CA2399689A1 - Gene cluster encoding a nystatin polyketide synthase and its manipulation and utility - Google Patents

Gene cluster encoding a nystatin polyketide synthase and its manipulation and utility Download PDF

Info

Publication number
CA2399689A1
CA2399689A1 CA002399689A CA2399689A CA2399689A1 CA 2399689 A1 CA2399689 A1 CA 2399689A1 CA 002399689 A CA002399689 A CA 002399689A CA 2399689 A CA2399689 A CA 2399689A CA 2399689 A1 CA2399689 A1 CA 2399689A1
Authority
CA
Canada
Prior art keywords
seq
pks
nystatin
nucleic acid
acid molecule
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002399689A
Other languages
English (en)
French (fr)
Inventor
Trond Erling Ellingsen
Havard Sletta
Ole-Martin Gulliksen
Sergey Borisovich Zotchev
Olga Nikolayivna Sekurova
Espen Fjaervik
Trygve Brautaset
Arne Reidar Stroom
Svein Valla
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sinvent AS
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0002840A external-priority patent/GB0002840D0/en
Priority claimed from GB0008786A external-priority patent/GB0008786D0/en
Priority claimed from GB0009387A external-priority patent/GB0009387D0/en
Application filed by Individual filed Critical Individual
Publication of CA2399689A1 publication Critical patent/CA2399689A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Plant Pathology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CA002399689A 2000-02-08 2001-02-08 Gene cluster encoding a nystatin polyketide synthase and its manipulation and utility Abandoned CA2399689A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB0002840.7 2000-02-08
GB0002840A GB0002840D0 (en) 2000-02-08 2000-02-08 Novel genes and their manipulation and utility
GB0008786.6 2000-04-10
GB0008786A GB0008786D0 (en) 2000-04-10 2000-04-10 Novel genes and their manipulation and utility
GB0009387.2 2000-04-14
GB0009387A GB0009387D0 (en) 2000-04-14 2000-04-14 Novel genes and their manipulation and utility
PCT/GB2001/000509 WO2001059126A2 (en) 2000-02-08 2001-02-08 Gene cluster encoding a nystatin polyketide synthase and its manipulation and utility

Publications (1)

Publication Number Publication Date
CA2399689A1 true CA2399689A1 (en) 2001-08-16

Family

ID=27255517

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002399689A Abandoned CA2399689A1 (en) 2000-02-08 2001-02-08 Gene cluster encoding a nystatin polyketide synthase and its manipulation and utility

Country Status (7)

Country Link
US (3) US7141660B2 (https=)
EP (1) EP1255840A2 (https=)
JP (1) JP4902925B2 (https=)
AU (2) AU784995B2 (https=)
CA (1) CA2399689A1 (https=)
NO (1) NO332112B1 (https=)
WO (1) WO2001059126A2 (https=)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2360011A1 (en) 1999-01-05 2000-07-13 Trustees Of Boston University Ordered gene assembly
FR2907465A1 (fr) * 2006-10-18 2008-04-25 Commissariat Energie Atomique Polynucleotides et polypeptides codes par lesdits polynucleotides impliques dans la voie de biosynthese de la congocidine et ses derives
GB0712881D0 (en) * 2007-07-03 2007-08-15 Biosergen As Compounds
GB0805363D0 (en) 2008-03-20 2008-04-30 Sinvent As Novel NRPS-PKS gene cluster and its manipulation and utility
EP2546345A1 (en) * 2008-06-04 2013-01-16 Eisai R&D Management Co., Ltd. DNA encoding polypeptide involved in biosynthesis of herboxidiene
EP3247378B8 (en) 2015-01-09 2023-08-23 Revolution Medicines, Inc. Macrocyclic compounds that participate in cooperative binding and medical uses thereof
CN109641062A (zh) 2016-04-12 2019-04-16 华普卓威生物公司 用于产生化合物的组合物和方法
GB2553356A (en) * 2016-09-05 2018-03-07 Geomec Eng Ltd Improvements in or relating to geothermal power plants
US11479797B2 (en) * 2016-10-28 2022-10-25 Ginkgo Bioworks, Inc. Compositions and methods for the production of compounds
CN110423790B (zh) * 2019-08-16 2021-04-02 上海交通大学 一种抗真菌四霉素b定向高产的代谢工程方法
TW202132316A (zh) 2019-11-04 2021-09-01 美商銳新醫藥公司 Ｒａｓ抑制劑
AU2020377925A1 (en) 2019-11-04 2022-05-05 Revolution Medicines, Inc. Ras inhibitors
IL322454A (en) 2019-11-04 2025-09-01 Revolution Medicines Inc ras inhibitors
US11049590B1 (en) 2020-02-12 2021-06-29 Peptilogics, Inc. Artificial intelligence engine architecture for generating candidate drugs
CA3194067A1 (en) 2020-09-15 2022-03-24 Revolution Medicines, Inc. Ras inhibitors
US11403316B2 (en) 2020-11-23 2022-08-02 Peptilogics, Inc. Generating enhanced graphical user interfaces for presentation of anti-infective design spaces for selecting drug candidates
KR20240017811A (ko) 2021-05-05 2024-02-08 레볼루션 메디슨즈, 인크. 암의 치료를 위한 ras 억제제
US11512345B1 (en) 2021-05-07 2022-11-29 Peptilogics, Inc. Methods and apparatuses for generating peptides by synthesizing a portion of a design space to identify peptides having non-canonical amino acids
AR127308A1 (es) 2021-10-08 2024-01-10 Revolution Medicines Inc Inhibidores ras
GB202207185D0 (en) 2022-05-17 2022-06-29 Sintef Tto As Novel antibiotic compound

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2654339B1 (fr) 1989-11-14 1994-10-28 Mayoly Spindler Laboratoires Nouveaux derives solubles et non toxiques des macrolides polyeniques basiques, leur preparation et leurs applications.
US5210226A (en) 1990-02-02 1993-05-11 Xechem Inc. Method for separating and purifying polyene macrolide antibiotics
DE59106126D1 (de) * 1990-03-07 1995-09-07 Hoffmann La Roche Verfahren zur herstellung von derivaten der ascorbinsäure.
US5712146A (en) 1993-09-20 1998-01-27 The Leland Stanford Junior University Recombinant combinatorial genetic library for the production of novel polyketides
CA2188257A1 (en) 1994-04-22 1995-11-02 Juan Jose R. Coque Dna encoding cephamycin biosynthesis late enzymes
CA2197524A1 (en) 1996-02-22 1997-08-22 Bradley Stuart Dehoff Polyketide synthase genes
NZ500693A (en) 1997-04-30 2004-01-30 Kosan Biosciences Inc Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold
US5981721A (en) * 1997-10-23 1999-11-09 Karykion Corporation Polyene macrolide schiff bases, their alkyl esters and processes for preparing polyene macrolide alkyl ester salts thereof
WO2000077222A1 (en) 1999-06-14 2000-12-21 Dsm N.V. Genes encoding enzymes in the biosynthesis of pimaricin and the application thereof

Also Published As

Publication number Publication date
AU2006206147A1 (en) 2006-09-28
NO20023741L (no) 2002-10-07
NO332112B1 (no) 2012-06-25
AU3203401A (en) 2001-08-20
WO2001059126A3 (en) 2002-03-14
US7851183B2 (en) 2010-12-14
NO20023741D0 (no) 2002-08-07
WO2001059126A2 (en) 2001-08-16
JP2003528592A (ja) 2003-09-30
US7141660B2 (en) 2006-11-28
AU2006206147B2 (en) 2008-12-18
US20040115762A1 (en) 2004-06-17
AU784995B2 (en) 2006-08-17
US7709231B2 (en) 2010-05-04
EP1255840A2 (en) 2002-11-13
US20100216870A1 (en) 2010-08-26
US20080119541A1 (en) 2008-05-22
JP4902925B2 (ja) 2012-03-21

Similar Documents

Publication Publication Date Title
AU784995B2 (en) Novel genes encoding a nystatin polyketide synthase and their manipulation and utility
US6251636B1 (en) Recombinant oleandolide polyketide synthase
JPH09224686A (ja) プラテノリドシンターゼ遺伝子
US6265202B1 (en) DNA encoding methymycin and pikromycin
KR102776146B1 (ko) 켈리마이신 생합성 유전자 클러스터
US20030175888A1 (en) Discrete acyltransferases associated with type I polyketide synthases and methods of use
KR100882692B1 (ko) 부테닐-스피노신 살충제 생산을 위한 생합성 유전자
CN107540682A (zh) 曲张链丝菌素衍生物及其制备方法和应用
US20040219645A1 (en) Polyketides and their synthesis
US20030171562A1 (en) Genes and proteins for the biosynthesis of polyketides
US20030064491A1 (en) Genes and proteins involved in the biosynthesis of enediyne ring structures
US20040091975A1 (en) Midecamycin biosynthetic genes
US20030113874A1 (en) Genes and proteins for the biosynthesis of rosaramicin
KR100549690B1 (ko) 에프알-008 폴리케타이드 합성에 관여하는 유전자
CN114517175A (zh) 基因工程菌及其应用
US20030157654A1 (en) Biosynthesis of enediyne compounds by manipulation of C-1027 gene pathway
KR20100089370A (ko) 슈도노카디아 오토트로피카의 신규한 폴리엔 생합성 유전자
US20030073824A1 (en) DNA encoding methymycin and pikromycin
CN107541523B (zh) 曲张链丝菌素生物合成基因簇及其应用
US20040132055A1 (en) Recombinant chalcomycin polyketide synthase and modifying genes
CN101027395A (zh) 用于制备复合聚酮化合物的生物合成基因簇
KR20080032641A (ko) 티오코랄린의 생합성에 수반되는 유전자 및 그의 이종적생산
WO2004018703A2 (en) Recombinant chalcomycin polyketide synthase and modifying genes
CN101302528A (zh) 参与螺旋霉素生物合成的多肽、编码这些多肽的核苷酸序列及其应用
HK1114125A (en) Genes encoding the synthetic pathway for the production of disorazole

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued

Effective date: 20131218