NO313010B1 - Eskuletinderivater, fremgangsmåte for fremstilling derav, preparat, kulturskål og sett, samt fremgangsmåte for påvisningog/eller identifikasjon av en mikroorganisme i en pröve - Google Patents
Eskuletinderivater, fremgangsmåte for fremstilling derav, preparat, kulturskål og sett, samt fremgangsmåte for påvisningog/eller identifikasjon av en mikroorganisme i en pröve Download PDFInfo
- Publication number
- NO313010B1 NO313010B1 NO19985070A NO985070A NO313010B1 NO 313010 B1 NO313010 B1 NO 313010B1 NO 19985070 A NO19985070 A NO 19985070A NO 985070 A NO985070 A NO 985070A NO 313010 B1 NO313010 B1 NO 313010B1
- Authority
- NO
- Norway
- Prior art keywords
- general formula
- compound
- cyclohexenoesculetin
- alkyl
- glucoside
- Prior art date
Links
- 244000005700 microbiome Species 0.000 title claims abstract description 20
- 238000001514 detection method Methods 0.000 title claims abstract description 17
- 238000000034 method Methods 0.000 title claims description 28
- 238000002360 preparation method Methods 0.000 title claims description 13
- 239000000758 substrate Substances 0.000 claims abstract description 35
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 45
- 239000002609 medium Substances 0.000 claims description 28
- 230000007062 hydrolysis Effects 0.000 claims description 22
- 238000006460 hydrolysis reaction Methods 0.000 claims description 22
- 239000007787 solid Substances 0.000 claims description 18
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- 239000002253 acid Substances 0.000 claims description 9
- 125000004432 carbon atom Chemical group C* 0.000 claims description 8
- 229910052739 hydrogen Inorganic materials 0.000 claims description 8
- 239000001257 hydrogen Substances 0.000 claims description 8
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- 150000003839 salts Chemical class 0.000 claims description 8
- 230000013595 glycosylation Effects 0.000 claims description 6
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- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 5
- 229930182478 glucoside Natural products 0.000 claims description 5
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 claims description 4
- 229910019142 PO4 Inorganic materials 0.000 claims description 4
- 230000032050 esterification Effects 0.000 claims description 4
- 238000005886 esterification reaction Methods 0.000 claims description 4
- 239000001963 growth medium Substances 0.000 claims description 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 4
- 239000010452 phosphate Substances 0.000 claims description 4
- IAJILQKETJEXLJ-QTBDOELSSA-N aldehydo-D-glucuronic acid Chemical compound O=C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C(O)=O IAJILQKETJEXLJ-QTBDOELSSA-N 0.000 claims description 3
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 3
- 239000012472 biological sample Substances 0.000 claims description 3
- 239000008280 blood Substances 0.000 claims description 3
- 210000004369 blood Anatomy 0.000 claims description 3
- 235000020774 essential nutrients Nutrition 0.000 claims description 3
- 229930182480 glucuronide Natural products 0.000 claims description 3
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- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 3
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- 239000011707 mineral Substances 0.000 claims description 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-N phosphoric acid Substances OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 3
- OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 claims description 2
- 125000005157 alkyl carboxy group Chemical group 0.000 claims description 2
- 239000003242 anti bacterial agent Substances 0.000 claims description 2
- 229940088710 antibiotic agent Drugs 0.000 claims description 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 2
- WQZGKKKJIJFFOK-FPRJBGLDSA-N beta-D-galactose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-FPRJBGLDSA-N 0.000 claims description 2
- AEMOLEFTQBMNLQ-QIUUJYRFSA-N beta-D-glucuronic acid Chemical compound O[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-QIUUJYRFSA-N 0.000 claims description 2
- 238000001574 biopsy Methods 0.000 claims description 2
- 150000007942 carboxylates Chemical group 0.000 claims description 2
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- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 claims description 2
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- 230000015572 biosynthetic process Effects 0.000 abstract description 20
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- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 15
- 229930182470 glycoside Natural products 0.000 description 13
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- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 description 4
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 4
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- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 4
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- 239000007864 aqueous solution Substances 0.000 description 4
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 4
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- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 4
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- 125000001400 nonyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000006916 nutrient agar Substances 0.000 description 1
- WWZKQHOCKIZLMA-UHFFFAOYSA-M octanoate Chemical compound CCCCCCCC([O-])=O WWZKQHOCKIZLMA-UHFFFAOYSA-M 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- RGSFGYAAUTVSQA-UHFFFAOYSA-N pentamethylene Natural products C1CCCC1 RGSFGYAAUTVSQA-UHFFFAOYSA-N 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- SUSQOBVLVYHIEX-UHFFFAOYSA-N phenylacetonitrile Chemical compound N#CCC1=CC=CC=C1 SUSQOBVLVYHIEX-UHFFFAOYSA-N 0.000 description 1
- RLOWWWKZYUNIDI-UHFFFAOYSA-N phosphinic chloride Chemical compound ClP=O RLOWWWKZYUNIDI-UHFFFAOYSA-N 0.000 description 1
- FAIAAWCVCHQXDN-UHFFFAOYSA-N phosphorus trichloride Chemical compound ClP(Cl)Cl FAIAAWCVCHQXDN-UHFFFAOYSA-N 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 150000003053 piperidines Chemical class 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 230000000135 prohibitive effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 229960001225 rifampicin Drugs 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 150000003335 secondary amines Chemical class 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- VFWRGKJLLYDFBY-UHFFFAOYSA-N silver;hydrate Chemical compound O.[Ag].[Ag] VFWRGKJLLYDFBY-UHFFFAOYSA-N 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- KKCBUQHMOMHUOY-UHFFFAOYSA-N sodium oxide Chemical compound [O-2].[Na+].[Na+] KKCBUQHMOMHUOY-UHFFFAOYSA-N 0.000 description 1
- 229910001948 sodium oxide Inorganic materials 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 241000894007 species Species 0.000 description 1
- UNFWWIHTNXNPBV-WXKVUWSESA-N spectinomycin Chemical compound O([C@@H]1[C@@H](NC)[C@@H](O)[C@H]([C@@H]([C@H]1O1)O)NC)[C@]2(O)[C@H]1O[C@H](C)CC2=O UNFWWIHTNXNPBV-WXKVUWSESA-N 0.000 description 1
- 229960000268 spectinomycin Drugs 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- DKVBOUDTNWVDEP-NJCHZNEYSA-N teicoplanin aglycone Chemical group N([C@H](C(N[C@@H](C1=CC(O)=CC(O)=C1C=1C(O)=CC=C2C=1)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)OC=1C=C3C=C(C=1O)OC1=CC=C(C=C1Cl)C[C@H](C(=O)N1)NC([C@H](N)C=4C=C(O5)C(O)=CC=4)=O)C(=O)[C@@H]2NC(=O)[C@@H]3NC(=O)[C@@H]1C1=CC5=CC(O)=C1 DKVBOUDTNWVDEP-NJCHZNEYSA-N 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
- 229930101283 tetracycline Natural products 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 239000012137 tryptone Substances 0.000 description 1
- ORHBXUUXSCNDEV-UHFFFAOYSA-N umbelliferone Chemical compound C1=CC(=O)OC2=CC(O)=CC=C21 ORHBXUUXSCNDEV-UHFFFAOYSA-N 0.000 description 1
- HFTAFOQKODTIJY-UHFFFAOYSA-N umbelliferone Natural products Cc1cc2C=CC(=O)Oc2cc1OCC=CC(C)(C)O HFTAFOQKODTIJY-UHFFFAOYSA-N 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 238000005757 von Pechmann cycloaddition reaction Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
- 239000004246 zinc acetate Substances 0.000 description 1
- 150000008494 α-glucosides Chemical class 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
- C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
- C07D311/14—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 6 and unsubstituted in position 7
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/6552—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring
- C07F9/65522—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring condensed with carbocyclic rings or carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/06—Benzopyran radicals
- C07H17/065—Benzo[b]pyrans
- C07H17/075—Benzo[b]pyran-2-ones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2334/00—O-linked chromogens for determinations of hydrolase enzymes, e.g. glycosidases, phosphatases, esterases
- C12Q2334/20—Coumarin derivatives
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/975—Kit
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Toxicology (AREA)
- General Engineering & Computer Science (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Furan Compounds (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Pyrane Compounds (AREA)
- Manufacture And Refinement Of Metals (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9609024.6A GB9609024D0 (en) | 1996-05-01 | 1996-05-01 | Compounds |
| PCT/GB1997/001202 WO1997041138A2 (en) | 1996-05-01 | 1997-05-01 | Esculetin derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO985070D0 NO985070D0 (no) | 1998-10-30 |
| NO985070L NO985070L (no) | 1998-10-30 |
| NO313010B1 true NO313010B1 (no) | 2002-07-29 |
Family
ID=10792941
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19985070A NO313010B1 (no) | 1996-05-01 | 1998-10-30 | Eskuletinderivater, fremgangsmåte for fremstilling derav, preparat, kulturskål og sett, samt fremgangsmåte for påvisningog/eller identifikasjon av en mikroorganisme i en pröve |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US6008008A (de) |
| EP (1) | EP0900230B1 (de) |
| JP (1) | JP4155599B2 (de) |
| KR (1) | KR100517757B1 (de) |
| AT (1) | ATE210674T1 (de) |
| AU (1) | AU713108B2 (de) |
| CA (1) | CA2253506C (de) |
| DE (1) | DE69709092T2 (de) |
| DK (1) | DK0900230T3 (de) |
| ES (1) | ES2169859T3 (de) |
| GB (1) | GB9609024D0 (de) |
| NO (1) | NO313010B1 (de) |
| NZ (1) | NZ332606A (de) |
| PT (1) | PT900230E (de) |
| WO (1) | WO1997041138A2 (de) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9609024D0 (en) * | 1996-05-01 | 1996-07-03 | Idg Uk Ltd | Compounds |
| DE69814361T2 (de) | 1997-06-04 | 2004-02-19 | The Newcastle Upon Tyne Hospitals National Health Service Trust | Identifikation von salmonella |
| US7344854B2 (en) * | 1999-07-20 | 2008-03-18 | Micrology Laboratories, Llc | Test media for quantitative or qualitative identification and differentiation of general coliforms, E. coli, Aeromonas spp and Salmonella spp in a test sample |
| US6350588B1 (en) * | 1999-07-20 | 2002-02-26 | Micrology Laboratories, Llc | Test media and quantitative or qualitative method for identification and differentiation of biological materials in a test sample |
| US7273719B2 (en) * | 1999-07-20 | 2007-09-25 | Micrology Laboratories, Llc | Test media for quantitative or qualitative identification and differentiation of general coliforms, E coli, Aeromonas spp and Salmonella spp materials in a test sample |
| FR2800377B1 (fr) | 1999-10-28 | 2003-05-09 | Bio Merieux | Substrat enzymatique, procede de synthese et utilisations |
| FR2810676B1 (fr) * | 2000-06-27 | 2003-03-07 | Alain Rambach | Milieu de culture pour la detection et/ou la discrimination des bacteries du genre vibrio et procede de mise en oeuvre |
| US20070155701A1 (en) * | 2002-08-23 | 2007-07-05 | Alexandros Makriyannis | Keto cannabinoids with therapeutic indications |
| US7538233B2 (en) * | 2003-09-05 | 2009-05-26 | Aventis Pharmaceuticals Inc. | Coumarins as iNOS inhibitors |
| US7094528B2 (en) * | 2004-06-30 | 2006-08-22 | Kimberly-Clark Worldwide, Inc. | Magnetic enzyme detection techniques |
| US7906276B2 (en) * | 2004-06-30 | 2011-03-15 | Kimberly-Clark Worldwide, Inc. | Enzymatic detection techniques |
| US7504235B2 (en) | 2005-08-31 | 2009-03-17 | Kimberly-Clark Worldwide, Inc. | Enzyme detection technique |
| US8758989B2 (en) * | 2006-04-06 | 2014-06-24 | Kimberly-Clark Worldwide, Inc. | Enzymatic detection techniques |
| US7897360B2 (en) | 2006-12-15 | 2011-03-01 | Kimberly-Clark Worldwide, Inc. | Enzyme detection techniques |
| JP5996841B2 (ja) * | 2007-05-21 | 2016-09-21 | ウェイク・フォレスト・ユニヴァーシティ・ヘルス・サイエンシズ | 尿由来の前駆細胞およびその使用方法 |
| FR2926563B1 (fr) * | 2008-01-21 | 2013-04-26 | Biomerieux Sa | Procede de detection et/ou d'identification de clostridium difficile |
| WO2010065239A1 (en) * | 2008-12-05 | 2010-06-10 | Wake Forest University Health Sciences | Stem cells from urine and methods for using the same |
| FR2964978B1 (fr) * | 2010-09-21 | 2013-11-15 | J Soufflet Ets | Nouveaux substrats fluorescents, procede d'obtention de ces produits et leur application |
| WO2012166848A2 (en) * | 2011-05-31 | 2012-12-06 | Board Of Regents Of The University Of Texas System | Methods and compositions for the detection of functional clostridium difficile toxins |
| GB201319768D0 (en) | 2013-11-08 | 2013-12-25 | Glycosynth Ltd | Naphthalene derived chromogenic enzyme substrates |
| FR3019833A1 (fr) * | 2014-04-11 | 2015-10-16 | Balel S A | Procede de detection et d'identification de clostridium difficile |
| EP3857220B1 (de) | 2018-09-24 | 2023-01-18 | 4GENE GmbH | Verfahren, vorrichtung und indikator zur lokalisation von überhitzungsschäden |
| WO2020247723A1 (en) | 2019-06-06 | 2020-12-10 | Albert Einstein College Of Medicine | Rapid synthesis of metal nanoparticles |
| KR102664861B1 (ko) * | 2024-01-17 | 2024-05-10 | 주식회사 바오젠 | 바이오리노베이션에 의해 얻은 신규 화합물 및 이를 포함하는 탈모 예방 또는 치료용 조성물 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59192099A (ja) * | 1983-04-12 | 1984-10-31 | Ajinomoto Co Inc | 微生物菌数の測定法 |
| US5055594A (en) * | 1990-07-19 | 1991-10-08 | Becton, Dickinson And Company | Fluorogenic trypotophanase substrates |
| JPH06312925A (ja) * | 1993-03-02 | 1994-11-08 | Kureha Chem Ind Co Ltd | 軟骨保護剤及び新規エスクレチン誘導体 |
| WO1994024119A1 (fr) * | 1993-04-13 | 1994-10-27 | Morinaga Milk Industry Co., Ltd. | Derive de coumarine et son utilisation |
| JP2902318B2 (ja) * | 1994-12-28 | 1999-06-07 | 呉羽化学工業株式会社 | エスクレチン誘導体、その製造方法及びマトリックスメタロプロテアーゼ阻害剤 |
| GB9609024D0 (en) * | 1996-05-01 | 1996-07-03 | Idg Uk Ltd | Compounds |
-
1996
- 1996-05-01 GB GBGB9609024.6A patent/GB9609024D0/en active Pending
-
1997
- 1997-05-01 DK DK97918287T patent/DK0900230T3/da active
- 1997-05-01 JP JP53867697A patent/JP4155599B2/ja not_active Expired - Fee Related
- 1997-05-01 CA CA002253506A patent/CA2253506C/en not_active Expired - Lifetime
- 1997-05-01 DE DE69709092T patent/DE69709092T2/de not_active Expired - Lifetime
- 1997-05-01 ES ES97918287T patent/ES2169859T3/es not_active Expired - Lifetime
- 1997-05-01 KR KR1019980708651A patent/KR100517757B1/ko not_active Expired - Fee Related
- 1997-05-01 WO PCT/GB1997/001202 patent/WO1997041138A2/en not_active Ceased
- 1997-05-01 AU AU26469/97A patent/AU713108B2/en not_active Expired
- 1997-05-01 EP EP97918287A patent/EP0900230B1/de not_active Expired - Lifetime
- 1997-05-01 PT PT97918287T patent/PT900230E/pt unknown
- 1997-05-01 NZ NZ332606A patent/NZ332606A/en not_active IP Right Cessation
- 1997-05-01 AT AT97918287T patent/ATE210674T1/de active
-
1998
- 1998-10-30 NO NO19985070A patent/NO313010B1/no not_active IP Right Cessation
- 1998-11-02 US US09/184,231 patent/US6008008A/en not_active Expired - Lifetime
-
1999
- 1999-12-28 US US09/472,980 patent/US6287798B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0900230A2 (de) | 1999-03-10 |
| EP0900230B1 (de) | 2001-12-12 |
| WO1997041138A3 (en) | 1997-12-11 |
| ES2169859T3 (es) | 2002-07-16 |
| WO1997041138A2 (en) | 1997-11-06 |
| PT900230E (pt) | 2002-05-31 |
| KR100517757B1 (ko) | 2006-06-21 |
| NO985070D0 (no) | 1998-10-30 |
| GB9609024D0 (en) | 1996-07-03 |
| CA2253506A1 (en) | 1997-11-06 |
| DK0900230T3 (da) | 2002-04-08 |
| DE69709092D1 (de) | 2002-01-24 |
| JP4155599B2 (ja) | 2008-09-24 |
| ATE210674T1 (de) | 2001-12-15 |
| JP2000510457A (ja) | 2000-08-15 |
| NZ332606A (en) | 1999-10-28 |
| DE69709092T2 (de) | 2002-08-22 |
| KR20000065074A (ko) | 2000-11-06 |
| CA2253506C (en) | 2007-09-25 |
| US6287798B1 (en) | 2001-09-11 |
| NO985070L (no) | 1998-10-30 |
| US6008008A (en) | 1999-12-28 |
| AU2646997A (en) | 1997-11-19 |
| AU713108B2 (en) | 1999-11-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK1K | Patent expired |