션 메디슨즈, 인크. 암의 치료를 위한 ras 억제제
US11512345B1 (en) 2021-05-07 2022-11-29 Peptilogics, Inc. Methods and apparatuses for generating peptides by synthesizing a portion of a design space to identify peptides having non-canonical amino acids
AR127308A1 (es) 2021-10-08 2024-01-10 Revolution Medicines Inc Inhibidores ras
GB202207185D0 (en) 2022-05-17 2022-06-29 Sintef Tto As Novel antibiotic compound

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2654339B1 (fr) 1989-11-14 1994-10-28 Mayoly Spindler Laboratoires Nouveaux derives solubles et non toxiques des macrolides polyeniques basiques, leur preparation et leurs applications.
US5210226A (en) 1990-02-02 1993-05-11 Xechem Inc. Method for separating and purifying polyene macrolide antibiotics
DE59106126D1 (de) * 1990-03-07 1995-09-07 Hoffmann La Roche Verfahren zur herstellung von derivaten der ascorbinsäure.
US5712146A (en) 1993-09-20 1998-01-27 The Leland Stanford Junior University Recombinant combinatorial genetic library for the production of novel polyketides
CA2188257A1 (en) 1994-04-22 1995-11-02 Juan Jose R. Coque Dna encoding cephamycin biosynthesis late enzymes
CA2197524A1 (en) 1996-02-22 1997-08-22 Bradley Stuart Dehoff Polyketide synthase genes
NZ500693A (en) 1997-04-30 2004-01-30 Kosan Biosciences Inc Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold
US5981721A (en) * 1997-10-23 1999-11-09 Karykion Corporation Polyene macrolide schiff bases, their alkyl esters and processes for preparing polyene macrolide alkyl ester salts thereof
WO2000077222A1 (en) 1999-06-14 2000-12-21 Dsm N.V. Genes encoding enzymes in the biosynthesis of pimaricin and the application thereof

Also Published As

Publication number Publication date
AU2006206147A1 (en) 2006-09-28
NO20023741L (no) 2002-10-07
AU3203401A (en) 2001-08-20
WO2001059126A3 (en) 2002-03-14
US7851183B2 (en) 2010-12-14
NO20023741D0 (no) 2002-08-07
WO2001059126A2 (en) 2001-08-16
JP2003528592A (ja) 2003-09-30
US7141660B2 (en) 2006-11-28
AU2006206147B2 (en) 2008-12-18
US20040115762A1 (en) 2004-06-17
AU784995B2 (en) 2006-08-17
US7709231B2 (en) 2010-05-04
EP1255840A2 (en) 2002-11-13
US20100216870A1 (en) 2010-08-26
CA2399689A1 (en) 2001-08-16
US20080119541A1 (en) 2008-05-22
JP4902925B2 (ja) 2012-03-21

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