NO316916B1 - Anvendelse av en bispesifikk antistoffkonstruksjon som er rettet mot CCR5 og CD3 for fremstilling av en farmasoytisk sammensetning for behandling av kronisk artritt, autoimmunesykdommer, allergiske reaksjoner eller for reduksjon av kjemokinreseptoruttrykk - Google Patents
Anvendelse av en bispesifikk antistoffkonstruksjon som er rettet mot CCR5 og CD3 for fremstilling av en farmasoytisk sammensetning for behandling av kronisk artritt, autoimmunesykdommer, allergiske reaksjoner eller for reduksjon av kjemokinreseptoruttrykk Download PDFInfo
- Publication number
- NO316916B1 NO316916B1 NO20014346A NO20014346A NO316916B1 NO 316916 B1 NO316916 B1 NO 316916B1 NO 20014346 A NO20014346 A NO 20014346A NO 20014346 A NO20014346 A NO 20014346A NO 316916 B1 NO316916 B1 NO 316916B1
- Authority
- NO
- Norway
- Prior art keywords
- antibody
- ccr5
- chemokine receptor
- chemokine
- antigen
- Prior art date
Links
- 108050000299 Chemokine receptor Proteins 0.000 title claims abstract description 39
- 102000009410 Chemokine receptor Human genes 0.000 title claims abstract description 39
- 208000023275 Autoimmune disease Diseases 0.000 title claims abstract description 11
- 101710149870 C-C chemokine receptor type 5 Proteins 0.000 title claims abstract 4
- 102100035875 C-C chemokine receptor type 5 Human genes 0.000 title claims abstract 4
- 238000011282 treatment Methods 0.000 title claims description 13
- 238000002360 preparation method Methods 0.000 title claims description 10
- 206010003246 arthritis Diseases 0.000 title claims description 8
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 8
- 230000009467 reduction Effects 0.000 title claims description 5
- 206010020751 Hypersensitivity Diseases 0.000 title description 2
- 230000008685 targeting Effects 0.000 title 1
- 210000004027 cell Anatomy 0.000 claims abstract description 59
- 210000001744 T-lymphocyte Anatomy 0.000 claims abstract description 27
- 210000001616 monocyte Anatomy 0.000 claims abstract description 24
- 210000002540 macrophage Anatomy 0.000 claims abstract description 13
- 108700011778 CCR5 Proteins 0.000 claims abstract description 11
- 208000026935 allergic disease Diseases 0.000 claims abstract description 7
- 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 claims description 21
- 239000000427 antigen Substances 0.000 claims description 18
- 108091007433 antigens Proteins 0.000 claims description 18
- 102000036639 antigens Human genes 0.000 claims description 18
- 210000000265 leukocyte Anatomy 0.000 claims description 14
- 239000012636 effector Substances 0.000 claims description 12
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims description 8
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims description 8
- 239000012634 fragment Substances 0.000 claims description 8
- 150000001413 amino acids Chemical class 0.000 claims description 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 3
- ZVEUWSJUXREOBK-DKWTVANSSA-N 2-aminoacetic acid;(2s)-2-amino-3-hydroxypropanoic acid Chemical compound NCC(O)=O.OC[C@H](N)C(O)=O ZVEUWSJUXREOBK-DKWTVANSSA-N 0.000 claims description 2
- 101000946926 Homo sapiens C-C chemokine receptor type 5 Proteins 0.000 claims description 2
- 210000004443 dendritic cell Anatomy 0.000 claims description 2
- 102000048160 human CCR5 Human genes 0.000 claims description 2
- 102000019034 Chemokines Human genes 0.000 abstract description 44
- 108010012236 Chemokines Proteins 0.000 abstract description 44
- 208000037976 chronic inflammation Diseases 0.000 abstract description 3
- 238000002650 immunosuppressive therapy Methods 0.000 abstract description 3
- 208000037893 chronic inflammatory disorder Diseases 0.000 abstract description 2
- 239000003053 toxin Substances 0.000 description 35
- 231100000765 toxin Toxicity 0.000 description 35
- 108700012359 toxins Proteins 0.000 description 35
- FUFLCEKSBBHCMO-UHFFFAOYSA-N 11-dehydrocorticosterone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)C(=O)CO)C4C3CCC2=C1 FUFLCEKSBBHCMO-UHFFFAOYSA-N 0.000 description 11
- MFYSYFVPBJMHGN-ZPOLXVRWSA-N Cortisone Chemical compound O=C1CC[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 MFYSYFVPBJMHGN-ZPOLXVRWSA-N 0.000 description 11
- MFYSYFVPBJMHGN-UHFFFAOYSA-N Cortisone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)(O)C(=O)CO)C4C3CCC2=C1 MFYSYFVPBJMHGN-UHFFFAOYSA-N 0.000 description 11
- 229960004544 cortisone Drugs 0.000 description 11
- 238000002560 therapeutic procedure Methods 0.000 description 11
- 230000000694 effects Effects 0.000 description 9
- 238000000034 method Methods 0.000 description 9
- 208000012659 Joint disease Diseases 0.000 description 8
- 239000003795 chemical substances by application Substances 0.000 description 8
- 230000006378 damage Effects 0.000 description 7
- 206010023203 Joint destruction Diseases 0.000 description 6
- 206010028980 Neoplasm Diseases 0.000 description 6
- 210000004978 chinese hamster ovary cell Anatomy 0.000 description 6
- 238000010276 construction Methods 0.000 description 6
- 238000004132 cross linking Methods 0.000 description 6
- 230000008901 benefit Effects 0.000 description 5
- 201000011510 cancer Diseases 0.000 description 5
- 238000011534 incubation Methods 0.000 description 5
- 230000004054 inflammatory process Effects 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 102000004169 proteins and genes Human genes 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 5
- 102100032367 C-C motif chemokine 5 Human genes 0.000 description 4
- 108010055166 Chemokine CCL5 Proteins 0.000 description 4
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 4
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 230000004927 fusion Effects 0.000 description 4
- 238000000338 in vitro Methods 0.000 description 4
- 238000002347 injection Methods 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- 210000001503 joint Anatomy 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 206010061218 Inflammation Diseases 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 108020001507 fusion proteins Proteins 0.000 description 3
- 102000037865 fusion proteins Human genes 0.000 description 3
- 125000000487 histidyl group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 description 3
- 238000001727 in vivo Methods 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 230000002757 inflammatory effect Effects 0.000 description 3
- 238000000746 purification Methods 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 102100032366 C-C motif chemokine 7 Human genes 0.000 description 2
- 101710155834 C-C motif chemokine 7 Proteins 0.000 description 2
- 102100034871 C-C motif chemokine 8 Human genes 0.000 description 2
- 101710155833 C-C motif chemokine 8 Proteins 0.000 description 2
- 102100031650 C-X-C chemokine receptor type 4 Human genes 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 101000922348 Homo sapiens C-X-C chemokine receptor type 4 Proteins 0.000 description 2
- 206010062016 Immunosuppression Diseases 0.000 description 2
- 241001529936 Murinae Species 0.000 description 2
- 241000589516 Pseudomonas Species 0.000 description 2
- 208000025747 Rheumatic disease Diseases 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000004913 activation Effects 0.000 description 2
- 230000000202 analgesic effect Effects 0.000 description 2
- 239000003435 antirheumatic agent Substances 0.000 description 2
- 239000008365 aqueous carrier Substances 0.000 description 2
- 239000002981 blocking agent Substances 0.000 description 2
- 230000030833 cell death Effects 0.000 description 2
- 230000009089 cytolysis Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 210000000987 immune system Anatomy 0.000 description 2
- 230000001506 immunosuppresive effect Effects 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 210000004698 lymphocyte Anatomy 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- AEUKDPKXTPNBNY-XEYRWQBLSA-N mcp 2 Chemical compound C([C@@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CS)NC(=O)[C@H](C)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)C1=CC=CC=C1 AEUKDPKXTPNBNY-XEYRWQBLSA-N 0.000 description 2
- 238000007911 parenteral administration Methods 0.000 description 2
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 2
- 206010039073 rheumatoid arthritis Diseases 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 230000001629 suppression Effects 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 108020004414 DNA Proteins 0.000 description 1
- 102100024746 Dihydrofolate reductase Human genes 0.000 description 1
- 108010053187 Diphtheria Toxin Proteins 0.000 description 1
- 102000016607 Diphtheria Toxin Human genes 0.000 description 1
- 238000012413 Fluorescence activated cell sorting analysis Methods 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 102000012745 Immunoglobulin Subunits Human genes 0.000 description 1
- 108010079585 Immunoglobulin Subunits Proteins 0.000 description 1
- 206010023215 Joint effusion Diseases 0.000 description 1
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 1
- 208000019693 Lung disease Diseases 0.000 description 1
- 206010029164 Nephrotic syndrome Diseases 0.000 description 1
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- 208000001132 Osteoporosis Diseases 0.000 description 1
- 101150030083 PE38 gene Proteins 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 206010036030 Polyarthritis Diseases 0.000 description 1
- 101000762949 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) Exotoxin A Proteins 0.000 description 1
- 108700033844 Pseudomonas aeruginosa toxA Proteins 0.000 description 1
- 108020004511 Recombinant DNA Proteins 0.000 description 1
- 208000001647 Renal Insufficiency Diseases 0.000 description 1
- 208000007107 Stomach Ulcer Diseases 0.000 description 1
- 239000007983 Tris buffer Substances 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 238000001042 affinity chromatography Methods 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000001741 anti-phlogistic effect Effects 0.000 description 1
- 230000001363 autoimmune Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 239000012928 buffer substance Substances 0.000 description 1
- 230000005754 cellular signaling Effects 0.000 description 1
- 238000012412 chemical coupling Methods 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000006020 chronic inflammation Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000011443 conventional therapy Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000003013 cytotoxicity Effects 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
- 239000000850 decongestant Substances 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000000779 depleting effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 108020001096 dihydrofolate reductase Proteins 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 239000013604 expression vector Substances 0.000 description 1
- 150000002333 glycines Chemical class 0.000 description 1
- 230000003054 hormonal effect Effects 0.000 description 1
- 210000004408 hybridoma Anatomy 0.000 description 1
- 239000002596 immunotoxin Substances 0.000 description 1
- 231100000608 immunotoxin Toxicity 0.000 description 1
- 230000002637 immunotoxin Effects 0.000 description 1
- 229940051026 immunotoxin Drugs 0.000 description 1
- 208000027866 inflammatory disease Diseases 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 230000000622 irritating effect Effects 0.000 description 1
- 210000000629 knee joint Anatomy 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 238000012153 long-term therapy Methods 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 229960000485 methotrexate Drugs 0.000 description 1
- 208000009928 nephrosis Diseases 0.000 description 1
- 231100001027 nephrosis Toxicity 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
- 239000011886 peripheral blood Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 238000010188 recombinant method Methods 0.000 description 1
- 238000003757 reverse transcription PCR Methods 0.000 description 1
- 230000003637 steroidlike Effects 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 210000001179 synovial fluid Anatomy 0.000 description 1
- 238000007910 systemic administration Methods 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 230000005740 tumor formation Effects 0.000 description 1
- 239000013598 vector Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/642—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a cytokine, e.g. IL2, chemokine, growth factors or interferons being the inactive part of the conjugate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pain & Pain Management (AREA)
- Molecular Biology (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19910891 | 1999-03-11 | ||
| PCT/EP2000/002154 WO2000053633A2 (de) | 1999-03-11 | 2000-03-10 | Antikörper- und chemokinkonstrukte, die gegen ccr5 gerichtet sind, und ihre verwendung in der behandlung von autoimmunkrankheiten |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20014346D0 NO20014346D0 (no) | 2001-09-06 |
| NO20014346L NO20014346L (no) | 2001-09-27 |
| NO316916B1 true NO316916B1 (no) | 2004-06-21 |
Family
ID=7900625
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20014346A NO316916B1 (no) | 1999-03-11 | 2001-09-06 | Anvendelse av en bispesifikk antistoffkonstruksjon som er rettet mot CCR5 og CD3 for fremstilling av en farmasoytisk sammensetning for behandling av kronisk artritt, autoimmunesykdommer, allergiske reaksjoner eller for reduksjon av kjemokinreseptoruttrykk |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP1161456B1 (xx) |
| JP (1) | JP2002540771A (xx) |
| CN (1) | CN1345336A (xx) |
| AT (1) | ATE286074T1 (xx) |
| AU (1) | AU4104700A (xx) |
| CA (1) | CA2366713A1 (xx) |
| CZ (1) | CZ20013270A3 (xx) |
| DE (1) | DE50009113D1 (xx) |
| ES (1) | ES2233359T3 (xx) |
| HU (1) | HUP0200484A2 (xx) |
| IL (1) | IL145335A0 (xx) |
| NO (1) | NO316916B1 (xx) |
| SK (1) | SK12782001A3 (xx) |
| TR (1) | TR200102779T2 (xx) |
| WO (1) | WO2000053633A2 (xx) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6528625B1 (en) | 1996-10-28 | 2003-03-04 | Millennium Pharmaceuticals, Inc. | Anti-CCR5 antibodies and kits comprising same |
| WO2002020615A2 (en) * | 2000-09-08 | 2002-03-14 | Micromet Ag | Antibody and/or chemokine constructs which bind to a chemokine receptor and their use in immunological disorders |
| DE60203324T2 (de) * | 2001-12-21 | 2006-04-06 | Micromet Ag | Einzelne und duale anti-cd4-rantes chemokin/zytokin konstrukte |
| TW200720289A (en) | 2005-04-01 | 2007-06-01 | Hoffmann La Roche | Antibodies against CCR5 and uses thereof |
| JP2010500984A (ja) | 2006-08-17 | 2010-01-14 | エフ．ホフマン−ラ ロシュ アーゲー | Ｃｃｒ５に対する抗体と抗膜融合ペプチドとの抱合体 |
| TW200817438A (en) | 2006-08-17 | 2008-04-16 | Hoffmann La Roche | A conjugate of an antibody against CCR5 and an antifusogenic peptide |
| EP2074147B1 (en) | 2006-09-29 | 2012-03-21 | F. Hoffmann-La Roche AG | Antibodies against ccr5 and uses thereof |
| CL2008000707A1 (es) | 2007-03-13 | 2008-09-22 | Hoffmann La Roche | Conjugado de polipeptidos antifusogenicos y polipeptidos derivados de la cabeza globular del factor del complemento c1q; composicion farmaceutica que lo comprende; su uso para tratar infecciones viricas; y metodo de produccion. |
| TW202323302A (zh) | 2010-11-30 | 2023-06-16 | 日商中外製藥股份有限公司 | 細胞傷害誘導治療劑 |
| WO2013024022A1 (en) | 2011-08-12 | 2013-02-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for treatment of pulmonary hypertension |
| JP6629187B2 (ja) | 2014-04-07 | 2020-01-15 | 中外製薬株式会社 | 免疫活性化抗原結合分子 |
| EA201692287A1 (ru) | 2014-05-13 | 2017-06-30 | Чугаи Сеияку Кабушики Каиша | Антигенсвязывающая молекула, перенаправляющая т-клетки на клетки, обладающие иммуносупрессорной функцией |
| EP3378487B1 (en) | 2015-11-18 | 2022-03-16 | Chugai Seiyaku Kabushiki Kaisha | Combination therapy using t cell redirection antigen binding molecule against cell having immunosuppressing function |
| WO2017086419A1 (ja) | 2015-11-18 | 2017-05-26 | 中外製薬株式会社 | 液性免疫応答の増強方法 |
| US11629196B2 (en) | 2020-04-27 | 2023-04-18 | Incelldx, Inc. | Method of treating SARS-CoV-2-associated hypercytokinemia by administering a human monoclonal antibody (PRO-140) that inhibits CCR5/CCL5 binding interactions |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6428788B1 (en) * | 1995-03-15 | 2002-08-06 | Penn State University | Compositions and methods for specifically targeting tumors |
| US6528625B1 (en) * | 1996-10-28 | 2003-03-04 | Millennium Pharmaceuticals, Inc. | Anti-CCR5 antibodies and kits comprising same |
| ZA985542B (en) * | 1997-07-03 | 1999-04-07 | Smithkline Beecham Corp | Substituted benzanilides as CCR5 receptor ligands antiinflammatory agents and antiviral agents |
| CA2335105C (en) * | 1998-07-22 | 2010-05-11 | Osprey Pharmaceuticals Limited | Methods and compositions for treating secondary tissue damage and other inflammatory conditions and disorders |
-
2000
- 2000-03-10 CN CN00804846A patent/CN1345336A/zh active Pending
- 2000-03-10 HU HU0200484A patent/HUP0200484A2/hu unknown
- 2000-03-10 CA CA002366713A patent/CA2366713A1/en not_active Abandoned
- 2000-03-10 WO PCT/EP2000/002154 patent/WO2000053633A2/de active IP Right Grant
- 2000-03-10 IL IL14533500A patent/IL145335A0/xx unknown
- 2000-03-10 AT AT00920490T patent/ATE286074T1/de not_active IP Right Cessation
- 2000-03-10 TR TR2001/02779T patent/TR200102779T2/xx unknown
- 2000-03-10 AU AU41047/00A patent/AU4104700A/en not_active Abandoned
- 2000-03-10 CZ CZ20013270A patent/CZ20013270A3/cs unknown
- 2000-03-10 ES ES00920490T patent/ES2233359T3/es not_active Expired - Lifetime
- 2000-03-10 DE DE50009113T patent/DE50009113D1/de not_active Expired - Fee Related
- 2000-03-10 EP EP00920490A patent/EP1161456B1/de not_active Expired - Lifetime
- 2000-03-10 JP JP2000604068A patent/JP2002540771A/ja active Pending
- 2000-03-10 SK SK1278-2001A patent/SK12782001A3/sk not_active Application Discontinuation
-
2001
- 2001-09-06 NO NO20014346A patent/NO316916B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE50009113D1 (de) | 2005-02-03 |
| SK12782001A3 (sk) | 2002-03-05 |
| CA2366713A1 (en) | 2000-09-14 |
| WO2000053633A3 (de) | 2000-11-16 |
| CN1345336A (zh) | 2002-04-17 |
| ES2233359T3 (es) | 2005-06-16 |
| EP1161456A2 (de) | 2001-12-12 |
| CZ20013270A3 (cs) | 2002-02-13 |
| IL145335A0 (en) | 2002-06-30 |
| JP2002540771A (ja) | 2002-12-03 |
| TR200102779T2 (tr) | 2002-03-21 |
| NO20014346L (no) | 2001-09-27 |
| HUP0200484A2 (en) | 2002-06-29 |
| EP1161456B1 (de) | 2004-12-29 |
| NO20014346D0 (no) | 2001-09-06 |
| WO2000053633A2 (de) | 2000-09-14 |
| AU4104700A (en) | 2000-09-28 |
| ATE286074T1 (de) | 2005-01-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US12065492B2 (en) | Anti-B7-H6 antibody, fusion proteins, and methods of using the same | |
| US11174306B2 (en) | Chimeric antigen receptor effector cell switches with humanized targeting moieties and/or optimized chimeric antigen receptor interacting domains and uses thereof | |
| US10758556B2 (en) | Anthracycline-based antibody drug conjugates having high in vivo tolerability | |
| CN107849148B (zh) | 三特异性结合蛋白质及使用方法 | |
| US10800828B2 (en) | Switchable non-scFv chimeric receptors, switches, and methods of use thereof to treat cancer | |
| US9316646B2 (en) | Anti-human ROR1 antibodies | |
| NO316916B1 (no) | Anvendelse av en bispesifikk antistoffkonstruksjon som er rettet mot CCR5 og CD3 for fremstilling av en farmasoytisk sammensetning for behandling av kronisk artritt, autoimmunesykdommer, allergiske reaksjoner eller for reduksjon av kjemokinreseptoruttrykk | |
| KR20120100914A (ko) | 에프라투주맙을 이용한 자가면역 및 염증 질환의 치료 | |
| AU665763B2 (en) | Interleukin receptor targeted molecules for treatment of inflammatory arthritis | |
| JPH0641423B2 (ja) | 細胞毒性薬剤組成物及び細胞毒性薬剤キット | |
| EP2600882B1 (de) | ANTIKÖRPER GEGEN 6-SULFO LacNAc POSITIVE HUMANE DENDRITISCHE ZELLEN UND DEREN VERWENDUNG | |
| JP2022546384A (ja) | 免疫耐性エラスチン様組換ペプチドおよび使用方法 | |
| US20240336690A1 (en) | Anti cd154 antibody and use thereof | |
| WO2023061502A1 (zh) | 一种双特异性结合分子 | |
| US12121527B2 (en) | Anthracycline-based antibody drug conjugates having high in vivo tolerability | |
| EP4382537A1 (en) | Anti cd154 antibody and use thereof | |
| JPWO2022068810A5 (xx) | ||
| Gupta et al. | Immunomodulation by interleukin-2 receptor targeted therapy | |
| JP2007530438A (ja) | 免疫原性を低下させた抗ｃｒ１抗体及び組成物並びにそれに基づく治療法 | |
| JPWO2022064043A5 (xx) |