NO328830B1 - Forbedret fluorescens-maler I - Google Patents
Forbedret fluorescens-maler I Download PDFInfo
- Publication number
- NO328830B1 NO328830B1 NO19995282A NO995282A NO328830B1 NO 328830 B1 NO328830 B1 NO 328830B1 NO 19995282 A NO19995282 A NO 19995282A NO 995282 A NO995282 A NO 995282A NO 328830 B1 NO328830 B1 NO 328830B1
- Authority
- NO
- Norway
- Prior art keywords
- fluorescence
- light
- sensing device
- hole
- analyte
- Prior art date
Links
- 239000011159 matrix material Substances 0.000 claims abstract description 40
- 239000012491 analyte Substances 0.000 claims abstract description 29
- 239000007788 liquid Substances 0.000 claims abstract description 12
- 230000002238 attenuated effect Effects 0.000 claims abstract description 5
- 239000000758 substrate Substances 0.000 claims description 26
- 239000004065 semiconductor Substances 0.000 claims description 20
- 230000003287 optical effect Effects 0.000 claims description 16
- 238000000034 method Methods 0.000 claims description 13
- 239000007789 gas Substances 0.000 claims description 10
- 229920000642 polymer Polymers 0.000 claims description 10
- 230000007704 transition Effects 0.000 claims description 9
- 230000000903 blocking effect Effects 0.000 claims description 7
- 239000011248 coating agent Substances 0.000 claims description 6
- 238000000576 coating method Methods 0.000 claims description 6
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 4
- 239000001301 oxygen Substances 0.000 claims description 4
- 229910052760 oxygen Inorganic materials 0.000 claims description 4
- 230000004044 response Effects 0.000 claims description 4
- 238000013461 design Methods 0.000 claims description 3
- MOBZIKDAUJCZDU-UHFFFAOYSA-L 4,7-diphenyl-1,10-phenanthroline;ruthenium(2+);diperchlorate Chemical compound [Ru+2].[O-]Cl(=O)(=O)=O.[O-]Cl(=O)(=O)=O.C1=CC=CC=C1C1=CC=NC2=C1C=CC1=C(C=3C=CC=CC=3)C=CN=C21.C1=CC=CC=C1C1=CC=NC2=C1C=CC1=C(C=3C=CC=CC=3)C=CN=C21.C1=CC=CC=C1C1=CC=NC2=C1C=CC1=C(C=3C=CC=CC=3)C=CN=C21 MOBZIKDAUJCZDU-UHFFFAOYSA-L 0.000 claims description 2
- 238000005530 etching Methods 0.000 claims description 2
- 230000005284 excitation Effects 0.000 claims description 2
- 230000004888 barrier function Effects 0.000 claims 1
- 239000003269 fluorescent indicator Substances 0.000 abstract 2
- 230000002596 correlated effect Effects 0.000 abstract 1
- 239000004020 conductor Substances 0.000 description 23
- 239000000463 material Substances 0.000 description 18
- 230000000873 masking effect Effects 0.000 description 5
- 239000004593 Epoxy Substances 0.000 description 4
- 238000000151 deposition Methods 0.000 description 4
- 238000001802 infusion Methods 0.000 description 4
- 239000000853 adhesive Substances 0.000 description 3
- 230000001070 adhesive effect Effects 0.000 description 3
- 230000003321 amplification Effects 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 238000003199 nucleic acid amplification method Methods 0.000 description 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 235000011449 Rosa Nutrition 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 238000005520 cutting process Methods 0.000 description 2
- 230000008021 deposition Effects 0.000 description 2
- 230000008020 evaporation Effects 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 239000012327 Ruthenium complex Substances 0.000 description 1
- 229910004298 SiO 2 Inorganic materials 0.000 description 1
- 229910010413 TiO 2 Inorganic materials 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 230000027734 detection of oxygen Effects 0.000 description 1
- 238000010894 electron beam technology Methods 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 239000004816 latex Substances 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 239000012811 non-conductive material Substances 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 229920005573 silicon-containing polymer Polymers 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
- G01N21/6454—Individual samples arranged in a regular 2D-array, e.g. multiwell plates using an integrated detector array
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N2021/7769—Measurement method of reaction-produced change in sensor
- G01N2021/7786—Fluorescence
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Plasma & Fusion (AREA)
- Optics & Photonics (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Luminescent Compositions (AREA)
- Dental Preparations (AREA)
- Geophysics And Detection Of Objects (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/855,234 US5894351A (en) | 1997-05-13 | 1997-05-13 | Fluorescence sensing device |
| PCT/US1998/009588 WO1998052024A1 (fr) | 1997-05-13 | 1998-05-12 | Dispositif capteur a fluorescence ameliore |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO995282D0 NO995282D0 (no) | 1999-10-28 |
| NO995282L NO995282L (no) | 2000-01-10 |
| NO328830B1 true NO328830B1 (no) | 2010-05-25 |
Family
ID=25320700
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19995282A NO328830B1 (no) | 1997-05-13 | 1999-10-28 | Forbedret fluorescens-maler I |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5894351A (fr) |
| EP (1) | EP0981736B1 (fr) |
| JP (1) | JP4088352B2 (fr) |
| KR (1) | KR100508666B1 (fr) |
| CN (1) | CN1146726C (fr) |
| AT (1) | ATE229178T1 (fr) |
| AU (1) | AU723849B2 (fr) |
| CA (1) | CA2287307C (fr) |
| DE (1) | DE69809902T2 (fr) |
| DK (1) | DK0981736T3 (fr) |
| ES (1) | ES2187968T3 (fr) |
| HK (1) | HK1023401A1 (fr) |
| NO (1) | NO328830B1 (fr) |
| PT (1) | PT981736E (fr) |
| TW (1) | TW385365B (fr) |
| WO (1) | WO1998052024A1 (fr) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070225612A1 (en) * | 1996-07-15 | 2007-09-27 | Mace Leslie E | Metabolic measurements system including a multiple function airway adapter |
| DE19725050C2 (de) * | 1997-06-13 | 1999-06-24 | Fraunhofer Ges Forschung | Anordnung zur Detektion biochemischer oder chemischer Substanzen mittels Fluoreszenzlichtanregung und Verfahren zu deren Herstellung |
| US6572561B2 (en) | 1998-01-16 | 2003-06-03 | Healthetech, Inc. | Respiratory calorimeter |
| JP4238390B2 (ja) * | 1998-02-27 | 2009-03-18 | 株式会社ニコン | 照明装置、該照明装置を備えた露光装置および該露光装置を用いて半導体デバイスを製造する方法 |
| US6922576B2 (en) * | 1998-06-19 | 2005-07-26 | Becton, Dickinson And Company | Micro optical sensor device |
| US6535753B1 (en) * | 1998-08-20 | 2003-03-18 | Microsense International, Llc | Micro-invasive method for painless detection of analytes in extra-cellular space |
| US20090011945A1 (en) * | 1999-07-28 | 2009-01-08 | Bright Frank V | Method For Making Microsensor Arrays For Detecting Analytes |
| US6492182B1 (en) * | 1999-07-28 | 2002-12-10 | The Research Foundation Of State University Of New York | Microsensor arrays and method of using same for detecting analytes |
| US6612306B1 (en) | 1999-10-13 | 2003-09-02 | Healthetech, Inc. | Respiratory nitric oxide meter |
| AU1655901A (en) * | 1999-11-12 | 2001-06-06 | E.I. Du Pont De Nemours And Company | Fluorometer with low heat-generating light source |
| DK2292626T3 (da) | 2000-08-04 | 2014-06-10 | Senseonics Inc | Påvisning af analytter i vandige miljøer |
| AU2001296456A1 (en) | 2000-09-29 | 2002-04-08 | Healthetech, Inc. | Indirect calorimetry system |
| US7470420B2 (en) | 2000-12-05 | 2008-12-30 | The Regents Of The University Of California | Optical determination of glucose utilizing boronic acid adducts |
| US6653141B2 (en) | 2000-12-05 | 2003-11-25 | The Regents Of The University Of California | Polyhydroxyl-substituted organic molecule sensing method and device |
| US6627177B2 (en) | 2000-12-05 | 2003-09-30 | The Regents Of The University Of California | Polyhydroxyl-substituted organic molecule sensing optical in vivo method utilizing a boronic acid adduct and the device thereof |
| US20020119581A1 (en) * | 2001-01-05 | 2002-08-29 | Daniloff George Y. | Detection of analytes |
| US6844563B2 (en) * | 2001-05-22 | 2005-01-18 | Matsushita Electric Industrial Co., Ltd. | Fluorescence detecting device with integrated circuit and photodiode, and detection method |
| TWI293363B (en) * | 2001-12-11 | 2008-02-11 | Sensors For Med & Science Inc | High performance fluorescent optical sensor |
| US6855556B2 (en) | 2002-01-04 | 2005-02-15 | Becton, Dickinson And Company | Binding protein as biosensors |
| US20030153026A1 (en) * | 2002-01-04 | 2003-08-14 | Javier Alarcon | Entrapped binding protein as biosensors |
| US6867420B2 (en) * | 2002-06-03 | 2005-03-15 | The Regents Of The University Of California | Solid-state detector and optical system for microchip analyzers |
| US7108659B2 (en) * | 2002-08-01 | 2006-09-19 | Healthetech, Inc. | Respiratory analyzer for exercise use |
| US20040161853A1 (en) * | 2003-02-13 | 2004-08-19 | Zhongping Yang | Implantable chemical sensor with rugged optical coupler |
| US20040175821A1 (en) * | 2003-03-07 | 2004-09-09 | Ehman Michael F. | Integrated photodetector for heavy metals and biological activity analysis |
| SG10201403905YA (en) * | 2003-04-15 | 2014-10-30 | Sensors For Med & Science Inc | System and method for attenuating the effect of ambient light on an optical sensor |
| US20040234962A1 (en) * | 2003-05-02 | 2004-11-25 | Javier Alarcon | Multicoated or multilayer entrapment matrix for protein biosensor |
| US7713745B2 (en) | 2004-04-13 | 2010-05-11 | Sensors For Medicine And Science, Inc. | Non-covalent immobilization of indicator molecules |
| US20050234316A1 (en) * | 2004-04-16 | 2005-10-20 | Sensors For Medicine And Science, Inc. | Housing for a circuit that is to be implanted in-vivo and process of making the same |
| ATE476659T1 (de) * | 2004-06-09 | 2010-08-15 | Becton Dickinson Co | Sensor für mehrere analyte |
| JP5011650B2 (ja) * | 2005-04-01 | 2012-08-29 | パナソニック株式会社 | 光検知方法 |
| JP5041714B2 (ja) * | 2006-03-13 | 2012-10-03 | 信越化学工業株式会社 | マイクロチップ及びマイクロチップ製造用ｓｏｉ基板 |
| WO2007124464A2 (fr) | 2006-04-20 | 2007-11-01 | Becton, Dickinson And Company | Protéines thermostables et procédés pour les préparer et les utiliser |
| JP5638343B2 (ja) | 2010-10-25 | 2014-12-10 | テルモ株式会社 | 蛍光センサ |
| TWI592663B (zh) | 2011-03-15 | 2017-07-21 | 醫藥及科學感應公司 | 氧化敏感性材料之整合催化保護 |
| WO2012169230A1 (fr) * | 2011-06-08 | 2012-12-13 | オリンパス株式会社 | Capteur de fluorescence |
| WO2012169236A1 (fr) * | 2011-06-08 | 2012-12-13 | オリンパス株式会社 | Capteur fluorescent et procédé de fabrication de capteur fluorescent |
| JP2014224680A (ja) * | 2011-09-12 | 2014-12-04 | テルモ株式会社 | 蛍光センサーおよびアナライト成分測定方法 |
| JP6087337B2 (ja) * | 2012-02-16 | 2017-03-01 | テルモ株式会社 | 蛍光センサおよびセンサシステム |
| US8906320B1 (en) | 2012-04-16 | 2014-12-09 | Illumina, Inc. | Biosensors for biological or chemical analysis and systems and methods for same |
| WO2014045388A1 (fr) * | 2012-09-21 | 2014-03-27 | テルモ株式会社 | Capteur de lumière fluorescente |
| WO2014045387A1 (fr) * | 2012-09-21 | 2014-03-27 | テルモ株式会社 | Capteur fluorescent |
| US9963556B2 (en) | 2013-09-18 | 2018-05-08 | Senseonics, Incorporated | Critical point drying of hydrogels in analyte sensors |
| US10254225B2 (en) | 2013-12-10 | 2019-04-09 | Illumina, Inc. | Biosensors for biological or chemical analysis and methods of manufacturing the same |
| KR101569515B1 (ko) * | 2014-08-13 | 2015-11-27 | (주)옵토레인 | 측광형 발광소자가 내장된 바이오칩 및 그 제조방법 |
| DE102015211909A1 (de) * | 2015-06-26 | 2016-12-29 | Robert Bosch Gmbh | Kostengünstiges Pulsoxymeter |
| MY194772A (en) | 2017-12-26 | 2022-12-15 | Illumina Inc | Sensor System |
| JP2018141790A (ja) * | 2018-03-26 | 2018-09-13 | 株式会社ジャパンディスプレイ | 検体検出チップ |
| US10782236B2 (en) | 2018-06-11 | 2020-09-22 | Semiconductor Components Industries, Llc | Methods and apparatus for a biosensor |
| EP3767276A1 (fr) * | 2019-07-19 | 2021-01-20 | Sensirion AG | Capteur de carbone organique total avec un photodétecteur sensible aux uv comprenant une couche de conversion déscendante |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0725269A3 (fr) * | 1995-02-03 | 1997-12-17 | Motorola, Inc. | Capteur optique et procédé correspondant |
| US5517313A (en) * | 1995-02-21 | 1996-05-14 | Colvin, Jr.; Arthur E. | Fluorescent optical sensor |
| US5591407A (en) * | 1995-04-21 | 1997-01-07 | American Research Corporation Of Virginia | Laser diode sensor |
-
1997
- 1997-05-13 US US08/855,234 patent/US5894351A/en not_active Expired - Lifetime
-
1998
- 1998-05-12 CA CA002287307A patent/CA2287307C/fr not_active Expired - Fee Related
- 1998-05-12 WO PCT/US1998/009588 patent/WO1998052024A1/fr active IP Right Grant
- 1998-05-12 AT AT98922204T patent/ATE229178T1/de active
- 1998-05-12 EP EP98922204A patent/EP0981736B1/fr not_active Expired - Lifetime
- 1998-05-12 DE DE69809902T patent/DE69809902T2/de not_active Expired - Lifetime
- 1998-05-12 PT PT98922204T patent/PT981736E/pt unknown
- 1998-05-12 AU AU74803/98A patent/AU723849B2/en not_active Ceased
- 1998-05-12 KR KR10-1999-7010500A patent/KR100508666B1/ko not_active IP Right Cessation
- 1998-05-12 JP JP54938198A patent/JP4088352B2/ja not_active Expired - Fee Related
- 1998-05-12 DK DK98922204T patent/DK0981736T3/da active
- 1998-05-12 ES ES98922204T patent/ES2187968T3/es not_active Expired - Lifetime
- 1998-05-12 CN CNB988050242A patent/CN1146726C/zh not_active Expired - Fee Related
- 1998-05-13 TW TW087107405A patent/TW385365B/zh not_active IP Right Cessation
-
1999
- 1999-10-28 NO NO19995282A patent/NO328830B1/no not_active IP Right Cessation
-
2000
- 2000-04-19 HK HK00102351A patent/HK1023401A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DK0981736T3 (da) | 2003-03-31 |
| CA2287307C (fr) | 2007-07-10 |
| CN1255973A (zh) | 2000-06-07 |
| EP0981736A1 (fr) | 2000-03-01 |
| EP0981736B1 (fr) | 2002-12-04 |
| NO995282L (no) | 2000-01-10 |
| DE69809902T2 (de) | 2003-05-28 |
| ES2187968T3 (es) | 2003-06-16 |
| AU7480398A (en) | 1998-12-08 |
| ATE229178T1 (de) | 2002-12-15 |
| NO995282D0 (no) | 1999-10-28 |
| KR100508666B1 (ko) | 2005-08-17 |
| HK1023401A1 (en) | 2000-09-08 |
| DE69809902D1 (de) | 2003-01-16 |
| US5894351A (en) | 1999-04-13 |
| WO1998052024A1 (fr) | 1998-11-19 |
| CN1146726C (zh) | 2004-04-21 |
| CA2287307A1 (fr) | 1998-11-19 |
| PT981736E (pt) | 2003-04-30 |
| JP4088352B2 (ja) | 2008-05-21 |
| TW385365B (en) | 2000-03-21 |
| JP2001525930A (ja) | 2001-12-11 |
| KR20010012545A (ko) | 2001-02-15 |
| AU723849B2 (en) | 2000-09-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |