JP4902925B2 - ナイスタチンポリケチドシンターゼをコードする新規の遺伝子、およびそれらの取扱ならびに用途 - Google Patents

ナイスタチンポリケチドシンターゼをコードする新規の遺伝子、およびそれらの取扱ならびに用途 Download PDF

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Publication number
JP4902925B2
JP4902925B2 JP2001558462A JP2001558462A JP4902925B2 JP 4902925 B2 JP4902925 B2 JP 4902925B2 JP 2001558462 A JP2001558462 A JP 2001558462A JP 2001558462 A JP2001558462 A JP 2001558462A JP 4902925 B2 JP4902925 B2 JP 4902925B2
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Prior art keywords
nystatin
seq
pks
nucleic acid
acid molecule
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JP2001558462A
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Japanese (ja)
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JP2003528592A (ja
JP2003528592A5 (https=
Inventor
ボリソビッチ ゾチェフ，セルゲイ
ニコライブナ セクロヴァ，オルガ
フヤルヴィク，エスペン
ブラウタセット，トライヴェ
ストレム，アーネ，ライダー
ヴァラ，スヴァイン
エリングセン，トロンド，アーリング
スレッタ，ホヴァルド
グリクセン，オレ−マーティン
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Sinvent AS
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Sinvent AS
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Priority claimed from GB0002840A external-priority patent/GB0002840D0/en
Priority claimed from GB0008786A external-priority patent/GB0008786D0/en
Priority claimed from GB0009387A external-priority patent/GB0009387D0/en
Application filed by Sinvent AS filed Critical Sinvent AS
Publication of JP2003528592A publication Critical patent/JP2003528592A/ja
Publication of JP2003528592A5 publication Critical patent/JP2003528592A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Plant Pathology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP2001558462A 2000-02-08 2001-02-08 ナイスタチンポリケチドシンターゼをコードする新規の遺伝子、およびそれらの取扱ならびに用途 Expired - Fee Related JP4902925B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB0002840.7 2000-02-08
GB0002840A GB0002840D0 (en) 2000-02-08 2000-02-08 Novel genes and their manipulation and utility
GB0008786.6 2000-04-10
GB0008786A GB0008786D0 (en) 2000-04-10 2000-04-10 Novel genes and their manipulation and utility
GB0009387.2 2000-04-14
GB0009387A GB0009387D0 (en) 2000-04-14 2000-04-14 Novel genes and their manipulation and utility
PCT/GB2001/000509 WO2001059126A2 (en) 2000-02-08 2001-02-08 Gene cluster encoding a nystatin polyketide synthase and its manipulation and utility

Publications (3)

Publication Number Publication Date
JP2003528592A JP2003528592A (ja) 2003-09-30
JP2003528592A5 JP2003528592A5 (https=) 2008-05-08
JP4902925B2 true JP4902925B2 (ja) 2012-03-21

Family

ID=27255517

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001558462A Expired - Fee Related JP4902925B2 (ja) 2000-02-08 2001-02-08 ナイスタチンポリケチドシンターゼをコードする新規の遺伝子、およびそれらの取扱ならびに用途

Country Status (7)

Country Link
US (3) US7141660B2 (https=)
EP (1) EP1255840A2 (https=)
JP (1) JP4902925B2 (https=)
AU (2) AU784995B2 (https=)
CA (1) CA2399689A1 (https=)
NO (1) NO332112B1 (https=)
WO (1) WO2001059126A2 (https=)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2360011A1 (en) 1999-01-05 2000-07-13 Trustees Of Boston University Ordered gene assembly
FR2907465A1 (fr) * 2006-10-18 2008-04-25 Commissariat Energie Atomique Polynucleotides et polypeptides codes par lesdits polynucleotides impliques dans la voie de biosynthese de la congocidine et ses derives
GB0712881D0 (en) * 2007-07-03 2007-08-15 Biosergen As Compounds
GB0805363D0 (en) 2008-03-20 2008-04-30 Sinvent As Novel NRPS-PKS gene cluster and its manipulation and utility
EP2546345A1 (en) * 2008-06-04 2013-01-16 Eisai R&D Management Co., Ltd. DNA encoding polypeptide involved in biosynthesis of herboxidiene
EP3247378B8 (en) 2015-01-09 2023-08-23 Revolution Medicines, Inc. Macrocyclic compounds that participate in cooperative binding and medical uses thereof
CN109641062A (zh) 2016-04-12 2019-04-16 华普卓威生物公司 用于产生化合物的组合物和方法
GB2553356A (en) * 2016-09-05 2018-03-07 Geomec Eng Ltd Improvements in or relating to geothermal power plants
US11479797B2 (en) * 2016-10-28 2022-10-25 Ginkgo Bioworks, Inc. Compositions and methods for the production of compounds
CN110423790B (zh) * 2019-08-16 2021-04-02 上海交通大学 一种抗真菌四霉素b定向高产的代谢工程方法
TW202132316A (zh) 2019-11-04 2021-09-01 美商銳新醫藥公司 Ｒａｓ抑制劑
AU2020377925A1 (en) 2019-11-04 2022-05-05 Revolution Medicines, Inc. Ras inhibitors
IL322454A (en) 2019-11-04 2025-09-01 Revolution Medicines Inc ras inhibitors
US11049590B1 (en) 2020-02-12 2021-06-29 Peptilogics, Inc. Artificial intelligence engine architecture for generating candidate drugs
CA3194067A1 (en) 2020-09-15 2022-03-24 Revolution Medicines, Inc. Ras inhibitors
US11403316B2 (en) 2020-11-23 2022-08-02 Peptilogics, Inc. Generating enhanced graphical user interfaces for presentation of anti-infective design spaces for selecting drug candidates
KR20240017811A (ko) 2021-05-05 2024-02-08 레볼루션 메디슨즈, 인크. 암의 치료를 위한 ras 억제제
US11512345B1 (en) 2021-05-07 2022-11-29 Peptilogics, Inc. Methods and apparatuses for generating peptides by synthesizing a portion of a design space to identify peptides having non-canonical amino acids
AR127308A1 (es) 2021-10-08 2024-01-10 Revolution Medicines Inc Inhibidores ras
GB202207185D0 (en) 2022-05-17 2022-06-29 Sintef Tto As Novel antibiotic compound

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2654339B1 (fr) 1989-11-14 1994-10-28 Mayoly Spindler Laboratoires Nouveaux derives solubles et non toxiques des macrolides polyeniques basiques, leur preparation et leurs applications.
US5210226A (en) 1990-02-02 1993-05-11 Xechem Inc. Method for separating and purifying polyene macrolide antibiotics
DE59106126D1 (de) * 1990-03-07 1995-09-07 Hoffmann La Roche Verfahren zur herstellung von derivaten der ascorbinsäure.
US5712146A (en) 1993-09-20 1998-01-27 The Leland Stanford Junior University Recombinant combinatorial genetic library for the production of novel polyketides
CA2188257A1 (en) 1994-04-22 1995-11-02 Juan Jose R. Coque Dna encoding cephamycin biosynthesis late enzymes
CA2197524A1 (en) 1996-02-22 1997-08-22 Bradley Stuart Dehoff Polyketide synthase genes
NZ500693A (en) 1997-04-30 2004-01-30 Kosan Biosciences Inc Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold
US5981721A (en) * 1997-10-23 1999-11-09 Karykion Corporation Polyene macrolide schiff bases, their alkyl esters and processes for preparing polyene macrolide alkyl ester salts thereof
WO2000077222A1 (en) 1999-06-14 2000-12-21 Dsm N.V. Genes encoding enzymes in the biosynthesis of pimaricin and the application thereof

Also Published As

Publication number Publication date
AU2006206147A1 (en) 2006-09-28
NO20023741L (no) 2002-10-07
NO332112B1 (no) 2012-06-25
AU3203401A (en) 2001-08-20
WO2001059126A3 (en) 2002-03-14
US7851183B2 (en) 2010-12-14
NO20023741D0 (no) 2002-08-07
WO2001059126A2 (en) 2001-08-16
JP2003528592A (ja) 2003-09-30
US7141660B2 (en) 2006-11-28
AU2006206147B2 (en) 2008-12-18
US20040115762A1 (en) 2004-06-17
AU784995B2 (en) 2006-08-17
US7709231B2 (en) 2010-05-04
EP1255840A2 (en) 2002-11-13
US20100216870A1 (en) 2010-08-26
CA2399689A1 (en) 2001-08-16
US20080119541A1 (en) 2008-05-22

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