NO320120B1 - Isolert intakt aminoterminalt propeptid av type 1 prokollagen, fremgangsmate for fremstilling derav, antistoff spesifikt for nevnte propeptid, fremgangsmate for analyse av nevnte propeptid, og analysetestsett som omfatter antistoffet og fremgangsmate for separasjon av to former av propeptid. - Google Patents
Isolert intakt aminoterminalt propeptid av type 1 prokollagen, fremgangsmate for fremstilling derav, antistoff spesifikt for nevnte propeptid, fremgangsmate for analyse av nevnte propeptid, og analysetestsett som omfatter antistoffet og fremgangsmate for separasjon av to former av propeptid. Download PDFInfo
- Publication number
- NO320120B1 NO320120B1 NO19961543A NO961543A NO320120B1 NO 320120 B1 NO320120 B1 NO 320120B1 NO 19961543 A NO19961543 A NO 19961543A NO 961543 A NO961543 A NO 961543A NO 320120 B1 NO320120 B1 NO 320120B1
- Authority
- NO
- Norway
- Prior art keywords
- propeptide
- antibody
- procollagen
- type
- amino
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 45
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 title claims description 6
- 238000000926 separation method Methods 0.000 title claims description 5
- 108010050808 Procollagen Proteins 0.000 title description 11
- 238000013096 assay test Methods 0.000 title 1
- 102100036213 Collagen alpha-2(I) chain Human genes 0.000 claims description 45
- 101000875067 Homo sapiens Collagen alpha-2(I) chain Proteins 0.000 claims description 45
- 238000004458 analytical method Methods 0.000 claims description 17
- 239000003550 marker Substances 0.000 claims description 14
- 239000000463 material Substances 0.000 claims description 8
- 238000000746 purification Methods 0.000 claims description 7
- 102000004190 Enzymes Human genes 0.000 claims description 6
- 108090000790 Enzymes Proteins 0.000 claims description 6
- 102000035195 Peptidases Human genes 0.000 claims description 6
- 108091005804 Peptidases Proteins 0.000 claims description 6
- 238000004587 chromatography analysis Methods 0.000 claims description 6
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- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 2
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- VDQQXEISLMTGAB-UHFFFAOYSA-N chloramine T Chemical compound [Na+].CC1=CC=C(S(=O)(=O)[N-]Cl)C=C1 VDQQXEISLMTGAB-UHFFFAOYSA-N 0.000 description 1
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- 229960001479 tosylchloramide sodium Drugs 0.000 description 1
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- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Urology & Nephrology (AREA)
- Genetics & Genomics (AREA)
- Hematology (AREA)
- Zoology (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9507985.1A GB9507985D0 (en) | 1995-04-19 | 1995-04-19 | Antibody to aminoterminal propeptide to type 1 procollagen and assay method using it |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO961543D0 NO961543D0 (no) | 1996-04-18 |
| NO961543L NO961543L (no) | 1996-10-21 |
| NO320120B1 true NO320120B1 (no) | 2005-10-31 |
Family
ID=10773218
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19961543A NO320120B1 (no) | 1995-04-19 | 1996-04-18 | Isolert intakt aminoterminalt propeptid av type 1 prokollagen, fremgangsmate for fremstilling derav, antistoff spesifikt for nevnte propeptid, fremgangsmate for analyse av nevnte propeptid, og analysetestsett som omfatter antistoffet og fremgangsmate for separasjon av to former av propeptid. |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US5895746A (ja) |
| EP (1) | EP0738735B1 (ja) |
| JP (1) | JP3245052B2 (ja) |
| AT (1) | ATE250084T1 (ja) |
| AU (1) | AU707232B2 (ja) |
| CA (1) | CA2174559C (ja) |
| DE (1) | DE69629976T2 (ja) |
| DK (1) | DK0738735T3 (ja) |
| ES (1) | ES2207665T3 (ja) |
| GB (1) | GB9507985D0 (ja) |
| NO (1) | NO320120B1 (ja) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030087318A1 (en) * | 1994-04-18 | 2003-05-08 | Lallone Roger L. | Antibodies against an extracellular matrix complex and their use in the detection of cancer |
| US20030082179A1 (en) * | 2001-07-03 | 2003-05-01 | Hutchison James Scott | Parathyroid hormone antibodies and related methods |
| CN102690347B (zh) * | 2012-05-18 | 2014-06-25 | 北京北方生物技术研究所 | 分离i型前胶原氨基末端肽的方法 |
| KR20210093251A (ko) * | 2018-10-16 | 2021-07-27 | 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 | 암 및 다른 질환의 진단 및 치료를 위한 병원성 세포외 매트릭스의 동정 및 표적화 |
| US20210371825A1 (en) * | 2018-10-16 | 2021-12-02 | Board Of Regents, The University Of Texas System | Compositions for and methods of producing tumor organoids |
| CN111007269A (zh) * | 2019-11-15 | 2020-04-14 | 迪瑞医疗科技股份有限公司 | 总ⅰ型胶原氨基端延长肽化学发光免疫检测试剂盒及其制备方法 |
| CN112326972A (zh) * | 2020-10-30 | 2021-02-05 | 安徽理工大学 | 一种检测血清中完整pinp的化学发光定量检测试剂盒 |
| WO2023182353A1 (ja) * | 2022-03-25 | 2023-09-28 | 積水メディカル株式会社 | 免疫学的検出方法及び免疫学的検出キット |
| WO2023182343A1 (ja) * | 2022-03-25 | 2023-09-28 | 積水メディカル株式会社 | 免疫学的検出方法及び免疫学的検出キット |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2208865B (en) * | 1987-08-19 | 1991-12-11 | Farmos Group Ltd | Purified propeptide of procollagen type iii, antibody to the propeptide and assay method using the antibody. |
| GB9014220D0 (en) * | 1990-06-26 | 1990-08-15 | Farmos Yhtymy Oy | Method for the immunlolgical determinition of the carboxyterminal propeptide of type i procollagen |
| GB9105893D0 (en) * | 1991-03-20 | 1991-05-08 | Orion Yhtymae Oy | Bone resorption assay based on a peptide liberated during collagen degradation |
| WO1993015107A1 (en) * | 1992-01-31 | 1993-08-05 | Baylink David J | Amino procollagen 1(i) peptides |
-
1995
- 1995-04-19 GB GBGB9507985.1A patent/GB9507985D0/en active Pending
- 1995-06-07 US US08/480,822 patent/US5895746A/en not_active Expired - Lifetime
-
1996
- 1996-04-16 DE DE69629976T patent/DE69629976T2/de not_active Expired - Lifetime
- 1996-04-16 ES ES96302639T patent/ES2207665T3/es not_active Expired - Lifetime
- 1996-04-16 DK DK96302639T patent/DK0738735T3/da active
- 1996-04-16 EP EP96302639A patent/EP0738735B1/en not_active Expired - Lifetime
- 1996-04-16 AT AT96302639T patent/ATE250084T1/de active
- 1996-04-17 AU AU50695/96A patent/AU707232B2/en not_active Expired
- 1996-04-18 JP JP12246896A patent/JP3245052B2/ja not_active Expired - Lifetime
- 1996-04-18 NO NO19961543A patent/NO320120B1/no not_active IP Right Cessation
- 1996-04-19 CA CA2174559A patent/CA2174559C/en not_active Expired - Lifetime
-
1998
- 1998-03-02 US US09/033,311 patent/US6090920A/en not_active Expired - Lifetime
- 1998-03-02 US US09/033,310 patent/US6093803A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DK0738735T3 (da) | 2003-12-29 |
| AU5069596A (en) | 1996-10-31 |
| NO961543L (no) | 1996-10-21 |
| EP0738735A3 (en) | 1999-01-20 |
| NO961543D0 (no) | 1996-04-18 |
| ES2207665T3 (es) | 2004-06-01 |
| EP0738735B1 (en) | 2003-09-17 |
| GB9507985D0 (en) | 1995-06-07 |
| EP0738735A2 (en) | 1996-10-23 |
| JPH08291197A (ja) | 1996-11-05 |
| CA2174559C (en) | 2010-10-19 |
| CA2174559A1 (en) | 1996-10-20 |
| US6090920A (en) | 2000-07-18 |
| DE69629976T2 (de) | 2004-07-22 |
| DE69629976D1 (de) | 2003-10-23 |
| ATE250084T1 (de) | 2003-10-15 |
| US5895746A (en) | 1999-04-20 |
| US6093803A (en) | 2000-07-25 |
| JP3245052B2 (ja) | 2002-01-07 |
| AU707232B2 (en) | 1999-07-08 |
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