NO312296B1 - Benzoksazinon-dopamin-D4-reseptor-antagonister, anvendelse derav, samt farmasöytisk preparat - Google Patents
Benzoksazinon-dopamin-D4-reseptor-antagonister, anvendelse derav, samt farmasöytisk preparat Download PDFInfo
- Publication number
- NO312296B1 NO312296B1 NO19985531A NO985531A NO312296B1 NO 312296 B1 NO312296 B1 NO 312296B1 NO 19985531 A NO19985531 A NO 19985531A NO 985531 A NO985531 A NO 985531A NO 312296 B1 NO312296 B1 NO 312296B1
- Authority
- NO
- Norway
- Prior art keywords
- benzo
- ylmethyl
- oxazin
- piperazin
- compound according
- Prior art date
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- -1 Benzoxazinone-dopamine Chemical compound 0.000 title claims abstract description 15
- 229940124243 Dopamine D4 receptor antagonist Drugs 0.000 title description 2
- 239000003814 drug Substances 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims abstract description 59
- 150000003839 salts Chemical class 0.000 claims abstract description 15
- 239000001257 hydrogen Substances 0.000 claims abstract description 14
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 14
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 14
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract description 13
- 150000001408 amides Chemical class 0.000 claims abstract description 10
- 150000002148 esters Chemical class 0.000 claims abstract description 9
- 125000005420 sulfonamido group Chemical group S(=O)(=O)(N*)* 0.000 claims abstract description 9
- 239000000651 prodrug Substances 0.000 claims abstract description 8
- 229940002612 prodrug Drugs 0.000 claims abstract description 8
- 229910052736 halogen Inorganic materials 0.000 claims abstract description 5
- 150000002367 halogens Chemical class 0.000 claims abstract description 5
- 125000001624 naphthyl group Chemical group 0.000 claims abstract description 5
- 125000001424 substituent group Chemical group 0.000 claims abstract description 5
- 238000002360 preparation method Methods 0.000 claims description 28
- 208000028017 Psychotic disease Diseases 0.000 claims description 10
- 201000000980 schizophrenia Diseases 0.000 claims description 9
- 125000000335 thiazolyl group Chemical group 0.000 claims description 6
- HQQTZCPKNZVLFF-UHFFFAOYSA-N 4h-1,2-benzoxazin-3-one Chemical group C1=CC=C2ONC(=O)CC2=C1 HQQTZCPKNZVLFF-UHFFFAOYSA-N 0.000 claims description 5
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 3
- GPGUDXIKRCJQNT-UHFFFAOYSA-N 4-[4-[(3-oxo-4h-1,4-benzoxazin-6-yl)methyl]piperazin-1-yl]benzenesulfonamide Chemical compound C1=CC(S(=O)(=O)N)=CC=C1N1CCN(CC=2C=C3NC(=O)COC3=CC=2)CC1 GPGUDXIKRCJQNT-UHFFFAOYSA-N 0.000 claims description 3
- NFRIERLNKMVOKN-UHFFFAOYSA-N 6-[(4-phenylpiperazin-1-yl)methyl]-4h-1,4-benzoxazin-3-one Chemical compound C1=C2NC(=O)COC2=CC=C1CN(CC1)CCN1C1=CC=CC=C1 NFRIERLNKMVOKN-UHFFFAOYSA-N 0.000 claims description 3
- RCWYEZYTOVCNOJ-UHFFFAOYSA-N 6-[[4-(3,4-dimethylphenyl)piperazin-1-yl]methyl]-4h-1,4-benzoxazin-3-one Chemical compound C1=C(C)C(C)=CC=C1N1CCN(CC=2C=C3NC(=O)COC3=CC=2)CC1 RCWYEZYTOVCNOJ-UHFFFAOYSA-N 0.000 claims description 3
- RKZVRIHTYWJVDD-UHFFFAOYSA-N 6-[[4-(4-methylphenyl)piperazin-1-yl]methyl]-4h-1,4-benzoxazin-3-one Chemical compound C1=CC(C)=CC=C1N1CCN(CC=2C=C3NC(=O)COC3=CC=2)CC1 RKZVRIHTYWJVDD-UHFFFAOYSA-N 0.000 claims description 3
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- CBXCPBUEXACCNR-UHFFFAOYSA-N tetraethylammonium Chemical compound CC[N+](CC)(CC)CC CBXCPBUEXACCNR-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1838396P | 1996-05-29 | 1996-05-29 | |
| US4020897P | 1997-03-06 | 1997-03-06 | |
| PCT/US1997/008524 WO1997045419A1 (en) | 1996-05-29 | 1997-05-20 | Benzoxazinone dopamine d4 receptor antagonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO985531L NO985531L (no) | 1998-11-27 |
| NO985531D0 NO985531D0 (no) | 1998-11-27 |
| NO312296B1 true NO312296B1 (no) | 2002-04-22 |
Family
ID=26691052
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19985531A NO312296B1 (no) | 1996-05-29 | 1998-11-27 | Benzoksazinon-dopamin-D4-reseptor-antagonister, anvendelse derav, samt farmasöytisk preparat |
Country Status (37)
| Country | Link |
|---|---|
| EP (1) | EP0906294B1 (zh) |
| JP (1) | JP2000511534A (zh) |
| KR (1) | KR20000016151A (zh) |
| CN (1) | CN1074764C (zh) |
| AR (1) | AR008372A1 (zh) |
| AT (1) | ATE231846T1 (zh) |
| AU (1) | AU731104B2 (zh) |
| BG (1) | BG64049B1 (zh) |
| BR (1) | BR9709630A (zh) |
| CA (1) | CA2253406A1 (zh) |
| CO (1) | CO4940505A1 (zh) |
| CZ (1) | CZ384698A3 (zh) |
| DE (1) | DE69718786T2 (zh) |
| DK (1) | DK0906294T3 (zh) |
| EA (1) | EA001486B1 (zh) |
| EE (1) | EE03686B1 (zh) |
| ES (1) | ES2191180T3 (zh) |
| GE (1) | GEP20012389B (zh) |
| HK (1) | HK1019737A1 (zh) |
| HN (1) | HN1997000075A (zh) |
| HR (1) | HRP970301B1 (zh) |
| HU (1) | HUP9903758A3 (zh) |
| ID (1) | ID17266A (zh) |
| IL (1) | IL126895A (zh) |
| NO (1) | NO312296B1 (zh) |
| NZ (1) | NZ332737A (zh) |
| PA (1) | PA8431101A1 (zh) |
| PE (1) | PE69398A1 (zh) |
| PL (1) | PL330195A1 (zh) |
| PT (1) | PT906294E (zh) |
| RO (1) | RO120845B1 (zh) |
| SI (1) | SI0906294T1 (zh) |
| SK (1) | SK282703B6 (zh) |
| SV (1) | SV1997000047A (zh) |
| TW (1) | TW542833B (zh) |
| UY (1) | UY24569A1 (zh) |
| WO (1) | WO1997045419A1 (zh) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6177422B1 (en) | 1996-05-29 | 2001-01-23 | Warner-Lambert Company | Benzoxazinone dopamine D4 receptor antagonists |
| GB9801392D0 (en) * | 1998-01-22 | 1998-03-18 | Smithkline Beecham Plc | Novel compounds |
| US6291463B1 (en) | 1998-06-30 | 2001-09-18 | Neurogen Corporation | 1-(Benzothiazol-2-yl)-4-(1-phenylmethyl) piperazines: dopamine receptor subtype specific ligands |
| WO2000000482A1 (en) * | 1998-06-30 | 2000-01-06 | Neurogen Corporation | 1-(benzothiazol-2-yl)-4-(1-phenylmethyl)piperazines: dopamine receptor subtype specific ligands |
| EP1091949A2 (en) * | 1998-06-30 | 2001-04-18 | Neurogen Corporation | 6-(4-arylalkylpiperazin-1-yl)benzodioxane and 6-(4-arylalkylpiperazin-1-yl)chromane derivatives: dopamine receptor subtype specific ligands |
| US6177566B1 (en) | 1998-06-30 | 2001-01-23 | Neurogen Corporation | 6-(4-arylalkylpiperazin-1-yl) benzodioxane and 6-(4-arylalkylpiperazin-1-yl) chromane derivatives: dopamine receptor subtype specific ligands |
| DE19844291A1 (de) * | 1998-09-18 | 2000-03-23 | Schering Ag | Benzoxazin- und Benzothiazin-Derivate und deren Verwendung in Arzneimitteln |
| GB9912411D0 (en) * | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| DE60127434T2 (de) | 2000-10-26 | 2007-11-29 | Smithkline Beecham P.L.C., Brentford | Benzoxazinonderivative, deren herstellung und verwendung |
| GB0203804D0 (en) | 2002-02-18 | 2002-04-03 | Glaxo Group Ltd | Compounds |
| GB0209244D0 (en) * | 2002-04-23 | 2002-06-05 | Glaxo Group Ltd | Compounds |
| GB0227240D0 (en) * | 2002-11-21 | 2002-12-31 | Glaxo Group Ltd | Compounds |
| ES2232292B1 (es) * | 2003-07-30 | 2006-11-01 | Laboratorios Del Dr. Esteve, S.A. | Compuestos sulfonamidicos derivados de benzoxazinona, su preparacion y uso como medicamentos. |
| CN100455573C (zh) * | 2005-11-11 | 2009-01-28 | 华东理工大学 | 一种制备1,4-苯并噁唑嗪-3-酮化合物的微波合成方法 |
| KR200482995Y1 (ko) | 2015-08-19 | 2017-03-23 | 이현진 | 물 공급부를 구비하는 얼음 트레이 |
| CA3215823A1 (en) * | 2021-04-23 | 2022-10-27 | Peng Gao | Heterocyclic derivative inhibitor and preparation method therefor and application thereof |
| WO2023207283A1 (en) * | 2022-04-28 | 2023-11-02 | Ningbo Newbay Technology Development Co., Ltd | Compounds as parp1 inhibitiors |
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|---|---|---|---|---|
| US4613598A (en) * | 1984-03-13 | 1986-09-23 | Mitsubishi Chemical Industries Limited | Piperazine derivatives and their acid addition salts |
| EP0233728A1 (en) * | 1986-02-11 | 1987-08-26 | Takeda Chemical Industries, Ltd. | 1,4-Benzoxazine derivatives their production and use |
| US5523299A (en) * | 1992-08-06 | 1996-06-04 | Smithkline Beecham Plc | 5-(2-oxyphenyl)-pyrrole derivatives as dopamine D3 receptor antagonists |
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1997
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