NO325242B1 - Nye amidinoderivater, anvendelse og fremstilling derav, samt farmasoytisk preparat - Google Patents
Nye amidinoderivater, anvendelse og fremstilling derav, samt farmasoytisk preparat Download PDFInfo
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- NO325242B1 NO325242B1 NO20030675A NO20030675A NO325242B1 NO 325242 B1 NO325242 B1 NO 325242B1 NO 20030675 A NO20030675 A NO 20030675A NO 20030675 A NO20030675 A NO 20030675A NO 325242 B1 NO325242 B1 NO 325242B1
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- Prior art keywords
- compound
- formula
- pharmaceutically acceptable
- compounds
- acceptable salt
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- KMTWTTUPPAJQMM-UHFFFAOYSA-N o-[(5-methyl-1,2-oxazol-3-yl)methyl]hydroxylamine Chemical compound CC1=CC(CON)=NO1 KMTWTTUPPAJQMM-UHFFFAOYSA-N 0.000 description 1
- XYEOALKITRFCJJ-UHFFFAOYSA-N o-benzylhydroxylamine Chemical compound NOCC1=CC=CC=C1 XYEOALKITRFCJJ-UHFFFAOYSA-N 0.000 description 1
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- QEVHRUUCFGRFIF-MDEJGZGSSA-N reserpine Chemical compound O([C@H]1[C@@H]([C@H]([C@H]2C[C@@H]3C4=C(C5=CC=C(OC)C=C5N4)CCN3C[C@H]2C1)C(=O)OC)OC)C(=O)C1=CC(OC)=C(OC)C(OC)=C1 QEVHRUUCFGRFIF-MDEJGZGSSA-N 0.000 description 1
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- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
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- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- MNWBNISUBARLIT-UHFFFAOYSA-N sodium cyanide Chemical compound [Na+].N#[C-] MNWBNISUBARLIT-UHFFFAOYSA-N 0.000 description 1
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- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical class NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 description 1
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- YFMZQCCTZUJXEB-UHFFFAOYSA-N tris(methylsulfanyl)methane Chemical compound CSC(SC)SC YFMZQCCTZUJXEB-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/53—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/54—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0002921A SE0002921D0 (sv) | 2000-08-16 | 2000-08-16 | Pharmaceutically useful compounds |
| SE0002922A SE0002922D0 (sv) | 2000-08-16 | 2000-08-16 | Pharmaceutically useful compounds |
| US09/900,903 US6433186B1 (en) | 2000-08-16 | 2001-07-10 | Amidino derivatives and their use as thormbin inhibitors |
| PCT/SE2001/001751 WO2002014270A1 (en) | 2000-08-16 | 2001-08-13 | New amidino derivatives and their use as thrombin inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20030675L NO20030675L (no) | 2003-02-11 |
| NO20030675D0 NO20030675D0 (no) | 2003-02-11 |
| NO325242B1 true NO325242B1 (no) | 2008-03-03 |
Family
ID=27354584
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20030675A NO325242B1 (no) | 2000-08-16 | 2003-02-11 | Nye amidinoderivater, anvendelse og fremstilling derav, samt farmasoytisk preparat |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP1311480B1 (de) |
| JP (1) | JP2004506039A (de) |
| CN (1) | CN1205183C (de) |
| AT (1) | ATE407116T1 (de) |
| AU (2) | AU2001280395B2 (de) |
| BR (1) | BR0113212A (de) |
| CA (1) | CA2415383C (de) |
| DE (1) | DE60135665D1 (de) |
| DK (1) | DK1311480T3 (de) |
| ES (1) | ES2311538T3 (de) |
| HK (1) | HK1053121A1 (de) |
| IL (1) | IL154077A0 (de) |
| MX (1) | MXPA03000643A (de) |
| NO (1) | NO325242B1 (de) |
| NZ (1) | NZ523598A (de) |
| PT (1) | PT1311480E (de) |
| SI (1) | SI1311480T1 (de) |
| WO (1) | WO2002014270A1 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7129233B2 (en) | 2000-12-01 | 2006-10-31 | Astrazeneca Ab | Mandelic acid derivatives and their use as thrombin inhibitors |
| SE0102921D0 (sv) | 2001-08-30 | 2001-08-30 | Astrazeneca Ab | Pharmaceutically useful compounds |
| US7018642B2 (en) | 2001-04-27 | 2006-03-28 | The Procter & Gamble Company | Compounds, compositions, and methods for controlling biofilms |
| SE0201658D0 (sv) * | 2002-05-31 | 2002-05-31 | Astrazeneca Ab | Immediate release pharmaceutical formulation |
| SE0201659D0 (sv) | 2002-05-31 | 2002-05-31 | Astrazeneca Ab | Modified release pharmaceutical formulation |
| SE0201661D0 (sv) | 2002-05-31 | 2002-05-31 | Astrazeneca Ab | New salts |
| GB0503672D0 (en) * | 2005-02-23 | 2005-03-30 | Astrazeneca Ab | New process |
| EP2512466A4 (de) | 2009-12-18 | 2013-07-03 | Activesite Pharmaceuticals Inc | Prodrugs von plasmakallikreinhemmern |
| US9206123B2 (en) | 2009-12-18 | 2015-12-08 | Activesite Pharmaceuticals, Inc. | Prodrugs of inhibitors of plasma kallikrein |
| EP2697196A1 (de) | 2011-04-13 | 2014-02-19 | Activesite Pharmaceuticals, Inc. | Prodrugs von plasmakallikreinhemmern |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SA96170106A (ar) * | 1995-07-06 | 2005-12-03 | أسترا أكتيبولاج | مشتقات حامض أميني جديدة |
| SE9602263D0 (sv) * | 1996-06-07 | 1996-06-07 | Astra Ab | New amino acid derivatives |
| WO2000042059A1 (en) * | 1999-01-13 | 2000-07-20 | Astrazeneca Ab | New amidinobenzylamine derivatives and their use as thrombin inhibitors |
-
2001
- 2001-08-13 MX MXPA03000643A patent/MXPA03000643A/es active IP Right Grant
- 2001-08-13 PT PT01958778T patent/PT1311480E/pt unknown
- 2001-08-13 CN CNB018141250A patent/CN1205183C/zh not_active Expired - Fee Related
- 2001-08-13 AT AT01958778T patent/ATE407116T1/de not_active IP Right Cessation
- 2001-08-13 CA CA002415383A patent/CA2415383C/en not_active Expired - Fee Related
- 2001-08-13 SI SI200130875T patent/SI1311480T1/sl unknown
- 2001-08-13 JP JP2002519415A patent/JP2004506039A/ja active Pending
- 2001-08-13 NZ NZ523598A patent/NZ523598A/en unknown
- 2001-08-13 AU AU2001280395A patent/AU2001280395B2/en not_active Ceased
- 2001-08-13 AU AU8039501A patent/AU8039501A/xx active Pending
- 2001-08-13 IL IL15407701A patent/IL154077A0/xx unknown
- 2001-08-13 DK DK01958778T patent/DK1311480T3/da active
- 2001-08-13 BR BR0113212-1A patent/BR0113212A/pt not_active IP Right Cessation
- 2001-08-13 ES ES01958778T patent/ES2311538T3/es not_active Expired - Lifetime
- 2001-08-13 DE DE60135665T patent/DE60135665D1/de not_active Expired - Lifetime
- 2001-08-13 WO PCT/SE2001/001751 patent/WO2002014270A1/en active IP Right Grant
- 2001-08-13 EP EP01958778A patent/EP1311480B1/de not_active Expired - Lifetime
-
2003
- 2003-02-11 NO NO20030675A patent/NO325242B1/no not_active IP Right Cessation
- 2003-07-30 HK HK03105489.4A patent/HK1053121A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU8039501A (en) | 2002-02-25 |
| CA2415383C (en) | 2009-11-24 |
| BR0113212A (pt) | 2003-07-08 |
| DE60135665D1 (de) | 2008-10-16 |
| SI1311480T1 (sl) | 2008-12-31 |
| AU2001280395B2 (en) | 2005-11-24 |
| ES2311538T3 (es) | 2009-02-16 |
| EP1311480B1 (de) | 2008-09-03 |
| NO20030675L (no) | 2003-02-11 |
| HK1053121A1 (en) | 2003-10-10 |
| NZ523598A (en) | 2004-10-29 |
| EP1311480A1 (de) | 2003-05-21 |
| DK1311480T3 (da) | 2008-12-01 |
| IL154077A0 (en) | 2003-07-31 |
| CN1205183C (zh) | 2005-06-08 |
| CA2415383A1 (en) | 2002-02-21 |
| MXPA03000643A (es) | 2003-06-06 |
| WO2002014270A1 (en) | 2002-02-21 |
| PT1311480E (pt) | 2008-11-11 |
| JP2004506039A (ja) | 2004-02-26 |
| ATE407116T1 (de) | 2008-09-15 |
| CN1446199A (zh) | 2003-10-01 |
| NO20030675D0 (no) | 2003-02-11 |
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