NO20045374L - Cyanoguanidinprodroger - Google Patents
CyanoguanidinprodrogerInfo
- Publication number
- NO20045374L NO20045374L NO20045374A NO20045374A NO20045374L NO 20045374 L NO20045374 L NO 20045374L NO 20045374 A NO20045374 A NO 20045374A NO 20045374 A NO20045374 A NO 20045374A NO 20045374 L NO20045374 L NO 20045374L
- Authority
- NO
- Norway
- Prior art keywords
- sub
- cyanoguanidinprodroger
- prodrugs
- cancers
- human
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4425—Pyridinium derivatives, e.g. pralidoxime, pyridostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Adhesives Or Adhesive Processes (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38083602P | 2002-05-17 | 2002-05-17 | |
| PCT/DK2003/000318 WO2003097601A1 (en) | 2002-05-17 | 2003-05-15 | Cyanoguanidine prodrugs |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20045374L true NO20045374L (no) | 2004-12-08 |
| NO330183B1 NO330183B1 (no) | 2011-02-28 |
Family
ID=29550021
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20045374A NO330183B1 (no) | 2002-05-17 | 2004-12-08 | Cyanoguanidinprodroger |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US20070249676A1 (no) |
| EP (1) | EP1507760B1 (no) |
| JP (1) | JP4625694B2 (no) |
| KR (1) | KR101010871B1 (no) |
| CN (1) | CN100503570C (no) |
| AT (1) | ATE368649T1 (no) |
| AU (1) | AU2003229534B2 (no) |
| BR (1) | BR0309996A (no) |
| CA (1) | CA2485351C (no) |
| DE (1) | DE60315288T2 (no) |
| ES (1) | ES2290454T3 (no) |
| HK (1) | HK1076812A1 (no) |
| IL (1) | IL165086A (no) |
| IS (1) | IS7562A (no) |
| MX (1) | MXPA04011322A (no) |
| NO (1) | NO330183B1 (no) |
| PL (1) | PL228742B1 (no) |
| RU (1) | RU2326867C2 (no) |
| WO (1) | WO2003097601A1 (no) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7253193B2 (en) | 2002-05-17 | 2007-08-07 | Leo Pharma A/S | Cyanoguanidine prodrugs |
| CA2594508C (en) | 2004-12-22 | 2013-10-01 | Leo Pharma A/S | Cyanoguanidine compounds |
| EP1917244A2 (de) | 2005-08-24 | 2008-05-07 | Abbott GmbH & Co. KG | Hetaryl substituierte guanidinverbindungen und ihre verwendung als bindungspartner für 5-ht5-rezeptoren |
| EP2197443A4 (en) * | 2007-09-26 | 2014-01-01 | Gemin X Pharmaceuticals Canada Inc | COMPOSITIONS AND METHODS FOR INFLUENCING NAD + CONTENT USING A NICOTINAMIDE PHOSPHORIBOSYL TRANSFERASE INHIBITOR |
| RU2011111728A (ru) | 2008-08-29 | 2012-10-10 | Топотаргет А/С (Dk) | Новые производные мочевины и тиомочевины |
| CA2751495C (en) | 2009-02-06 | 2013-08-20 | Tianjin Hemay Bio-Tech Co., Ltd. | Pharmaceutical compositions comprising a pyridyl cyanoguanidine and cyclodextrin and/or derivatives thereof |
| EP2453883A1 (en) | 2009-07-17 | 2012-05-23 | Topo Target A/S | Method for predicting the utility of administering nicotinic acid or a precursor or prodrug thereof to reduce the severity of side-effects of cancer treatment with nicotinamide phosphoribosyltransferase inhibitors |
| US8912184B1 (en) | 2010-03-01 | 2014-12-16 | Alzheimer's Institute Of America, Inc. | Therapeutic and diagnostic methods |
| WO2011121055A1 (en) | 2010-03-31 | 2011-10-06 | Topotarget A/S | Pyridinyl derivatives comprising a cyanoguanidine or squaric acid moiety |
| WO2012137225A1 (en) * | 2011-04-08 | 2012-10-11 | Sphaera Pharma Pvt. Ltd | Substituted methylformyl reagents and method of using same to modify physicochemical and/or pharmacokinetic properties of compounds |
| AU2013284487A1 (en) * | 2012-06-27 | 2015-02-19 | Sunflower Research Llc | Compounds and therapeutic uses thereof |
| CN116640238B (zh) * | 2023-05-30 | 2024-05-03 | 华侨大学 | 一种胍基吡啶壳聚糖鎓盐及其制备方法和应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5919816A (en) * | 1994-11-14 | 1999-07-06 | Bionumerik Pharmaceuticals, Inc. | Formulations and methods of reducing toxicity of antineoplastic agents |
| GB9711125D0 (en) * | 1997-05-29 | 1997-07-23 | Leo Pharm Prod Ltd | Novel cyanoguanidines |
| WO2000061559A1 (en) * | 1999-04-09 | 2000-10-19 | Shionogi Bioresearch Corp. | N-substituted cyanoguanidine compounds |
| AU1494702A (en) * | 2000-11-21 | 2002-06-03 | Leo Pharma As | Cyanoguanidine prodrugs |
| US20030045515A1 (en) * | 2001-05-24 | 2003-03-06 | Lise Binderup | Combination medicament for treatment of neoplastic diseases |
| PL372761A1 (en) * | 2002-05-17 | 2005-08-08 | Leo Pharma A/S | Cyanoguanidine prodrugs |
-
2003
- 2003-05-15 ES ES03722311T patent/ES2290454T3/es not_active Expired - Lifetime
- 2003-05-15 DE DE60315288T patent/DE60315288T2/de not_active Expired - Lifetime
- 2003-05-15 CN CNB038140772A patent/CN100503570C/zh not_active Expired - Fee Related
- 2003-05-15 MX MXPA04011322A patent/MXPA04011322A/es active IP Right Grant
- 2003-05-15 RU RU2004136991/04A patent/RU2326867C2/ru active
- 2003-05-15 EP EP03722311A patent/EP1507760B1/en not_active Expired - Lifetime
- 2003-05-15 JP JP2004505334A patent/JP4625694B2/ja not_active Expired - Fee Related
- 2003-05-15 KR KR1020047018603A patent/KR101010871B1/ko active IP Right Grant
- 2003-05-15 BR BR0309996-2A patent/BR0309996A/pt not_active Application Discontinuation
- 2003-05-15 AU AU2003229534A patent/AU2003229534B2/en not_active Ceased
- 2003-05-15 CA CA2485351A patent/CA2485351C/en not_active Expired - Lifetime
- 2003-05-15 PL PL372769A patent/PL228742B1/pl unknown
- 2003-05-15 AT AT03722311T patent/ATE368649T1/de not_active IP Right Cessation
- 2003-05-15 WO PCT/DK2003/000318 patent/WO2003097601A1/en active IP Right Grant
-
2004
- 2004-11-08 IL IL165086A patent/IL165086A/en active IP Right Grant
- 2004-11-29 IS IS7562A patent/IS7562A/is unknown
- 2004-12-08 NO NO20045374A patent/NO330183B1/no not_active IP Right Cessation
-
2005
- 2005-10-10 HK HK05108938.3A patent/HK1076812A1/xx not_active IP Right Cessation
-
2007
- 2007-06-28 US US11/823,571 patent/US20070249676A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20070249676A1 (en) | 2007-10-25 |
| CN100503570C (zh) | 2009-06-24 |
| JP4625694B2 (ja) | 2011-02-02 |
| RU2326867C2 (ru) | 2008-06-20 |
| HK1076812A1 (en) | 2006-01-27 |
| JP2005538949A (ja) | 2005-12-22 |
| DE60315288D1 (de) | 2007-09-13 |
| ES2290454T3 (es) | 2008-02-16 |
| KR20050016412A (ko) | 2005-02-21 |
| BR0309996A (pt) | 2005-02-22 |
| NO330183B1 (no) | 2011-02-28 |
| CN1662501A (zh) | 2005-08-31 |
| CA2485351A1 (en) | 2003-11-27 |
| IL165086A (en) | 2011-11-30 |
| IL165086A0 (en) | 2005-12-18 |
| IS7562A (is) | 2004-11-29 |
| PL372769A1 (en) | 2005-08-08 |
| AU2003229534B2 (en) | 2009-08-27 |
| DE60315288T2 (de) | 2008-04-10 |
| KR101010871B1 (ko) | 2011-01-26 |
| AU2003229534A1 (en) | 2003-12-02 |
| EP1507760A1 (en) | 2005-02-23 |
| PL228742B1 (pl) | 2018-05-30 |
| ATE368649T1 (de) | 2007-08-15 |
| EP1507760B1 (en) | 2007-08-01 |
| CA2485351C (en) | 2011-12-06 |
| WO2003097601A1 (en) | 2003-11-27 |
| RU2004136991A (ru) | 2005-06-10 |
| MXPA04011322A (es) | 2005-02-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |