NO313519B1 - Heterocykliske karboksylsyre-derivater, preparater inneholdende dem, og anvendelse av dem til fremstilling av slikepreparater - Google Patents
Heterocykliske karboksylsyre-derivater, preparater inneholdende dem, og anvendelse av dem til fremstilling av slikepreparater Download PDFInfo
- Publication number
- NO313519B1 NO313519B1 NO19992976A NO992976A NO313519B1 NO 313519 B1 NO313519 B1 NO 313519B1 NO 19992976 A NO19992976 A NO 19992976A NO 992976 A NO992976 A NO 992976A NO 313519 B1 NO313519 B1 NO 313519B1
- Authority
- NO
- Norway
- Prior art keywords
- carboxylic acid
- inhibitors
- acid derivatives
- endothelin
- compounds
- Prior art date
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- 238000002360 preparation method Methods 0.000 title claims description 14
- -1 Heterocyclic carboxylic acid derivatives Chemical class 0.000 title claims description 12
- 150000001875 compounds Chemical class 0.000 claims description 34
- 229910052739 hydrogen Inorganic materials 0.000 claims description 15
- 108050009340 Endothelin Proteins 0.000 claims description 13
- 102000002045 Endothelin Human genes 0.000 claims description 13
- ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 claims description 13
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims description 9
- 239000000126 substance Substances 0.000 claims description 9
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 7
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- 229910052760 oxygen Inorganic materials 0.000 claims description 7
- 229910052783 alkali metal Inorganic materials 0.000 claims description 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 6
- UUUHXMGGBIUAPW-UHFFFAOYSA-N 1-[1-[2-[[5-amino-2-[[1-[5-(diaminomethylideneamino)-2-[[1-[3-(1h-indol-3-yl)-2-[(5-oxopyrrolidine-2-carbonyl)amino]propanoyl]pyrrolidine-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbon Chemical compound C1CCC(C(=O)N2C(CCC2)C(O)=O)N1C(=O)C(C(C)CC)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C1CCCN1C(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C1CCC(=O)N1 UUUHXMGGBIUAPW-UHFFFAOYSA-N 0.000 claims description 5
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/14—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/14—Oxygen atoms
- C07D237/16—Two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/18—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D253/075—Two hetero atoms, in positions 3 and 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/08—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 condensed with carbocyclic rings or ring systems
- C07D253/10—Condensed 1,2,4-triazines; Hydrogenated condensed 1,2,4-triazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE1996152763 DE19652763A1 (de) | 1996-12-18 | 1996-12-18 | Heterozyklische Carbonsäurederivate, ihre Herstellung und Verwendung als Endothelinrezeptorantagonisten |
| DE1997100884 DE19700884A1 (de) | 1997-01-13 | 1997-01-13 | Heterozyklische Carbonsäurederivate, ihre Herstellung und Verwendung als Endothelinrezeptorantagonisten |
| PCT/EP1997/006778 WO1998027070A1 (de) | 1996-12-18 | 1997-12-04 | Heterozyklische carbonsäurederivate, ihre herstellung und verwendung als endothelinrezeptorantagonisten |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO992976L NO992976L (no) | 1999-06-17 |
| NO992976D0 NO992976D0 (no) | 1999-06-17 |
| NO313519B1 true NO313519B1 (no) | 2002-10-14 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19992976A NO313519B1 (no) | 1996-12-18 | 1999-06-17 | Heterocykliske karboksylsyre-derivater, preparater inneholdende dem, og anvendelse av dem til fremstilling av slikepreparater |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6448248B1 (es) |
| EP (1) | EP0946524A1 (es) |
| JP (1) | JP2001506243A (es) |
| KR (1) | KR20000057642A (es) |
| CN (1) | CN1247533A (es) |
| AR (1) | AR010359A1 (es) |
| AU (1) | AU740351B2 (es) |
| BG (1) | BG103502A (es) |
| BR (1) | BR9714047A (es) |
| CA (1) | CA2275256A1 (es) |
| CO (1) | CO4930270A1 (es) |
| HR (1) | HRP970686A2 (es) |
| HU (1) | HUP0000553A3 (es) |
| ID (1) | ID26234A (es) |
| IL (1) | IL130251A0 (es) |
| NO (1) | NO313519B1 (es) |
| NZ (1) | NZ336157A (es) |
| PL (1) | PL334014A1 (es) |
| SK (1) | SK77799A3 (es) |
| TR (1) | TR199901416T2 (es) |
| WO (1) | WO1998027070A1 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU750755B2 (en) * | 1997-09-26 | 2002-07-25 | Abbvie Deutschland Gmbh & Co Kg | Endothelin antagonist and a renin-angiotensin system inhibitor as a combined preparation |
| DE19743143A1 (de) * | 1997-09-30 | 1999-04-01 | Knoll Ag | Pharmazeutische Kombinationspräparate |
| CN1123342C (zh) * | 1997-10-17 | 2003-10-08 | 欧洲基因有限公司 | 肾素－血管紧张素系统的抑制剂的用途 |
| DE19806438A1 (de) * | 1998-02-17 | 1999-08-19 | Basf Ag | Neue Carbonsäurederivate mit 5-substituiertem Pyrimidinring, ihre Herstellung und Verwendung |
| DE19858779A1 (de) * | 1998-12-18 | 2000-06-21 | Basf Ag | Neue ß-Amido und ß-Sulfonamidocarbonsäurederivate, ihre Herstellung und Verwendung als Endothelinrezeptorantagonisten |
| DE19924892A1 (de) * | 1999-06-01 | 2000-12-07 | Basf Ag | Neue Carbonsäurederivate mit arylsubstituierten Stickstoffheterocyclen, ihre Herstellung und Verwendung als Endothelin Rezeptorantagonisten |
| CA2386230C (en) * | 1999-10-06 | 2009-05-05 | Basf Aktiengesellschaft | Modulators of cytokine mediated signalling pathways and integrin .alpha.v.beta.3 receptor antagonists for combination therapy |
| FI20010233A0 (fi) * | 2001-02-08 | 2001-02-08 | Orion Corp | Menetelmä sydämen vajaatoiminnan hoitoon |
| WO2003006041A1 (fr) * | 2001-07-12 | 2003-01-23 | Takeda Chemical Industries, Ltd. | Agents prophylactiques/therapeutiques contre les tumeurs malignes |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2671551B1 (fr) * | 1991-01-15 | 1993-03-12 | Adir | Nouveaux composes de structure aryl triazinique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| DE19533023B4 (de) * | 1994-10-14 | 2007-05-16 | Basf Ag | Neue Carbonsäurederivate, ihre Herstellung und Verwendung |
| DE19614534A1 (de) * | 1996-04-12 | 1997-10-16 | Basf Ag | Neue Carbonsäurederivate, ihre Herstellung und Verwendung |
| DE19614533A1 (de) | 1996-04-12 | 1997-10-16 | Basf Ag | Neue alpha-Hydroxysäurederivate, ihre Herstellung und Verwendung |
| DE19614542A1 (de) | 1996-04-12 | 1997-10-16 | Basf Ag | Neue Carbonsäurederivate, ihre Herstellung und Verwendung |
-
1997
- 1997-12-04 JP JP52724798A patent/JP2001506243A/ja active Pending
- 1997-12-04 SK SK777-99A patent/SK77799A3/sk unknown
- 1997-12-04 BR BR9714047-3A patent/BR9714047A/pt not_active IP Right Cessation
- 1997-12-04 IL IL13025197A patent/IL130251A0/xx unknown
- 1997-12-04 US US09/319,876 patent/US6448248B1/en not_active Expired - Fee Related
- 1997-12-04 HU HU0000553A patent/HUP0000553A3/hu unknown
- 1997-12-04 WO PCT/EP1997/006778 patent/WO1998027070A1/de not_active Application Discontinuation
- 1997-12-04 KR KR1019990705445A patent/KR20000057642A/ko not_active Application Discontinuation
- 1997-12-04 CA CA002275256A patent/CA2275256A1/en not_active Abandoned
- 1997-12-04 CN CN97181869A patent/CN1247533A/zh active Pending
- 1997-12-04 AU AU56594/98A patent/AU740351B2/en not_active Ceased
- 1997-12-04 ID IDW990558A patent/ID26234A/id unknown
- 1997-12-04 TR TR1999/01416T patent/TR199901416T2/xx unknown
- 1997-12-04 PL PL97334014A patent/PL334014A1/xx unknown
- 1997-12-04 EP EP97952876A patent/EP0946524A1/de not_active Withdrawn
- 1997-12-04 NZ NZ336157A patent/NZ336157A/xx unknown
- 1997-12-16 HR HR19700884.4A patent/HRP970686A2/hr not_active Application Discontinuation
- 1997-12-16 AR ARP970105907A patent/AR010359A1/es not_active Application Discontinuation
- 1997-12-17 CO CO97073662A patent/CO4930270A1/es unknown
-
1999
- 1999-06-17 NO NO19992976A patent/NO313519B1/no not_active IP Right Cessation
- 1999-06-18 BG BG103502A patent/BG103502A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2001506243A (ja) | 2001-05-15 |
| CO4930270A1 (es) | 2000-06-27 |
| IL130251A0 (en) | 2000-06-01 |
| PL334014A1 (en) | 2000-01-31 |
| NO992976L (no) | 1999-06-17 |
| HUP0000553A3 (en) | 2001-08-28 |
| BG103502A (en) | 2000-07-31 |
| AR010359A1 (es) | 2000-06-07 |
| CA2275256A1 (en) | 1998-06-25 |
| AU5659498A (en) | 1998-07-15 |
| NO992976D0 (no) | 1999-06-17 |
| BR9714047A (pt) | 2000-05-09 |
| EP0946524A1 (de) | 1999-10-06 |
| SK77799A3 (en) | 2000-02-14 |
| US6448248B1 (en) | 2002-09-10 |
| ID26234A (id) | 2000-12-07 |
| HRP970686A2 (en) | 1998-10-31 |
| WO1998027070A1 (de) | 1998-06-25 |
| NZ336157A (en) | 2000-10-27 |
| HUP0000553A1 (hu) | 2001-04-28 |
| KR20000057642A (ko) | 2000-09-25 |
| CN1247533A (zh) | 2000-03-15 |
| AU740351B2 (en) | 2001-11-01 |
| TR199901416T2 (xx) | 1999-08-23 |
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