NO324731B1 - Karbocyklisk hemisulfat, anvendelse og fremstilling derav, samt farmasoytisk formulering og dikarboksylatsalt, gutarsalt og monosulfat, benzoat eller salicylatsalt - Google Patents
Karbocyklisk hemisulfat, anvendelse og fremstilling derav, samt farmasoytisk formulering og dikarboksylatsalt, gutarsalt og monosulfat, benzoat eller salicylatsalt Download PDFInfo
- Publication number
- NO324731B1 NO324731B1 NO19995622A NO995622A NO324731B1 NO 324731 B1 NO324731 B1 NO 324731B1 NO 19995622 A NO19995622 A NO 19995622A NO 995622 A NO995622 A NO 995622A NO 324731 B1 NO324731 B1 NO 324731B1
- Authority
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- Norway
- Prior art keywords
- salt
- amino
- methanol
- purin
- cyclopropylamino
- Prior art date
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- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
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- 229960001936 indinavir Drugs 0.000 description 1
- CBVCZFGXHXORBI-PXQQMZJSSA-N indinavir Chemical compound C([C@H](N(CC1)C[C@@H](O)C[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H]2C3=CC=CC=C3C[C@H]2O)C(=O)NC(C)(C)C)N1CC1=CC=CN=C1 CBVCZFGXHXORBI-PXQQMZJSSA-N 0.000 description 1
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- KELNNWMENBUHNS-NSHDSACASA-N isopropyl (2s)-2-ethyl-7-fluoro-3-oxo-3,4-dihydroquinoxaline-1(2h)-carboxylate Chemical compound FC1=CC=C2NC(=O)[C@H](CC)N(C(=O)OC(C)C)C2=C1 KELNNWMENBUHNS-NSHDSACASA-N 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
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- 235000010355 mannitol Nutrition 0.000 description 1
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- 239000001788 mono and diglycerides of fatty acids Substances 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 201000006417 multiple sclerosis Diseases 0.000 description 1
- 229960000884 nelfinavir Drugs 0.000 description 1
- QAGYKUNXZHXKMR-HKWSIXNMSA-N nelfinavir Chemical compound CC1=C(O)C=CC=C1C(=O)N[C@H]([C@H](O)CN1[C@@H](C[C@@H]2CCCC[C@@H]2C1)C(=O)NC(C)(C)C)CSC1=CC=CC=C1 QAGYKUNXZHXKMR-HKWSIXNMSA-N 0.000 description 1
- 230000000926 neurological effect Effects 0.000 description 1
- 229960000689 nevirapine Drugs 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 239000003883 ointment base Substances 0.000 description 1
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- 239000003973 paint Substances 0.000 description 1
- 208000021090 palsy Diseases 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 239000008177 pharmaceutical agent Substances 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
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- 229960000311 ritonavir Drugs 0.000 description 1
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- 229960004889 salicylic acid Drugs 0.000 description 1
- 229960001852 saquinavir Drugs 0.000 description 1
- QWAXKHKRTORLEM-UGJKXSETSA-N saquinavir Chemical compound C([C@@H]([C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)C=1N=C2C=CC=CC2=CC=1)C1=CC=CC=C1 QWAXKHKRTORLEM-UGJKXSETSA-N 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 238000005563 spheronization Methods 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 229960001203 stavudine Drugs 0.000 description 1
- 239000012258 stirred mixture Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 239000001117 sulphuric acid Substances 0.000 description 1
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- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000007916 tablet composition Substances 0.000 description 1
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
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- HBOMLICNUCNMMY-XLPZGREQSA-N zidovudine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](N=[N+]=[N-])C1 HBOMLICNUCNMMY-XLPZGREQSA-N 0.000 description 1
- 229960002555 zidovudine Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
- Seasonings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9709945.1A GB9709945D0 (en) | 1997-05-17 | 1997-05-17 | A novel salt |
| PCT/EP1998/002835 WO1998052949A1 (en) | 1997-05-17 | 1998-05-14 | Carbocyclic nucleoside hemisulfate and its use in treating viral infections |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO995622D0 NO995622D0 (no) | 1999-11-16 |
| NO995622L NO995622L (no) | 2000-01-14 |
| NO324731B1 true NO324731B1 (no) | 2007-12-03 |
Family
ID=10812407
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19995622A NO324731B1 (no) | 1997-05-17 | 1999-11-16 | Karbocyklisk hemisulfat, anvendelse og fremstilling derav, samt farmasoytisk formulering og dikarboksylatsalt, gutarsalt og monosulfat, benzoat eller salicylatsalt |
Country Status (51)
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9802472D0 (en) * | 1998-02-06 | 1998-04-01 | Glaxo Group Ltd | Pharmaceutical compositions |
| HU226998B1 (en) * | 2000-11-23 | 2010-04-28 | Richter Gedeon Nyrt | Desloratadine hemisulphate, process for the preparation thereof and pharmaceutical compositions containing the same |
| GB0320738D0 (en) | 2003-09-04 | 2003-10-08 | Glaxo Group Ltd | Novel process |
| EP1905772A1 (en) * | 2006-09-28 | 2008-04-02 | Esteve Quimica, S.A. | Process for the preparation of abacavir |
| AU2007301934A1 (en) * | 2006-09-28 | 2008-04-03 | Esteve Quimica, S.A. | Process for the preparation of abacavir |
| EP2085397A1 (en) | 2008-01-21 | 2009-08-05 | Esteve Quimica, S.A. | Crystalline form of abacavir |
| EP2218721A1 (en) * | 2009-02-11 | 2010-08-18 | LEK Pharmaceuticals d.d. | Novel salts of sitagliptin |
| EP2305680A3 (en) | 2009-09-30 | 2011-05-18 | Aurobindo Pharma Limited | Novel salts of (1S,4R)-cis-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol |
| KR20170078868A (ko) | 2010-01-27 | 2017-07-07 | 비이브 헬쓰케어 컴퍼니 | 항바이러스 치료 |
| ES2729824T3 (es) | 2011-04-08 | 2019-11-06 | Laurus Labs Ltd | Formas sólidas de compuestos antirretrovirales, procedimiento para la preparación y composición farmacéutica de los mismos |
| US9457028B2 (en) | 2013-02-27 | 2016-10-04 | Kyoto University | Pharmaceutical composition for use in prevention or treatment of cancer |
| CN104788451A (zh) * | 2014-01-21 | 2015-07-22 | 浙江九洲药业股份有限公司 | 一种阿巴卡韦的制备方法 |
| CN105315280A (zh) * | 2014-06-06 | 2016-02-10 | 上海迪赛诺化学制药有限公司 | 一种阿巴卡韦结晶体及其制备方法 |
| US10874687B1 (en) | 2020-02-27 | 2020-12-29 | Atea Pharmaceuticals, Inc. | Highly active compounds against COVID-19 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY104575A (en) * | 1989-12-22 | 1994-04-30 | The Wellcome Foundation Ltd | Therapeutic nucleosides. |
| GB9417249D0 (en) | 1994-08-26 | 1994-10-19 | Wellcome Found | A novel salt |
| MY115461A (en) * | 1995-03-30 | 2003-06-30 | Wellcome Found | Synergistic combinations of zidovudine, 1592u89 and 3tc |
| ATE230267T1 (de) * | 1996-06-25 | 2003-01-15 | Glaxo Group Ltd | Zusammensetzungen enthaltend vx478, zidovudine und 159u89 für die verwendung in der behandlung von hiv |
-
1997
- 1997-05-17 GB GBGB9709945.1A patent/GB9709945D0/en active Pending
-
1998
- 1998-04-15 TN TNTNSN98065A patent/TNSN98065A1/fr unknown
- 1998-05-14 ID IDW991393A patent/ID24910A/id unknown
- 1998-05-14 TR TR1999/02810T patent/TR199902810T2/xx unknown
- 1998-05-14 AU AU77655/98A patent/AU739953B2/en not_active Expired
- 1998-05-14 RS YUP-595/99A patent/RS49655B/sr unknown
- 1998-05-14 MY MYPI98002147A patent/MY120151A/en unknown
- 1998-05-14 AR ARP980102251A patent/AR015668A1/es active IP Right Grant
- 1998-05-14 GB GB0010222A patent/GB2348202B/en not_active Expired - Lifetime
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- 1998-05-14 PT PT98925601T patent/PT983271E/pt unknown
- 1998-05-14 GE GEAP19985087A patent/GEP20022680B/en unknown
- 1998-05-14 HU HU0002754A patent/HU226563B1/hu unknown
- 1998-05-14 NZ NZ500865A patent/NZ500865A/en not_active IP Right Cessation
- 1998-05-14 SK SK1561-99A patent/SK285159B6/sk not_active IP Right Cessation
- 1998-05-14 JP JP54991098A patent/JP3150711B2/ja not_active Expired - Lifetime
- 1998-05-14 PL PL98336888A patent/PL189527B1/pl unknown
- 1998-05-14 EA EA199900944A patent/EA001809B1/ru not_active IP Right Cessation
- 1998-05-14 NZ NZ510622A patent/NZ510622A/en not_active IP Right Cessation
- 1998-05-14 US US09/423,982 patent/US6294540B1/en not_active Expired - Lifetime
- 1998-05-14 DK DK98925601T patent/DK0983271T3/da active
- 1998-05-14 AT AT98925601T patent/ATE259811T1/de active
- 1998-05-14 IL IL13279398A patent/IL132793A0/xx active IP Right Grant
- 1998-05-14 ES ES98925601T patent/ES2214712T3/es not_active Expired - Lifetime
- 1998-05-14 EG EG52698A patent/EG23836A/xx active
- 1998-05-14 KR KR10-1999-7010584A patent/KR100521292B1/ko not_active IP Right Cessation
- 1998-05-14 WO PCT/EP1998/002835 patent/WO1998052949A1/en active Search and Examination
- 1998-05-14 SI SI9830615T patent/SI0983271T1/xx unknown
- 1998-05-14 AP APAP/P/1999/001688A patent/AP2009A/en active
- 1998-05-14 GB GB9926839A patent/GB2340491B/en not_active Expired - Lifetime
- 1998-05-14 CA CA002289753A patent/CA2289753C/en not_active Expired - Lifetime
- 1998-05-14 EE EEP199900537A patent/EE03924B1/xx unknown
- 1998-05-14 DE DE1998621758 patent/DE69821758T2/de not_active Expired - Lifetime
- 1998-05-14 BR BRPI9809126A patent/BRPI9809126B8/pt not_active IP Right Cessation
- 1998-05-14 CO CO98027044A patent/CO4940435A1/es unknown
- 1998-05-14 HN HN1998000071A patent/HN1998000071A/es unknown
- 1998-05-15 SV SV1998000057A patent/SV1998000057A/es active IP Right Grant
- 1998-05-15 HR HR980265A patent/HRP980265B1/xx not_active IP Right Cessation
- 1998-05-15 TW TW087107544A patent/TW480259B/zh not_active IP Right Cessation
- 1998-05-15 UY UY25004A patent/UY25004A1/es not_active IP Right Cessation
- 1998-05-16 JO JO19982032A patent/JO2032B1/en active
- 1998-05-17 DZ DZ980103A patent/DZ2493A1/xx active
- 1998-06-21 SA SA98190179A patent/SA98190179B1/ar unknown
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1999
- 1999-11-08 IL IL132793A patent/IL132793A/en not_active IP Right Cessation
- 1999-11-11 IS IS5246A patent/IS2207B/is unknown
- 1999-11-16 NO NO19995622A patent/NO324731B1/no not_active IP Right Cessation
- 1999-11-16 OA OA9900249A patent/OA11304A/en unknown
- 1999-12-07 BG BG103959A patent/BG64390B1/bg unknown
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2000
- 2000-03-07 MA MA25078A patent/MA26498A1/fr unknown
- 2000-05-11 JP JP2000138178A patent/JP2000327679A/ja active Pending
- 2000-06-07 HK HK00103423A patent/HK1024236A1/xx not_active IP Right Cessation
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2007
- 2007-01-02 AR ARP070100006A patent/AR059120A2/es active IP Right Grant
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| Date | Code | Title | Description |
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| MK1K | Patent expired |