NO325594B1 - En ny krystallinsk form av 6-hydroksy-3-(4-[2-(piperidin-1-yl)etoksy]fenoksy)-2-(4-metoksyfenyl)benzo[b]tiofen hydroklorid, fremgangsmate for dets fremstilling samt farmasoytisk formulering. - Google Patents
En ny krystallinsk form av 6-hydroksy-3-(4-[2-(piperidin-1-yl)etoksy]fenoksy)-2-(4-metoksyfenyl)benzo[b]tiofen hydroklorid, fremgangsmate for dets fremstilling samt farmasoytisk formulering. Download PDFInfo
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- NO325594B1 NO325594B1 NO20003876A NO20003876A NO325594B1 NO 325594 B1 NO325594 B1 NO 325594B1 NO 20003876 A NO20003876 A NO 20003876A NO 20003876 A NO20003876 A NO 20003876A NO 325594 B1 NO325594 B1 NO 325594B1
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- iii
- water
- estrogen
- compound according
- phenoxy
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Classifications
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- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/64—Oxygen atoms
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- C—CHEMISTRY; METALLURGY
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- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
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- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Reproductive Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cell Biology (AREA)
- Obesity (AREA)
- Biotechnology (AREA)
- Hospice & Palliative Care (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Vascular Medicine (AREA)
- Psychiatry (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14618499P | 1999-07-29 | 1999-07-29 | |
| US14764299P | 1999-08-06 | 1999-08-06 | |
| US14982099P | 1999-08-19 | 1999-08-19 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20003876D0 NO20003876D0 (no) | 2000-07-28 |
| NO20003876L NO20003876L (no) | 2001-01-30 |
| NO325594B1 true NO325594B1 (no) | 2008-06-23 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20003876A NO325594B1 (no) | 1999-07-29 | 2000-07-28 | En ny krystallinsk form av 6-hydroksy-3-(4-[2-(piperidin-1-yl)etoksy]fenoksy)-2-(4-metoksyfenyl)benzo[b]tiofen hydroklorid, fremgangsmate for dets fremstilling samt farmasoytisk formulering. |
Country Status (45)
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
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| HUP0302190A3 (en) * | 2000-05-08 | 2009-03-30 | Lilly Co Eli | Stabilized formulations of 6-hydroxy-3-(4-[2-(piperidin-1-yl) ethoxy]phenoxy)-2-(4-methoxyphenyl)benzo[b]thiophene and salts thereof |
| EP1757291A3 (en) * | 2000-05-08 | 2009-07-15 | Eli Lilly & Company | Stabilized formulations of 6-hydroxy-3-(4-[2-(piperidin-1-YL)ethoxy]phenoxy)-2-(4-methoxyphenyl)benzo[b]thiophene and salts thereof |
| US7122203B2 (en) | 2000-05-08 | 2006-10-17 | Eli Lilly And Company | Stabilized formulations of 6-hydroxy-3-(-4-[2-(piperidin-1-yl) ethoxy]phenoxy)-2-(4-methoxyphenyl) benzo[b]thiophene and salts thereof |
| AU2005200809B2 (en) * | 2000-05-08 | 2006-05-11 | Eli Lilly And Company | Stabilized Formulations of 6-hydroxy-3-(4-[2-(piperidin-1-yl) Ethoxy]phenoxy)-2-(4-methoxyphenyl) Benzo[b]thiophene and Salts Thereof |
| CZ20031098A3 (cs) * | 2000-10-20 | 2003-08-13 | Eli Lilly And Company | Nová krystalická forma 6-hydroxy-3-(4-[2-(piperidin-1-yl)ethoxy]fenoxy)-2-(4-methoxyfenyl)benzo[b]thiofen hydrochloridu |
| AU2002230409A1 (en) | 2000-11-27 | 2002-06-03 | Eli Lilly And Company | Process for preparing 3-aryl-benzo(b)thiophenes |
| DK1773811T3 (da) * | 2004-07-22 | 2010-12-13 | Lilly Co Eli | Krystallinsk variabelt hydrat af (s)-6-(4-(2-((3-(9h-carbazol-4-yloxy)-2-hydroxypropyl)amin)-2-methylpropyl)phenoxy)-3-pyridincarboxamid-hemisuccinatsalt |
| CN101087618A (zh) * | 2004-12-23 | 2007-12-12 | 航行药物公司 | 醋酸亮丙瑞林和乙酰胆碱酯酶抑制剂或nmda受体抑制剂在阿尔茨海默氏病治疗中的应用 |
| WO2006088648A1 (en) * | 2005-02-11 | 2006-08-24 | Eli Lilly And Company | Compositions and methods for treating dyslipidemia |
| DE102008057230A1 (de) * | 2008-11-11 | 2010-05-12 | Bayer Schering Pharma Aktiengesellschaft | Synergistische pharmazeutische Kombination mit einem Estrogenrezeptorantagonisten und einem Progestin |
| CN113325183B (zh) * | 2021-06-01 | 2022-11-15 | 中国医学科学院北京协和医院 | 一种用于鉴别诊断em/fem的试剂盒 |
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| US5510357A (en) * | 1995-02-28 | 1996-04-23 | Eli Lilly And Company | Benzothiophene compounds as anti-estrogenic agents |
| SG90193A1 (en) * | 1995-02-28 | 2002-07-23 | Lilly Co Eli | Benzothiophene compounds, intermediates, compositions, and methods |
| ZA982877B (en) * | 1997-04-09 | 1999-10-04 | Lilly Co Eli | Treatment of central nervous system disorders with selective estrogen receptor modulators. |
| WO2001009116A2 (en) * | 1999-07-29 | 2001-02-08 | Eli Lilly And Company | A NOVEL CRYSTALLINE FORM OF 6-HYDROXY-3- (4-[2-(PIPERIDIN-1-YL) ETHOXY]PHENOXY)- 2-(4-METHOXYPHENYL)BENZO[b]THIOPHENE HYDROCHLORIDE |
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- 2000-07-28 HU HU0003005A patent/HUP0003005A2/hu unknown
- 2000-07-28 GR GR20000100264A patent/GR20000100264A/el not_active IP Right Cessation
- 2000-07-28 BR BR0003211-5A patent/BR0003211A/pt not_active Application Discontinuation
- 2000-07-28 LT LT2000075A patent/LT4789B/lt not_active IP Right Cessation
- 2000-07-28 FR FR0009972A patent/FR2798384B1/fr not_active Expired - Fee Related
- 2000-07-28 AU AU48911/00A patent/AU779559B2/en not_active Ceased
- 2000-07-28 CN CNB001222406A patent/CN1138771C/zh not_active Expired - Fee Related
- 2000-07-28 SV SV2000000134A patent/SV2002000134A/es unknown
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- 2000-07-28 TW TW089115152A patent/TWI271403B/zh not_active IP Right Cessation
- 2000-07-28 PL PL00341748A patent/PL341748A1/xx not_active Application Discontinuation
- 2000-07-28 PT PT102501A patent/PT102501A/pt not_active IP Right Cessation
- 2000-07-28 IT IT2000MI001758A patent/IT1318659B1/it active
- 2000-07-28 GB GB0018636A patent/GB2352716A/en not_active Withdrawn
- 2000-07-28 KR KR1020000043586A patent/KR100733094B1/ko not_active IP Right Cessation
- 2000-07-28 SI SI200000173A patent/SI20427B/sl not_active IP Right Cessation
- 2000-07-28 MX MXPA00007462A patent/MXPA00007462A/es active IP Right Grant
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- 2000-07-28 JP JP2000228949A patent/JP2001048880A/ja active Pending
- 2000-07-28 NO NO20003876A patent/NO325594B1/no not_active IP Right Cessation
- 2000-07-28 AR ARP000103929A patent/AR029176A1/es not_active Application Discontinuation
- 2000-07-28 DE DE10036855A patent/DE10036855A1/de not_active Withdrawn
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2001
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