NO323372B1 - 11 β-langkjedede, substituerte ostratriener, metoder for deres fremstilling, farmasoytiske preparater inneholdende angitte ostratriener, og deres anvendelse for fremstilling av medisiner - Google Patents
11 β-langkjedede, substituerte ostratriener, metoder for deres fremstilling, farmasoytiske preparater inneholdende angitte ostratriener, og deres anvendelse for fremstilling av medisiner Download PDFInfo
- Publication number
- NO323372B1 NO323372B1 NO20016330A NO20016330A NO323372B1 NO 323372 B1 NO323372 B1 NO 323372B1 NO 20016330 A NO20016330 A NO 20016330A NO 20016330 A NO20016330 A NO 20016330A NO 323372 B1 NO323372 B1 NO 323372B1
- Authority
- NO
- Norway
- Prior art keywords
- diol
- pentyl
- triene
- lip
- methyl
- Prior art date
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- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 13
- 150000002164 estratrienes Chemical class 0.000 claims abstract description 11
- 238000004519 manufacturing process Methods 0.000 claims abstract description 7
- 125000004433 nitrogen atom Chemical group N* 0.000 claims abstract description 6
- 229910052717 sulfur Inorganic materials 0.000 claims abstract description 6
- 125000004434 sulfur atom Chemical group 0.000 claims abstract description 4
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 claims description 68
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- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims description 47
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- OSMADJAEHVCZKN-QMMMGPOBSA-N tert-butyl (2s)-2-(bromomethyl)pyrrolidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCC[C@H]1CBr OSMADJAEHVCZKN-QMMMGPOBSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Led Device Packages (AREA)
- Led Devices (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19929715A DE19929715A1 (de) | 1999-06-24 | 1999-06-24 | 11ß-langkettig-substituierte Estratriene, Verfahren zur Herstellung , pharmazeutische Präparate, die diese 11ß-langkettig-substituierten Estratriene enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln |
| PCT/EP2000/005969 WO2001000652A2 (de) | 1999-06-24 | 2000-06-26 | 11β-LANGKETTIG-SUBSTITUIERTE ESTRATRIENE, VERFAHREN ZUR HERSTELLUNG, PHARMAZEUTISCHE PRÄPARATE, DIE DIESE 11β-LANGKETTIG-SUBSTITUIERTEN ESTRATRIENE ENTHALTEN, SOWIE DEREN VERWENDUNG ZUR HERSTELLUNG VON ARZNEIMITTELN |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20016330D0 NO20016330D0 (no) | 2001-12-21 |
| NO20016330L NO20016330L (no) | 2002-01-31 |
| NO323372B1 true NO323372B1 (no) | 2007-04-16 |
Family
ID=7912903
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20016330A NO323372B1 (no) | 1999-06-24 | 2001-12-21 | 11 β-langkjedede, substituerte ostratriener, metoder for deres fremstilling, farmasoytiske preparater inneholdende angitte ostratriener, og deres anvendelse for fremstilling av medisiner |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6790842B1 (pt) |
| EP (1) | EP1187846B1 (pt) |
| JP (1) | JP2003503419A (pt) |
| AT (1) | ATE360027T1 (pt) |
| AU (1) | AU6152400A (pt) |
| DE (2) | DE19929715A1 (pt) |
| DK (1) | DK1187846T3 (pt) |
| ES (1) | ES2283307T3 (pt) |
| NO (1) | NO323372B1 (pt) |
| PT (1) | PT1187846E (pt) |
| WO (1) | WO2001000652A2 (pt) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070129282A1 (en) * | 1998-11-24 | 2007-06-07 | Ahlem Clarence N | Pharmaceutical treatments and compositions |
| DK1955700T3 (da) | 1999-09-30 | 2011-05-23 | Harbor Biosciences Inc | Terapeutisk behandling af androgenreceptor-betingede lidelser |
| CN101510468B (zh) * | 2001-04-12 | 2012-01-18 | 昭和电工株式会社 | 铌电容器的制备方法 |
| DE10214179A1 (de) * | 2002-03-27 | 2003-10-16 | Schering Ag | 11beta-substituierte 19-Nor-17alpha-pregna-1,3,5(10)-trien-17beta-ole mit einem 21,16alpha-Laktonring |
| EP1615944A4 (en) * | 2003-04-01 | 2010-08-11 | Harbor Biosciences Inc | ANTI-ORANGE PROBLEMS WITH MARGINAL AGONIST EFFECT AND METHOD OF USE |
| DE102006054535A1 (de) * | 2006-11-15 | 2008-05-21 | Bayer Schering Pharma Aktiengesellschaft | Progesteronrezeptorantagonisten |
| WO2011092127A1 (en) | 2010-01-26 | 2011-08-04 | Bayer Schering Pharma Aktiengesellschaft | 14,17-bridged estratriene derivatives comprising heterocyclic bioisosteres for the phenolic a-ring |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2640977A2 (en) | 1982-06-11 | 1990-06-29 | Roussel Uclaf | New position-11 substituted 19-norsteroids and their application as medicinal products. |
| FR2643638B1 (fr) * | 1989-02-24 | 1991-06-14 | Roussel Uclaf | Nouveaux 19-nor steroides ayant en position 11beta une chaine carbonee comportant une fonction amide ou carbamate, leur procede de preparation et les intermediaires de ce procede, leur application comme medicaments et les compositions pharmaceutiques les contenant |
| DE69128820T2 (de) * | 1990-08-14 | 1998-06-10 | Hoechst Marion Roussel Inc | Neue 19-Nor Steroide, die eine Amid tragende Gruppe in der 11-Beta-Stelle haben, ihre Herstellung, ihre Verwendung als Medikamente und pharmazeutische Präparate davon |
| FR2685332A1 (fr) | 1991-12-20 | 1993-06-25 | Roussel Uclaf | Nouveaux 19-nor sterouides ayant en position 11beta une chaine thiocarbonee, leur procede de preparation et les intermediaires et leur application a titre de medicaments. |
| US5965551A (en) * | 1996-02-21 | 1999-10-12 | North Carolina State University | Method of treating alopecia |
| FR2757519B1 (fr) * | 1996-12-23 | 1999-06-11 | Hoechst Marion Roussel Inc | Steroides substitues en position 11, leur procede de preparation, leur application comme medicament et les compositions pharmaceutiques les renfermant |
| FR2757399B1 (fr) * | 1996-12-23 | 1999-12-17 | Hoechst Marion Roussel Inc | Application de composes steroides substitues en 11 pour la fabrication de medicaments ayant une activite estrogene dissociee |
| FR2771096B1 (fr) * | 1997-11-17 | 2000-08-11 | Hoechst Marion Roussel Inc | Nouveaux 19-nor steroides, substitues en position 11beta, procede et intermediaires de preparation, application comme medicaments et compositions pharmaceutiques les renfermant |
| WO2000031112A1 (en) * | 1998-11-20 | 2000-06-02 | Akzo Nobel N.V. | Estrogenic estra-1,3,5(10)-trienes with differential effects on the alpha and beta estrogen receptors, having a linear hydrocarbon chain of from 5-9 carbon atoms in position 11 |
-
1999
- 1999-06-24 DE DE19929715A patent/DE19929715A1/de not_active Withdrawn
-
2000
- 2000-06-26 US US10/018,429 patent/US6790842B1/en not_active Expired - Fee Related
- 2000-06-26 DK DK00947882T patent/DK1187846T3/da active
- 2000-06-26 WO PCT/EP2000/005969 patent/WO2001000652A2/de active IP Right Grant
- 2000-06-26 DE DE50014263T patent/DE50014263D1/de not_active Expired - Fee Related
- 2000-06-26 EP EP00947882A patent/EP1187846B1/de not_active Expired - Lifetime
- 2000-06-26 AT AT00947882T patent/ATE360027T1/de not_active IP Right Cessation
- 2000-06-26 ES ES00947882T patent/ES2283307T3/es not_active Expired - Lifetime
- 2000-06-26 JP JP2001507059A patent/JP2003503419A/ja active Pending
- 2000-06-26 PT PT00947882T patent/PT1187846E/pt unknown
- 2000-06-26 AU AU61524/00A patent/AU6152400A/en not_active Abandoned
-
2001
- 2001-12-21 NO NO20016330A patent/NO323372B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1187846B1 (de) | 2007-04-18 |
| NO20016330D0 (no) | 2001-12-21 |
| PT1187846E (pt) | 2007-05-31 |
| JP2003503419A (ja) | 2003-01-28 |
| DK1187846T3 (da) | 2007-07-02 |
| ES2283307T3 (es) | 2007-11-01 |
| WO2001000652A3 (de) | 2001-05-10 |
| EP1187846A2 (de) | 2002-03-20 |
| NO20016330L (no) | 2002-01-31 |
| DE50014263D1 (de) | 2007-05-31 |
| WO2001000652A2 (de) | 2001-01-04 |
| DE19929715A1 (de) | 2000-12-28 |
| ATE360027T1 (de) | 2007-05-15 |
| AU6152400A (en) | 2001-01-31 |
| US6790842B1 (en) | 2004-09-14 |
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| MM1K | Lapsed by not paying the annual fees |