NO20023741L - Genklynge som koder for en nystatin-polyketidsyntase og dens manipulering og anvendelse - Google Patents

Genklynge som koder for en nystatin-polyketidsyntase og dens manipulering og anvendelse

Info

Publication number
NO20023741L
NO20023741L NO20023741A NO20023741A NO20023741L NO 20023741 L NO20023741 L NO 20023741L NO 20023741 A NO20023741 A NO 20023741A NO 20023741 A NO20023741 A NO 20023741A NO 20023741 L NO20023741 L NO 20023741L
Authority
NO
Norway
Prior art keywords
seq
nucleotide sequence
sequence
nystatin
manipulation
Prior art date
Application number
NO20023741A
Other languages
English (en)
Other versions
NO332112B1 (no
NO20023741D0 (no
Inventor
Sergey Borisovich Zotchev
Olga Nikolayivna Sekurova
Espen Fjaervik
Trygve Brautaset
Arne Reidar Stroem
Svein Valla
Trond E Ellingsen
Haavard Sletta
Ole-Martin Gullicksen
Original Assignee
Sinvent As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0002840A external-priority patent/GB0002840D0/en
Priority claimed from GB0008786A external-priority patent/GB0008786D0/en
Priority claimed from GB0009387A external-priority patent/GB0009387D0/en
Application filed by Sinvent As filed Critical Sinvent As
Publication of NO20023741D0 publication Critical patent/NO20023741D0/no
Publication of NO20023741L publication Critical patent/NO20023741L/no
Publication of NO332112B1 publication Critical patent/NO332112B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Veterinary Medicine (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Oppfinnelsen tilveiebringer et nukleinsyremolekyl omfattende:. (a) en nukleotidsekvens som vist i SEKV ID nr.35; eller. (b) en nukleotidsekvens som er komplementet til SEKV ID nr. 35; eller (c) en nukleotidsekvens som er degenerert med SEKV ID nr. 35; eller (d) en nukleotidsekvens som under betingelser med høy stringens hybridiserer til SEKV ID nr. 35, til komplementet til SEKV ID nr. 35 eller til en hybridiserings-probe som stammer fra SEKV ID nr. 35 eller komplementet til denne; eller (e) en nukleotidsekvens som har minst 80% sekvensidentitet med SEKV ID nr. 35; eller (f) en nukleotidsekvens som har minst 65% sekvensidentitet med SEKV ID nr. 35, hvornevnte sekvens fortrinnsvis koder for, eller er komplementær til en sekvens som koder for, et nystatin-PKS-enzym eller en del derav.Det er også tilveiebrakt en del av slike molekyler og polypeptider (og deler derav) kodet for av et slikt nukleinsyremolekyl, samt anvendelse av slike molekyler og polypeptider til å gjøre nystatin-biosyntesen lettere og til syntetisering av nystatin-derivater, samt nytt polyketid som makrolidstrukturer.
NO20023741A 2000-02-08 2002-08-07 Isolert, syntetisk eller rekombinant nukleinsyremolekyl og polypeptid, ekspresjonsvektor, fremgangsmate for a produsere nystatin eller et nystatinderivat, anvendelse av et nukleinsyremolekyl, fremgangsmate for fremstilling av et modifisert PKS-system og nystatin, modifisert PKS-system, vertscelle, nystatinderivat samt antibiotikum. NO332112B1 (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0002840A GB0002840D0 (en) 2000-02-08 2000-02-08 Novel genes and their manipulation and utility
GB0008786A GB0008786D0 (en) 2000-04-10 2000-04-10 Novel genes and their manipulation and utility
GB0009387A GB0009387D0 (en) 2000-04-14 2000-04-14 Novel genes and their manipulation and utility
PCT/GB2001/000509 WO2001059126A2 (en) 2000-02-08 2001-02-08 Gene cluster encoding a nystatin polyketide synthase and its manipulation and utility

Publications (3)

Publication Number Publication Date
NO20023741D0 NO20023741D0 (no) 2002-08-07
NO20023741L true NO20023741L (no) 2002-10-07
NO332112B1 NO332112B1 (no) 2012-06-25

Family

ID=27255517

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20023741A NO332112B1 (no) 2000-02-08 2002-08-07 Isolert, syntetisk eller rekombinant nukleinsyremolekyl og polypeptid, ekspresjonsvektor, fremgangsmate for a produsere nystatin eller et nystatinderivat, anvendelse av et nukleinsyremolekyl, fremgangsmate for fremstilling av et modifisert PKS-system og nystatin, modifisert PKS-system, vertscelle, nystatinderivat samt antibiotikum.

Country Status (7)

Country Link
US (3) US7141660B2 (no)
EP (1) EP1255840A2 (no)
JP (1) JP4902925B2 (no)
AU (2) AU784995B2 (no)
CA (1) CA2399689A1 (no)
NO (1) NO332112B1 (no)
WO (1) WO2001059126A2 (no)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2907465A1 (fr) * 2006-10-18 2008-04-25 Commissariat Energie Atomique Polynucleotides et polypeptides codes par lesdits polynucleotides impliques dans la voie de biosynthese de la congocidine et ses derives
GB0712881D0 (en) 2007-07-03 2007-08-15 Biosergen As Compounds
GB0805363D0 (en) 2008-03-20 2008-04-30 Sinvent As Novel NRPS-PKS gene cluster and its manipulation and utility
WO2009147984A1 (ja) * 2008-06-04 2009-12-10 エーザイ・アール・アンド・ディー・マネジメント株式会社 ハーボキシジエンの生合成に関与するポリペプチドをコードするｄｎａ
EP3247378B8 (en) 2015-01-09 2023-08-23 Revolution Medicines, Inc. Macrocyclic compounds that participate in cooperative binding and medical uses thereof
ES2921056T3 (es) 2016-04-12 2022-08-17 Warp Drive Bio Inc Composiciones y métodos para la producción de compuestos
GB2553356A (en) * 2016-09-05 2018-03-07 Geomec Eng Ltd Improvements in or relating to geothermal power plants
CA3042231A1 (en) * 2016-10-28 2018-05-03 Ginkgo Bioworks, Inc. Compositions and methods for the production of compounds
CN110423790B (zh) * 2019-08-16 2021-04-02 上海交通大学 一种抗真菌四霉素b定向高产的代谢工程方法
EP4055028A1 (en) 2019-11-04 2022-09-14 Revolution Medicines, Inc. Ras inhibitors
MX2022005359A (es) 2019-11-04 2022-06-02 Revolution Medicines Inc Inhibidores de ras.
AU2020379731A1 (en) 2019-11-04 2022-05-05 Revolution Medicines, Inc. Ras inhibitors
KR20230067635A (ko) 2020-09-15 2023-05-16 레볼루션 메디슨즈, 인크. 암의 치료에서 ras 억제제로서 인돌 유도체
US20220165359A1 (en) 2020-11-23 2022-05-26 Peptilogics, Inc. Generating anti-infective design spaces for selecting drug candidates
GB202207185D0 (en) 2022-05-17 2022-06-29 Sintef Tto As Novel antibiotic compound

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2654339B1 (fr) * 1989-11-14 1994-10-28 Mayoly Spindler Laboratoires Nouveaux derives solubles et non toxiques des macrolides polyeniques basiques, leur preparation et leurs applications.
US5210226A (en) * 1990-02-02 1993-05-11 Xechem Inc. Method for separating and purifying polyene macrolide antibiotics
EP0471805B1 (de) * 1990-03-07 1995-08-02 F. Hoffmann-La Roche Ag Verfahren zur herstellung von derivaten der ascorbinsäure
US5712146A (en) 1993-09-20 1998-01-27 The Leland Stanford Junior University Recombinant combinatorial genetic library for the production of novel polyketides
WO1995029253A1 (en) 1994-04-22 1995-11-02 Merck & Co., Inc. Dna encoding cephamycin biosynthesis late enzymes
CA2197524A1 (en) 1996-02-22 1997-08-22 Bradley Stuart Dehoff Polyketide synthase genes
JP2001524829A (ja) 1997-04-30 2001-12-04 コーサン バイオサイエンシーズ，インコーポレイテッド 足場としてモジュラー性ｐｋｓ遺伝子クラスターを使用して生成されるコンビナトリアルなポリケチドライブラリー
US5981721A (en) * 1997-10-23 1999-11-09 Karykion Corporation Polyene macrolide schiff bases, their alkyl esters and processes for preparing polyene macrolide alkyl ester salts thereof
EP1185668A1 (en) 1999-06-14 2002-03-13 Dsm N.V. Genes encoding enzymes in the biosynthesis of pimaricin and the application thereof

Also Published As

Publication number Publication date
US20080119541A1 (en) 2008-05-22
AU784995B2 (en) 2006-08-17
NO332112B1 (no) 2012-06-25
AU2006206147A1 (en) 2006-09-28
EP1255840A2 (en) 2002-11-13
NO20023741D0 (no) 2002-08-07
JP4902925B2 (ja) 2012-03-21
US7141660B2 (en) 2006-11-28
US20100216870A1 (en) 2010-08-26
AU2006206147B2 (en) 2008-12-18
US7851183B2 (en) 2010-12-14
CA2399689A1 (en) 2001-08-16
JP2003528592A (ja) 2003-09-30
WO2001059126A2 (en) 2001-08-16
WO2001059126A3 (en) 2002-03-14
US7709231B2 (en) 2010-05-04
US20040115762A1 (en) 2004-06-17
AU3203401A (en) 2001-08-20

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