NO320494B1 - Renset protein med antagonistisk aktivitet mot minst en av forbindelsene valgt fra gruppen bestaende av interleukin-1-a og interleikun-1-b, isolert DNA sekvens, vektor, vertscelle, og fremgangsmater og anvendelser derav. - Google Patents
Renset protein med antagonistisk aktivitet mot minst en av forbindelsene valgt fra gruppen bestaende av interleukin-1-a og interleikun-1-b, isolert DNA sekvens, vektor, vertscelle, og fremgangsmater og anvendelser derav. Download PDFInfo
- Publication number
- NO320494B1 NO320494B1 NO19971624A NO971624A NO320494B1 NO 320494 B1 NO320494 B1 NO 320494B1 NO 19971624 A NO19971624 A NO 19971624A NO 971624 A NO971624 A NO 971624A NO 320494 B1 NO320494 B1 NO 320494B1
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- lra
- icel
- sequence
- interleukin
- dna sequence
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Classifications
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI942097A IT1270662B (it) | 1994-10-13 | 1994-10-13 | Antagonista della interleuchina-1 |
| PCT/EP1995/004023 WO1996012022A1 (en) | 1994-10-13 | 1995-10-12 | Intracellular isoform of the interleukin-1 receptor antagonist |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO971624D0 NO971624D0 (no) | 1997-04-09 |
| NO971624L NO971624L (no) | 1997-05-30 |
| NO320494B1 true NO320494B1 (no) | 2005-12-12 |
Family
ID=11369705
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19971624A NO320494B1 (no) | 1994-10-13 | 1997-04-09 | Renset protein med antagonistisk aktivitet mot minst en av forbindelsene valgt fra gruppen bestaende av interleukin-1-a og interleikun-1-b, isolert DNA sekvens, vektor, vertscelle, og fremgangsmater og anvendelser derav. |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US5739282A (de) |
| EP (1) | EP0786002B1 (de) |
| JP (1) | JPH10509306A (de) |
| KR (1) | KR100237936B1 (de) |
| CN (2) | CN1224707C (de) |
| AT (1) | ATE303439T1 (de) |
| BR (1) | BR9509317A (de) |
| CA (1) | CA2202470C (de) |
| DE (1) | DE69534419T2 (de) |
| EE (1) | EE03697B1 (de) |
| ES (1) | ES2243942T3 (de) |
| HK (2) | HK1002659A1 (de) |
| IT (1) | IT1270662B (de) |
| MX (1) | MX9702616A (de) |
| NO (1) | NO320494B1 (de) |
| PT (1) | PT786002E (de) |
| RU (1) | RU2193064C2 (de) |
| UA (1) | UA65522C2 (de) |
| WO (1) | WO1996012022A1 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5075222A (en) * | 1988-05-27 | 1991-12-24 | Synergen, Inc. | Interleukin-1 inhibitors |
| US5872095A (en) * | 1990-05-01 | 1999-02-16 | Chiron Corporation | IL-1 receptor antagonists medicaments |
| IL129669A0 (en) | 1996-10-31 | 2000-02-29 | Applied Research Systems | Ice inhibiting peptides |
| JP4771563B2 (ja) * | 1996-12-06 | 2011-09-14 | アムジエン・インコーポレーテツド | Ｉｌ−１媒介疾患を処置するためにｉｌ−１インヒビターを使用する組合せ療法 |
| US6294170B1 (en) | 1997-08-08 | 2001-09-25 | Amgen Inc. | Composition and method for treating inflammatory diseases |
| IL126562A0 (en) * | 1998-10-14 | 1999-08-17 | Interpharm Lab Ltd | Expression and secretion of icil-1 receptor antagonist type ii |
| US20020077276A1 (en) * | 1999-04-27 | 2002-06-20 | Fredeking Terry M. | Compositions and methods for treating hemorrhagic virus infections and other disorders |
| US7166712B2 (en) * | 2000-07-12 | 2007-01-23 | Philadelphia, Health And Education Corporation | Mammalian MDM2 binding proteins and uses thereof |
| EP1703893B1 (de) * | 2003-12-23 | 2012-04-11 | Genentech, Inc. | Neue anti-il 13-antikörper und verwendungen dafür |
| AU2005269995C1 (en) | 2004-07-06 | 2011-12-01 | Zymogenetics, Inc. | Pharmaceutical composition comprising FGF18 and IL-1 antagonist and method of use |
| CN101918018B (zh) | 2007-11-14 | 2012-12-05 | 再生医药有限公司 | 使用白介素-1受体拮抗剂作为骨髓保护剂的方法 |
| CN101690801B (zh) | 2009-10-26 | 2012-08-01 | 上海交通大学 | 白细胞介素-1受体拮抗剂的用途及其药物组合物 |
| US9359405B2 (en) | 2011-03-14 | 2016-06-07 | Phlogo Aps | Antagonists of the interleukin-1 receptor |
| JP6234446B2 (ja) | 2012-06-08 | 2017-11-22 | アルカーメス，インコーポレイテッド | ムチンドメインポリペプチドに連結された活性タンパク質を含む融合ポリペプチド |
| US20160000936A1 (en) | 2014-06-10 | 2016-01-07 | Abbvie Inc. | Biomarkers for inflammatory disease and methods of using same |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR0148009B1 (ko) * | 1988-05-27 | 1998-08-01 | 그래고리 비. 아보트 | 인터루킨-1 억제제 |
| HUT64582A (en) * | 1989-11-29 | 1994-01-28 | Synergen Inc | Method for producing recombinant human interleukin-1 inhibitor |
| AU649245B2 (en) * | 1990-04-02 | 1994-05-19 | Amgen, Inc. | Methods for treating interleukin-1 mediated diseases |
| AU7683391A (en) * | 1990-04-27 | 1991-11-27 | Upjohn Company, The | Modified interleukin-1 inhibitors |
| ATE178094T1 (de) * | 1990-05-01 | 1999-04-15 | Chiron Corp | Interleukin-i antagonist und seine verwendung |
-
1994
- 1994-10-13 IT ITMI942097A patent/IT1270662B/it active IP Right Grant
-
1995
- 1995-06-07 US US08/476,860 patent/US5739282A/en not_active Expired - Fee Related
- 1995-10-12 ES ES95936482T patent/ES2243942T3/es not_active Expired - Lifetime
- 1995-10-12 CA CA002202470A patent/CA2202470C/en not_active Expired - Fee Related
- 1995-10-12 CN CNB951956647A patent/CN1224707C/zh not_active Expired - Fee Related
- 1995-10-12 AT AT95936482T patent/ATE303439T1/de not_active IP Right Cessation
- 1995-10-12 KR KR1019970701931A patent/KR100237936B1/ko not_active IP Right Cessation
- 1995-10-12 PT PT95936482T patent/PT786002E/pt unknown
- 1995-10-12 CN CNB200510053993XA patent/CN100363053C/zh not_active Expired - Fee Related
- 1995-10-12 EP EP95936482A patent/EP0786002B1/de not_active Expired - Lifetime
- 1995-10-12 WO PCT/EP1995/004023 patent/WO1996012022A1/en active IP Right Grant
- 1995-10-12 MX MX9702616A patent/MX9702616A/es not_active IP Right Cessation
- 1995-10-12 BR BR9509317A patent/BR9509317A/pt not_active Application Discontinuation
- 1995-10-12 DE DE69534419T patent/DE69534419T2/de not_active Expired - Fee Related
- 1995-10-12 RU RU97107461/13A patent/RU2193064C2/ru not_active IP Right Cessation
- 1995-10-12 JP JP8512932A patent/JPH10509306A/ja active Pending
- 1995-10-12 EE EE9700090A patent/EE03697B1/xx not_active IP Right Cessation
- 1995-12-10 UA UA97052129A patent/UA65522C2/uk unknown
-
1997
- 1997-04-09 NO NO19971624A patent/NO320494B1/no not_active IP Right Cessation
-
1998
- 1998-02-27 HK HK98101565A patent/HK1002659A1/xx not_active IP Right Cessation
-
2006
- 2006-03-22 HK HK06103612A patent/HK1081124A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EE9700090A (et) | 1997-10-15 |
| NO971624L (no) | 1997-05-30 |
| KR970706391A (ko) | 1997-11-03 |
| EP0786002B1 (de) | 2005-08-31 |
| CA2202470A1 (en) | 1996-04-25 |
| HK1002659A1 (en) | 1998-09-11 |
| BR9509317A (pt) | 1997-10-14 |
| CN100363053C (zh) | 2008-01-23 |
| CA2202470C (en) | 2008-09-16 |
| EE03697B1 (et) | 2002-04-15 |
| IT1270662B (it) | 1997-05-07 |
| CN1224707C (zh) | 2005-10-26 |
| CN1679919A (zh) | 2005-10-12 |
| JPH10509306A (ja) | 1998-09-14 |
| ITMI942097A0 (it) | 1994-10-13 |
| MX9702616A (es) | 1998-04-30 |
| WO1996012022A1 (en) | 1996-04-25 |
| EP0786002A1 (de) | 1997-07-30 |
| ES2243942T3 (es) | 2005-12-01 |
| AU701471B2 (en) | 1999-01-28 |
| US5739282A (en) | 1998-04-14 |
| AU3841795A (en) | 1996-05-06 |
| DE69534419T2 (de) | 2006-06-14 |
| DE69534419D1 (de) | 2005-10-06 |
| UA65522C2 (en) | 2004-04-15 |
| NO971624D0 (no) | 1997-04-09 |
| RU2193064C2 (ru) | 2002-11-20 |
| HK1081124A1 (en) | 2006-05-12 |
| CN1161058A (zh) | 1997-10-01 |
| ATE303439T1 (de) | 2005-09-15 |
| ITMI942097A1 (it) | 1996-04-13 |
| KR100237936B1 (ko) | 2000-01-15 |
| PT786002E (pt) | 2005-11-30 |
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