NO327238B1 - Metode for den setespesifikke fremstilling av hGRF-PEG konjugater, GRF-PEG-konjugat, anvendelse derav for fremstilling av et medikament og en farmasoytisk sammensetning omfattende samme. - Google Patents
Metode for den setespesifikke fremstilling av hGRF-PEG konjugater, GRF-PEG-konjugat, anvendelse derav for fremstilling av et medikament og en farmasoytisk sammensetning omfattende samme. Download PDFInfo
- Publication number
- NO327238B1 NO327238B1 NO20002664A NO20002664A NO327238B1 NO 327238 B1 NO327238 B1 NO 327238B1 NO 20002664 A NO20002664 A NO 20002664A NO 20002664 A NO20002664 A NO 20002664A NO 327238 B1 NO327238 B1 NO 327238B1
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- Norway
- Prior art keywords
- hgrf
- peg
- lys
- stated
- conjugates
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Birds (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97121264A EP0922446A1 (de) | 1997-12-03 | 1997-12-03 | Lösungsphase Verfahrung zur ortspezifischer Herstellung von GRF-PEG Konjugaten |
| PCT/EP1998/007748 WO1999027897A1 (en) | 1997-12-03 | 1998-12-01 | Site-specific preparation of polyethylene glycol-grf conjugates |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20002664D0 NO20002664D0 (no) | 2000-05-24 |
| NO20002664L NO20002664L (no) | 2000-07-13 |
| NO327238B1 true NO327238B1 (no) | 2009-05-18 |
Family
ID=8227732
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20002664A NO327238B1 (no) | 1997-12-03 | 2000-05-24 | Metode for den setespesifikke fremstilling av hGRF-PEG konjugater, GRF-PEG-konjugat, anvendelse derav for fremstilling av et medikament og en farmasoytisk sammensetning omfattende samme. |
Country Status (30)
| Country | Link |
|---|---|
| US (3) | US6528485B1 (de) |
| EP (2) | EP0922446A1 (de) |
| JP (2) | JP2001524505A (de) |
| KR (1) | KR100561768B1 (de) |
| CN (1) | CN1149967C (de) |
| AR (1) | AR017780A1 (de) |
| AT (1) | ATE236607T1 (de) |
| AU (1) | AU755285B2 (de) |
| BG (1) | BG64815B1 (de) |
| BR (1) | BR9815159A (de) |
| CA (1) | CA2312004C (de) |
| DE (1) | DE69813291T2 (de) |
| DK (1) | DK1037587T3 (de) |
| EA (1) | EA004269B1 (de) |
| EE (1) | EE200000319A (de) |
| ES (1) | ES2194376T3 (de) |
| HK (1) | HK1034203A1 (de) |
| HU (1) | HUP0100507A3 (de) |
| IL (2) | IL136551A0 (de) |
| NO (1) | NO327238B1 (de) |
| NZ (1) | NZ504570A (de) |
| PL (1) | PL192082B1 (de) |
| PT (1) | PT1037587E (de) |
| SI (1) | SI1037587T1 (de) |
| SK (1) | SK8242000A3 (de) |
| TR (1) | TR200001615T2 (de) |
| TW (1) | TWI254641B (de) |
| UA (1) | UA73716C2 (de) |
| WO (1) | WO1999027897A1 (de) |
| ZA (1) | ZA9811068B (de) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20010055581A1 (en) | 1994-03-18 | 2001-12-27 | Lawrence Tamarkin | Composition and method for delivery of biologically-active factors |
| US6407218B1 (en) * | 1997-11-10 | 2002-06-18 | Cytimmune Sciences, Inc. | Method and compositions for enhancing immune response and for the production of in vitro mabs |
| US7229841B2 (en) * | 2001-04-30 | 2007-06-12 | Cytimmune Sciences, Inc. | Colloidal metal compositions and methods |
| AU2001295589B2 (en) * | 2000-10-05 | 2005-10-13 | Ares Trading S.A. | Regioselective liquid phase pegylation |
| EP1234583A1 (de) * | 2001-02-23 | 2002-08-28 | F. Hoffmann-La Roche Ag | PEG-Konjugate des HGF-NK4 |
| US20030171285A1 (en) * | 2001-11-20 | 2003-09-11 | Finn Rory F. | Chemically-modified human growth hormone conjugates |
| EP1465933B1 (de) * | 2002-01-16 | 2007-08-29 | Biocompatibles UK Limited | Polymerkonjugate |
| US7998705B2 (en) * | 2002-08-06 | 2011-08-16 | FUJIFILM Diosynth Biotechnologies U.S.A., Inc | Increased dynamic binding capacity in ion exchange chromatography by addition of polyethylene glycol |
| CN1688696A (zh) * | 2002-09-18 | 2005-10-26 | 蒙特利尔大学医疗中心 | Ghrh类似物 |
| GB0301014D0 (en) * | 2003-01-16 | 2003-02-19 | Biocompatibles Ltd | Conjugation reactions |
| WO2004065412A1 (en) * | 2003-01-18 | 2004-08-05 | Pegsphere Co., Ltd. | Peptides having protected amines of untargeted sites, methods for production thereof and of specifically conjugated peg peptides using the same |
| US20050058658A1 (en) * | 2003-07-15 | 2005-03-17 | Barros Research Institute | Compositions and methods for immunotherapy of human immunodeficiency virus (HIV) |
| EP1644408A1 (de) * | 2003-07-15 | 2006-04-12 | Barros Research Institute | Eimeria tenella-antigen zur immuntherapie von kokzidiose |
| AU2004311630A1 (en) * | 2003-12-02 | 2005-07-21 | Cytimmune Sciences, Inc. | Methods and compositions for the production of monoclonal antibodies |
| CA2554755A1 (en) * | 2004-01-28 | 2005-08-11 | Cytimmune Sciences, Inc. | Functionalized colloidal metal compositions and methods |
| CN100355784C (zh) * | 2004-02-12 | 2007-12-19 | 江苏恒瑞医药股份有限公司 | 聚乙二醇修饰α－干扰素1b的制备方法 |
| US20050261475A1 (en) * | 2004-02-13 | 2005-11-24 | Harvard Medical School | Solid-phase capture-release-tag methods for phosphoproteomic analyses |
| US6986264B1 (en) * | 2004-07-15 | 2006-01-17 | Carrier Corporation | Economized dehumidification system |
| EP2371856B1 (de) | 2004-11-12 | 2022-05-18 | Bayer HealthCare LLC | Ortsgerichtete Modifizierung von FVIII |
| BRPI0614185B1 (pt) * | 2005-07-26 | 2015-10-27 | Rhodia | polímero com grupos substituintes poli (alquileneoxi) pendentes, composição de cuidados pessoais e método para cuidar do cabelo ou da pele |
| US20070238656A1 (en) * | 2006-04-10 | 2007-10-11 | Eastman Kodak Company | Functionalized poly(ethylene glycol) |
| US20080096819A1 (en) | 2006-05-02 | 2008-04-24 | Allozyne, Inc. | Amino acid substituted molecules |
| JP5313129B2 (ja) | 2006-05-02 | 2013-10-09 | アロザイン， インコーポレイテッド | 非天然アミノ酸置換ポリペプチド |
| EP2054074B8 (de) * | 2006-08-04 | 2014-11-12 | Prolong Pharmaceuticals, LLC | Modifiziertes erythropoietin |
| US20080083154A1 (en) * | 2006-10-05 | 2008-04-10 | Timothy M Gregory | Bait retention fish hook |
| CA2707840A1 (en) | 2007-08-20 | 2009-02-26 | Allozyne, Inc. | Amino acid substituted molecules |
| EP2200932A4 (de) * | 2007-09-21 | 2014-09-10 | Cytimmune Sciences Inc | Nanotherapeutische kolloidale metallzusammensetzungen und verfahren |
| US20110014118A1 (en) * | 2007-09-21 | 2011-01-20 | Lawrence Tamarkin | Nanotherapeutic colloidal metal compositions and methods |
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