NO322206B1 - Farmasoytisk sammensetning som har antitumoraktivitet med reduserte bivirkninger, inneholdende et antitumormiddel og O-(3-piperidino-2-hydroksy-1-propyl) nikotin amidoksim og anvendelse av amidoksimet til fremstilling av en antitumor farmasoytisk sammensetning som reduserer bivirkningene. - Google Patents

Farmasoytisk sammensetning som har antitumoraktivitet med reduserte bivirkninger, inneholdende et antitumormiddel og O-(3-piperidino-2-hydroksy-1-propyl) nikotin amidoksim og anvendelse av amidoksimet til fremstilling av en antitumor farmasoytisk sammensetning som reduserer bivirkningene. Download PDF

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Publication number
NO322206B1
NO322206B1 NO19996349A NO996349A NO322206B1 NO 322206 B1 NO322206 B1 NO 322206B1 NO 19996349 A NO19996349 A NO 19996349A NO 996349 A NO996349 A NO 996349A NO 322206 B1 NO322206 B1 NO 322206B1
Authority
NO
Norway
Prior art keywords
pharmaceutical composition
antitumor
side effects
group
amidoxime
Prior art date
Application number
NO19996349A
Other languages
English (en)
Norwegian (no)
Other versions
NO996349D0 (no
NO996349L (no
Inventor
Balazs Suemegi
Original Assignee
N Gene Res Lab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by N Gene Res Lab Inc filed Critical N Gene Res Lab Inc
Publication of NO996349D0 publication Critical patent/NO996349D0/no
Publication of NO996349L publication Critical patent/NO996349L/no
Publication of NO322206B1 publication Critical patent/NO322206B1/no

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
NO19996349A 1997-06-23 1999-12-20 Farmasoytisk sammensetning som har antitumoraktivitet med reduserte bivirkninger, inneholdende et antitumormiddel og O-(3-piperidino-2-hydroksy-1-propyl) nikotin amidoksim og anvendelse av amidoksimet til fremstilling av en antitumor farmasoytisk sammensetning som reduserer bivirkningene. NO322206B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU9701081A HU9701081D0 (en) 1997-06-23 1997-06-23 Pharmaceutical composition of antitumoral activity
PCT/IB1998/000961 WO1998058676A1 (en) 1997-06-23 1998-06-22 Pharmaceutical composition having enhanced antitumor activity and/or reduced side effects, containing an antitumor agent and an hydroxamic acid derivative

Publications (3)

Publication Number Publication Date
NO996349D0 NO996349D0 (no) 1999-12-20
NO996349L NO996349L (no) 2000-02-23
NO322206B1 true NO322206B1 (no) 2006-08-28

Family

ID=89995266

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19996349A NO322206B1 (no) 1997-06-23 1999-12-20 Farmasoytisk sammensetning som har antitumoraktivitet med reduserte bivirkninger, inneholdende et antitumormiddel og O-(3-piperidino-2-hydroksy-1-propyl) nikotin amidoksim og anvendelse av amidoksimet til fremstilling av en antitumor farmasoytisk sammensetning som reduserer bivirkningene.

Country Status (25)

Country Link
US (4) US6440998B1 (ru)
EP (1) EP0993304B1 (ru)
JP (1) JP2002508762A (ru)
KR (1) KR20010020496A (ru)
CN (1) CN1127984C (ru)
AT (1) ATE235918T1 (ru)
AU (1) AU735922B2 (ru)
BR (1) BR9810312A (ru)
CA (1) CA2294913C (ru)
CZ (1) CZ298468B6 (ru)
DE (1) DE69812949T2 (ru)
DK (1) DK0993304T3 (ru)
ES (1) ES2195344T3 (ru)
HK (1) HK1029941A1 (ru)
HU (1) HU9701081D0 (ru)
IL (1) IL133508A (ru)
NO (1) NO322206B1 (ru)
NZ (1) NZ502039A (ru)
PL (1) PL191718B1 (ru)
PT (1) PT993304E (ru)
RU (2) RU2214238C2 (ru)
SK (1) SK282877B6 (ru)
TR (1) TR199903214T2 (ru)
UA (1) UA64757C2 (ru)
WO (1) WO1998058676A1 (ru)

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US20030158220A1 (en) * 1997-11-03 2003-08-21 Foss Joseph F. Use of methylnaltrexone and related compounds to treat chronic opioid use side effects
DK2368554T3 (en) * 2003-04-08 2015-01-26 Progenics Pharm Inc A pharmaceutical composition comprising methylnaltrexone
US8524731B2 (en) 2005-03-07 2013-09-03 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
US8518962B2 (en) 2005-03-07 2013-08-27 The University Of Chicago Use of opioid antagonists
US9662325B2 (en) 2005-03-07 2017-05-30 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
MX2007010833A (es) * 2005-03-07 2009-02-17 Univ Chicago Uso de antagonistas opioides para atenuar proliferacion y migracion de células endoteliales.
AR057035A1 (es) 2005-05-25 2007-11-14 Progenics Pharm Inc SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS
AR057325A1 (es) * 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos
TW200817048A (en) * 2006-09-08 2008-04-16 Wyeth Corp Dry powder compound formulations and uses thereof
US20080108602A1 (en) * 2006-11-02 2008-05-08 N-Gene Research Laboratories, Inc. Prevention of obesity in antipsychotic, antidepressant and antiepileptic medication
US7763601B2 (en) * 2006-11-02 2010-07-27 N-Gene Research Laboratories, Inc. Prevention and treatment of obesity
SI2565195T1 (sl) 2007-03-29 2015-09-30 Wyeth Llc Periferalni opioidni receptorji in antagonisti in njih uporaba
CA2865661C (en) 2007-03-29 2016-05-17 Progenics Pharmaceuticals, Inc. Peripheral opioid receptor antagonists and uses thereof
CN101801979A (zh) 2007-03-29 2010-08-11 普罗热尼奇制药公司 (r)-n-溴化甲基纳曲酮的晶体形式及其用途
MX2010004859A (es) * 2007-10-30 2010-06-21 Trophos Nueva composicion para tratar los efectos secundarios del tratamiento anticanceroso.
US20090281143A1 (en) * 2007-12-10 2009-11-12 N-Gene Research Laboratories, Inc. Dose Reduction of a Cannabinoid CB1 Receptor Antagonist in the Treatment of Overweight or Obesity
JP5358587B2 (ja) 2008-02-06 2013-12-04 プロジェニックス・ファーマシューティカルス・インコーポレイテッド (r),(r)−2,2’−ビス−メチルナルトレキソンの製造及び用途
CA2719134C (en) * 2008-03-21 2015-06-30 The University Of Chicago Treatment with opioid antagonists and mtor inhibitors
CA2676881C (en) 2008-09-30 2017-04-25 Wyeth Peripheral opioid receptor antagonists and uses thereof
ITMI20110792A1 (it) 2011-05-09 2012-11-10 Probiotical Spa Ceppi di batteri appartenenti al genere bifidobacterium per uso nel trattamento della ipercolesterolemia.
ITMI20110791A1 (it) 2011-05-09 2012-11-10 Probiotical Spa Ceppi di batteri in grado di metabolizzare gli ossalati.
ITMI20110793A1 (it) 2011-05-09 2012-11-10 Probiotical Spa Ceppi di batteri probiotici e composizione sinbiotica contenente gli stessi destinata alla alimentazione dei neonati.
HUP1100444A2 (en) 2011-08-17 2013-02-28 Pharma Gene Sa Pharmaceutical composition
HUP1100445A2 (en) * 2011-08-17 2013-02-28 Pharma Gene Sa Pharmaceutical composition
RU2522548C2 (ru) * 2012-09-26 2014-07-20 Федеральное государственное бюджетное учреждение науки Институт кристаллографии им. А.В. Шубникова Российской академии наук (ИК РАН) Ингибитор уридинфосфорилаз
US9938279B2 (en) * 2013-04-09 2018-04-10 Energenesis Biomedical Co., Ltd Method for treating disease or condition susceptible to amelioration by AMPK activators and compounds of formula which are useful to activate AMP-activated protein kinase (AMPK)
CN116492347A (zh) * 2013-09-18 2023-07-28 华安医学股份有限公司 一种活化ampk的化合物及其用途
RU2679136C1 (ru) * 2018-03-13 2019-02-06 Федеральное государственное бюджетное научное учреждение "Федеральный исследовательский центр "Красноярский научный центр Сибирского отделения Российской академии наук" (ФИЦ КНЦ СО РАН, КНЦ СО РАН) Способ получения препарата на основе взаимодействия цис-диамин(циклобутан-1,1-дикарбоксилат-о,о')платины(ii) с арабиногалактаном
HUP1800298A1 (hu) 2018-08-30 2020-05-28 N Gene Res Laboratories Inc Gyógyszerkombináció béta-receptor blokkolók hatásának módosítására és a mellékhatások csökkentésére

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US4308399A (en) * 1977-08-30 1981-12-29 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. O-(3-Amino-2-hydroxy-propyl)-amidoxime derivatives, process for the preparation thereof and pharmaceutical compositions containing same
HU207988B (en) * 1988-10-20 1993-07-28 Biorex Kutato Fejlesztoe Kft Process for producing halogenides of o-/3-amino-2-hydroxy-propyl/hydroximic acid and pharmaceutical compositions containing them as active components
HUT54347A (en) * 1989-01-10 1991-02-28 Chinoin Gyogyszer Es Vegyeszet Improved process for producing amidoximes
CN1090186C (zh) * 1993-03-31 2002-09-04 麦克公司 治疗aids药物组合物中的hiv蛋白酶抑制剂
TW381025B (en) * 1993-08-05 2000-02-01 Hoffmann La Roche Pharmaceutical composition containing a glucosidase inhibitor and a lipase inhibitor
HU9502843D0 (en) * 1995-09-29 1995-11-28 Livigene Ltd Pharmaceutical composition
UA64716C2 (en) * 1996-08-09 2004-03-15 Pharmaceuticals for therapy or prevention of illnesses connected with dysfunction of vascular endothelial cells

Also Published As

Publication number Publication date
CZ462599A3 (cs) 2000-05-17
SK282877B6 (sk) 2003-01-09
NO996349D0 (no) 1999-12-20
PT993304E (pt) 2003-08-29
RU2254129C2 (ru) 2005-06-20
US6720337B2 (en) 2004-04-13
US20030069270A1 (en) 2003-04-10
EP0993304A1 (en) 2000-04-19
CZ298468B6 (cs) 2007-10-10
ES2195344T3 (es) 2003-12-01
ATE235918T1 (de) 2003-04-15
US6440998B1 (en) 2002-08-27
US20020147213A1 (en) 2002-10-10
RU2214238C2 (ru) 2003-10-20
CA2294913A1 (en) 1998-12-30
DE69812949T2 (de) 2004-02-05
IL133508A (en) 2005-11-20
NZ502039A (en) 2002-03-28
IL133508A0 (en) 2001-04-30
NO996349L (no) 2000-02-23
US20030050345A1 (en) 2003-03-13
PL337719A1 (en) 2000-08-28
HU9701081D0 (en) 1997-08-28
KR20010020496A (ko) 2001-03-15
TR199903214T2 (xx) 2000-12-21
WO1998058676A1 (en) 1998-12-30
JP2002508762A (ja) 2002-03-19
US6656955B2 (en) 2003-12-02
CN1127984C (zh) 2003-11-19
PL191718B1 (pl) 2006-06-30
SK176499A3 (en) 2000-09-12
CN1263471A (zh) 2000-08-16
UA64757C2 (ru) 2004-03-15
BR9810312A (pt) 2000-09-19
DE69812949D1 (de) 2003-05-08
EP0993304B1 (en) 2003-04-02
HK1029941A1 (en) 2001-04-20
AU7783798A (en) 1999-01-04
AU735922B2 (en) 2001-07-19
DK0993304T3 (da) 2003-07-28
US6838469B2 (en) 2005-01-04
CA2294913C (en) 2008-12-16

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