NO319278B1 - Fremgangsmate for fremstilling av clavamer ved fermentering hvor nivaene av ammoniakk holdes lave under fermenteringen. - Google Patents
Fremgangsmate for fremstilling av clavamer ved fermentering hvor nivaene av ammoniakk holdes lave under fermenteringen. Download PDFInfo
- Publication number
- NO319278B1 NO319278B1 NO19972647A NO972647A NO319278B1 NO 319278 B1 NO319278 B1 NO 319278B1 NO 19972647 A NO19972647 A NO 19972647A NO 972647 A NO972647 A NO 972647A NO 319278 B1 NO319278 B1 NO 319278B1
- Authority
- NO
- Norway
- Prior art keywords
- fermentation
- urease
- ammonia
- microorganism
- clavam
- Prior art date
Links
- 238000000855 fermentation Methods 0.000 title claims abstract description 41
- 230000004151 fermentation Effects 0.000 title claims abstract description 41
- 238000000034 method Methods 0.000 title claims abstract description 30
- WSHJJCPTKWSMRR-RXMQYKEDSA-N penam Chemical compound S1CCN2C(=O)C[C@H]21 WSHJJCPTKWSMRR-RXMQYKEDSA-N 0.000 title claims abstract description 13
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 title claims description 65
- 229910021529 ammonia Inorganic materials 0.000 title claims description 32
- 238000002360 preparation method Methods 0.000 title abstract 2
- 108010046334 Urease Proteins 0.000 claims abstract description 34
- HZZVJAQRINQKSD-UHFFFAOYSA-N Clavulanic acid Natural products OC(=O)C1C(=CCO)OC2CC(=O)N21 HZZVJAQRINQKSD-UHFFFAOYSA-N 0.000 claims description 28
- HZZVJAQRINQKSD-PBFISZAISA-N clavulanic acid Chemical group OC(=O)[C@H]1C(=C/CO)/O[C@@H]2CC(=O)N21 HZZVJAQRINQKSD-PBFISZAISA-N 0.000 claims description 28
- 229960003324 clavulanic acid Drugs 0.000 claims description 27
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 24
- 244000005700 microbiome Species 0.000 claims description 14
- 239000004202 carbamide Substances 0.000 claims description 13
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 12
- 229910052757 nitrogen Inorganic materials 0.000 claims description 12
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 9
- 150000001875 compounds Chemical class 0.000 claims description 7
- 238000011084 recovery Methods 0.000 claims description 5
- 241000187747 Streptomyces Species 0.000 claims description 4
- 230000001376 precipitating effect Effects 0.000 claims description 2
- 230000001629 suppression Effects 0.000 claims description 2
- 108090000790 Enzymes Proteins 0.000 abstract description 6
- 102000004190 Enzymes Human genes 0.000 abstract description 6
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 description 8
- 238000006243 chemical reaction Methods 0.000 description 4
- BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 description 3
- 238000010561 standard procedure Methods 0.000 description 3
- 229920001817 Agar Polymers 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- 239000002585 base Substances 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 230000006696 biosynthetic metabolic pathway Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000009615 deamination Effects 0.000 description 2
- 238000006481 deamination reaction Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000010353 genetic engineering Methods 0.000 description 2
- 239000012429 reaction media Substances 0.000 description 2
- WTLKTXIHIHFSGU-UHFFFAOYSA-N 2-nitrosoguanidine Chemical compound NC(N)=NN=O WTLKTXIHIHFSGU-UHFFFAOYSA-N 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 229930186147 Cephalosporin Natural products 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- 108090000204 Dipeptidase 1 Proteins 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- 108010073771 Soybean Proteins Proteins 0.000 description 1
- 241000187180 Streptomyces sp. Species 0.000 description 1
- 229910021536 Zeolite Inorganic materials 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 150000008044 alkali metal hydroxides Chemical class 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000003781 beta lactamase inhibitor Substances 0.000 description 1
- 102000006635 beta-lactamase Human genes 0.000 description 1
- 229940126813 beta-lactamase inhibitor Drugs 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 229940124587 cephalosporin Drugs 0.000 description 1
- 150000001780 cephalosporins Chemical class 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229940090805 clavulanate Drugs 0.000 description 1
- 230000002153 concerted effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 235000013312 flour Nutrition 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000002054 inoculum Substances 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 238000010369 molecular cloning Methods 0.000 description 1
- 238000002703 mutagenesis Methods 0.000 description 1
- 231100000350 mutagenesis Toxicity 0.000 description 1
- 239000003471 mutagenic agent Substances 0.000 description 1
- 231100000707 mutagenic chemical Toxicity 0.000 description 1
- 230000003505 mutagenic effect Effects 0.000 description 1
- 150000002960 penicillins Chemical class 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229940001941 soy protein Drugs 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- AAKBLFQBZDFKMP-UHFFFAOYSA-H trimagnesium azane diphosphate Chemical compound N.[Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O AAKBLFQBZDFKMP-UHFFFAOYSA-H 0.000 description 1
- 150000003672 ureas Chemical class 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000010457 zeolite Substances 0.000 description 1
- 229940126085 β‑Lactamase Inhibitor Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/886—Streptomyces
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Catalysts (AREA)
- Saccharide Compounds (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9424950.5A GB9424950D0 (en) | 1994-12-10 | 1994-12-10 | Novel process |
| PCT/EP1995/004888 WO1996018743A1 (en) | 1994-12-10 | 1995-12-07 | Process for the fermentative preparation of clavam derivatives whereby the levels of ammonia and urea in the fermentation medium are kept low |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO972647L NO972647L (no) | 1997-06-09 |
| NO972647D0 NO972647D0 (no) | 1997-06-09 |
| NO319278B1 true NO319278B1 (no) | 2005-07-11 |
Family
ID=10765725
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19972647A NO319278B1 (no) | 1994-12-10 | 1997-06-09 | Fremgangsmate for fremstilling av clavamer ved fermentering hvor nivaene av ammoniakk holdes lave under fermenteringen. |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US5985624A (hu) |
| EP (1) | EP0796340B1 (hu) |
| JP (1) | JP3916251B2 (hu) |
| KR (1) | KR100411839B1 (hu) |
| CN (1) | CN1119423C (hu) |
| AT (1) | ATE233322T1 (hu) |
| AU (1) | AU702660B2 (hu) |
| BR (1) | BR9509878A (hu) |
| CA (1) | CA2207411A1 (hu) |
| CZ (1) | CZ292673B6 (hu) |
| DE (1) | DE69529765T2 (hu) |
| DK (1) | DK0796340T3 (hu) |
| ES (1) | ES2193207T3 (hu) |
| FI (1) | FI972446A (hu) |
| GB (1) | GB9424950D0 (hu) |
| HU (1) | HU221755B1 (hu) |
| MX (1) | MX9704279A (hu) |
| NO (1) | NO319278B1 (hu) |
| NZ (1) | NZ298035A (hu) |
| PL (1) | PL184403B1 (hu) |
| WO (1) | WO1996018743A1 (hu) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR015825A1 (es) * | 1997-05-28 | 2001-05-30 | Gist Brocades Bv | Produccion fermentativa de acido clavulanico bajo condiciones controladas de fosfato |
| WO2000018947A1 (en) * | 1998-09-29 | 2000-04-06 | Dsm N.V. | Fermentation of clavulanic acid at a controlled level of ammonia |
| US6440708B1 (en) * | 1998-09-29 | 2002-08-27 | Dsm N.V. | Fermentation of clavulanic acid at a controlled level of ammonia |
| JP2003304893A (ja) * | 2002-04-16 | 2003-10-28 | Sumitomo Heavy Ind Ltd | 有機酸の製造方法及び製造装置並びに有機酸の保存方法 |
| US7790231B2 (en) * | 2003-07-10 | 2010-09-07 | Brewer Science Inc. | Automated process and apparatus for planarization of topographical surfaces |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1508977A (en) * | 1974-04-20 | 1978-04-26 | Beecham Group Ltd | Beta-lactam antibiotic from streptomyces clavuligerus |
| US4110165A (en) * | 1974-04-20 | 1978-08-29 | Beecham Group Limited | Process for the production of clavulanic acid |
| US5100635A (en) * | 1990-07-31 | 1992-03-31 | The Boc Group, Inc. | Carbon dioxide production from combustion exhaust gases with nitrogen and argon by-product recovery |
| ES2130392T3 (es) * | 1992-12-02 | 1999-07-01 | Smithkline Beecham Plc | Procedimiento para la preparacion de acido clavulanico. |
-
1994
- 1994-12-10 GB GBGB9424950.5A patent/GB9424950D0/en active Pending
-
1995
- 1995-12-07 KR KR1019970703840A patent/KR100411839B1/ko not_active IP Right Cessation
- 1995-12-07 PL PL95320662A patent/PL184403B1/pl not_active IP Right Cessation
- 1995-12-07 AT AT95942115T patent/ATE233322T1/de not_active IP Right Cessation
- 1995-12-07 HU HU9702106A patent/HU221755B1/hu not_active IP Right Cessation
- 1995-12-07 DE DE69529765T patent/DE69529765T2/de not_active Revoked
- 1995-12-07 WO PCT/EP1995/004888 patent/WO1996018743A1/en not_active Application Discontinuation
- 1995-12-07 MX MX9704279A patent/MX9704279A/es not_active IP Right Cessation
- 1995-12-07 DK DK95942115T patent/DK0796340T3/da active
- 1995-12-07 CN CN95196726A patent/CN1119423C/zh not_active Expired - Fee Related
- 1995-12-07 AU AU43432/96A patent/AU702660B2/en not_active Ceased
- 1995-12-07 US US08/860,043 patent/US5985624A/en not_active Expired - Lifetime
- 1995-12-07 EP EP95942115A patent/EP0796340B1/en not_active Revoked
- 1995-12-07 CA CA002207411A patent/CA2207411A1/en not_active Abandoned
- 1995-12-07 BR BR9509878A patent/BR9509878A/pt not_active Application Discontinuation
- 1995-12-07 JP JP51825196A patent/JP3916251B2/ja not_active Expired - Fee Related
- 1995-12-07 CZ CZ19971771A patent/CZ292673B6/cs not_active IP Right Cessation
- 1995-12-07 NZ NZ298035A patent/NZ298035A/xx unknown
- 1995-12-07 ES ES95942115T patent/ES2193207T3/es not_active Expired - Lifetime
-
1997
- 1997-06-09 NO NO19972647A patent/NO319278B1/no unknown
- 1997-06-09 FI FI972446A patent/FI972446A/fi not_active IP Right Cessation
-
1999
- 1999-09-29 US US09/408,340 patent/US6235506B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| GB9424950D0 (en) | 1995-02-08 |
| CZ177197A3 (en) | 1997-09-17 |
| PL184403B1 (pl) | 2002-10-31 |
| NZ298035A (en) | 1999-01-28 |
| CN1169162A (zh) | 1997-12-31 |
| NO972647L (no) | 1997-06-09 |
| DE69529765D1 (de) | 2003-04-03 |
| EP0796340A1 (en) | 1997-09-24 |
| JPH10510426A (ja) | 1998-10-13 |
| NO972647D0 (no) | 1997-06-09 |
| PL320662A1 (en) | 1997-10-13 |
| CA2207411A1 (en) | 1996-06-20 |
| EP0796340B1 (en) | 2003-02-26 |
| ATE233322T1 (de) | 2003-03-15 |
| FI972446A0 (fi) | 1997-06-09 |
| US5985624A (en) | 1999-11-16 |
| WO1996018743A1 (en) | 1996-06-20 |
| FI972446A (fi) | 1997-06-09 |
| AU4343296A (en) | 1996-07-03 |
| JP3916251B2 (ja) | 2007-05-16 |
| BR9509878A (pt) | 1997-11-25 |
| AU702660B2 (en) | 1999-02-25 |
| DE69529765T2 (de) | 2003-10-16 |
| MX9704279A (es) | 1997-09-30 |
| HUT77082A (hu) | 1998-03-02 |
| US6235506B1 (en) | 2001-05-22 |
| ES2193207T3 (es) | 2003-11-01 |
| KR100411839B1 (ko) | 2004-02-18 |
| CZ292673B6 (cs) | 2003-11-12 |
| DK0796340T3 (da) | 2003-05-05 |
| CN1119423C (zh) | 2003-08-27 |
| HU221755B1 (hu) | 2002-12-28 |
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