NO313385B1 - Nye glycosylerte ginkgolidderivater, anvendelse og fremstilling derav samt farmasöytisk preparat - Google Patents
Nye glycosylerte ginkgolidderivater, anvendelse og fremstilling derav samt farmasöytisk preparat Download PDFInfo
- Publication number
- NO313385B1 NO313385B1 NO19995685A NO995685A NO313385B1 NO 313385 B1 NO313385 B1 NO 313385B1 NO 19995685 A NO19995685 A NO 19995685A NO 995685 A NO995685 A NO 995685A NO 313385 B1 NO313385 B1 NO 313385B1
- Authority
- NO
- Norway
- Prior art keywords
- residue
- ginkgolide
- derivatives
- product according
- benzyl
- Prior art date
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- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
- 239000001095 magnesium carbonate Substances 0.000 description 1
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 1
- 235000014380 magnesium carbonate Nutrition 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- CBBVHSHLSCZIHD-UHFFFAOYSA-N mercury silver Chemical compound [Ag].[Hg] CBBVHSHLSCZIHD-UHFFFAOYSA-N 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 239000000693 micelle Substances 0.000 description 1
- 150000002772 monosaccharides Chemical class 0.000 description 1
- 239000012452 mother liquor Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 238000006303 photolysis reaction Methods 0.000 description 1
- 230000015843 photosynthesis, light reaction Effects 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920006316 polyvinylpyrrolidine Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000012047 saturated solution Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 229940037128 systemic glucocorticoids Drugs 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9706111A FR2763592B1 (fr) | 1997-05-20 | 1997-05-20 | Nouveaux derives glycosyles des ginkgolides, leur application en tant que medicaments et compositions pharmaceutiques les contenant |
| PCT/FR1998/001016 WO1998052959A1 (fr) | 1997-05-20 | 1998-05-20 | Nouveaux derives glycosyles des ginkgolides, leur application en tant que medicaments et compositions pharmaceutiques les contenant |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO995685D0 NO995685D0 (no) | 1999-11-19 |
| NO995685L NO995685L (no) | 1999-11-19 |
| NO313385B1 true NO313385B1 (no) | 2002-09-23 |
Family
ID=9507018
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19995685A NO313385B1 (no) | 1997-05-20 | 1999-11-19 | Nye glycosylerte ginkgolidderivater, anvendelse og fremstilling derav samt farmasöytisk preparat |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6143725A (de) |
| EP (1) | EP0983287B1 (de) |
| JP (1) | JP2001527568A (de) |
| KR (1) | KR20010012727A (de) |
| CN (1) | CN1260801A (de) |
| AT (1) | ATE234319T1 (de) |
| AU (1) | AU7775398A (de) |
| CA (1) | CA2289594A1 (de) |
| DE (1) | DE69812086D1 (de) |
| FR (1) | FR2763592B1 (de) |
| NO (1) | NO313385B1 (de) |
| WO (1) | WO1998052959A1 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60215671T2 (de) * | 2001-07-11 | 2007-09-06 | The Trustees Of Columbia University In The City Of New York | Verfahren zur isolierung von terpentrilactonen (ginkgoliden, bilobaliden) aus blättern und pharmazeutische pulver aus ginkgo biloba |
| FR2842425B1 (fr) * | 2002-07-16 | 2005-04-08 | Sod Conseils Rech Applic | Utilisation d'extraits de ginkgo biloba pour favoriser la masse musculaire au detriment de la masse graisseuse |
| FR2827518B1 (fr) * | 2001-07-17 | 2005-07-08 | Sod Conseils Rech Applic | Utilisation d'extraits de ginkgo biloba pour preparer un medicament destine a traiter la sarcopenie |
| US7145021B2 (en) * | 2002-03-29 | 2006-12-05 | The Trustees Of Columbia University In The City Of New York | Analogs of terpene trilactones from Ginkgo biloba and related compounds and uses thereof |
| US6693091B2 (en) | 2002-03-29 | 2004-02-17 | The Trustees Of Columbia University In The City Of New York | Analogs of terpene trilactones from Ginkgo biloba for bioorganic and imaging studies |
| US7429670B2 (en) * | 2003-08-27 | 2008-09-30 | The Trustees Of Columbia University In The City Of New York | Synthesis of derivatives of ginkgolide C |
| US7763741B2 (en) | 2003-11-12 | 2010-07-27 | The Trustees Of Columbia University In The City Of New York | Separation of ginkgolides and bilobalide from G. biloba |
| US20090156668A1 (en) * | 2004-03-19 | 2009-06-18 | The Trustees Of Columbia University In The City Of New York | Ginkgolide Compounds, Compositions, And Extracts, And Uses Thereof |
| WO2006083366A2 (en) * | 2004-11-23 | 2006-08-10 | The Trustees Of Columbia University In The City Of New York | Preparation of ginkgolide and f-seco-ginkgolide lactols |
| US20090221019A1 (en) * | 2005-06-22 | 2009-09-03 | Koji Nakanishi | Core-Modified Terpene Trilactones From Ginkgo Biloba Extract and Biological Evaluation Thereof |
| CN101880286B (zh) * | 2009-05-08 | 2014-11-12 | 北京美倍他药物研究有限公司 | 银杏内酯b的水溶性氨基酸酯衍生物 |
| CN110054634B (zh) | 2019-04-24 | 2023-07-21 | 复旦大学 | 银杏内酯b衍生物及其盐，及其制备方法和用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8418424D0 (en) * | 1984-07-19 | 1984-08-22 | Scras | Inhibition of platelets aggregation |
| GB8725871D0 (en) * | 1987-11-04 | 1987-12-09 | Scras | Ginkgolide derivatives |
| US5002965A (en) * | 1989-05-09 | 1991-03-26 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Use of ginkgolides to prevent reperfusion injury in organ transplantation |
| US6030621A (en) * | 1998-03-19 | 2000-02-29 | De Long; Xie | Ginkgo biloba composition, method to prepare the same and uses thereof |
-
1997
- 1997-05-20 FR FR9706111A patent/FR2763592B1/fr not_active Expired - Fee Related
-
1998
- 1998-05-20 WO PCT/FR1998/001016 patent/WO1998052959A1/fr not_active Ceased
- 1998-05-20 EP EP98925761A patent/EP0983287B1/de not_active Expired - Lifetime
- 1998-05-20 CN CN98806205A patent/CN1260801A/zh active Pending
- 1998-05-20 CA CA002289594A patent/CA2289594A1/fr not_active Abandoned
- 1998-05-20 JP JP55005998A patent/JP2001527568A/ja active Pending
- 1998-05-20 DE DE69812086T patent/DE69812086D1/de not_active Expired - Lifetime
- 1998-05-20 AT AT98925761T patent/ATE234319T1/de not_active IP Right Cessation
- 1998-05-20 AU AU77753/98A patent/AU7775398A/en not_active Abandoned
- 1998-05-20 KR KR1019997010688A patent/KR20010012727A/ko not_active Withdrawn
- 1998-05-20 US US09/424,207 patent/US6143725A/en not_active Expired - Fee Related
-
1999
- 1999-11-19 NO NO19995685A patent/NO313385B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU7775398A (en) | 1998-12-11 |
| NO995685D0 (no) | 1999-11-19 |
| WO1998052959A1 (fr) | 1998-11-26 |
| FR2763592B1 (fr) | 1999-07-16 |
| EP0983287B1 (de) | 2003-03-12 |
| EP0983287A1 (de) | 2000-03-08 |
| FR2763592A1 (fr) | 1998-11-27 |
| ATE234319T1 (de) | 2003-03-15 |
| NO995685L (no) | 1999-11-19 |
| DE69812086D1 (de) | 2003-04-17 |
| KR20010012727A (ko) | 2001-02-26 |
| CA2289594A1 (fr) | 1998-11-26 |
| US6143725A (en) | 2000-11-07 |
| CN1260801A (zh) | 2000-07-19 |
| JP2001527568A (ja) | 2001-12-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |
Free format text: LAPSED IN NOVEMBER 2003 |