NO323856B1 - Dermale anestetika, deres fremstilling, sammensetninger inneholdende dem og deres anvendelse. - Google Patents
Dermale anestetika, deres fremstilling, sammensetninger inneholdende dem og deres anvendelse. Download PDFInfo
- Publication number
- NO323856B1 NO323856B1 NO20016037A NO20016037A NO323856B1 NO 323856 B1 NO323856 B1 NO 323856B1 NO 20016037 A NO20016037 A NO 20016037A NO 20016037 A NO20016037 A NO 20016037A NO 323856 B1 NO323856 B1 NO 323856B1
- Authority
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- Norway
- Prior art keywords
- compound
- hydrogen
- formula
- piperidine
- composition
- Prior art date
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- 230000002500 effect on skin Effects 0.000 title claims abstract description 25
- -1 their preparation Substances 0.000 title claims description 32
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- 239000003193 general anesthetic agent Substances 0.000 title description 5
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- 238000000034 method Methods 0.000 claims abstract description 20
- 239000003589 local anesthetic agent Substances 0.000 claims abstract description 12
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
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- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Anesthesiology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13835399P | 1999-06-10 | 1999-06-10 | |
| US17926700P | 2000-01-31 | 2000-01-31 | |
| PCT/US2000/015490 WO2000076510A1 (en) | 1999-06-10 | 2000-06-06 | Dermal anesthetic agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20016037D0 NO20016037D0 (no) | 2001-12-10 |
| NO20016037L NO20016037L (no) | 2002-02-11 |
| NO323856B1 true NO323856B1 (no) | 2007-07-16 |
Family
ID=26836123
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20016037A NO323856B1 (no) | 1999-06-10 | 2001-12-10 | Dermale anestetika, deres fremstilling, sammensetninger inneholdende dem og deres anvendelse. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6413987B1 (pt) |
| EP (1) | EP1185267B1 (pt) |
| JP (1) | JP2003501469A (pt) |
| CN (1) | CN1355700A (pt) |
| AT (1) | ATE335482T1 (pt) |
| AU (1) | AU777517B2 (pt) |
| BR (1) | BR0011028A (pt) |
| CA (1) | CA2376819C (pt) |
| CY (1) | CY1105721T1 (pt) |
| DE (1) | DE60029954T2 (pt) |
| DK (1) | DK1185267T3 (pt) |
| ES (1) | ES2267546T3 (pt) |
| IL (2) | IL146190A0 (pt) |
| MX (1) | MXPA01012632A (pt) |
| NO (1) | NO323856B1 (pt) |
| NZ (1) | NZ515143A (pt) |
| PT (1) | PT1185267E (pt) |
| WO (1) | WO2000076510A1 (pt) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1321139B1 (en) * | 2001-12-21 | 2006-08-23 | CHIESI FARMACEUTICI S.p.A. | 2-Indanylamino deratives for the therapy of chronic, acute or inflammatory pain |
| MXPA05005580A (es) * | 2002-11-26 | 2005-11-23 | Maruishi Pharma | Derivados de isoindolina. |
| US7718674B2 (en) | 2004-09-27 | 2010-05-18 | Bridge Pharma, Inc. | Methods of relieving neuropathic pain with the S-isomer of 2-{2[N-(2-indanyl)-N-phenylamino]ethyl}piperidine |
| WO2006037047A2 (en) * | 2004-09-27 | 2006-04-06 | Bridge Pharma, Inc. | The r-isomer of 2-{2-[n-(2-indanyl)-n-phenylamino]ethyl}piperidine and other dermal anesthetic agents |
| US20090137628A1 (en) * | 2005-09-23 | 2009-05-28 | Bridge Pharma, Inc. | Formulations of Indanylamines and the Use Thereof as Local Anesthetics and as Medication for Chronic Pain |
| US20110218218A1 (en) * | 2005-09-23 | 2011-09-08 | Bridge Pharma, Inc. | Formulations Of Indanylamines And The Use Thereof As Local Anesthetics And As Medication For Chronic Pain |
| US7592458B2 (en) | 2006-07-21 | 2009-09-22 | Wright George E | Dermal anesthetic compounds and pharmaceutical compositions for inducing local anesthesia and mitigating neuropathic pain |
| DK2244737T3 (da) * | 2008-01-22 | 2019-07-08 | Univ Texas | Flygtige anæstetiske sammensætninger omfattende ekstraktionsopløsningsmidler til regional anæstesi og/eller smertelindring |
| CN103547566B (zh) * | 2011-02-18 | 2017-05-31 | 阿萨纳生物科技有限责任公司 | 氨基茚满化合物及其治疗疼痛的用途 |
| US8809372B2 (en) | 2011-09-30 | 2014-08-19 | Asana Biosciences, Llc | Pyridine derivatives |
| WO2013063127A1 (en) | 2011-10-24 | 2013-05-02 | Endo Pharmaceuticals Inc. | Cyclohexylamines |
| WO2014028675A1 (en) * | 2012-08-15 | 2014-02-20 | Endo Pharmaceuticals Inc. | Use of aminoindane compounds in treating overactive bladder and interstitial cystitis |
| ES2901481T3 (es) | 2015-11-23 | 2022-03-22 | Nortic Holdings Inc | Pulverización filmógena tópica |
| WO2020131380A1 (en) | 2018-12-19 | 2020-06-25 | Nortic Holdings Inc. | Therapeutic composition of intranasal lidocaine |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE760018A (fr) * | 1969-12-19 | 1971-06-08 | Christiaens Sa A | Nouveau derives du 2-amino-indane, leur preparation et leur utilisation |
| US3923813A (en) | 1969-12-19 | 1975-12-02 | Christiaens Sa A | Derivatives of 2-aminoindanes |
| AR206505A1 (es) * | 1972-09-18 | 1976-07-30 | Christiaens Sa A | Procedimiento para obtener nuevos derivados de n-fenil-n-aminoalquil-2-aminoindano |
| ZA738419B (en) | 1972-11-06 | 1974-09-25 | Christiaens Sa A | New derivatives of 2-aminoindane,the preparation and use thereof |
| GB1462036A (en) * | 1973-02-05 | 1977-01-19 | Manuf Prod Pharma | Aminoindane derivatives |
| GB1468347A (en) * | 1973-03-02 | 1977-03-23 | Christiaens Sa A | Aminoindanes |
-
2000
- 2000-06-06 CA CA002376819A patent/CA2376819C/en not_active Expired - Fee Related
- 2000-06-06 ES ES00941227T patent/ES2267546T3/es not_active Expired - Lifetime
- 2000-06-06 DE DE60029954T patent/DE60029954T2/de not_active Expired - Fee Related
- 2000-06-06 IL IL14619000A patent/IL146190A0/xx unknown
- 2000-06-06 US US09/588,582 patent/US6413987B1/en not_active Expired - Fee Related
- 2000-06-06 CN CN00808753A patent/CN1355700A/zh active Pending
- 2000-06-06 AT AT00941227T patent/ATE335482T1/de not_active IP Right Cessation
- 2000-06-06 WO PCT/US2000/015490 patent/WO2000076510A1/en active IP Right Grant
- 2000-06-06 DK DK00941227T patent/DK1185267T3/da active
- 2000-06-06 AU AU55963/00A patent/AU777517B2/en not_active Ceased
- 2000-06-06 EP EP00941227A patent/EP1185267B1/en not_active Expired - Lifetime
- 2000-06-06 JP JP2001502843A patent/JP2003501469A/ja active Pending
- 2000-06-06 NZ NZ515143A patent/NZ515143A/en not_active IP Right Cessation
- 2000-06-06 BR BR0011028-0A patent/BR0011028A/pt not_active Application Discontinuation
- 2000-06-06 MX MXPA01012632A patent/MXPA01012632A/es active IP Right Grant
- 2000-06-06 PT PT00941227T patent/PT1185267E/pt unknown
-
2001
- 2001-10-25 IL IL146190A patent/IL146190A/en not_active IP Right Cessation
- 2001-12-10 NO NO20016037A patent/NO323856B1/no unknown
-
2006
- 2006-10-23 CY CY20061101516T patent/CY1105721T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO20016037L (no) | 2002-02-11 |
| ATE335482T1 (de) | 2006-09-15 |
| DE60029954D1 (de) | 2006-09-21 |
| AU5596300A (en) | 2001-01-02 |
| CA2376819C (en) | 2008-09-02 |
| PT1185267E (pt) | 2006-12-29 |
| BR0011028A (pt) | 2002-02-19 |
| CY1105721T1 (el) | 2010-12-22 |
| WO2000076510A9 (en) | 2002-07-04 |
| EP1185267A4 (en) | 2003-09-03 |
| EP1185267A1 (en) | 2002-03-13 |
| AU777517B2 (en) | 2004-10-21 |
| DE60029954T2 (de) | 2007-03-08 |
| IL146190A (en) | 2008-11-03 |
| ES2267546T3 (es) | 2007-03-16 |
| MXPA01012632A (es) | 2004-03-19 |
| IL146190A0 (en) | 2002-07-25 |
| WO2000076510A1 (en) | 2000-12-21 |
| EP1185267B1 (en) | 2006-08-09 |
| US6413987B1 (en) | 2002-07-02 |
| JP2003501469A (ja) | 2003-01-14 |
| CA2376819A1 (en) | 2000-12-21 |
| NZ515143A (en) | 2004-05-28 |
| NO20016037D0 (no) | 2001-12-10 |
| CN1355700A (zh) | 2002-06-26 |
| DK1185267T3 (da) | 2006-12-11 |
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