NO326517B1 - Anvendelse av biologisk aktive vitamin D-forbindelser for fremstilling av et medikament for profylakse og terapeutisk behandling av inflammatorisk tarmsykdom hvor behandlingen ikke forer til alvorlig hyperkalsemi - Google Patents
Anvendelse av biologisk aktive vitamin D-forbindelser for fremstilling av et medikament for profylakse og terapeutisk behandling av inflammatorisk tarmsykdom hvor behandlingen ikke forer til alvorlig hyperkalsemi Download PDFInfo
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- NO326517B1 NO326517B1 NO20022974A NO20022974A NO326517B1 NO 326517 B1 NO326517 B1 NO 326517B1 NO 20022974 A NO20022974 A NO 20022974A NO 20022974 A NO20022974 A NO 20022974A NO 326517 B1 NO326517 B1 NO 326517B1
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- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/469,985 US6358939B1 (en) | 1999-12-21 | 1999-12-21 | Use of biologically active vitamin D compounds for the prevention and treatment of inflammatory bowel disease |
PCT/US2000/034913 WO2001046132A1 (en) | 1999-12-21 | 2000-12-21 | Use of biologically active vitamin d compounds for the prevention and treatment of inflammatory bowel disease |
Publications (3)
Publication Number | Publication Date |
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NO20022974D0 NO20022974D0 (no) | 2002-06-20 |
NO20022974L NO20022974L (no) | 2002-08-20 |
NO326517B1 true NO326517B1 (no) | 2008-12-22 |
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Application Number | Title | Priority Date | Filing Date |
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NO20022974A NO326517B1 (no) | 1999-12-21 | 2002-06-20 | Anvendelse av biologisk aktive vitamin D-forbindelser for fremstilling av et medikament for profylakse og terapeutisk behandling av inflammatorisk tarmsykdom hvor behandlingen ikke forer til alvorlig hyperkalsemi |
Country Status (9)
Country | Link |
---|---|
US (2) | US6358939B1 (de) |
EP (1) | EP1240136A4 (de) |
JP (1) | JP2004502638A (de) |
KR (1) | KR100660508B1 (de) |
AU (1) | AU781113B2 (de) |
CA (1) | CA2395200A1 (de) |
MX (1) | MXPA02006257A (de) |
NO (1) | NO326517B1 (de) |
WO (1) | WO2001046132A1 (de) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6087350A (en) * | 1997-08-29 | 2000-07-11 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Use of pretreatment chemicals to enhance efficacy of cytotoxic agents |
EP1233942A2 (de) * | 1999-12-02 | 2002-08-28 | The Penn State Research Foundation | Behandlung von entzündlichen darmerkrankungen mit vitamin d-verbindungen |
US6989377B2 (en) * | 1999-12-21 | 2006-01-24 | Wisconsin Alumni Research Foundation | Treating vitamin D responsive diseases |
AU2002220029B2 (en) * | 2000-11-14 | 2007-09-06 | Techlab, Inc. | Method for differentiating between irritable bowel syndrome and inflammatory bowel disease using lactoferrin as marker |
US7582670B2 (en) * | 2001-12-13 | 2009-09-01 | Natrogen Therapeutics, Inc. | Methods of treating an inflammatory-related disease |
WO2004063345A2 (en) * | 2003-01-10 | 2004-07-29 | Eli Lilly And Company | Vesicant treatment with phenyl-phenyl type vitamin d receptor modulators |
EP1603530A1 (de) * | 2003-03-04 | 2005-12-14 | Teva Pharmaceutical Industries Limited | Kombinationstherapie mit glatirameracetat und alphacalcidol zur behandlung von multipler sklerose |
GB0307865D0 (en) * | 2003-04-04 | 2003-05-14 | Novartis Ag | Pharmaceutical composition |
US20050148557A1 (en) * | 2003-07-29 | 2005-07-07 | Jin Tian | Use of Vitamin Ds to treat kidney disease |
US20050192255A1 (en) * | 2003-07-30 | 2005-09-01 | Jin Tian | Use of Vitamin Ds or Vitamin D analogs to treat cardiovascular disease |
US20050209203A1 (en) * | 2003-07-30 | 2005-09-22 | Jin Tian | Use of vitamin Ds or vitamin D analogs to treat cardiovascular disease |
US20060171983A1 (en) * | 2003-07-30 | 2006-08-03 | Jin Tian | Use of Vitamin D receptor activators or Vitamin D analogs to treat cardiovascular disease |
US7704980B2 (en) * | 2003-10-08 | 2010-04-27 | Wisconsin Alumni Research Foundation | Treatment of inflammatory bowel disease with 2-methylene-19-nor-vitamin D compounds |
GB0513984D0 (en) * | 2005-07-07 | 2005-08-17 | Teva Pharma | Dosage form |
EP2129382A4 (de) | 2007-02-21 | 2011-01-19 | Univ Michigan | Zusammensetzungen und verfahren zur herzmuskelberuhigung |
WO2008121386A2 (en) * | 2007-03-30 | 2008-10-09 | Amgen Inc. | Calcimimetic compounds for use in the treatment of bowel disorders |
JP2010524973A (ja) * | 2007-04-18 | 2010-07-22 | ジョンズ ホプキンス ユニバーシティ | カルシトリオールの低カルシウム血性、高抗増殖性類似体 |
US8318708B2 (en) * | 2007-11-06 | 2012-11-27 | Salk Institute For Biological Studies | Use of vitamin D receptor agonists, ligands, and precursors to treat pancreatic fibrosis |
WO2009062132A2 (en) | 2007-11-09 | 2009-05-14 | California Institute Of Technology | Immunomodulating compounds and related compositions and methods |
CN107019795A (zh) * | 2009-01-27 | 2017-08-08 | 博格有限责任公司 | 用于减轻与化疗有关的副作用的维生素d3化合物 |
MX366076B (es) | 2009-08-14 | 2019-06-27 | Berg Llc | Vitamina d3 y analogos de la misma para tratar alopecia. |
WO2011063241A1 (en) | 2009-11-20 | 2011-05-26 | Rigel Pharmaceuticals, Inc. | 2,4-pyrimidinediamine compounds and prodrugs thereof and their uses |
WO2011127302A2 (en) | 2010-04-07 | 2011-10-13 | Yue Shen | Vehicle for delivering a compound to a mucous membrane and related compositions, methods and systems |
JP6067550B2 (ja) | 2010-04-13 | 2017-01-25 | ライジェル ファーマシューティカルズ, インコーポレイテッド | 2,4−ピリミジンジアミン化合物およびそのプロドラッグならびにそれらの使用 |
WO2012103532A1 (en) * | 2011-01-28 | 2012-08-02 | Mazmanian Sarkis K | Combinatorial vitamin d and probiotic therapy for inflammatory bowel disease |
WO2013009945A1 (en) | 2011-07-12 | 2013-01-17 | The Brigham And Women's Hospital, Inc. | Lipid-containing psa compositions, methods of isolation and methods of use thereof |
HUE025567T2 (en) * | 2011-08-19 | 2016-02-29 | Maria Clementine Martin Klosterfrau Vertriebsges Mbh | Agents containing vasoconstrictors for combination therapy |
CA2909941A1 (en) | 2013-04-24 | 2014-10-30 | Salk Institute For Biological Studies | Vitamin d receptor/smad genomic circuit gates fibrotic response |
EP2994161B1 (de) | 2013-05-10 | 2020-10-28 | California Institute of Technology | Probiotische prävention und behandlung von dickdarmkrebs |
NZ714801A (en) | 2013-05-29 | 2021-07-30 | Berg Llc | Preventing or mitigating chemotherapy induced alopecia using vitamin d |
CA2914487A1 (en) | 2013-06-05 | 2014-12-11 | Salk Institute For Biological Studies | Vitamin d receptor agonists to treat diseases involving cxcl12 activity |
EP3220961B1 (de) | 2014-10-22 | 2023-07-05 | Extend Biosciences, Inc. | Therapeutische vitamin-d-konjugate |
WO2016065052A1 (en) | 2014-10-22 | 2016-04-28 | Extend Biosciences, Inc. | Insulin vitamin d conjugates |
KR102343093B1 (ko) | 2015-02-23 | 2021-12-24 | 삼성전자주식회사 | 식기 세척기 및 그 제어방법 |
US11331335B2 (en) | 2015-06-10 | 2022-05-17 | California Institute Of Technology | Sepsis treatment and related compositions methods and systems |
CN108135167B (zh) | 2015-08-19 | 2021-07-09 | 哈佛学院院长及董事 | 脂化psa组合物和方法 |
WO2018014012A1 (en) | 2016-07-15 | 2018-01-18 | President And Fellows Of Harvard College | Glycolipid compositions and methods of use |
WO2019023149A1 (en) | 2017-07-24 | 2019-01-31 | Salk Institute For Biological Studies | USE OF BROMODOMAIN-CONTAINING PROTEIN-9 ANTAGONISTS IN ASSOCIATION WITH VITAMIN D RECEPTOR AGONISTS IN THE TREATMENT OF DIABETES |
Family Cites Families (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4312806A (en) | 1981-03-02 | 1982-01-26 | G. D. Searle & Co. | Method and compounds for treating inflammatory bowel disease |
US4638043A (en) | 1984-11-13 | 1987-01-20 | Thermedics, Inc. | Drug release system |
US5310732A (en) | 1986-02-03 | 1994-05-10 | The Scripps Research Institute | 2-halo-2'-deoxyadenosines in the treatment of rheumatoid arthritis |
US5518725A (en) | 1989-09-25 | 1996-05-21 | University Of Utah Research Foundation | Vaccine compositions and method for induction of mucosal immune response via systemic vaccination |
US5824313A (en) | 1989-09-25 | 1998-10-20 | University Of Utah Research Foundation | Vaccine compositions and method for induction of mucosal immune response via systemic vaccination |
US5643602A (en) | 1989-11-22 | 1997-07-01 | Astra Aktiebolag | Oral composition for the treatment of inflammatory bowel disease |
US5216002A (en) | 1989-12-21 | 1993-06-01 | Eli Lilly And Company | Method of treating inflammatory bowel disease |
JP2811353B2 (ja) | 1990-07-06 | 1998-10-15 | ゼリア新薬工業株式会社 | 炎症性腸疾患予防・治療剤 |
CA2049481A1 (en) | 1990-08-27 | 1992-02-28 | Jill Ann Panetta | Method of treating inflammatory bowel disease |
US5391555A (en) | 1991-11-12 | 1995-02-21 | Miles Inc. | Methods for treating inflammatory bowel disease with leukotriene synthesis inhibitors |
DE4141746A1 (de) | 1991-12-13 | 1993-06-17 | Schering Ag | 20-methyl-substituierte vitamin d-derivate |
US5932214A (en) | 1994-08-11 | 1999-08-03 | Biogen, Inc. | Treatment for inflammatory bowel disease with VLA-4 blockers |
DK64592D0 (da) | 1992-05-14 | 1992-05-14 | Carlbiotech Ltd As | Peptider til terapeutisk behandling |
DE4221961A1 (de) * | 1992-06-30 | 1994-01-05 | Schering Ag | 22-En-25-oxa-Derivate in der Vitamin D-Reihe, Verfahren zu ihrer Herstellung, diese Derivate enthaltenen pharmazeutische Präparate sowie deren Verwendung als Arzneimittel |
US5294630A (en) | 1992-07-07 | 1994-03-15 | Eli Lilly And Company | Treatment of inflammatory bowel disease |
US5368854A (en) | 1992-08-20 | 1994-11-29 | Schering Corporation | Use of IL-10 to treat inflammatory bowel disease |
IL107185A (en) * | 1992-10-06 | 1998-02-22 | Schering Ag | History of 52-carboxylic acid, processes for their preparation and pharmaceutical preparations containing them |
GB9223061D0 (en) | 1992-11-04 | 1992-12-16 | Leo Pharm Prod Ltd | Chemical compounds |
DK0813865T3 (da) | 1993-04-20 | 2001-11-19 | Hexal Ag | Plaster med virksomt stof |
GB9309422D0 (en) | 1993-05-07 | 1993-06-23 | Res Inst Medicine Chem | Chemical compounds |
GB9314400D0 (en) | 1993-07-12 | 1993-08-25 | Leo Pharm Prod Ltd | Produktionsaktieselskab) chemical compounds |
GB9315253D0 (en) | 1993-07-23 | 1993-09-08 | Res Inst Medicine Chem | Chemical compounds |
US5420109A (en) | 1993-11-12 | 1995-05-30 | Houghten Pharmaceuticals, Inc. | Cytokine restraining agents |
GB9325415D0 (en) | 1993-12-13 | 1994-02-16 | Res Inst Medicine Chem | Chemical compounds |
DE4405545A1 (de) * | 1994-02-22 | 1995-08-31 | Dietl Hans | Fettlösliche Vitamine enthaltende Zubereitung zur oralen Applikation |
GB9405715D0 (en) | 1994-03-23 | 1994-05-11 | Res Inst Medicine Chem | Chemical compounds |
GB2292079B (en) | 1994-08-12 | 1998-07-15 | Flexpharm Ltd | Coated prednisolone preparation for the treatment of inflamatory bowel disease |
DK0717034T3 (da) | 1994-12-14 | 1999-10-18 | Duphar Int Res | Vitamin D-forbindelser og fremgangsmåde til fremstilling af disse forbindelser |
CA2210106A1 (en) | 1995-01-23 | 1996-08-01 | Yoshiyuki Ono | Vitamin d3 derivatives having a substituent at the 2-position |
US5877168A (en) | 1995-02-10 | 1999-03-02 | Chugai Seiyaku Kabushiki Kaisha | Vitamin D derivative with substituent at the 2β-position |
US5981597A (en) * | 1995-02-13 | 1999-11-09 | Trustees Of The University Of Pennsylvania | Differentiating agents for the treatment of inflammatory intestinal diseases |
US5569680A (en) | 1995-02-13 | 1996-10-29 | Trustees Of The Univ. Of Penna | Method of treating inflammatory bowel disease with tributyrin |
GB9509764D0 (en) | 1995-05-15 | 1995-07-05 | Tillotts Pharma Ag | Treatment of inflammatory bowel disease using oral dosage forms of omega-3 polyunsaturated acids |
UA48973C2 (uk) | 1995-06-07 | 2002-09-16 | Орто-Макнейл Фармасьютікалз Інк. | Трансдермальний пластир на основі 17-деацетилноргестимату для попередження овуляції |
US5711964A (en) | 1995-06-07 | 1998-01-27 | United States Of America | Method for the intracellular delivery of biomolecules using liposomes containing cationic lipids and vitamin D |
US5851548A (en) | 1995-06-07 | 1998-12-22 | Gen-Probe Incorporated | Liposomes containing cationic lipids and vitamin D |
US5952317A (en) | 1995-09-21 | 1999-09-14 | Wisconsin Alumni Research Foundation | Calcitriol derivatives and their uses |
DE69606680T2 (de) | 1995-10-30 | 2000-08-17 | Hoffmann La Roche | 1-Alpha, 26-dihydroxy-D-homo-vitamin D3 |
US5889028A (en) | 1996-02-09 | 1999-03-30 | Mayo Foundation For Medical Education And Research | Colonic delivery of nicotine to treat inflammatory bowel disease |
US5716946A (en) | 1996-02-13 | 1998-02-10 | Wisconsin Alumni Research Foundation | Multiple sclerosis treatment |
AU710931B2 (en) | 1996-02-28 | 1999-09-30 | Sumitomo Pharmaceuticals Company, Limited | Crystalline vitamin D derivative |
GB9607034D0 (en) | 1996-04-03 | 1996-06-05 | Leo Pharm Prod Ltd | Chemical compounds |
EP0892638B1 (de) | 1996-04-04 | 2002-11-13 | Cilag AG | Topische vitamin d zusammensetzung auf liposomenbasis |
US5891865A (en) | 1996-10-04 | 1999-04-06 | Wisconsin Alumni Research Foundation | Treatment of arthritic disease induced by infectious agents |
NL1006072C2 (nl) | 1997-05-16 | 1998-11-17 | Jacobs Johannes J | Vergister voor het onder aërobe omstandigheden vergisten van dierlijke mest, inrichting en werkwijze voor het onder aërobe omstandigheden vergisten van dierlijke mest onder toepassing van een dergelijke vergister. |
ATE322477T1 (de) * | 1997-05-16 | 2006-04-15 | Woman & Infants Hospital | 3-epi-vitamin d2 verbindungen und ihre anwendungen |
EP0981523B1 (de) * | 1997-05-16 | 2005-12-07 | Woman & Infants Hospital | Zyklische äther vitamin d3 verbindungen, 1alfa(oh) 3-epi-vitamin d3 verbindungen und deren verwendungen |
US5936105A (en) | 1997-06-13 | 1999-08-10 | Tetrionics, Inc. | 14-EPI-19-nor-vitamin D compounds and methods |
EP0927721A1 (de) * | 1997-12-17 | 1999-07-07 | Schering Aktiengesellschaft | Neue Vitamin D-Derivate mit Phosphoratomen in den Seitenketten, Zwischenprodukte bei ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln |
US6214373B1 (en) * | 1999-10-07 | 2001-04-10 | Snowden-Sutton Associates, Inc. | Nutritional composition for treating inflammatory bowel diseases |
US20030188756A1 (en) * | 2002-08-19 | 2003-10-09 | Cantorna Margherita T | Treatment of inflammatory bowel disease with vitamin d compounds |
EP1233942A2 (de) * | 1999-12-02 | 2002-08-28 | The Penn State Research Foundation | Behandlung von entzündlichen darmerkrankungen mit vitamin d-verbindungen |
DE60105035T2 (de) * | 2000-09-08 | 2005-08-18 | Wisconsin Alumni Research Foundation, Madison | 1alpha-hydroxy-2-methylene-19-nor-homopregnacalciferol und seine therapeutische verwendungen |
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1999
- 1999-12-21 US US09/469,985 patent/US6358939B1/en not_active Expired - Fee Related
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2000
- 2000-12-21 EP EP00986687A patent/EP1240136A4/de not_active Ceased
- 2000-12-21 MX MXPA02006257A patent/MXPA02006257A/es active IP Right Grant
- 2000-12-21 JP JP2001547043A patent/JP2004502638A/ja not_active Withdrawn
- 2000-12-21 AU AU22878/01A patent/AU781113B2/en not_active Ceased
- 2000-12-21 CA CA002395200A patent/CA2395200A1/en not_active Abandoned
- 2000-12-21 KR KR1020027008018A patent/KR100660508B1/ko not_active IP Right Cessation
- 2000-12-21 WO PCT/US2000/034913 patent/WO2001046132A1/en active IP Right Grant
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2001
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2002
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Also Published As
Publication number | Publication date |
---|---|
NO20022974L (no) | 2002-08-20 |
NO20022974D0 (no) | 2002-06-20 |
JP2004502638A (ja) | 2004-01-29 |
WO2001046132A1 (en) | 2001-06-28 |
AU781113B2 (en) | 2005-05-05 |
US6858595B2 (en) | 2005-02-22 |
EP1240136A4 (de) | 2004-05-26 |
KR20020084075A (ko) | 2002-11-04 |
CA2395200A1 (en) | 2001-06-28 |
EP1240136A1 (de) | 2002-09-18 |
KR100660508B1 (ko) | 2006-12-22 |
US20020128241A1 (en) | 2002-09-12 |
MXPA02006257A (es) | 2004-12-06 |
AU2287801A (en) | 2001-07-03 |
US6358939B1 (en) | 2002-03-19 |
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