NO312458B1 - IL-8-reseptor antagonister, fremgangsmåte for fremstilling derav og farmasöytisk preparat - Google Patents
IL-8-reseptor antagonister, fremgangsmåte for fremstilling derav og farmasöytisk preparat Download PDFInfo
- Publication number
- NO312458B1 NO312458B1 NO19990668A NO990668A NO312458B1 NO 312458 B1 NO312458 B1 NO 312458B1 NO 19990668 A NO19990668 A NO 19990668A NO 990668 A NO990668 A NO 990668A NO 312458 B1 NO312458 B1 NO 312458B1
- Authority
- NO
- Norway
- Prior art keywords
- cyano
- cyanoguanidine
- formula
- compound
- hydroxy
- Prior art date
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- 239000005720 sucrose Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 229960001367 tartaric acid Drugs 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 229950011008 tetrachloroethylene Drugs 0.000 description 1
- AXZWODMDQAVCJE-UHFFFAOYSA-L tin(II) chloride (anhydrous) Chemical compound [Cl-].[Cl-].[Sn+2] AXZWODMDQAVCJE-UHFFFAOYSA-L 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 230000009529 traumatic brain injury Effects 0.000 description 1
- JLTRXTDYQLMHGR-UHFFFAOYSA-N trimethylaluminium Chemical compound C[Al](C)C JLTRXTDYQLMHGR-UHFFFAOYSA-N 0.000 description 1
- 210000003556 vascular endothelial cell Anatomy 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/66—Nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/28—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to cyano groups, e.g. cyanoguanidines, dicyandiamides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2341496P | 1996-08-15 | 1996-08-15 | |
| PCT/US1997/014581 WO1998006397A1 (en) | 1996-08-15 | 1997-08-15 | Il-8 receptor antagonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO990668D0 NO990668D0 (no) | 1999-02-12 |
| NO990668L NO990668L (no) | 1999-04-12 |
| NO312458B1 true NO312458B1 (no) | 2002-05-13 |
Family
ID=21814968
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19990668A NO312458B1 (no) | 1996-08-15 | 1999-02-12 | IL-8-reseptor antagonister, fremgangsmåte for fremstilling derav og farmasöytisk preparat |
| NO20016067A NO314301B1 (no) | 1996-08-15 | 2001-12-12 | Fremgangsmåte for fremstilling av IL-8-reseptor-antagonister |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20016067A NO314301B1 (no) | 1996-08-15 | 2001-12-12 | Fremgangsmåte for fremstilling av IL-8-reseptor-antagonister |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6204294B1 (cs) |
| EP (1) | EP0929302A4 (cs) |
| JP (1) | JP2000516619A (cs) |
| KR (1) | KR20000030003A (cs) |
| CN (1) | CN1152675C (cs) |
| AR (1) | AR008290A1 (cs) |
| AU (1) | AU723816B2 (cs) |
| BR (1) | BR9711140A (cs) |
| CA (1) | CA2263388A1 (cs) |
| CO (1) | CO5031286A1 (cs) |
| CZ (1) | CZ46799A3 (cs) |
| IL (1) | IL128501A0 (cs) |
| NO (2) | NO312458B1 (cs) |
| PL (1) | PL331539A1 (cs) |
| TR (1) | TR199900318T2 (cs) |
| TW (1) | TW461878B (cs) |
| WO (1) | WO1998006397A1 (cs) |
| ZA (1) | ZA977301B (cs) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU735545B2 (en) | 1996-05-24 | 2001-07-12 | Neurosearch A/S | Phenyl derivatives containing an acidic group, their preparation and their use as chloride channel blockers |
| JP2000513360A (ja) | 1996-06-27 | 2000-10-10 | スミスクライン・ビーチャム・コーポレイション | Ｉｌ―８レセプターアンタゴニスト |
| US6335352B1 (en) * | 1996-08-15 | 2002-01-01 | Smithkline Beecham Corporation | IL-8 receptor antagonists |
| ATE258444T1 (de) * | 1998-03-13 | 2004-02-15 | Univ British Columbia | Therapeutische chemokine rezeptor antagonisten |
| CA2245224A1 (en) * | 1998-08-14 | 2000-02-14 | Jiang-Hong Giong | Chemokine receptor antagonists and chemotherapeutics |
| CA2305787A1 (en) * | 2000-05-09 | 2001-11-09 | The University Of British Columbia | Cxcr4 antagonist treatment of hematopoietic cells |
| AR029637A1 (es) | 1999-05-28 | 2003-07-10 | Smithkline Beecham Corp | Compuestos de guanidina, antagonistas de los receptores de la il-8, una composicion farmaceutica que los contiene y el uso de los mismos para la manufactura de un medicamento |
| CO5170528A1 (es) * | 1999-05-28 | 2002-06-27 | Smithkline Beecham Corp | Antagonistas de los receptores de la il-8 nistas del recpetor de la il-8 |
| ECSP003525A (es) * | 1999-06-16 | 2002-01-25 | Smithkline Beecham Corp | Antagonistas del receptor de il- 8 iv |
| UY26627A1 (es) * | 2000-03-24 | 2001-09-28 | Smithkline Beecham Corp | Antagonistas de receptores de il-8 |
| US7368425B2 (en) * | 2006-03-24 | 2008-05-06 | Chemokine Therapeutics Corp. | Cyclic peptides for modulating growth of neo-vessels and their use in therapeutic angiogenesis |
| US20050059584A1 (en) * | 2002-08-16 | 2005-03-17 | Ahmed Merzouk | Novel chemokine mimetics synthesis and their use |
| CA2335109A1 (en) * | 2000-04-12 | 2001-10-12 | Chemokine Therapeutics Corporation | Cxcr4 agonist treatment of hematopoietic cells |
| US7378098B2 (en) * | 2000-04-12 | 2008-05-27 | The University Of British Columbia | CXC chemokine receptor 4 agonist peptides |
| EP1273571A4 (en) | 2000-04-14 | 2003-05-02 | Kureha Chemical Ind Co Ltd | NITROGEN COMPOUNDS AND ANTIVIRAL MEDICATIONS CONTAINING THEM |
| US6515001B2 (en) | 2001-03-05 | 2003-02-04 | Chemokine Therapeutic Corporation | IL-8 receptor ligands-drugs for inflammatory and autoimmune diseases |
| EP1389460A1 (en) * | 2001-05-24 | 2004-02-18 | Kureha Chemical Industry Co., Ltd. | Cxcr4-antagonistic drugs comprising nitrogen-containing compound |
| JP3714948B2 (ja) * | 2002-09-11 | 2005-11-09 | 呉羽化学工業株式会社 | アミン化合物及びその用途 |
| MY143477A (en) * | 2002-10-29 | 2011-05-31 | Smithkline Beecham Corp | Il-8 receptor antagonists |
| US7932281B2 (en) | 2004-03-10 | 2011-04-26 | Kureha Corporation | Amine-based compound and use thereof |
| MXPA06013118A (es) | 2004-05-12 | 2007-02-28 | Schering Corp | Antagonistas de cxcr1 y cxcr2 de quimocina. |
| CN101039652A (zh) * | 2004-08-16 | 2007-09-19 | 宝洁公司 | 2－(氨基或取代的氨基)－5,6－取代的苯酚化合物，包含该化合物的染料组合物以及它们的应用 |
| EP1634573A1 (en) * | 2004-08-16 | 2006-03-15 | The Procter and Gamble Company | 2-(Amino or substituted Amino)-5,6-substituted Phenol compounds, dyeing compositions containing them, and use thereof |
| US20070249625A1 (en) * | 2004-10-20 | 2007-10-25 | Jakob Busch-Petersen | Il-8 Receptor Antagonists |
| MY145810A (en) * | 2006-04-21 | 2012-04-30 | Smithkline Beecham Corp | Il-8 receptor antagonists |
| RU2008145871A (ru) * | 2006-04-21 | 2010-05-27 | Смитклайн Бичам Корпорейшн (US) | Антагонисты рецептора il-8 |
| TW200817006A (en) * | 2006-06-23 | 2008-04-16 | Smithkline Beecham Corp | IL-8 receptor antagonist |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US537186A (en) * | 1895-04-09 | Jacob ebert | ||
| US4269837A (en) * | 1980-02-19 | 1981-05-26 | Pfizer Inc. | Hypoglycemic guanylamidines, compositions and use |
| NZ229828A (en) * | 1988-08-09 | 1992-03-26 | Squibb & Sons Inc | Aryl cyanoguanidine derivatives and pharmaceutical compositions |
| JP2742084B2 (ja) * | 1989-03-13 | 1998-04-22 | キヤノン株式会社 | グアニジン二量化物およびグアニジン二量化物を含有する静電荷像現像用トナー |
| US5214208A (en) * | 1989-03-13 | 1993-05-25 | Canon Kabushiki Kaisha | Toner containing a dimer of diarylguanidine type compound for developing electrostatic image |
| US5792444A (en) * | 1989-05-09 | 1998-08-11 | The General Hospital Corporation | Labeled chemotactic peptides to image focal sites of infection or inflammation |
| US5371086A (en) | 1991-03-15 | 1994-12-06 | The Green Cross Corporation | Aminopyridine compounds |
| AU4530693A (en) | 1992-08-13 | 1994-03-15 | Upjohn Company, The | Cyanoguanidines as potassium channel blockers |
| DK41193D0 (da) * | 1993-04-07 | 1993-04-07 | Neurosearch As | Ionkanalaabnere |
| US5401758A (en) | 1993-10-07 | 1995-03-28 | Bristol-Myers Squibb Company | Pyridinyl cyanoguanidine compounds |
-
1997
- 1997-08-12 AR ARP970103665A patent/AR008290A1/es not_active Application Discontinuation
- 1997-08-14 ZA ZA9707301A patent/ZA977301B/xx unknown
- 1997-08-15 WO PCT/US1997/014581 patent/WO1998006397A1/en not_active Application Discontinuation
- 1997-08-15 JP JP10510106A patent/JP2000516619A/ja not_active Ceased
- 1997-08-15 BR BR9711140A patent/BR9711140A/pt not_active Application Discontinuation
- 1997-08-15 PL PL97331539A patent/PL331539A1/xx unknown
- 1997-08-15 KR KR1019997001283A patent/KR20000030003A/ko not_active Ceased
- 1997-08-15 CN CNB971986037A patent/CN1152675C/zh not_active Expired - Fee Related
- 1997-08-15 CA CA002263388A patent/CA2263388A1/en not_active Abandoned
- 1997-08-15 AU AU40750/97A patent/AU723816B2/en not_active Ceased
- 1997-08-15 US US09/230,977 patent/US6204294B1/en not_active Expired - Fee Related
- 1997-08-15 TR TR1999/00318T patent/TR199900318T2/xx unknown
- 1997-08-15 IL IL12850197A patent/IL128501A0/xx unknown
- 1997-08-15 CO CO97047171A patent/CO5031286A1/es unknown
- 1997-08-15 EP EP19970938425 patent/EP0929302A4/en not_active Withdrawn
- 1997-08-15 CZ CZ99467A patent/CZ46799A3/cs unknown
- 1997-10-03 TW TW086111871A patent/TW461878B/zh not_active IP Right Cessation
-
1999
- 1999-02-12 NO NO19990668A patent/NO312458B1/no not_active IP Right Cessation
-
2001
- 2001-12-12 NO NO20016067A patent/NO314301B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CN1152675C (zh) | 2004-06-09 |
| NO990668L (no) | 1999-04-12 |
| TR199900318T2 (xx) | 1999-05-21 |
| PL331539A1 (en) | 1999-07-19 |
| IL128501A0 (en) | 2000-01-31 |
| NO314301B1 (no) | 2003-03-03 |
| CZ46799A3 (cs) | 1999-12-15 |
| TW461878B (en) | 2001-11-01 |
| NO20016067D0 (no) | 2001-12-12 |
| BR9711140A (pt) | 1999-08-17 |
| WO1998006397A1 (en) | 1998-02-19 |
| AU4075097A (en) | 1998-03-06 |
| CA2263388A1 (en) | 1998-02-19 |
| ZA977301B (en) | 1998-02-16 |
| CN1232398A (zh) | 1999-10-20 |
| AR008290A1 (es) | 1999-12-29 |
| NO990668D0 (no) | 1999-02-12 |
| NO20016067L (no) | 1999-04-12 |
| KR20000030003A (ko) | 2000-05-25 |
| US6204294B1 (en) | 2001-03-20 |
| EP0929302A1 (en) | 1999-07-21 |
| AU723816B2 (en) | 2000-09-07 |
| CO5031286A1 (es) | 2001-04-27 |
| EP0929302A4 (en) | 2002-10-31 |
| JP2000516619A (ja) | 2000-12-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |