NO330183B1 - Cyanoguanidinprodroger - Google Patents
Cyanoguanidinprodroger Download PDFInfo
- Publication number
- NO330183B1 NO330183B1 NO20045374A NO20045374A NO330183B1 NO 330183 B1 NO330183 B1 NO 330183B1 NO 20045374 A NO20045374 A NO 20045374A NO 20045374 A NO20045374 A NO 20045374A NO 330183 B1 NO330183 B1 NO 330183B1
- Authority
- NO
- Norway
- Prior art keywords
- tert
- piperidyl
- butoxycarbonyl
- hexyl
- cyano
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 claims description 99
- 239000000203 mixture Substances 0.000 claims description 37
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- 125000000217 alkyl group Chemical group 0.000 claims description 8
- UUAGVPDTFQKJSV-UHFFFAOYSA-N tert-butyl 4-[2-(chloromethoxycarbonyloxy)ethyl]piperidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCC(CCOC(=O)OCCl)CC1 UUAGVPDTFQKJSV-UHFFFAOYSA-N 0.000 claims description 8
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
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- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Biomedical Technology (AREA)
- Endocrinology (AREA)
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- Oncology (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Neurology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Adhesives Or Adhesive Processes (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38083602P | 2002-05-17 | 2002-05-17 | |
| PCT/DK2003/000318 WO2003097601A1 (en) | 2002-05-17 | 2003-05-15 | Cyanoguanidine prodrugs |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20045374L NO20045374L (no) | 2004-12-08 |
| NO330183B1 true NO330183B1 (no) | 2011-02-28 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20045374A NO330183B1 (no) | 2002-05-17 | 2004-12-08 | Cyanoguanidinprodroger |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US20070249676A1 (de) |
| EP (1) | EP1507760B1 (de) |
| JP (1) | JP4625694B2 (de) |
| KR (1) | KR101010871B1 (de) |
| CN (1) | CN100503570C (de) |
| AT (1) | ATE368649T1 (de) |
| AU (1) | AU2003229534B2 (de) |
| BR (1) | BR0309996A (de) |
| CA (1) | CA2485351C (de) |
| DE (1) | DE60315288T2 (de) |
| ES (1) | ES2290454T3 (de) |
| HK (1) | HK1076812A1 (de) |
| IL (1) | IL165086A (de) |
| IS (1) | IS7562A (de) |
| MX (1) | MXPA04011322A (de) |
| NO (1) | NO330183B1 (de) |
| PL (1) | PL228742B1 (de) |
| RU (1) | RU2326867C2 (de) |
| WO (1) | WO2003097601A1 (de) |
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| US7253193B2 (en) | 2002-05-17 | 2007-08-07 | Leo Pharma A/S | Cyanoguanidine prodrugs |
| CA2594508C (en) | 2004-12-22 | 2013-10-01 | Leo Pharma A/S | Cyanoguanidine compounds |
| US9296697B2 (en) | 2005-08-24 | 2016-03-29 | Abbott Laboratories | Hetaryl-substituted guanidine compounds and use thereof as binding partners for 5-HT5-receptors |
| CA2701071C (en) * | 2007-09-26 | 2018-03-27 | Gemin X Pharmaceuticals Canada Inc. | Compositions and methods for effecting nad+ levels using a nicotinamide phosphoribosyl transferase inhibitor |
| JP5688367B2 (ja) | 2008-08-29 | 2015-03-25 | トポターゲット・アクティーゼルスカブＴｏｐｏＴａｒｇｅｔ Ａ／Ｓ | 新規なウレアおよびチオウレア誘導体 |
| JP5580339B2 (ja) | 2009-02-06 | 2014-08-27 | ティエンジン ホーメイ バイオ−テック カンパニー， リミテッド | ピリジルシアノグアニジンを含む薬物組成物、該組成物の製造方法及び応用 |
| WO2011006988A1 (en) | 2009-07-17 | 2011-01-20 | Topotarget A/S | Method for predicting the utility of administering nicotinic acid or a precursor or prodrug thereof to reduce the severity of side-effects of cancer treatment with nicotinamide phosphoribosyltransferase inhibitors |
| US8912184B1 (en) | 2010-03-01 | 2014-12-16 | Alzheimer's Institute Of America, Inc. | Therapeutic and diagnostic methods |
| WO2011121055A1 (en) | 2010-03-31 | 2011-10-06 | Topotarget A/S | Pyridinyl derivatives comprising a cyanoguanidine or squaric acid moiety |
| WO2012137225A1 (en) * | 2011-04-08 | 2012-10-11 | Sphaera Pharma Pvt. Ltd | Substituted methylformyl reagents and method of using same to modify physicochemical and/or pharmacokinetic properties of compounds |
| MX2015000101A (es) * | 2012-06-27 | 2015-06-22 | Alzheimer S Inst Of America Inc | Compuestos y usos terapéuticos de los mismos. |
| CN116640238B (zh) * | 2023-05-30 | 2024-05-03 | 华侨大学 | 一种胍基吡啶壳聚糖鎓盐及其制备方法和应用 |
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| US5919816A (en) * | 1994-11-14 | 1999-07-06 | Bionumerik Pharmaceuticals, Inc. | Formulations and methods of reducing toxicity of antineoplastic agents |
| GB9711125D0 (en) * | 1997-05-29 | 1997-07-23 | Leo Pharm Prod Ltd | Novel cyanoguanidines |
| AU4076500A (en) * | 1999-04-09 | 2000-11-14 | Shionogi Bioresearch Corp. | (n)-substituted cyanoguanidine compounds |
| AU1494702A (en) * | 2000-11-21 | 2002-06-03 | Leo Pharma As | Cyanoguanidine prodrugs |
| US20030045515A1 (en) * | 2001-05-24 | 2003-03-06 | Lise Binderup | Combination medicament for treatment of neoplastic diseases |
| MXPA04011324A (es) * | 2002-05-17 | 2005-02-17 | Leo Pharma As | Profarmacos de cianoguanidina. |
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2003
- 2003-05-15 CN CNB038140772A patent/CN100503570C/zh not_active Expired - Fee Related
- 2003-05-15 RU RU2004136991/04A patent/RU2326867C2/ru active
- 2003-05-15 ES ES03722311T patent/ES2290454T3/es not_active Expired - Lifetime
- 2003-05-15 AT AT03722311T patent/ATE368649T1/de not_active IP Right Cessation
- 2003-05-15 WO PCT/DK2003/000318 patent/WO2003097601A1/en active IP Right Grant
- 2003-05-15 MX MXPA04011322A patent/MXPA04011322A/es active IP Right Grant
- 2003-05-15 CA CA2485351A patent/CA2485351C/en not_active Expired - Lifetime
- 2003-05-15 KR KR1020047018603A patent/KR101010871B1/ko active IP Right Grant
- 2003-05-15 PL PL372769A patent/PL228742B1/pl unknown
- 2003-05-15 JP JP2004505334A patent/JP4625694B2/ja not_active Expired - Fee Related
- 2003-05-15 AU AU2003229534A patent/AU2003229534B2/en not_active Ceased
- 2003-05-15 BR BR0309996-2A patent/BR0309996A/pt not_active Application Discontinuation
- 2003-05-15 DE DE60315288T patent/DE60315288T2/de not_active Expired - Lifetime
- 2003-05-15 EP EP03722311A patent/EP1507760B1/de not_active Expired - Lifetime
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2004
- 2004-11-08 IL IL165086A patent/IL165086A/en active IP Right Grant
- 2004-11-29 IS IS7562A patent/IS7562A/is unknown
- 2004-12-08 NO NO20045374A patent/NO330183B1/no not_active IP Right Cessation
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2005
- 2005-10-10 HK HK05108938.3A patent/HK1076812A1/xx not_active IP Right Cessation
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2007
- 2007-06-28 US US11/823,571 patent/US20070249676A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2005538949A (ja) | 2005-12-22 |
| JP4625694B2 (ja) | 2011-02-02 |
| ATE368649T1 (de) | 2007-08-15 |
| AU2003229534B2 (en) | 2009-08-27 |
| IL165086A0 (en) | 2005-12-18 |
| CA2485351C (en) | 2011-12-06 |
| HK1076812A1 (en) | 2006-01-27 |
| PL228742B1 (pl) | 2018-05-30 |
| EP1507760A1 (de) | 2005-02-23 |
| DE60315288D1 (de) | 2007-09-13 |
| KR20050016412A (ko) | 2005-02-21 |
| RU2326867C2 (ru) | 2008-06-20 |
| EP1507760B1 (de) | 2007-08-01 |
| WO2003097601A1 (en) | 2003-11-27 |
| US20070249676A1 (en) | 2007-10-25 |
| CN1662501A (zh) | 2005-08-31 |
| DE60315288T2 (de) | 2008-04-10 |
| RU2004136991A (ru) | 2005-06-10 |
| BR0309996A (pt) | 2005-02-22 |
| IS7562A (is) | 2004-11-29 |
| IL165086A (en) | 2011-11-30 |
| NO20045374L (no) | 2004-12-08 |
| AU2003229534A1 (en) | 2003-12-02 |
| CN100503570C (zh) | 2009-06-24 |
| ES2290454T3 (es) | 2008-02-16 |
| KR101010871B1 (ko) | 2011-01-26 |
| PL372769A1 (en) | 2005-08-08 |
| CA2485351A1 (en) | 2003-11-27 |
| MXPA04011322A (es) | 2005-02-17 |
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