NO315649B1 - Substituerte isokinolin-derivater, fremgangsmåte for fremstilling og anvendelse derav, samt farmasöytiske preparater inneholdende disseforbindelser - Google Patents
Substituerte isokinolin-derivater, fremgangsmåte for fremstilling og anvendelse derav, samt farmasöytiske preparater inneholdende disseforbindelser Download PDFInfo
- Publication number
- NO315649B1 NO315649B1 NO20003142A NO20003142A NO315649B1 NO 315649 B1 NO315649 B1 NO 315649B1 NO 20003142 A NO20003142 A NO 20003142A NO 20003142 A NO20003142 A NO 20003142A NO 315649 B1 NO315649 B1 NO 315649B1
- Authority
- NO
- Norway
- Prior art keywords
- tetrahydroisoquinolin
- methoxy
- trifluoromethylbenzamide
- chloro
- formula
- Prior art date
Links
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- 238000002360 preparation method Methods 0.000 title claims description 21
- 238000000034 method Methods 0.000 title description 30
- 125000002183 isoquinolinyl group Chemical class C1(=NC=CC2=CC=CC=C12)* 0.000 title 1
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 20
- 150000003839 salts Chemical class 0.000 claims description 18
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 16
- 208000035475 disorder Diseases 0.000 claims description 15
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- 238000006243 chemical reaction Methods 0.000 claims description 12
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- 229910052736 halogen Inorganic materials 0.000 claims description 11
- 150000002431 hydrogen Chemical group 0.000 claims description 11
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Classifications
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Addiction (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9726695.1A GB9726695D0 (en) | 1997-12-17 | 1997-12-17 | Novel compounds |
| PCT/GB1998/003785 WO1999031068A1 (en) | 1997-12-17 | 1998-12-16 | Substituted isoquinoline derivatives and their use as anticonvulsants |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20003142D0 NO20003142D0 (no) | 2000-06-16 |
| NO20003142L NO20003142L (no) | 2000-06-16 |
| NO315649B1 true NO315649B1 (no) | 2003-10-06 |
Family
ID=10823780
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20003142A NO315649B1 (no) | 1997-12-17 | 2000-06-16 | Substituerte isokinolin-derivater, fremgangsmåte for fremstilling og anvendelse derav, samt farmasöytiske preparater inneholdende disseforbindelser |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US6248754B1 (bg) |
| EP (1) | EP1042296B1 (bg) |
| JP (1) | JP2002508360A (bg) |
| KR (1) | KR20010033194A (bg) |
| CN (1) | CN1125052C (bg) |
| AP (1) | AP2000001832A0 (bg) |
| AR (1) | AR014942A1 (bg) |
| AT (1) | ATE260258T1 (bg) |
| AU (1) | AU744451B2 (bg) |
| BG (1) | BG104607A (bg) |
| BR (1) | BR9813642A (bg) |
| CA (1) | CA2315079A1 (bg) |
| CO (1) | CO5080731A1 (bg) |
| DE (1) | DE69821988T2 (bg) |
| EA (1) | EA200000657A1 (bg) |
| ES (1) | ES2216333T3 (bg) |
| GB (1) | GB9726695D0 (bg) |
| HU (2) | HUP0000987A3 (bg) |
| ID (1) | ID24810A (bg) |
| IL (1) | IL136382A0 (bg) |
| MA (1) | MA26583A1 (bg) |
| NO (1) | NO315649B1 (bg) |
| NZ (1) | NZ504706A (bg) |
| OA (1) | OA11526A (bg) |
| PE (1) | PE20000006A1 (bg) |
| PL (1) | PL341222A1 (bg) |
| SK (1) | SK9142000A3 (bg) |
| TR (1) | TR200001791T2 (bg) |
| WO (1) | WO1999031068A1 (bg) |
| ZA (1) | ZA9811503B (bg) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20010016657A1 (en) * | 1997-03-18 | 2001-08-23 | Smithkline Beecham P.L.C. | Substituted isoquinoline derivatives and their use as anticonvulsants |
| EP1023269A4 (en) * | 1997-09-30 | 2001-06-27 | Molecular Design Int | BETA3-ADRENORECEPTOR AGONISTS, AGONIST COMPOSITIONS AND METHODS OF USE |
| GB9915589D0 (en) | 1999-07-02 | 1999-09-01 | Smithkline Beecham Plc | Novel compounds |
| WO2001042224A1 (en) * | 1999-12-09 | 2001-06-14 | Mitsubishi Pharma Corporation | Carboxyamido derivatives |
| US6593341B2 (en) | 2001-03-29 | 2003-07-15 | Molecular Design International, Inc. | β3-adrenoreceptor agonists, agonist compositions and methods of making and using the same |
| US7173032B2 (en) | 2001-09-21 | 2007-02-06 | Reddy Us Therapeutics, Inc. | Methods and compositions of novel triazine compounds |
| US6596734B1 (en) | 2002-10-11 | 2003-07-22 | Molecular Design International, Inc. | Tetrahydroisoquinoline compounds for use as β3-adrenoreceptor agonists |
| US7119214B2 (en) * | 2004-04-13 | 2006-10-10 | Cephalon France | Thio-substituted tricyclic and bicyclic aromatic methanesulfinyl derivatives |
| GB0619176D0 (en) * | 2006-09-29 | 2006-11-08 | Lectus Therapeutics Ltd | Ion channel modulators & uses thereof |
| TWI459947B (zh) | 2007-06-26 | 2014-11-11 | Otsuka Pharma Co Ltd | 苯并氮呯化合物及藥學製劑 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4022900A (en) * | 1970-09-09 | 1977-05-10 | Marion Laboratories, Inc. | Compositions containing 1,2,3,4-tetrahydroisoquinolines used as hypotensive agents |
| TR199802745T2 (xx) * | 1996-06-17 | 1999-04-21 | Smithkline Beecham Plc | �kameli benzamid t�revleri ve bunlar�n ihtiya�lar� durdurucu veya engelleyici maddeler olarak kullan�lmas�. |
| BR9809047A (pt) | 1997-03-18 | 2000-08-01 | Smithkline Beecham Plc | Derivados de isoquinolina substituìda e o uso dos mesmos como anticonvulsivantes |
-
1997
- 1997-12-17 GB GBGB9726695.1A patent/GB9726695D0/en not_active Ceased
-
1998
- 1998-03-16 HU HU0000987A patent/HUP0000987A3/hu unknown
- 1998-12-15 ZA ZA9811503A patent/ZA9811503B/xx unknown
- 1998-12-15 MA MA25393A patent/MA26583A1/fr unknown
- 1998-12-16 AU AU15724/99A patent/AU744451B2/en not_active Ceased
- 1998-12-16 US US09/581,647 patent/US6248754B1/en not_active Expired - Fee Related
- 1998-12-16 CN CN98813570A patent/CN1125052C/zh not_active Expired - Fee Related
- 1998-12-16 DE DE69821988T patent/DE69821988T2/de not_active Expired - Fee Related
- 1998-12-16 ES ES98960040T patent/ES2216333T3/es not_active Expired - Lifetime
- 1998-12-16 AT AT98960040T patent/ATE260258T1/de not_active IP Right Cessation
- 1998-12-16 TR TR2000/01791T patent/TR200001791T2/xx unknown
- 1998-12-16 JP JP2000538995A patent/JP2002508360A/ja active Pending
- 1998-12-16 EA EA200000657A patent/EA200000657A1/ru unknown
- 1998-12-16 AP APAP/P/2000/001832A patent/AP2000001832A0/en unknown
- 1998-12-16 NZ NZ504706A patent/NZ504706A/xx unknown
- 1998-12-16 CA CA002315079A patent/CA2315079A1/en not_active Abandoned
- 1998-12-16 PL PL98341222A patent/PL341222A1/xx unknown
- 1998-12-16 OA OA1200000180A patent/OA11526A/en unknown
- 1998-12-16 BR BR9813642-9A patent/BR9813642A/pt not_active Application Discontinuation
- 1998-12-16 WO PCT/GB1998/003785 patent/WO1999031068A1/en not_active Application Discontinuation
- 1998-12-16 PE PE1998001234A patent/PE20000006A1/es not_active Application Discontinuation
- 1998-12-16 SK SK914-2000A patent/SK9142000A3/sk unknown
- 1998-12-16 ID IDW20001157A patent/ID24810A/id unknown
- 1998-12-16 EP EP98960040A patent/EP1042296B1/en not_active Expired - Lifetime
- 1998-12-16 KR KR1020007006579A patent/KR20010033194A/ko not_active Application Discontinuation
- 1998-12-16 IL IL13638298A patent/IL136382A0/xx unknown
- 1998-12-16 HU HU0004663A patent/HUP0004663A3/hu unknown
- 1998-12-16 AR ARP980106398A patent/AR014942A1/es not_active Application Discontinuation
- 1998-12-17 CO CO98075174A patent/CO5080731A1/es unknown
-
2000
- 2000-06-16 NO NO20003142A patent/NO315649B1/no not_active IP Right Cessation
- 2000-07-13 BG BG104607A patent/BG104607A/bg unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |