MA26425A1 - Derives de lactames, procede pour leur preparation et compositions pharmaceutiques les contenant - Google Patents

Derives de lactames, procede pour leur preparation et compositions pharmaceutiques les contenant

Info

Publication number
MA26425A1
MA26425A1 MA24535A MA24535A MA26425A1 MA 26425 A1 MA26425 A1 MA 26425A1 MA 24535 A MA24535 A MA 24535A MA 24535 A MA24535 A MA 24535A MA 26425 A1 MA26425 A1 MA 26425A1
Authority
MA
Morocco
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
lactam derivatives
lactam
Prior art date
Application number
MA24535A
Other languages
English (en)
Inventor
R Howard Harry
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of MA26425A1 publication Critical patent/MA26425A1/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24Oxygen or sulfur atoms
    • C07D207/262-Pyrrolidones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/12Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36Oxygen or sulfur atoms
    • C07D207/382-Pyrrolones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/30Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32Oxygen atoms
    • C07D209/34Oxygen atoms in position 2
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74Oxygen atoms
    • C07D211/76Oxygen atoms attached in position 2 or 6
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/86Oxygen atoms
MA24535A 1996-03-29 1997-03-26 Derives de lactames, procede pour leur preparation et compositions pharmaceutiques les contenant MA26425A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1513496P 1996-03-29 1996-03-29

Publications (1)

Publication Number Publication Date
MA26425A1 true MA26425A1 (fr) 2004-12-20

Family

ID=21769713

Family Applications (1)

Application Number Title Priority Date Filing Date
MA24535A MA26425A1 (fr) 1996-03-29 1997-03-26 Derives de lactames, procede pour leur preparation et compositions pharmaceutiques les contenant

Country Status (40)

Country Link
US (2) US6462048B2 (fr)
EP (1) EP0894085B1 (fr)
JP (1) JP3118467B2 (fr)
KR (1) KR100305071B1 (fr)
CN (1) CN1128788C (fr)
AP (1) AP824A (fr)
AR (1) AR006390A1 (fr)
AT (1) ATE302182T1 (fr)
AU (1) AU706839B2 (fr)
BG (1) BG64176B1 (fr)
BR (1) BR9708581A (fr)
CA (1) CA2249603A1 (fr)
CO (1) CO4650033A1 (fr)
CZ (1) CZ293628B6 (fr)
DE (1) DE69733996T2 (fr)
DZ (1) DZ2198A1 (fr)
EA (1) EA001485B1 (fr)
ES (1) ES2246058T3 (fr)
HK (1) HK1019446A1 (fr)
HN (1) HN1997000023A (fr)
HR (1) HRP970175A2 (fr)
HU (1) HUP9902160A3 (fr)
ID (1) ID17781A (fr)
IL (1) IL125377A (fr)
IS (1) IS4813A (fr)
MA (1) MA26425A1 (fr)
MY (1) MY118498A (fr)
NO (1) NO312957B1 (fr)
NZ (1) NZ325914A (fr)
OA (1) OA10879A (fr)
PL (1) PL329170A1 (fr)
SK (1) SK131498A3 (fr)
TN (1) TNSN97056A1 (fr)
TR (1) TR199801929T2 (fr)
TW (1) TW413679B (fr)
UA (1) UA70284C2 (fr)
UY (1) UY24498A1 (fr)
WO (1) WO1997036867A1 (fr)
YU (1) YU11997A (fr)
ZA (1) ZA972690B (fr)

Families Citing this family (36)

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Publication number Priority date Publication date Assignee Title
JPH041367U (fr) * 1990-04-13 1992-01-08
US6906093B2 (en) 1995-06-07 2005-06-14 Sugen, Inc. Indolinone combinatorial libraries and related products and methods for the treatment of disease
US5880141A (en) * 1995-06-07 1999-03-09 Sugen, Inc. Benzylidene-Z-indoline compounds for the treatment of disease
US6147106A (en) 1997-08-20 2000-11-14 Sugen, Inc. Indolinone combinatorial libraries and related products and methods for the treatment of disease
US6696448B2 (en) 1996-06-05 2004-02-24 Sugen, Inc. 3-(piperazinylbenzylidenyl)-2-indolinone compounds and derivatives as protein tyrosine kinase inhibitors
US6423708B1 (en) * 1996-09-30 2002-07-23 Pfizer Inc Aralkyl and aralkylidene heterocyclic lactams and imides
GB9718913D0 (en) 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives
US6531502B1 (en) 1998-01-21 2003-03-11 Sugen, Inc. 3-Methylidenyl-2-indolinone modulators of protein kinase
DE19830201A1 (de) * 1998-07-07 2000-01-13 Boehringer Ingelheim Pharma Mittel mit antidepressiver Wirkung
CA2301899C (fr) * 1998-07-27 2008-11-18 Boehringer Ingelheim Pharma Kg Agent antidepresseur
US6624171B1 (en) 1999-03-04 2003-09-23 Smithkline Beecham Corporation Substituted aza-oxindole derivatives
GB9904933D0 (en) 1999-03-04 1999-04-28 Glaxo Group Ltd Compounds
US6492398B1 (en) 1999-03-04 2002-12-10 Smithkline Beechman Corporation Thiazoloindolinone compounds
DK1113015T3 (da) * 1999-12-29 2004-12-13 Pfizer Prod Inc Optisk aktive 3-[(2-piperazinyl-phenyl)methyl]-1-[4-(trifluormethyl)-phenyl]-2-pyrrolidinonforbindelser som 5-HT1D-receptor-selektive antagonister
US6620818B1 (en) 2000-03-01 2003-09-16 Smithkline Beecham Corporation Method for reducing the severity of side effects of chemotherapy and/or radiation therapy
EP1434774A1 (fr) 2001-10-10 2004-07-07 Sugen, Inc. Derives de 3- 4-(substitue heterocyclyl)-pyrrol-2-ylmethylidene]-2-indolinone utiles comme inhibiteurs des kinases
US8575169B2 (en) 2001-10-29 2013-11-05 Versi Group, Llc Method of treating sexual dysfunctions with delta opioid receptor agonist compounds
TWI263497B (en) * 2002-03-29 2006-10-11 Lilly Co Eli Pyridinoylpiperidines as 5-HT1F agonists
ATE473967T1 (de) * 2003-11-26 2010-07-15 Pfizer Prod Inc Aminopyrazolderivate als gsk-3-inhibitoren
BRPI0507190A (pt) * 2004-01-29 2007-06-26 Pfizer Prod Inc combinação de moduladores do ácido gama-aminobutìrico e antagonistas de 5-ht1b receptores
AU2005223481A1 (en) 2004-03-17 2005-09-29 Pfizer Products Inc. Novel benzyl(idene)-lactam derivatives
MXPA06013163A (es) * 2004-05-11 2007-02-13 Pfizer Prod Inc Combinacion de antipsicoticos atipicos y antagonistas del receptor 5-ht1b.
WO2005113535A2 (fr) * 2004-05-21 2005-12-01 Pfizer Products Inc. Derives pyrazinylmethyle-lactame
BRPI0512406A (pt) * 2004-06-25 2008-03-04 Pfizer Prod Inc piridil piperazinas, composições farmacêuticas compreendendo as mesmas e intermediário para a sìntese das piridil piperazinas
US8012969B2 (en) 2005-01-13 2011-09-06 Ge Healthcare Limited 11C-labeled benzyl-lactam compounds and their use as imaging agents
WO2006106416A1 (fr) * 2005-04-08 2006-10-12 Pfizer Products Inc. Pyridil-lactams et leur utilisation comme ligands de recepteurs 5-ht1
EP1891041A1 (fr) * 2005-06-17 2008-02-27 Pfizer Products Incorporated Metabolites de 1- [-6- (1-ethyl-l-hydroxy-propyl) -pyridin-3-yl]-3- [2- (4-methyl-piperazin-i-yl) -be nzyl]-pyrr0lidin-2-0ne utilises en tant qu'antagonistes du recepteur de serotonine
WO2007012964A1 (fr) * 2005-07-25 2007-02-01 Pfizer Products Inc. Préparation de composés d'alkylpipérazinylphényle par dédoublement classique
WO2007026224A2 (fr) * 2005-08-31 2007-03-08 Pfizer Products Inc. Composition d'antagoniste 5-ht1b pour le traitement de la depression, de l'anxiete et des troubles de la cognition
WO2007026219A2 (fr) * 2005-08-31 2007-03-08 Pfizer Products Inc. Composition d'antagonistes du recepteur 5-ht1b servant au traitement d'etats du systeme nerveux central
US20070096411A1 (en) * 2005-11-02 2007-05-03 Rempe Gary L Ii Device for retaining a kneeling rider on a gliding board
EP3610890A1 (fr) 2012-11-14 2020-02-19 The Johns Hopkins University Procédés et compositions de traitement de la schizophrénie
US10246436B2 (en) * 2015-09-02 2019-04-02 Trevena, Inc. 6-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same
US11702408B2 (en) 2017-02-17 2023-07-18 Trevena, Inc. 5-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same
CA3052479A1 (fr) 2017-02-17 2018-08-23 Trevena, Inc. Composes modulateurs du recepteur des opioides delta contenant des heterocycles aza a 7 chainons, et leurs procedes de preparation et d'utilisation
WO2020183011A1 (fr) 2019-03-14 2020-09-17 Institut Curie Inhibiteurs de htr1d et leurs utilisations dans le traitement du cancer

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US4078062A (en) * 1976-10-28 1978-03-07 E. R. Squibb & Sons, Inc. Substituted 2H-1,4-benzothiazin-3(4H)-ones
JPS62116557A (ja) 1985-11-15 1987-05-28 Takeda Chem Ind Ltd 置換ベンジルラクタム類
US5189179A (en) 1990-08-29 1993-02-23 Merrell Dow Pharmaceuticals Inc. Serotonin 5ht1a agonists
ATE204262T1 (de) 1991-09-18 2001-09-15 Glaxo Group Ltd Benzanilidderivate als 5-ht1d-antagonisten
ATE216371T1 (de) * 1991-10-11 2002-05-15 Du Pont Pharm Co Cyclische harnstoffe und analoga verwendbar als retrovirale proteasehemmer
US5436246A (en) * 1992-09-17 1995-07-25 Merrell Dow Pharmaceuticals Inc. Serotonin receptor agents
GB9410512D0 (en) * 1994-05-25 1994-07-13 Smithkline Beecham Plc Novel treatment
US5880141A (en) * 1995-06-07 1999-03-09 Sugen, Inc. Benzylidene-Z-indoline compounds for the treatment of disease
US6467084B1 (en) * 1999-12-16 2002-10-15 Emware, Inc. Systems and methods for reprogramming an embedded device with program code using relocatable program code

Also Published As

Publication number Publication date
ES2246058T3 (es) 2006-02-01
MY118498A (en) 2004-11-30
NO312957B1 (no) 2002-07-22
AP824A (en) 2000-04-28
TNSN97056A1 (fr) 2005-03-15
US6462048B2 (en) 2002-10-08
NO984513L (no) 1998-09-28
DE69733996D1 (de) 2005-09-22
KR20000005083A (ko) 2000-01-25
TR199801929T2 (xx) 1998-12-21
US20030027812A1 (en) 2003-02-06
HUP9902160A2 (hu) 1999-11-29
AU1317097A (en) 1997-10-22
ID17781A (id) 1998-01-29
CZ293628B6 (cs) 2004-06-16
BR9708581A (pt) 1999-08-03
EP0894085B1 (fr) 2005-08-17
ZA972690B (en) 1998-09-28
EA001485B1 (ru) 2001-04-23
CA2249603A1 (fr) 1997-10-09
DZ2198A1 (fr) 2002-12-02
ATE302182T1 (de) 2005-09-15
IS4813A (is) 1998-07-29
TW413679B (en) 2000-12-01
UA70284C2 (en) 2004-10-15
NZ325914A (en) 1999-09-29
IL125377A0 (en) 1999-03-12
US20020028821A1 (en) 2002-03-07
NO984513D0 (no) 1998-09-28
JP3118467B2 (ja) 2000-12-18
CZ305298A3 (cs) 1999-07-14
HUP9902160A3 (en) 2001-02-28
OA10879A (en) 2001-10-05
AP9700955A0 (en) 1997-04-30
BG64176B1 (bg) 2004-03-31
DE69733996T2 (de) 2006-07-20
JPH11506472A (ja) 1999-06-08
KR100305071B1 (ko) 2001-12-12
AU706839B2 (en) 1999-06-24
AR006390A1 (es) 1999-08-25
HRP970175A2 (en) 1998-12-31
YU11997A (sh) 1999-09-27
US6924289B2 (en) 2005-08-02
HK1019446A1 (en) 2000-02-11
CO4650033A1 (es) 1998-09-03
EA199800771A1 (ru) 1999-06-24
WO1997036867A1 (fr) 1997-10-09
EP0894085A1 (fr) 1999-02-03
PL329170A1 (en) 1999-03-15
UY24498A1 (es) 2000-09-29
CN1214043A (zh) 1999-04-14
SK131498A3 (en) 2000-09-12
BG102791A (en) 1999-11-30
HN1997000023A (es) 1997-06-05
CN1128788C (zh) 2003-11-26
IL125377A (en) 2005-07-25

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