NO319791B1 - Benzamidderivater og legemidler som inneholder disse, samt anvendelse av derivatene til fremstilling av medikamenter. - Google Patents
Benzamidderivater og legemidler som inneholder disse, samt anvendelse av derivatene til fremstilling av medikamenter. Download PDFInfo
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- NO319791B1 NO319791B1 NO20013816A NO20013816A NO319791B1 NO 319791 B1 NO319791 B1 NO 319791B1 NO 20013816 A NO20013816 A NO 20013816A NO 20013816 A NO20013816 A NO 20013816A NO 319791 B1 NO319791 B1 NO 319791B1
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- Prior art keywords
- acid
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- compound
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- amino
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- 239000003814 drug Substances 0.000 title claims description 17
- 229940079593 drug Drugs 0.000 title claims description 16
- 238000004519 manufacturing process Methods 0.000 title claims description 5
- 150000003936 benzamides Chemical class 0.000 title description 6
- 150000001875 compounds Chemical class 0.000 claims description 55
- 150000003839 salts Chemical class 0.000 claims description 26
- 125000004432 carbon atom Chemical group C* 0.000 claims description 13
- 230000004899 motility Effects 0.000 claims description 13
- 125000000217 alkyl group Chemical group 0.000 claims description 12
- 210000001035 gastrointestinal tract Anatomy 0.000 claims description 12
- 210000002784 stomach Anatomy 0.000 claims description 7
- 208000010643 digestive system disease Diseases 0.000 claims description 6
- 230000001225 therapeutic effect Effects 0.000 claims description 6
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- 239000004480 active ingredient Substances 0.000 claims description 4
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- 230000003449 preventive effect Effects 0.000 claims description 4
- 229910052799 carbon Inorganic materials 0.000 description 39
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- 239000002904 solvent Substances 0.000 description 23
- 238000004458 analytical method Methods 0.000 description 22
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 21
- 238000002360 preparation method Methods 0.000 description 18
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 15
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- 241000282472 Canis lupus familiaris Species 0.000 description 4
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- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 3
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- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 1
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- 239000007902 hard capsule Substances 0.000 description 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
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- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
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- OXNIZHLAWKMVMX-UHFFFAOYSA-N picric acid Chemical compound OC1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O OXNIZHLAWKMVMX-UHFFFAOYSA-N 0.000 description 1
- IUGYQRQAERSCNH-UHFFFAOYSA-N pivalic acid Chemical compound CC(C)(C)C(O)=O IUGYQRQAERSCNH-UHFFFAOYSA-N 0.000 description 1
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- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 235000011118 potassium hydroxide Nutrition 0.000 description 1
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- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 210000002460 smooth muscle Anatomy 0.000 description 1
- QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 description 1
- 239000012312 sodium hydride Substances 0.000 description 1
- 229910000104 sodium hydride Inorganic materials 0.000 description 1
- 235000011121 sodium hydroxide Nutrition 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 239000000021 stimulant Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 239000003760 tallow Substances 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- CKXZPVPIDOJLLM-UHFFFAOYSA-N tert-butyl n-piperidin-4-ylcarbamate Chemical compound CC(C)(C)OC(=O)NC1CCNCC1 CKXZPVPIDOJLLM-UHFFFAOYSA-N 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- 239000001069 triethyl citrate Substances 0.000 description 1
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 1
- 235000013769 triethyl citrate Nutrition 0.000 description 1
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- 229940005605 valeric acid Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nutrition Science (AREA)
- Epidemiology (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2703099 | 1999-02-04 | ||
| PCT/JP2000/000560 WO2000046201A1 (en) | 1999-02-04 | 2000-02-02 | Benzamide derivatives and drugs containing the same |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20013816D0 NO20013816D0 (no) | 2001-08-03 |
| NO20013816L NO20013816L (no) | 2001-08-03 |
| NO319791B1 true NO319791B1 (no) | 2005-09-12 |
Family
ID=12209686
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20013816A NO319791B1 (no) | 1999-02-04 | 2001-08-03 | Benzamidderivater og legemidler som inneholder disse, samt anvendelse av derivatene til fremstilling av medikamenter. |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US6638951B1 (cs) |
| EP (1) | EP1149832B1 (cs) |
| KR (1) | KR100775344B1 (cs) |
| CN (1) | CN1126738C (cs) |
| AR (1) | AR022338A1 (cs) |
| AT (1) | ATE230397T1 (cs) |
| AU (1) | AU755124B2 (cs) |
| BG (1) | BG65512B1 (cs) |
| BR (1) | BR0009135A (cs) |
| CA (1) | CA2362211C (cs) |
| CO (1) | CO5170447A1 (cs) |
| CZ (1) | CZ298219B6 (cs) |
| DE (1) | DE60001100T2 (cs) |
| DK (1) | DK1149832T3 (cs) |
| ES (1) | ES2189736T3 (cs) |
| HK (1) | HK1044947B (cs) |
| HU (1) | HUP0105359A3 (cs) |
| IL (2) | IL144525A0 (cs) |
| MX (1) | MXPA01007705A (cs) |
| MY (1) | MY122570A (cs) |
| NO (1) | NO319791B1 (cs) |
| PL (1) | PL203831B1 (cs) |
| PT (1) | PT1149832E (cs) |
| SK (1) | SK285679B6 (cs) |
| TR (1) | TR200102082T2 (cs) |
| TW (1) | TW527347B (cs) |
| WO (1) | WO2000046201A1 (cs) |
| ZA (1) | ZA200107244B (cs) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2001275326C1 (en) * | 2000-06-07 | 2006-09-21 | Aryx Therapeutics | Treatment of gastroesophageal reflux disease using piperidine derivatives |
| CA2551171C (en) * | 2003-12-23 | 2012-07-10 | Bio-Medisinsk Innovasjon As | Modulators of peripheral 5-ht receptors |
| US8138204B2 (en) | 2004-01-07 | 2012-03-20 | Aryx Therapeutics, Inc. | Stereoisomeric compounds and methods for the treatment of gastrointestinal and central nervous system disorders |
| ES2344568T3 (es) | 2004-01-07 | 2010-08-31 | Aryx Therapeutics, Inc. | Compuestos estereoisomeros y metodos para el tratamiento de trastornos gastrointestinales y del sistema nervioso central. |
| US8524736B2 (en) | 2004-01-07 | 2013-09-03 | Armetheon, Inc. | Stereoisomeric compounds and methods for the treatment of gastrointestinal and central nervous system disorders |
| WO2007028073A2 (en) | 2005-08-31 | 2007-03-08 | Aryx Therapeutics, Inc. | Synthetic methods and intermediates for stereoisomeric compounds useful for the treatment of gastrointestinal and central nervous system disorders |
| MX2008014450A (es) | 2006-05-18 | 2009-03-09 | Mannkind Corp | Inhibidores de cinasa intracelular. |
| WO2007149929A1 (en) * | 2006-06-23 | 2007-12-27 | Aryx Therapeutics, Inc. | Piperidine derivatives for the treatment of gastrointestinal and cns disorders |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8718345D0 (en) | 1987-08-03 | 1987-09-09 | Fordonal Sa | N-substituted benzamides |
| JP3104142B2 (ja) * | 1991-02-15 | 2000-10-30 | 北陸製薬株式会社 | ベンズアミド誘導体 |
| US5395832A (en) | 1991-02-15 | 1995-03-07 | Hokuriku Seiyaku Co., Ltd. | Benzamide derivatives |
| TW243449B (cs) | 1991-02-15 | 1995-03-21 | Hokuriku Pharmaceutical | |
| JPH11292846A (ja) | 1998-02-10 | 1999-10-26 | Hokuriku Seiyaku Co Ltd | ベンズアミド誘導体及びそれを含有する医薬 |
-
2000
- 2000-01-28 AR ARP000100389A patent/AR022338A1/es active IP Right Grant
- 2000-02-01 TW TW089101676A patent/TW527347B/zh not_active IP Right Cessation
- 2000-02-02 TR TR2001/02082T patent/TR200102082T2/xx unknown
- 2000-02-02 DE DE60001100T patent/DE60001100T2/de not_active Expired - Lifetime
- 2000-02-02 ES ES00902050T patent/ES2189736T3/es not_active Expired - Lifetime
- 2000-02-02 CZ CZ20012759A patent/CZ298219B6/cs not_active IP Right Cessation
- 2000-02-02 AT AT00902050T patent/ATE230397T1/de active
- 2000-02-02 WO PCT/JP2000/000560 patent/WO2000046201A1/ja not_active Ceased
- 2000-02-02 DK DK00902050T patent/DK1149832T3/da active
- 2000-02-02 PT PT00902050T patent/PT1149832E/pt unknown
- 2000-02-02 EP EP00902050A patent/EP1149832B1/en not_active Expired - Lifetime
- 2000-02-02 MX MXPA01007705A patent/MXPA01007705A/es not_active IP Right Cessation
- 2000-02-02 KR KR1020017009873A patent/KR100775344B1/ko not_active Expired - Fee Related
- 2000-02-02 HU HU0105359A patent/HUP0105359A3/hu unknown
- 2000-02-02 CA CA002362211A patent/CA2362211C/en not_active Expired - Fee Related
- 2000-02-02 PL PL349133A patent/PL203831B1/pl not_active IP Right Cessation
- 2000-02-02 SK SK1091-2001A patent/SK285679B6/sk not_active IP Right Cessation
- 2000-02-02 IL IL14452500A patent/IL144525A0/xx active IP Right Grant
- 2000-02-02 HK HK02106495.5A patent/HK1044947B/zh not_active IP Right Cessation
- 2000-02-02 BR BR0009135-9A patent/BR0009135A/pt not_active Application Discontinuation
- 2000-02-02 US US09/869,338 patent/US6638951B1/en not_active Expired - Fee Related
- 2000-02-02 CO CO00006272A patent/CO5170447A1/es not_active Application Discontinuation
- 2000-02-02 CN CN00803383A patent/CN1126738C/zh not_active Expired - Fee Related
- 2000-02-02 AU AU23244/00A patent/AU755124B2/en not_active Ceased
- 2000-02-03 MY MYPI20000376A patent/MY122570A/en unknown
-
2001
- 2001-07-24 IL IL144525A patent/IL144525A/en not_active IP Right Cessation
- 2001-08-03 NO NO20013816A patent/NO319791B1/no not_active IP Right Cessation
- 2001-08-22 BG BG105835A patent/BG65512B1/bg unknown
- 2001-08-31 ZA ZA2001/07244A patent/ZA200107244B/en unknown
-
2003
- 2003-10-27 US US10/692,786 patent/US20040087622A1/en not_active Abandoned
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| MM1K | Lapsed by not paying the annual fees |