NO322825B1 - Kinazolinoner, syntese av slike, anvendelse av slike for fremstilling av medikamenter for behandling av proliferative sykdommer, farmasoytiske preparater inneholdende slike forbindelser samt anvendelse in vitro for a hemme KSP-kinase. - Google Patents

Kinazolinoner, syntese av slike, anvendelse av slike for fremstilling av medikamenter for behandling av proliferative sykdommer, farmasoytiske preparater inneholdende slike forbindelser samt anvendelse in vitro for a hemme KSP-kinase. Download PDF

Info

Publication number
NO322825B1
NO322825B1 NO20021907A NO20021907A NO322825B1 NO 322825 B1 NO322825 B1 NO 322825B1 NO 20021907 A NO20021907 A NO 20021907A NO 20021907 A NO20021907 A NO 20021907A NO 322825 B1 NO322825 B1 NO 322825B1
Authority
NO
Norway
Prior art keywords
hydrogen
benzyl
ksp
compounds
ethyl
Prior art date
Application number
NO20021907A
Other languages
English (en)
Norwegian (no)
Other versions
NO20021907D0 (no
NO20021907L (no
Inventor
Jeffrey T Finer
Gustav Bergnes
Bainian Feng
Whitney W Smith
John C Chabala
Original Assignee
Cytokinetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cytokinetics Inc filed Critical Cytokinetics Inc
Publication of NO20021907D0 publication Critical patent/NO20021907D0/no
Publication of NO20021907L publication Critical patent/NO20021907L/no
Publication of NO322825B1 publication Critical patent/NO322825B1/no

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72Quinazolines; Hydrogenated quinazolines
    • C07D239/86Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88Oxygen atoms
    • C07D239/91Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Paints Or Removers (AREA)
  • Medicines Containing Plant Substances (AREA)
NO20021907A 1999-10-27 2002-04-23 Kinazolinoner, syntese av slike, anvendelse av slike for fremstilling av medikamenter for behandling av proliferative sykdommer, farmasoytiske preparater inneholdende slike forbindelser samt anvendelse in vitro for a hemme KSP-kinase. NO322825B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US19825399P 1999-10-27 1999-10-27
US21310400P 2000-06-21 2000-06-21
PCT/US2000/029585 WO2001030768A1 (fr) 1999-10-27 2000-10-26 Procedes et compositions utilisant des quinazolinones

Publications (3)

Publication Number Publication Date
NO20021907D0 NO20021907D0 (no) 2002-04-23
NO20021907L NO20021907L (no) 2002-06-07
NO322825B1 true NO322825B1 (no) 2006-12-11

Family

ID=26893612

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20021907A NO322825B1 (no) 1999-10-27 2002-04-23 Kinazolinoner, syntese av slike, anvendelse av slike for fremstilling av medikamenter for behandling av proliferative sykdommer, farmasoytiske preparater inneholdende slike forbindelser samt anvendelse in vitro for a hemme KSP-kinase.

Country Status (19)

Country Link
EP (2) EP1686120A3 (fr)
JP (2) JP2003512461A (fr)
KR (2) KR20050049562A (fr)
CN (1) CN100381428C (fr)
AT (1) ATE327224T1 (fr)
AU (2) AU774748B2 (fr)
BR (1) BR0015110A (fr)
CA (1) CA2388646C (fr)
CZ (1) CZ20021428A3 (fr)
DE (1) DE60028227T2 (fr)
ES (1) ES2263501T3 (fr)
HK (1) HK1045994A1 (fr)
HU (1) HUP0203430A3 (fr)
IL (2) IL149164A0 (fr)
MX (1) MXPA02004162A (fr)
NO (1) NO322825B1 (fr)
NZ (2) NZ518480A (fr)
PL (1) PL203998B1 (fr)
WO (1) WO2001030768A1 (fr)

Families Citing this family (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE342257T1 (de) 1999-08-27 2006-11-15 Chemocentryx Inc Heterozyclische verbindungen und verfahren zur modulierung von cxcr3 funktion
US20070021493A1 (en) 1999-09-16 2007-01-25 Curis, Inc. Mediators of hedgehog signaling pathways, compositions and uses related thereto
US7230000B1 (en) 1999-10-27 2007-06-12 Cytokinetics, Incorporated Methods and compositions utilizing quinazolinones
US7671200B2 (en) 1999-10-27 2010-03-02 Cytokinetics, Inc. Quinazolinone KSP inhibitors
US6545004B1 (en) * 1999-10-27 2003-04-08 Cytokinetics, Inc. Methods and compositions utilizing quinazolinones
US8852937B2 (en) 2000-03-30 2014-10-07 Curis, Inc. Small organic molecule regulators of cell proliferation
US7115653B2 (en) 2000-03-30 2006-10-03 Curis, Inc. Small organic molecule regulators of cell proliferation
US6667300B2 (en) 2000-04-25 2003-12-23 Icos Corporation Inhibitors of human phosphatidylinositol 3-kinase delta
JP4259877B2 (ja) * 2000-12-11 2009-04-30 アムジエン・インコーポレーテツド Cxcr3アンタゴニスト
US6992082B2 (en) 2001-01-19 2006-01-31 Cytokinetics, Inc. Phenothiazine kinesin inhibitors
US6809102B2 (en) 2001-03-29 2004-10-26 Bristol-Myers Squibb Company Cyano-substituted dihydropyrimidine compounds and their use to treat diseases
US6900214B2 (en) 2001-03-29 2005-05-31 Bristol-Myers Squibb Company Cyano-substituted dihydropyrimidine compounds and their use to treat diseases
US6794379B2 (en) 2001-06-06 2004-09-21 Tularik Inc. CXCR3 antagonists
OA12624A (en) 2001-06-22 2006-06-12 Pfizer Prod Inc Pharmaceutical compositions comprising low-solubility and/or acid-sensitive drugs and neutralized acidic polymers.
US8349853B2 (en) * 2001-09-05 2013-01-08 Minerva Biotechnologies Corporation Compositions and methods of treatment of cancer
US7060705B2 (en) 2001-11-07 2006-06-13 Merck & Co., Inc. Mitotic kinesin inhibitors
AU2002366103A1 (en) 2001-11-19 2003-06-10 Iconix Pharmaceuticals, Inc. Modulators of rho c activity
WO2003043995A1 (fr) * 2001-11-20 2003-05-30 Cytokinetics, Inc. Procede de racemisation de quinazolinones chirales
CA2468156A1 (fr) 2001-12-06 2003-06-19 Merck & Co., Inc. Inhibiteurs mitotiques de la kinesine
EP1458726B1 (fr) * 2001-12-06 2009-07-15 Merck & Co., Inc. Inhibiteurs miotitiques de la kinesine
US7244723B2 (en) 2001-12-06 2007-07-17 Merck & Co., Inc. Substituted furopyrimidinones as a mitotic kinesin inhibitors
ES2291543T3 (es) 2001-12-06 2008-03-01 MERCK & CO., INC. Inhibicion de kinesina mitotica.
EP1551812B1 (fr) * 2001-12-06 2009-03-04 Merck & Co., Inc. Inhibiteurs mitotiques de la kinesine
US7425636B2 (en) 2001-12-11 2008-09-16 Kyowa Hakko Kogyo Co., Ltd. Thiadiazoline derivative
WO2003094839A2 (fr) * 2002-05-09 2003-11-20 Cytokinetics, Inc. Composes, compositions et procedes
ATE356804T1 (de) * 2002-06-14 2007-04-15 Merck & Co Inc Inhibitoren von mitotischem kinesin
US6949538B2 (en) * 2002-07-17 2005-09-27 Cytokinetics, Inc. Compounds, compositions, and methods
US7208487B2 (en) * 2002-12-13 2007-04-24 Cytokinetics, Incorporated Compounds, compositions and methods
EP1608317B1 (fr) * 2003-03-25 2012-09-26 Takeda Pharmaceutical Company Limited Inhibiteurs de dipeptidyle peptidase
WO2004092123A2 (fr) * 2003-04-10 2004-10-28 Microbia, Inc. Inhibiteurs d'invasion fongique
WO2004092147A1 (fr) 2003-04-18 2004-10-28 Kyowa Hakko Kogyo Co., Ltd. Inihibiteur de kinesine de stade m
EP1636225B1 (fr) 2003-06-20 2010-02-24 Novartis Vaccines and Diagnostics, Inc. Composes de pyridino 1,2-a pyrimidin-4-one servant d'agents anticancereux
AU2004266629B2 (en) * 2003-08-15 2009-11-26 Merck Sharp & Dohme Corp. Mitotic kinesin inhibitors
WO2005051922A1 (fr) 2003-11-25 2005-06-09 Chiron Corporation Composes quinazolinone utilises en tant qu'agents anticancereux
JP2007513154A (ja) * 2003-12-08 2007-05-24 サイトキネティクス・インコーポレーテッド 化合物、組成物及び方法
US7662581B1 (en) 2003-12-18 2010-02-16 Novartis Vaccines And Diagnostics, Inc. Eg5 co-crystals
WO2005060654A2 (fr) 2003-12-19 2005-07-07 Merck & Co., Inc. Inhibiteurs de kinesines mitotiques
JPWO2005061707A1 (ja) * 2003-12-24 2007-07-12 協和醗酵工業株式会社 癌細胞のEg5阻害剤に対する感受性を判定する方法
US7608739B2 (en) * 2004-03-22 2009-10-27 Merck & Co. Inc. Mitotic kinesin inhibitors
DK1737831T3 (da) 2004-04-02 2013-08-19 Prana Biotechnology Ltd Neurologisk aktive forbindelser
LT2612862T (lt) 2004-05-13 2017-01-25 Icos Corporation Chinazolinonai kaip žmogaus fosfatidilinozitol-3-kinazės delta inhibitoriai
ATE404536T1 (de) 2004-05-21 2008-08-15 Novartis Vaccines & Diagnostic Substituierte chinolinderivate als inhibitoren von mitotischem kinesin
WO2005117889A1 (fr) * 2004-05-25 2005-12-15 Icos Corporation Methodes de traitement et/ou de prevention de la proliferation aberrante des cellules hematopoietiques
NZ552510A (en) 2004-06-18 2010-12-24 Novartis Vaccines & Diagnostic N-(1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl) benzamide derivatives and related compounds as kinesin spindle protein (KSP) inhibitors for the treatment of cancer
US7939538B2 (en) 2004-06-28 2011-05-10 Amgen Inc. Compounds, compositions and methods for prevention and treatment of inflammatory and immunoregulatory disorders and diseases
US7375102B2 (en) 2004-06-28 2008-05-20 Amgen Sf, Llc Tetrahydroquinazolin-4(3H)-one-related and tetrahydropyrido[2,3-D]pyrimidin-4(3H)-one-related compounds, compositions and methods for their use
US7271271B2 (en) 2004-06-28 2007-09-18 Amgen Sf, Llc Imidazolo-related compounds, compositions and methods for their use
CA2575188A1 (fr) 2004-08-18 2006-02-23 Astrazeneca Ab Enantiomeres de pyrimidones fusionnes selectionnes et utilisations dans le traitement et la prevention du cancer
EP1811844A4 (fr) * 2004-09-14 2009-12-02 Minerva Biotechnologies Corp Méthodes de diagnostic et de traitement du cancer
AU2005301133A1 (en) 2004-10-19 2006-05-11 Novartis Vaccines And Diagnostics Inc. Indole and benzimidazole derivatives
CA2595127A1 (fr) * 2005-01-19 2006-07-27 Paul J. Coleman Inhibiteurs mitotiques de la kinesine
DE102005011822A1 (de) * 2005-03-15 2006-09-21 Merck Patent Gmbh Phthalazinone
EP1908755A4 (fr) 2005-06-24 2009-06-24 Kyowa Hakko Kirin Co Ltd Agent thérapeutique contre la resténose
MY147188A (en) * 2005-08-09 2012-11-14 Novartis Ag Substituted imidazole compounds as ksp inhibitors
GB0603041D0 (en) 2006-02-15 2006-03-29 Angeletti P Ist Richerche Bio Therapeutic compounds
JP5489333B2 (ja) 2006-09-22 2014-05-14 メルク・シャープ・アンド・ドーム・コーポレーション 脂肪酸合成阻害剤を用いた治療の方法
US8916552B2 (en) 2006-10-12 2014-12-23 Astex Therapeutics Limited Pharmaceutical combinations
JP5528807B2 (ja) 2006-10-12 2014-06-25 アステックス、セラピューティックス、リミテッド 複合薬剤
US20110218176A1 (en) 2006-11-01 2011-09-08 Barbara Brooke Jennings-Spring Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
US8273747B2 (en) 2006-11-02 2012-09-25 Curis, Inc. Small organic molecule regulators of cell proliferation
AU2007323998B2 (en) 2006-11-13 2011-09-22 Novartis Ag Substituted pyrazole and triazole compounds as KSP inhibitors
US7820646B2 (en) 2007-01-05 2010-10-26 Novartis Vaccines And Diagnostics, Inc. Cyclized derivatives as Eg-5 inhibitors
PL2336120T3 (pl) 2007-01-10 2014-12-31 Msd Italia Srl Kombinacje zawierające indazole podstawione grupą amidową jako inhibitory polimerazy poli(ADP-rybozy) (PARP)
MX2009009304A (es) 2007-03-01 2009-11-18 Novartis Ag Inhibidores de cinasa pim y metodos para su uso.
KR20100017866A (ko) 2007-05-21 2010-02-16 노파르티스 아게 Csf-1r 억제제, 조성물 및 사용 방법
AU2008268613A1 (en) 2007-06-22 2008-12-31 Arqule, Inc. Quinazolinone compounds and methods of use thereof
AU2008269154B2 (en) 2007-06-27 2014-06-12 Merck Sharp & Dohme Llc 4-carboxybenzylamino derivatives as histone deacetylase inhibitors
JP5794919B2 (ja) 2008-11-13 2015-10-14 ギリアード カリストガ エルエルシー 血液学的な悪性疾患のための療法
US9492449B2 (en) 2008-11-13 2016-11-15 Gilead Calistoga Llc Therapies for hematologic malignancies
JP2013500257A (ja) 2009-07-21 2013-01-07 ギリアード カリストガ エルエルシー Pi3kインヒビターでの肝障害の処置
CA2805265A1 (fr) 2010-08-02 2012-02-09 Merck Sharp & Dohme Corp. Inhibition a mediation par interference arn de catenine (proteine associee a cadherine), expression du gene beta 1 (ctnnb1) a l'aide de petit acide nucleique interferent (sian)
CA2807307C (fr) 2010-08-17 2021-02-09 Merck Sharp & Dohme Corp. Inhibition mediee par des arn interferents de l'expression genique du virus de l'hepatite b (vhb) a l'aide de petits acides nucleiques interferents (pani)
EP2608669B1 (fr) 2010-08-23 2016-06-22 Merck Sharp & Dohme Corp. Nouveaux dérivés de pyrazolo[1,5-a]pyrimidine utilisés comme inhibiteurs de mtor
EP2615916B1 (fr) 2010-09-16 2017-01-04 Merck Sharp & Dohme Corp. Dérivés condensés de pyrazole utilisés comme nouveaux inhibiteurs erk
ES2663009T3 (es) 2010-10-29 2018-04-10 Sirna Therapeutics, Inc. Inhibición de la expresión génica mediada por interferencia por ARN utilizando ácidos nucleicos de interferencia cortos (ANic)
JP2014514321A (ja) 2011-04-21 2014-06-19 メルク・シャープ・アンド・ドーム・コーポレーション インスリン様増殖因子1受容体阻害剤
CA2864305C (fr) 2012-03-05 2021-02-16 Gilead Calistoga Llc Formes polymorphes de l'acide -2-(1-(9h-purine-6-ylamino)propyl)-5-fluoro-3-phenylquinazolin-4(3h)-one
EP3358013B1 (fr) 2012-05-02 2020-06-24 Sirna Therapeutics, Inc. Compositions d'acide nucléique interférent court (sina)
TW201437203A (zh) 2012-12-21 2014-10-01 Gilead Calistoga Llc 磷脂醯肌醇3-激酶之抑制劑
ES2677919T3 (es) 2012-12-21 2018-08-07 Gilead Calistoga Llc Aminoalquil-quinazolonas sustituidas con pirimidina como inhibidores de la fosfatidilinositol 3-quinasa
EP3008053B1 (fr) 2013-06-14 2018-03-21 Gilead Calistoga LLC Inhibiteurs de phosphatidylinositol 3-kinase
EP3041938A1 (fr) 2013-09-03 2016-07-13 Moderna Therapeutics, Inc. Polynucléotides circulaires
US9567337B2 (en) 2013-12-20 2017-02-14 Gilead Calistoga Llc Process methods for phosphatidylinositol 3-kinase inhibitors
WO2015095605A1 (fr) 2013-12-20 2015-06-25 Gilead Calistoga Llc Formes polymorphes d'un sel chlorhydrate de la (s)-2-(9h-purine-6-ylamino)propyl)-5-fluoro-3-phénylquinazolin-4(3h)-one
KR20170015508A (ko) 2014-06-13 2017-02-08 길리애드 사이언시즈, 인코포레이티드 포스파티딜이노시톨 3-키나제 억제제로서의 퀴나졸리논 유도체
WO2015191726A1 (fr) 2014-06-13 2015-12-17 Gilead Sciences, Inc. Inhibiteurs de la phosphatidylinositol 3-kinase
SG11201609540TA (en) 2014-06-13 2016-12-29 Gilead Sciences Inc Phosphatidylinositol 3-kinase inhibitors
US10092563B2 (en) 2014-06-13 2018-10-09 Gilead Sciences, Inc. Phosphatidylinositol 3-kinase inhibitors
JO3589B1 (ar) 2014-08-06 2020-07-05 Novartis Ag مثبطات كيناز البروتين c وطرق استخداماتها
WO2017003723A1 (fr) 2015-07-01 2017-01-05 Crinetics Pharmaceuticals, Inc. Modulateurs de la somatostatine et leurs utilisations
TW201825465A (zh) 2016-09-23 2018-07-16 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
TW201813963A (zh) 2016-09-23 2018-04-16 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
TW201815787A (zh) 2016-09-23 2018-05-01 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
WO2019023278A1 (fr) 2017-07-25 2019-01-31 Crinetics Pharmaceuticals, Inc. Modulateurs de la somatostatine et utilisations de ces derniers
CN111189935A (zh) * 2019-12-30 2020-05-22 卓和药业集团有限公司 盐酸右美托咪定的高效液相色谱分析方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU543928B2 (en) * 1981-01-16 1985-05-09 Masayuki Ishikawa 4(311)-quinazolinone derivatives
ES2245015T3 (es) * 1997-06-09 2005-12-16 Pfizer Products Inc. Quinazolin-4-onas como antagonistas de ampa.
US6545004B1 (en) * 1999-10-27 2003-04-08 Cytokinetics, Inc. Methods and compositions utilizing quinazolinones

Also Published As

Publication number Publication date
JP4116332B2 (ja) 2008-07-09
NO20021907D0 (no) 2002-04-23
EP1686120A2 (fr) 2006-08-02
KR20050049562A (ko) 2005-05-25
AU1439801A (en) 2001-05-08
HK1045994A1 (en) 2002-12-20
EP1226129B1 (fr) 2006-05-24
EP1226129A1 (fr) 2002-07-31
IL149164A (en) 2007-05-15
KR20020062930A (ko) 2002-07-31
NO20021907L (no) 2002-06-07
NZ518480A (en) 2004-02-27
ATE327224T1 (de) 2006-06-15
AU2004218601A1 (en) 2004-10-28
AU774748B2 (en) 2004-07-08
PL203998B1 (pl) 2009-11-30
NZ530074A (en) 2005-03-24
CA2388646A1 (fr) 2001-05-03
JP2003512461A (ja) 2003-04-02
DE60028227T2 (de) 2007-03-29
EP1686120A3 (fr) 2007-05-30
BR0015110A (pt) 2002-07-02
IL149164A0 (en) 2002-11-10
CA2388646C (fr) 2009-01-27
WO2001030768A1 (fr) 2001-05-03
JP2003048881A (ja) 2003-02-21
CN100381428C (zh) 2008-04-16
HUP0203430A3 (en) 2003-07-28
CN1413198A (zh) 2003-04-23
MXPA02004162A (es) 2003-08-20
PL354891A1 (en) 2004-03-22
CZ20021428A3 (cs) 2002-11-13
ES2263501T3 (es) 2006-12-16
WO2001030768A9 (fr) 2002-08-15
DE60028227D1 (de) 2006-06-29
HUP0203430A2 (en) 2003-05-28

Similar Documents

Publication Publication Date Title
NO322825B1 (no) Kinazolinoner, syntese av slike, anvendelse av slike for fremstilling av medikamenter for behandling av proliferative sykdommer, farmasoytiske preparater inneholdende slike forbindelser samt anvendelse in vitro for a hemme KSP-kinase.
NO324440B1 (no) Kinazolinoner, anvendelse av disse forbindelsene som medikament og i farmasoytiske preparater, anvendelse av disse forbindelsene for fremstilling av medikamenter for behandling av sykdommer og en in vitro metode for a hemme KSP-kinesin basert pa slike forbindelser
US7230000B1 (en) Methods and compositions utilizing quinazolinones
US8008311B2 (en) Methods and compostions utilizing quinazolinones
AU2001259270A1 (en) Methods and compositions utilizing quinazolinones
ZA200210133B (en) Methods and compositions utilizing quinazolinones.

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees