NO311494B1 - Doseringsform for behandling av mikrobiologiske tilstander i mennesker eller dyr, fremgangsmåte for sterilisering av engjenstand, steriliserende blanding, samt dyrefôrtillegg - Google Patents
Doseringsform for behandling av mikrobiologiske tilstander i mennesker eller dyr, fremgangsmåte for sterilisering av engjenstand, steriliserende blanding, samt dyrefôrtillegg Download PDFInfo
- Publication number
- NO311494B1 NO311494B1 NO19963446A NO963446A NO311494B1 NO 311494 B1 NO311494 B1 NO 311494B1 NO 19963446 A NO19963446 A NO 19963446A NO 963446 A NO963446 A NO 963446A NO 311494 B1 NO311494 B1 NO 311494B1
- Authority
- NO
- Norway
- Prior art keywords
- acidifying agent
- source
- pharmaceutically acceptable
- dosage form
- nitrite ions
- Prior art date
Links
- 241001465754 Metazoa Species 0.000 title claims abstract description 18
- 230000001954 sterilising effect Effects 0.000 title claims abstract description 15
- 239000002552 dosage form Substances 0.000 title claims abstract description 11
- 238000000034 method Methods 0.000 title claims abstract description 11
- 239000000203 mixture Substances 0.000 title claims abstract description 8
- 230000002906 microbiologic effect Effects 0.000 title claims description 6
- 239000006052 feed supplement Substances 0.000 title abstract 2
- 238000004659 sterilization and disinfection Methods 0.000 title 1
- 239000002535 acidifier Substances 0.000 claims abstract description 23
- 239000003937 drug carrier Substances 0.000 claims abstract description 6
- -1 nitrite ions Chemical class 0.000 claims description 18
- 239000002243 precursor Substances 0.000 claims description 15
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical group OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims description 14
- 229910001963 alkali metal nitrate Inorganic materials 0.000 claims description 12
- 150000001340 alkali metals Chemical class 0.000 claims description 12
- 229910001964 alkaline earth metal nitrate Inorganic materials 0.000 claims description 12
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 8
- 239000003085 diluting agent Substances 0.000 claims description 7
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims description 7
- 229960004889 salicylic acid Drugs 0.000 claims description 7
- 239000013589 supplement Substances 0.000 claims description 7
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 238000006243 chemical reaction Methods 0.000 claims description 5
- 239000006071 cream Substances 0.000 claims description 5
- 239000002674 ointment Substances 0.000 claims description 5
- 150000007524 organic acids Chemical group 0.000 claims description 5
- 235000010323 ascorbic acid Nutrition 0.000 claims description 4
- 229960005070 ascorbic acid Drugs 0.000 claims description 4
- 239000011668 ascorbic acid Substances 0.000 claims description 4
- 239000007788 liquid Substances 0.000 claims description 4
- 241000282887 Suidae Species 0.000 claims description 3
- 230000000844 anti-bacterial effect Effects 0.000 claims description 2
- 230000009286 beneficial effect Effects 0.000 claims description 2
- IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 abstract description 34
- 239000004599 antimicrobial Substances 0.000 abstract description 3
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000002538 fungal effect Effects 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
- MWUXSHHQAYIFBG-UHFFFAOYSA-N nitrogen oxide Inorganic materials O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 description 28
- 229910002651 NO3 Inorganic materials 0.000 description 17
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 17
- 239000002253 acid Substances 0.000 description 15
- LPXPTNMVRIOKMN-UHFFFAOYSA-M sodium nitrite Chemical compound [Na+].[O-]N=O LPXPTNMVRIOKMN-UHFFFAOYSA-M 0.000 description 12
- 230000000694 effects Effects 0.000 description 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
- 235000010288 sodium nitrite Nutrition 0.000 description 6
- 210000002784 stomach Anatomy 0.000 description 6
- 241000894006 Bacteria Species 0.000 description 5
- 244000005700 microbiome Species 0.000 description 5
- 230000003287 optical effect Effects 0.000 description 5
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 4
- 208000015181 infectious disease Diseases 0.000 description 4
- 230000007246 mechanism Effects 0.000 description 4
- 229910017604 nitric acid Inorganic materials 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 206010015150 Erythema Diseases 0.000 description 3
- 208000005577 Gastroenteritis Diseases 0.000 description 3
- 238000002835 absorbance Methods 0.000 description 3
- 235000019647 acidic taste Nutrition 0.000 description 3
- 230000002378 acidificating effect Effects 0.000 description 3
- 229910052757 nitrogen Inorganic materials 0.000 description 3
- 230000002829 reductive effect Effects 0.000 description 3
- 210000003296 saliva Anatomy 0.000 description 3
- 230000004083 survival effect Effects 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 2
- 241000233866 Fungi Species 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 235000005911 diet Nutrition 0.000 description 2
- 230000000378 dietary effect Effects 0.000 description 2
- 231100000321 erythema Toxicity 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 230000037406 food intake Effects 0.000 description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 description 2
- GPRLSGONYQIRFK-UHFFFAOYSA-N hydron Chemical compound [H+] GPRLSGONYQIRFK-UHFFFAOYSA-N 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 230000000968 intestinal effect Effects 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 description 2
- 210000003079 salivary gland Anatomy 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 235000019640 taste Nutrition 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 201000004647 tinea pedis Diseases 0.000 description 2
- 210000002438 upper gastrointestinal tract Anatomy 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 1
- 206010001986 Amoebic dysentery Diseases 0.000 description 1
- 108020000946 Bacterial DNA Proteins 0.000 description 1
- 241000222122 Candida albicans Species 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 208000002064 Dental Plaque Diseases 0.000 description 1
- 108010033478 E coli K88 antigen Proteins 0.000 description 1
- 241000305071 Enterobacterales Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- MBMLMWLHJBBADN-UHFFFAOYSA-N Ferrous sulfide Chemical compound [Fe]=S MBMLMWLHJBBADN-UHFFFAOYSA-N 0.000 description 1
- 241000589601 Francisella Species 0.000 description 1
- 206010017533 Fungal infection Diseases 0.000 description 1
- 241000590002 Helicobacter pylori Species 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010022678 Intestinal infections Diseases 0.000 description 1
- 102000005298 Iron-Sulfur Proteins Human genes 0.000 description 1
- 108010081409 Iron-Sulfur Proteins Proteins 0.000 description 1
- 241000186660 Lactobacillus Species 0.000 description 1
- 241001137872 Leishmania sp. Species 0.000 description 1
- 238000000585 Mann–Whitney U test Methods 0.000 description 1
- 241001467578 Microbacterium Species 0.000 description 1
- 208000031888 Mycoses Diseases 0.000 description 1
- 206010048685 Oral infection Diseases 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 206010037888 Rash pustular Diseases 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 241000607142 Salmonella Species 0.000 description 1
- 241000607768 Shigella Species 0.000 description 1
- 206010040844 Skin exfoliation Diseases 0.000 description 1
- 241001147693 Staphylococcus sp. Species 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 239000007979 citrate buffer Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000007123 defense Effects 0.000 description 1
- 208000002925 dental caries Diseases 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 230000035618 desquamation Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 230000002183 duodenal effect Effects 0.000 description 1
- 230000000369 enteropathogenic effect Effects 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 235000019249 food preservative Nutrition 0.000 description 1
- 239000005452 food preservative Substances 0.000 description 1
- 210000002683 foot Anatomy 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 229940037467 helicobacter pylori Drugs 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 244000000074 intestinal pathogen Species 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000003641 microbiacidal effect Effects 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 239000002324 mouth wash Substances 0.000 description 1
- 229940051866 mouthwash Drugs 0.000 description 1
- 150000002823 nitrates Chemical class 0.000 description 1
- 229940005654 nitrite ion Drugs 0.000 description 1
- 150000002826 nitrites Chemical class 0.000 description 1
- 150000004005 nitrosamines Chemical class 0.000 description 1
- 235000021590 normal diet Nutrition 0.000 description 1
- 230000024241 parasitism Effects 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 235000010333 potassium nitrate Nutrition 0.000 description 1
- 239000004323 potassium nitrate Substances 0.000 description 1
- 230000004224 protection Effects 0.000 description 1
- 230000009979 protective mechanism Effects 0.000 description 1
- 208000029561 pustule Diseases 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- BWMISRWJRUSYEX-SZKNIZGXSA-N terbinafine hydrochloride Chemical compound Cl.C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 BWMISRWJRUSYEX-SZKNIZGXSA-N 0.000 description 1
- 229940034610 toothpaste Drugs 0.000 description 1
- 239000000606 toothpaste Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000036269 ulceration Effects 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Inorganic Chemistry (AREA)
- Pain & Pain Management (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Fodder In General (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9403284A GB9403284D0 (en) | 1994-02-21 | 1994-02-21 | Acidified nitrite as antimicrobial agent |
| GB9404365A GB9404365D0 (en) | 1994-03-07 | 1994-03-07 | Acidified nitrate as antimicrobial agent |
| PCT/GB1995/000338 WO1995022335A1 (en) | 1994-02-21 | 1995-02-17 | Acidified nitrite as an antimicrobial agent |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO963446D0 NO963446D0 (no) | 1996-08-19 |
| NO963446L NO963446L (no) | 1996-10-21 |
| NO311494B1 true NO311494B1 (no) | 2001-12-03 |
Family
ID=26304368
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19963446A NO311494B1 (no) | 1994-02-21 | 1996-08-19 | Doseringsform for behandling av mikrobiologiske tilstander i mennesker eller dyr, fremgangsmåte for sterilisering av engjenstand, steriliserende blanding, samt dyrefôrtillegg |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0746327B1 (de) |
| JP (1) | JP3875262B2 (de) |
| KR (1) | KR100385297B1 (de) |
| CN (1) | CN1145491C (de) |
| AT (1) | ATE264685T1 (de) |
| AU (1) | AU693851B2 (de) |
| BR (1) | BR9507099A (de) |
| CA (1) | CA2183549C (de) |
| CZ (1) | CZ286286B6 (de) |
| DE (1) | DE69532921T2 (de) |
| DK (1) | DK0746327T3 (de) |
| ES (1) | ES2218541T3 (de) |
| FI (1) | FI114852B (de) |
| NO (1) | NO311494B1 (de) |
| PL (1) | PL180769B1 (de) |
| PT (1) | PT746327E (de) |
| WO (1) | WO1995022335A1 (de) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9804469D0 (en) * | 1998-03-02 | 1998-04-29 | Univ Aberdeen | Antiviral composition |
| US6709681B2 (en) | 1995-02-17 | 2004-03-23 | Aberdeen University | Acidified nitrite as an antimicrobial agent |
| SE9700617D0 (sv) * | 1997-02-21 | 1997-02-21 | Kjell Alving | New composition |
| AU5526399A (en) | 1998-08-28 | 2000-03-21 | University Of Bath, The | Improvements in or relating to the treatment of lesions |
| GB9905425D0 (en) * | 1999-03-09 | 1999-05-05 | Queen Mary & Westfield College | Pharmaceutical composition |
| GB0021317D0 (en) * | 2000-08-30 | 2000-10-18 | Queen Mary & Westfield College | Transdermal pharmaceutical delivery composition |
| GB0022084D0 (en) * | 2000-09-08 | 2000-10-25 | Univ Aberdeen | Treatment of multiply antibiotic-resistant organisms |
| US6432077B1 (en) * | 2000-12-26 | 2002-08-13 | Sensormedics Corporation | Device and method for treatment of surface infections with nitric oxide |
| GB0119011D0 (en) * | 2001-08-03 | 2001-09-26 | Univ Aberdeen | Treatment of nail infections |
| EP1455888B1 (de) | 2001-08-29 | 2009-04-29 | PharmaKodex Limited | Vorrichtung zur topischen verabreichung |
| GB0125222D0 (en) * | 2001-10-19 | 2001-12-12 | Barts & London Nhs Trust | Composition for the treatment of microbial infections |
| JP5564158B2 (ja) | 2003-07-09 | 2014-07-30 | ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ アズ リプレゼンテッド バイ ザ セクレタリー オブ ザ デパートメント オブ ヘルス アンド ヒューマン サービシーズ | 亜硝酸塩によって特定の心臓血管状態を処置する方法 |
| BRPI0606829A2 (pt) * | 2005-02-11 | 2009-07-21 | Nolabs Ab | dispositivo configurado, processo para fabricação de dispositivo configurado, usos de polìmero eluente de óxido nìtrico(no), método de tratamento e uso de óxido nìtrico(no) |
| WO2006125123A2 (en) | 2005-05-19 | 2006-11-23 | University Of Cincinnati | Methods for treating bacterial respiratory tract infections in an individual using acidified nitrite |
| JP5274248B2 (ja) | 2005-05-27 | 2013-08-28 | ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル | 酸化窒素治療及び医生物的応用のための酸化窒素放出粒子 |
| GB0604319D0 (en) * | 2006-03-03 | 2006-04-12 | Optinose As | Nasal delivery |
| GB0607402D0 (en) * | 2006-04-12 | 2006-05-24 | Barts & London Nhs Trust | Therapeutic composition and use |
| GB0618711D0 (en) * | 2006-09-22 | 2006-11-01 | Univ Exeter | Agricultural treatment |
| US9919072B2 (en) | 2009-08-21 | 2018-03-20 | Novan, Inc. | Wound dressings, methods of using the same and methods of forming the same |
| CN102711729B (zh) | 2009-08-21 | 2015-04-01 | 诺万公司 | 局部用凝胶 |
| US8591876B2 (en) | 2010-12-15 | 2013-11-26 | Novan, Inc. | Methods of decreasing sebum production in the skin |
| EP2681286B1 (de) | 2011-02-28 | 2018-08-15 | Novan, Inc. | Stickoxid-freisetzende s-nitrosothiol-modifizierte kieselsäureteilchen und verfahren zu ihrer herstellung |
| TW201521805A (zh) * | 2013-10-31 | 2015-06-16 | Advanced Plasma Therapies Inc | 使用電漿狀態之氧化氮來治療醫療狀況與疾病之方法 |
| JP2017519010A (ja) * | 2014-06-13 | 2017-07-13 | オリジン・インク | 動物の医学的状態と疾患を治療するようにプラズマ状態の一酸化窒素を利用する獣医学的方法 |
| MX2017007219A (es) * | 2014-12-05 | 2017-12-04 | Can Tech Inc | Suplemento y metodo para pienso animal. |
| US11547126B2 (en) | 2017-06-23 | 2023-01-10 | Can Technologies, Inc. | Method for improving meat quality |
| AU2020286987A1 (en) | 2019-06-04 | 2021-12-16 | Thirty Respiratory Limited | Methods and compositions for generating nitric oxide and uses thereof to deliver nitric oxide via the respiratory tract |
| CN114206325A (zh) | 2019-06-04 | 2022-03-18 | 三十控股有限公司 | 用于生成一氧化氮的方法和组合物及其用途 |
| CA3180336A1 (en) | 2020-04-23 | 2021-10-28 | Thirty Respiratory Limited | Methods and compositions for treating and combatting tuberculosis |
| CN115884758A (zh) | 2020-04-23 | 2023-03-31 | 三十呼吸有限公司 | 用于治疗SARS-CoV和SARS-CoV-2的一氧化氮或释放一氧化氮的组合物 |
| GB202101543D0 (en) | 2021-02-04 | 2021-03-24 | Thirty Respiratory Ltd | Vaping e-liquid composition and the use thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4191750A (en) * | 1976-03-08 | 1980-03-04 | Milton Hodosh | Method for treating canker sores |
| JPS5985278A (ja) * | 1982-11-05 | 1984-05-17 | Agency Of Ind Science & Technol | 食品の保存方法及び保存材 |
| JPH0622540B2 (ja) * | 1985-12-18 | 1994-03-30 | 株式会社祥光化学研究所 | 消臭抗菌能を有する構造物 |
-
1995
- 1995-02-17 DK DK95908347T patent/DK0746327T3/da active
- 1995-02-17 PL PL95316033A patent/PL180769B1/pl not_active IP Right Cessation
- 1995-02-17 CZ CZ19962456A patent/CZ286286B6/cs not_active IP Right Cessation
- 1995-02-17 DE DE69532921T patent/DE69532921T2/de not_active Expired - Lifetime
- 1995-02-17 PT PT95908347T patent/PT746327E/pt unknown
- 1995-02-17 BR BR9507099A patent/BR9507099A/pt not_active IP Right Cessation
- 1995-02-17 EP EP95908347A patent/EP0746327B1/de not_active Expired - Lifetime
- 1995-02-17 WO PCT/GB1995/000338 patent/WO1995022335A1/en active IP Right Grant
- 1995-02-17 KR KR1019960704590A patent/KR100385297B1/ko not_active IP Right Cessation
- 1995-02-17 CN CNB951921991A patent/CN1145491C/zh not_active Expired - Fee Related
- 1995-02-17 ES ES95908347T patent/ES2218541T3/es not_active Expired - Lifetime
- 1995-02-17 CA CA002183549A patent/CA2183549C/en not_active Expired - Fee Related
- 1995-02-17 AT AT95908347T patent/ATE264685T1/de not_active IP Right Cessation
- 1995-02-17 AU AU16699/95A patent/AU693851B2/en not_active Ceased
- 1995-02-17 JP JP52166995A patent/JP3875262B2/ja not_active Expired - Lifetime
-
1996
- 1996-08-16 FI FI963232A patent/FI114852B/fi active IP Right Grant
- 1996-08-19 NO NO19963446A patent/NO311494B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NO963446D0 (no) | 1996-08-19 |
| ATE264685T1 (de) | 2004-05-15 |
| EP0746327A1 (de) | 1996-12-11 |
| PL180769B1 (pl) | 2001-04-30 |
| JPH09508921A (ja) | 1997-09-09 |
| WO1995022335A1 (en) | 1995-08-24 |
| CZ286286B6 (cs) | 2000-03-15 |
| CA2183549C (en) | 2006-09-12 |
| PT746327E (pt) | 2004-06-30 |
| JP3875262B2 (ja) | 2007-01-31 |
| AU693851B2 (en) | 1998-07-09 |
| CN1145491C (zh) | 2004-04-14 |
| CA2183549A1 (en) | 1995-08-24 |
| FI963232A (fi) | 1996-09-12 |
| PL316033A1 (en) | 1996-12-23 |
| DE69532921T2 (de) | 2005-04-14 |
| FI963232A0 (fi) | 1996-08-16 |
| BR9507099A (pt) | 1997-09-16 |
| KR100385297B1 (ko) | 2003-10-10 |
| DK0746327T3 (da) | 2004-05-10 |
| CZ245696A3 (en) | 1997-01-15 |
| FI114852B (fi) | 2005-01-14 |
| NO963446L (no) | 1996-10-21 |
| EP0746327B1 (de) | 2004-04-21 |
| ES2218541T3 (es) | 2004-11-16 |
| AU1669995A (en) | 1995-09-04 |
| DE69532921D1 (de) | 2004-05-27 |
| CN1144484A (zh) | 1997-03-05 |
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| MM1K | Lapsed by not paying the annual fees |