NO312957B1 - Benzyl(iden)-laktamderivater, anvendelse derav og farmasöytisk sammensetning - Google Patents
Benzyl(iden)-laktamderivater, anvendelse derav og farmasöytisk sammensetning Download PDFInfo
- Publication number
- NO312957B1 NO312957B1 NO19984513A NO984513A NO312957B1 NO 312957 B1 NO312957 B1 NO 312957B1 NO 19984513 A NO19984513 A NO 19984513A NO 984513 A NO984513 A NO 984513A NO 312957 B1 NO312957 B1 NO 312957B1
- Authority
- NO
- Norway
- Prior art keywords
- methylpiperazin
- benzylidene
- disorder
- pyrrolidin
- formula
- Prior art date
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- 239000008194 pharmaceutical composition Substances 0.000 title claims description 15
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 title description 5
- 150000001875 compounds Chemical class 0.000 claims description 159
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 claims description 68
- 150000003839 salts Chemical class 0.000 claims description 45
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 27
- 208000035475 disorder Diseases 0.000 claims description 27
- -1 1-(3,4-dichlorophenyl)-3-[2-(4-methylpiperazin-1-yl)-benzylidene]-1,3-dihydro-indol-2-one Chemical compound 0.000 claims description 25
- 229910052739 hydrogen Inorganic materials 0.000 claims description 20
- 239000000126 substance Substances 0.000 claims description 20
- 239000001257 hydrogen Substances 0.000 claims description 19
- 239000003112 inhibitor Substances 0.000 claims description 18
- VGKDLMBJGBXTGI-SJCJKPOMSA-N sertraline Chemical compound C1([C@@H]2CC[C@@H](C3=CC=CC=C32)NC)=CC=C(Cl)C(Cl)=C1 VGKDLMBJGBXTGI-SJCJKPOMSA-N 0.000 claims description 18
- 229960002073 sertraline Drugs 0.000 claims description 17
- 208000018737 Parkinson disease Diseases 0.000 claims description 14
- 239000000460 chlorine Substances 0.000 claims description 14
- 241000124008 Mammalia Species 0.000 claims description 13
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- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 9
- 206010008025 Cerebellar ataxia Diseases 0.000 claims description 9
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- 229910052794 bromium Inorganic materials 0.000 claims description 9
- 229910052801 chlorine Inorganic materials 0.000 claims description 9
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- SVUVRUJADOUWEN-UHFFFAOYSA-N 1-(3,4-difluorophenyl)-3-[[2-(4-methylpiperazin-1-yl)phenyl]methylidene]pyrrolidin-2-one Chemical compound C1CN(C)CCN1C1=CC=CC=C1C=C1C(=O)N(C=2C=C(F)C(F)=CC=2)CC1 SVUVRUJADOUWEN-UHFFFAOYSA-N 0.000 claims description 3
- TWFJKRVEOJPLHP-UHFFFAOYSA-N 3-[[2-(4-methylpiperazin-1-yl)phenyl]methyl]-1-phenylpyrrolidin-2-one Chemical compound C1CN(C)CCN1C1=CC=CC=C1CC1C(=O)N(C=2C=CC=CC=2)CC1 TWFJKRVEOJPLHP-UHFFFAOYSA-N 0.000 claims description 3
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- 125000000649 benzylidene group Chemical group [H]C(=[*])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims description 3
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- OEFLQFJSZMVNQS-UHFFFAOYSA-N 1-(3,4-dichlorophenyl)-3-[[2-(4-methylpiperazin-1-yl)phenyl]methylidene]pyrrolidin-2-one Chemical compound C1CN(C)CCN1C1=CC=CC=C1C=C1C(=O)N(C=2C=C(Cl)C(Cl)=CC=2)CC1 OEFLQFJSZMVNQS-UHFFFAOYSA-N 0.000 claims description 2
- DHEGHIMXBFHOJK-UHFFFAOYSA-N 1-(3,4-dichlorophenyl)-3-[[2-[2-(dimethylamino)ethoxy]phenyl]methylidene]pyrrolidin-2-one Chemical compound CN(C)CCOC1=CC=CC=C1C=C1C(=O)N(C=2C=C(Cl)C(Cl)=CC=2)CC1 DHEGHIMXBFHOJK-UHFFFAOYSA-N 0.000 claims description 2
- BTYTYIJITBBUAC-UHFFFAOYSA-N 1-(3,4-dichlorophenyl)-3-[[5-fluoro-2-(4-methylpiperazin-1-yl)phenyl]methylidene]pyrrolidin-2-one Chemical compound C1CN(C)CCN1C1=CC=C(F)C=C1C=C1C(=O)N(C=2C=C(Cl)C(Cl)=CC=2)CC1 BTYTYIJITBBUAC-UHFFFAOYSA-N 0.000 claims description 2
- LWCHTDNWGXRROT-UHFFFAOYSA-N 1-(3,4-difluorophenyl)-3-[[2-(4-methylpiperazin-1-yl)phenyl]methyl]pyrrolidin-2-one Chemical compound C1CN(C)CCN1C1=CC=CC=C1CC1C(=O)N(C=2C=C(F)C(F)=CC=2)CC1 LWCHTDNWGXRROT-UHFFFAOYSA-N 0.000 claims description 2
- NBRKHSQLNPOVMR-UHFFFAOYSA-N 1-(4-chlorophenyl)-3-[[5-fluoro-2-(4-methylpiperazin-1-yl)phenyl]methylidene]piperidin-2-one Chemical compound C1CN(C)CCN1C1=CC=C(F)C=C1C=C1C(=O)N(C=2C=CC(Cl)=CC=2)CCC1 NBRKHSQLNPOVMR-UHFFFAOYSA-N 0.000 claims description 2
- WFZDDRBHAPGODK-UHFFFAOYSA-N 1-(4-methoxyphenyl)-3-[[2-(4-methylpiperazin-1-yl)phenyl]methylidene]-4h-quinolin-2-one Chemical compound C1=CC(OC)=CC=C1N(C1=O)C2=CC=CC=C2CC1=CC1=CC=CC=C1N1CCN(C)CC1 WFZDDRBHAPGODK-UHFFFAOYSA-N 0.000 claims description 2
- YMYPGNNKKHIXNU-UHFFFAOYSA-N 1-(4-methylphenyl)-3-[[2-(4-methylpiperazin-1-yl)phenyl]methylidene]pyrrolidin-2-one Chemical compound C1CN(C)CCN1C1=CC=CC=C1C=C1C(=O)N(C=2C=CC(C)=CC=2)CC1 YMYPGNNKKHIXNU-UHFFFAOYSA-N 0.000 claims description 2
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Classifications
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/38—2-Pyrrolones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
- C07D211/76—Oxygen atoms attached in position 2 or 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/86—Oxygen atoms
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- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
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- Endocrinology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1513496P | 1996-03-29 | 1996-03-29 | |
PCT/IB1997/000076 WO1997036867A1 (en) | 1996-03-29 | 1997-02-03 | Benzyl(idene)-lactam derivatives, their preparation and their use as selective (ant)agonists of 5-ht1a- and/or 5-ht1d receptors |
Publications (3)
Publication Number | Publication Date |
---|---|
NO984513L NO984513L (no) | 1998-09-28 |
NO984513D0 NO984513D0 (no) | 1998-09-28 |
NO312957B1 true NO312957B1 (no) | 2002-07-22 |
Family
ID=21769713
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO19984513A NO312957B1 (no) | 1996-03-29 | 1998-09-28 | Benzyl(iden)-laktamderivater, anvendelse derav og farmasöytisk sammensetning |
Country Status (40)
Country | Link |
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US (2) | US6462048B2 (sk) |
EP (1) | EP0894085B1 (sk) |
JP (1) | JP3118467B2 (sk) |
KR (1) | KR100305071B1 (sk) |
CN (1) | CN1128788C (sk) |
AP (1) | AP824A (sk) |
AR (1) | AR006390A1 (sk) |
AT (1) | ATE302182T1 (sk) |
AU (1) | AU706839B2 (sk) |
BG (1) | BG64176B1 (sk) |
BR (1) | BR9708581A (sk) |
CA (1) | CA2249603A1 (sk) |
CO (1) | CO4650033A1 (sk) |
CZ (1) | CZ293628B6 (sk) |
DE (1) | DE69733996T2 (sk) |
DZ (1) | DZ2198A1 (sk) |
EA (1) | EA001485B1 (sk) |
ES (1) | ES2246058T3 (sk) |
HK (1) | HK1019446A1 (sk) |
HN (1) | HN1997000023A (sk) |
HR (1) | HRP970175A2 (sk) |
HU (1) | HUP9902160A3 (sk) |
ID (1) | ID17781A (sk) |
IL (1) | IL125377A (sk) |
IS (1) | IS4813A (sk) |
MA (1) | MA26425A1 (sk) |
MY (1) | MY118498A (sk) |
NO (1) | NO312957B1 (sk) |
NZ (1) | NZ325914A (sk) |
OA (1) | OA10879A (sk) |
PL (1) | PL329170A1 (sk) |
SK (1) | SK131498A3 (sk) |
TN (1) | TNSN97056A1 (sk) |
TR (1) | TR199801929T2 (sk) |
TW (1) | TW413679B (sk) |
UA (1) | UA70284C2 (sk) |
UY (1) | UY24498A1 (sk) |
WO (1) | WO1997036867A1 (sk) |
YU (1) | YU11997A (sk) |
ZA (1) | ZA972690B (sk) |
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US6696448B2 (en) | 1996-06-05 | 2004-02-24 | Sugen, Inc. | 3-(piperazinylbenzylidenyl)-2-indolinone compounds and derivatives as protein tyrosine kinase inhibitors |
US6423708B1 (en) * | 1996-09-30 | 2002-07-23 | Pfizer Inc | Aralkyl and aralkylidene heterocyclic lactams and imides |
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US6531502B1 (en) | 1998-01-21 | 2003-03-11 | Sugen, Inc. | 3-Methylidenyl-2-indolinone modulators of protein kinase |
DE19830201A1 (de) * | 1998-07-07 | 2000-01-13 | Boehringer Ingelheim Pharma | Mittel mit antidepressiver Wirkung |
CA2301899C (en) * | 1998-07-27 | 2008-11-18 | Boehringer Ingelheim Pharma Kg | Agent with an antidepressant activity |
GB9904933D0 (en) | 1999-03-04 | 1999-04-28 | Glaxo Group Ltd | Compounds |
US6492398B1 (en) | 1999-03-04 | 2002-12-10 | Smithkline Beechman Corporation | Thiazoloindolinone compounds |
US6624171B1 (en) | 1999-03-04 | 2003-09-23 | Smithkline Beecham Corporation | Substituted aza-oxindole derivatives |
ES2225031T3 (es) * | 1999-12-29 | 2005-03-16 | Pfizer Products Inc. | Compuestos de 3-((2-piperazinil-fenil)metil)-1-(4-(trifluorometil)fenil)-2-pirrolidinona opticamente activos como antagonistas selectivos del receptor de 5-ht1d. |
US6620818B1 (en) | 2000-03-01 | 2003-09-16 | Smithkline Beecham Corporation | Method for reducing the severity of side effects of chemotherapy and/or radiation therapy |
EP1434774A1 (en) | 2001-10-10 | 2004-07-07 | Sugen, Inc. | 3-(4-substituted heterocyclyl)-pyrrol-2-ylmethylidene)-2-indolinone derivatives as protein kinase inhibitors |
PL372096A1 (en) | 2002-01-02 | 2005-07-11 | Ardent Pharmaceuticals, Inc. | Method of treating sexual dysfunctions with delta opioid receptor agonist compounds |
TWI263497B (en) * | 2002-03-29 | 2006-10-11 | Lilly Co Eli | Pyridinoylpiperidines as 5-HT1F agonists |
DE602004028150D1 (de) * | 2003-11-26 | 2010-08-26 | Pfizer Prod Inc | Aminopyrazolderivate als gsk-3-inhibitoren |
CA2553291A1 (en) * | 2004-01-29 | 2005-09-09 | Pfizer Products Inc. | Combination of .gamma.-aminobutyric acid modulators and 5-ht1b receptor antagonists |
JP4880583B2 (ja) | 2004-03-17 | 2012-02-22 | ファイザー・プロダクツ・インク | 新規なベンジル(ベンジリデン)−ラクタム誘導体 |
BRPI0510942A (pt) * | 2004-05-11 | 2007-07-17 | Pfizer Prod Inc | combinação de antipsicóticos atìpicos e antagonistas do receptor 5-ht1b |
BRPI0511419A (pt) * | 2004-05-21 | 2007-12-04 | Pfizer Prod Inc | derivado de lactama de pirazinilmetila |
BRPI0512406A (pt) * | 2004-06-25 | 2008-03-04 | Pfizer Prod Inc | piridil piperazinas, composições farmacêuticas compreendendo as mesmas e intermediário para a sìntese das piridil piperazinas |
WO2006075226A1 (en) * | 2005-01-13 | 2006-07-20 | Pfizer Products Inc. | 11c-labeled benzyl-lactam compounds and their use as imaging agents |
WO2006106416A1 (en) * | 2005-04-08 | 2006-10-12 | Pfizer Products Inc. | PYRIDIL-LACTAMS AND THEIR USE 5 -HTl RECEPTORS LIGAN |
JP2008543829A (ja) * | 2005-06-17 | 2008-12-04 | ファイザー・プロダクツ・インク | セロトニン受容体アンタゴニストとしての1−[6−(1−エチル−1−ヒドロキシ−プロピル)−ピリジン−3−イル]−3−[2−(4−メチル−ピペラジン−1−イル)−ベンジル]−ピロリジン−2−オンの代謝産物 |
WO2007012964A1 (en) * | 2005-07-25 | 2007-02-01 | Pfizer Products Inc. | Preparation of alkylpiperazinylphenyl compounds by classical resolution |
WO2007026224A2 (en) * | 2005-08-31 | 2007-03-08 | Pfizer Products Inc. | 5-ht1b antagonist composition for depression, anxiety and cognition |
WO2007026219A2 (en) * | 2005-08-31 | 2007-03-08 | Pfizer Products Inc. | Combinations of a 5-ht1b antagonist with a noradrenalin re-uptake inhibitor or a serotonin noradrenalin reutake inhibitor for treating cns conditions |
US20070096411A1 (en) * | 2005-11-02 | 2007-05-03 | Rempe Gary L Ii | Device for retaining a kneeling rider on a gliding board |
WO2014078568A1 (en) | 2012-11-14 | 2014-05-22 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
US10246436B2 (en) * | 2015-09-02 | 2019-04-02 | Trevena, Inc. | 6-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same |
JP7185633B2 (ja) | 2017-02-17 | 2022-12-07 | トレベナ・インコーポレイテッド | 7員アザ複素環を含有するデルタ-オピオイド受容体調節化合物、その使用方法及び製造方法 |
CN110520129A (zh) | 2017-02-17 | 2019-11-29 | 特维娜有限公司 | 含有5元氮杂杂环的δ阿片受体调节化合物及其使用和制备方法 |
WO2020183011A1 (en) | 2019-03-14 | 2020-09-17 | Institut Curie | Htr1d inhibitors and uses thereof in the treatment of cancer |
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US4078062A (en) | 1976-10-28 | 1978-03-07 | E. R. Squibb & Sons, Inc. | Substituted 2H-1,4-benzothiazin-3(4H)-ones |
JPS62116557A (ja) * | 1985-11-15 | 1987-05-28 | Takeda Chem Ind Ltd | 置換ベンジルラクタム類 |
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WO1993007128A1 (en) * | 1991-10-11 | 1993-04-15 | The Du Pont Merck Pharmaceutical Company | Cyclic ureas and analogues useful as retroviral protease inhibitiors |
US5436246A (en) | 1992-09-17 | 1995-07-25 | Merrell Dow Pharmaceuticals Inc. | Serotonin receptor agents |
GB9410512D0 (en) * | 1994-05-25 | 1994-07-13 | Smithkline Beecham Plc | Novel treatment |
US5880141A (en) * | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
US6467084B1 (en) * | 1999-12-16 | 2002-10-15 | Emware, Inc. | Systems and methods for reprogramming an embedded device with program code using relocatable program code |
-
1997
- 1997-02-03 BR BR9708581A patent/BR9708581A/pt not_active Application Discontinuation
- 1997-02-03 TR TR1998/01929T patent/TR199801929T2/xx unknown
- 1997-02-03 HU HU9902160A patent/HUP9902160A3/hu unknown
- 1997-02-03 CA CA002249603A patent/CA2249603A1/en not_active Abandoned
- 1997-02-03 EA EA199800771A patent/EA001485B1/ru not_active IP Right Cessation
- 1997-02-03 DE DE69733996T patent/DE69733996T2/de not_active Expired - Fee Related
- 1997-02-03 IL IL12537797A patent/IL125377A/xx not_active IP Right Cessation
- 1997-02-03 SK SK1314-98A patent/SK131498A3/sk unknown
- 1997-02-03 EP EP97900717A patent/EP0894085B1/en not_active Expired - Lifetime
- 1997-02-03 KR KR1019980707713A patent/KR100305071B1/ko not_active IP Right Cessation
- 1997-02-03 JP JP09535074A patent/JP3118467B2/ja not_active Expired - Fee Related
- 1997-02-03 PL PL97329170A patent/PL329170A1/xx unknown
- 1997-02-03 CN CN97193251A patent/CN1128788C/zh not_active Expired - Fee Related
- 1997-02-03 CZ CZ19983052A patent/CZ293628B6/cs not_active IP Right Cessation
- 1997-02-03 ES ES97900717T patent/ES2246058T3/es not_active Expired - Lifetime
- 1997-02-03 WO PCT/IB1997/000076 patent/WO1997036867A1/en active IP Right Grant
- 1997-02-03 NZ NZ325914A patent/NZ325914A/en unknown
- 1997-02-03 AT AT97900717T patent/ATE302182T1/de not_active IP Right Cessation
- 1997-02-03 AU AU13170/97A patent/AU706839B2/en not_active Ceased
- 1997-02-03 US US09/155,215 patent/US6462048B2/en not_active Expired - Fee Related
- 1997-02-04 TW TW086101295A patent/TW413679B/zh active
- 1997-02-06 HN HN1997000023A patent/HN1997000023A/es unknown
- 1997-03-02 UA UA98095077A patent/UA70284C2/uk unknown
- 1997-03-13 CO CO97013714A patent/CO4650033A1/es unknown
- 1997-03-21 UY UY24498A patent/UY24498A1/es not_active IP Right Cessation
- 1997-03-25 AR ARP970101200A patent/AR006390A1/es not_active Application Discontinuation
- 1997-03-26 TN TNTNSN97056A patent/TNSN97056A1/fr unknown
- 1997-03-26 DZ DZ970045A patent/DZ2198A1/fr active
- 1997-03-26 HR HR60/015,134A patent/HRP970175A2/hr not_active Application Discontinuation
- 1997-03-26 MA MA24535A patent/MA26425A1/fr unknown
- 1997-03-27 ZA ZA972690A patent/ZA972690B/xx unknown
- 1997-03-27 YU YU11997A patent/YU11997A/sh unknown
- 1997-03-27 ID IDP971025A patent/ID17781A/id unknown
- 1997-03-27 AP APAP/P/1997/000955A patent/AP824A/en active
- 1997-03-28 MY MYPI97001340A patent/MY118498A/en unknown
-
1998
- 1998-07-29 IS IS4813A patent/IS4813A/is unknown
- 1998-09-16 OA OA9800170A patent/OA10879A/en unknown
- 1998-09-24 BG BG102791A patent/BG64176B1/bg unknown
- 1998-09-28 NO NO19984513A patent/NO312957B1/no unknown
-
1999
- 1999-10-13 HK HK99104493A patent/HK1019446A1/xx not_active IP Right Cessation
-
2002
- 2002-08-15 US US10/219,692 patent/US6924289B2/en not_active Expired - Fee Related
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