NO317102B1 - 1,3,4 - oxadiazolonderivater - Google Patents
1,3,4 - oxadiazolonderivater Download PDFInfo
- Publication number
- NO317102B1 NO317102B1 NO20003825A NO20003825A NO317102B1 NO 317102 B1 NO317102 B1 NO 317102B1 NO 20003825 A NO20003825 A NO 20003825A NO 20003825 A NO20003825 A NO 20003825A NO 317102 B1 NO317102 B1 NO 317102B1
- Authority
- NO
- Norway
- Prior art keywords
- methyl
- phenyl
- chloro
- trifluoromethyl
- compound
- Prior art date
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- WTSXVIMLKCKWIW-UHFFFAOYSA-N 3h-1,3,4-oxadiazol-2-one Chemical class O=C1NN=CO1 WTSXVIMLKCKWIW-UHFFFAOYSA-N 0.000 title description 6
- 150000001875 compounds Chemical class 0.000 claims description 101
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 29
- 150000003839 salts Chemical class 0.000 claims description 24
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 19
- 238000002360 preparation method Methods 0.000 claims description 18
- 239000011575 calcium Substances 0.000 claims description 17
- -1 [[[4-chloro-2-[[5-[4-(trifluoromethyl)phenyl]-2,3-dihydro-2-oxo-1,3,4-oxadiazol-3-yl]methyl]phenoxy]caronyl] methyl]trimethylammonium Chemical compound 0.000 claims description 16
- 208000035475 disorder Diseases 0.000 claims description 16
- 231100000252 nontoxic Toxicity 0.000 claims description 16
- 230000003000 nontoxic effect Effects 0.000 claims description 16
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims description 15
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 15
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- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 13
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- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims description 11
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- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 claims description 9
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- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 2
- GQNJIAAAHUEJBM-UHFFFAOYSA-N 3-amino-2-[4-chloro-2-[[2-oxo-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-3-yl]methyl]phenyl]propanoic acid Chemical compound NCC(C(O)=O)C1=CC=C(Cl)C=C1CN1C(=O)OC(C=2C=CC(=CC=2)C(F)(F)F)=N1 GQNJIAAAHUEJBM-UHFFFAOYSA-N 0.000 claims description 2
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- MGOYBMFCELTAHS-UHFFFAOYSA-N methyl 3-(diethylamino)propanoate Chemical compound CCN(CC)CCC(=O)OC MGOYBMFCELTAHS-UHFFFAOYSA-N 0.000 claims 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
- C07D271/113—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7296698P | 1998-01-29 | 1998-01-29 | |
| US10227498P | 1998-09-29 | 1998-09-29 | |
| PCT/US1999/000910 WO1999038510A1 (en) | 1998-01-29 | 1999-01-15 | Derivatives of 1,3,4-oxadiazolone |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20003825L NO20003825L (no) | 2000-07-26 |
| NO20003825D0 NO20003825D0 (no) | 2000-07-26 |
| NO317102B1 true NO317102B1 (no) | 2004-08-09 |
Family
ID=26753969
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20003825A NO317102B1 (no) | 1998-01-29 | 2000-07-26 | 1,3,4 - oxadiazolonderivater |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US6034113A (es) |
| EP (1) | EP1051173A4 (es) |
| JP (1) | JP2002527352A (es) |
| KR (1) | KR20010077838A (es) |
| CN (1) | CN1150175C (es) |
| AR (1) | AR010712A1 (es) |
| AU (1) | AU735704B2 (es) |
| BG (1) | BG104706A (es) |
| BR (1) | BR9913010A (es) |
| CA (1) | CA2318830A1 (es) |
| CO (1) | CO5090837A1 (es) |
| EE (1) | EE04089B1 (es) |
| GE (1) | GEP20032914B (es) |
| HU (1) | HUP0102025A3 (es) |
| ID (1) | ID26909A (es) |
| IL (1) | IL137518A0 (es) |
| LT (1) | LT4838B (es) |
| LV (1) | LV12559B (es) |
| NO (1) | NO317102B1 (es) |
| NZ (1) | NZ505409A (es) |
| PL (1) | PL342060A1 (es) |
| RU (1) | RU2202548C2 (es) |
| SK (1) | SK10852000A3 (es) |
| TR (1) | TR200002019T2 (es) |
| TW (1) | TW550075B (es) |
| UA (1) | UA58579C2 (es) |
| WO (1) | WO1999038510A1 (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU736599B2 (en) * | 1998-01-29 | 2001-08-02 | Bristol-Myers Squibb Company | Amino acid derivatives of diaryl 1,3,4-oxadiazolone |
| IL144540A0 (en) * | 1999-01-29 | 2002-05-23 | Bristol Myers Squibb Co | Carbamate derivatives of diaryl 1,3,4,-oxadiazolone |
| US6297241B1 (en) | 1999-01-29 | 2001-10-02 | Bristol-Myers Squibb Company | Carbamate derivatives of diaryl 1,3,4-oxadiazolone |
| US6326388B1 (en) * | 1999-12-21 | 2001-12-04 | Celgene Corporation | Substituted 1,3,4-oxadiazoles and a method of reducing TNF-alpha level |
| MXPA03007397A (es) | 2001-02-20 | 2003-12-04 | Bristol Myers Squibb Co | Moduladores de canales de potasio kcnq y uso de los mismos en tratamiento de migrana y enfermedades mecanicamente relacionadas. |
| BR0208956A (pt) * | 2001-04-16 | 2004-07-13 | Tanabe Seiyaku Co | Abridor de canais de k ativados por cálcio de grande condutância |
| US6909027B1 (en) * | 2001-08-13 | 2005-06-21 | Perry Robins | Method of forming an in-situ film dressing and the composition of the film-forming material |
| US7119246B2 (en) * | 2002-06-25 | 2006-10-10 | Perry Robins | Method of treating acne |
| KR102443057B1 (ko) | 2012-01-18 | 2022-09-14 | 테크필즈 파마 코., 엘티디. | 폐 병태의 치료를 위한 고침투 전구약물 조성물 및 그의 약제학적 조성물 |
| JP5855599B2 (ja) * | 2013-04-30 | 2016-02-09 | テックフィールズ バイオケム カンパニー リミテッド | 非常に速い皮膚浸透率を有するアセトアミノフェン及び関連化合物の正荷電水溶性プロドラッグ |
| CN104710379B (zh) * | 2015-03-09 | 2017-01-18 | 华南理工大学 | 一种bms‑191011的合成方法 |
| JP6165816B2 (ja) * | 2015-10-01 | 2017-07-19 | テックフィールズ バイオケム カンパニー リミテッド | 非常に速い皮膚浸透率を有するアセトアミノフェン及び関連化合物の正荷電水溶性プロドラッグ |
| EP3585380A4 (en) * | 2017-02-24 | 2020-11-11 | Ovid Therapeutics Inc | METHODS FOR TREATMENT OF SEQUENCE DISEASES |
| CN110987847B (zh) * | 2019-12-11 | 2021-02-19 | 苏州今蓝纳米科技有限公司 | 1,3,4-噁二唑衍生物在检测酸以及数据加密和储存中的应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH583213A5 (es) * | 1973-05-21 | 1976-12-31 | Ciba Geigy Ag | |
| IT1251488B (it) * | 1991-09-17 | 1995-05-15 | Mini Ricerca Scient Tecnolog | Ossa(tia)diazol- e triazol-oni(tioni) ad attivita' acaricida ed insetticida |
| US5234947A (en) * | 1991-11-07 | 1993-08-10 | New York University | Potassium channel activating compounds and methods of use thereof |
| US5547966A (en) * | 1993-10-07 | 1996-08-20 | Bristol-Myers Squibb Company | Aryl urea and related compounds |
| TW467902B (en) * | 1996-07-31 | 2001-12-11 | Bristol Myers Squibb Co | Diphenyl heterocycles as potassium channel modulators |
| AU736599B2 (en) * | 1998-01-29 | 2001-08-02 | Bristol-Myers Squibb Company | Amino acid derivatives of diaryl 1,3,4-oxadiazolone |
-
1999
- 1999-01-15 SK SK1085-2000A patent/SK10852000A3/sk unknown
- 1999-01-15 NZ NZ505409A patent/NZ505409A/en unknown
- 1999-01-15 ID IDW20001421A patent/ID26909A/id unknown
- 1999-01-15 HU HU0102025A patent/HUP0102025A3/hu unknown
- 1999-01-15 BR BR9913010-6A patent/BR9913010A/pt not_active IP Right Cessation
- 1999-01-15 JP JP2000529243A patent/JP2002527352A/ja active Pending
- 1999-01-15 GE GEAP19995472A patent/GEP20032914B/en unknown
- 1999-01-15 US US09/232,033 patent/US6034113A/en not_active Expired - Fee Related
- 1999-01-15 TR TR2000/02019T patent/TR200002019T2/xx unknown
- 1999-01-15 UA UA2000085059A patent/UA58579C2/uk unknown
- 1999-01-15 EE EEP200000447A patent/EE04089B1/xx not_active IP Right Cessation
- 1999-01-15 RU RU2000122733/04A patent/RU2202548C2/ru not_active IP Right Cessation
- 1999-01-15 WO PCT/US1999/000910 patent/WO1999038510A1/en not_active Application Discontinuation
- 1999-01-15 KR KR1020007008227A patent/KR20010077838A/ko not_active Application Discontinuation
- 1999-01-15 CA CA002318830A patent/CA2318830A1/en not_active Abandoned
- 1999-01-15 PL PL99342060A patent/PL342060A1/xx unknown
- 1999-01-15 EP EP99902290A patent/EP1051173A4/en not_active Withdrawn
- 1999-01-15 AU AU22308/99A patent/AU735704B2/en not_active Ceased
- 1999-01-15 CN CNB998024112A patent/CN1150175C/zh not_active Expired - Fee Related
- 1999-01-15 IL IL13751899A patent/IL137518A0/xx unknown
- 1999-01-27 TW TW088101231A patent/TW550075B/zh not_active IP Right Cessation
- 1999-01-27 AR ARP990100312A patent/AR010712A1/es not_active Application Discontinuation
- 1999-01-28 CO CO99004746A patent/CO5090837A1/es unknown
-
2000
- 2000-07-14 LT LT2000068A patent/LT4838B/lt not_active IP Right Cessation
- 2000-07-26 NO NO20003825A patent/NO317102B1/no not_active IP Right Cessation
- 2000-08-03 LV LVP-00-103A patent/LV12559B/en unknown
- 2000-08-22 BG BG104706A patent/BG104706A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1150175C (zh) | 2004-05-19 |
| NZ505409A (en) | 2003-08-29 |
| LV12559A (en) | 2000-11-20 |
| HUP0102025A2 (hu) | 2001-11-28 |
| TR200002019T2 (tr) | 2000-11-21 |
| NO20003825L (no) | 2000-07-26 |
| KR20010077838A (ko) | 2001-08-20 |
| TW550075B (en) | 2003-09-01 |
| AU2230899A (en) | 1999-08-16 |
| AU735704B2 (en) | 2001-07-12 |
| BR9913010A (pt) | 2001-05-08 |
| HUP0102025A3 (en) | 2002-01-28 |
| EP1051173A4 (en) | 2002-07-31 |
| US6034113A (en) | 2000-03-07 |
| LT4838B (lt) | 2001-08-27 |
| CN1289249A (zh) | 2001-03-28 |
| ID26909A (id) | 2001-02-15 |
| UA58579C2 (uk) | 2003-08-15 |
| JP2002527352A (ja) | 2002-08-27 |
| PL342060A1 (en) | 2001-05-21 |
| BG104706A (en) | 2001-04-30 |
| LT2000068A (en) | 2001-03-26 |
| IL137518A0 (en) | 2001-07-24 |
| CA2318830A1 (en) | 1999-08-05 |
| EP1051173A1 (en) | 2000-11-15 |
| GEP20032914B (en) | 2003-03-25 |
| SK10852000A3 (sk) | 2002-02-05 |
| CO5090837A1 (es) | 2001-10-30 |
| WO1999038510A1 (en) | 1999-08-05 |
| RU2202548C2 (ru) | 2003-04-20 |
| LV12559B (en) | 2001-04-20 |
| EE04089B1 (et) | 2003-08-15 |
| AR010712A1 (es) | 2000-07-12 |
| NO20003825D0 (no) | 2000-07-26 |
| EE200000447A (et) | 2001-12-17 |
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| MM1K | Lapsed by not paying the annual fees |