NO310916B1 - 1-(1-2-disubstituert piperidinyl)-4-(kondensert imidazol)- piperidinderivater - Google Patents
1-(1-2-disubstituert piperidinyl)-4-(kondensert imidazol)- piperidinderivater Download PDFInfo
- Publication number
- NO310916B1 NO310916B1 NO19982405A NO982405A NO310916B1 NO 310916 B1 NO310916 B1 NO 310916B1 NO 19982405 A NO19982405 A NO 19982405A NO 982405 A NO982405 A NO 982405A NO 310916 B1 NO310916 B1 NO 310916B1
- Authority
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- Norway
- Prior art keywords
- formula
- radical
- alkyl
- hydrogen
- phenylmethyl
- Prior art date
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Classifications
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Neurosurgery (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Communicable Diseases (AREA)
- Physical Education & Sports Medicine (AREA)
- Anesthesiology (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP95203652 | 1995-12-27 | ||
| PCT/EP1996/005885 WO1997024356A1 (en) | 1995-12-27 | 1996-12-20 | 1-(1,2-disubstituted piperidinyl)-4-(fused imidazole)-piperidine derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO982405D0 NO982405D0 (no) | 1998-05-27 |
| NO982405L NO982405L (no) | 1998-08-19 |
| NO310916B1 true NO310916B1 (no) | 2001-09-17 |
Family
ID=8221024
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19982405A NO310916B1 (no) | 1995-12-27 | 1998-05-27 | 1-(1-2-disubstituert piperidinyl)-4-(kondensert imidazol)- piperidinderivater |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US6251894B1 (de) |
| EP (1) | EP0843679B1 (de) |
| JP (1) | JP4097043B2 (de) |
| KR (1) | KR100485147B1 (de) |
| CN (1) | CN1066733C (de) |
| AR (2) | AR005278A1 (de) |
| AT (1) | ATE208392T1 (de) |
| AU (1) | AU716071B2 (de) |
| BR (1) | BR9612307A (de) |
| CA (1) | CA2238817C (de) |
| CY (1) | CY2271B1 (de) |
| CZ (1) | CZ295861B6 (de) |
| DE (1) | DE69616802T2 (de) |
| DK (1) | DK0843679T3 (de) |
| EA (1) | EA001374B1 (de) |
| ES (1) | ES2167619T3 (de) |
| HK (1) | HK1011206A1 (de) |
| HU (1) | HU229766B1 (de) |
| IL (2) | IL124641A (de) |
| MY (1) | MY117680A (de) |
| NO (1) | NO310916B1 (de) |
| NZ (1) | NZ325845A (de) |
| PL (1) | PL183767B1 (de) |
| PT (1) | PT843679E (de) |
| SI (1) | SI0843679T1 (de) |
| SK (1) | SK283540B6 (de) |
| TR (1) | TR199801210T2 (de) |
| TW (1) | TW382017B (de) |
| WO (1) | WO1997024356A1 (de) |
| ZA (1) | ZA9610889B (de) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW527186B (en) | 1996-03-19 | 2003-04-11 | Janssen Pharmaceutica Nv | Fused imidazole derivatives as multidrug resistance modulators |
| DE69811689T2 (de) | 1997-09-18 | 2003-12-18 | Janssen Pharmaceutica N.V., Beerse | Kondensierte imidazolderivate zur erhöhung der oralen bioverfügbarkeit von pharmazeutika |
| PL196262B1 (pl) | 1998-12-19 | 2007-12-31 | Janssen Pharmaceutica Nv | Przeciwhistaminowy związek spiranowy, sposób jego otrzymywania i zastosowanie oraz kompozycja farmaceutyczna i związek spiranowy oraz sposób jego otrzymywania |
| AU7788500A (en) * | 1999-10-25 | 2001-05-08 | Janssen Pharmaceutica N.V. | Use of substance p antagonists for influencing the circadian timing system |
| CA2448735C (en) | 2001-06-12 | 2008-10-28 | Janssen Pharmaceutica N.V. | Novel substituted tetracyclic imidazole derivatives, processes for their preparation, pharmaceutical compositions comprising them and their use as a medicine |
| US20030083345A1 (en) * | 2001-07-10 | 2003-05-01 | Torsten Hoffmann | Method of treatment and/or prevention of brain, spinal or nerve injury |
| MXPA04004867A (es) * | 2001-11-23 | 2004-07-30 | Janssen Pharmaceutica Nv | El uso de antihistaminicos para la reduccion aguda de presion intracraneal elevada. |
| AU2002354104A1 (en) * | 2001-12-10 | 2003-06-23 | Kyorin Pharmaceutical Co., Ltd. | Fused bicyclic pyridine derivatives as tachykinin receptor antagonists |
| AU2003206722B2 (en) | 2002-01-16 | 2008-01-24 | Mercury Pharma Group Limited | Prucalopride-N-oxide |
| NZ533540A (en) * | 2002-01-18 | 2006-04-28 | Kyorin Seiyaku Kk | Fused bicyclic pyrimidine derivatives that act as effective tachykinin receptor antagonists such as NK1 to treat tachykinin receptor-related pathological conditions |
| DE60314238T2 (de) * | 2002-03-26 | 2008-01-31 | Kyorin Pharmaceutical Co., Ltd. | Kondensierte, bicyclische pyridinderivate als antagonisten des tachykininrezeptors |
| JO2696B1 (en) | 2002-12-23 | 2013-03-03 | شركة جانسين فارماسوتيكا ان. في | Derivatives of 1-piperdine-4-yl-4-biprolidine-3-yl-piperazine substituted and used as quinine antagonists |
| US7514424B2 (en) * | 2002-12-23 | 2009-04-07 | Janssen Pharmaceutica N.V. | Substituted 4-(4-piperidin-4-yl-piperazin-1-yl)-azepane derivatives and their use as neurokinin antagonists |
| JO2676B1 (en) | 2004-04-06 | 2012-06-17 | جانسين فارماسوتيكا ان. في | Derivatives of second-aza-spiro- (5,4) -dikan and their use as antihistamines |
| JO2525B1 (en) * | 2004-04-08 | 2010-03-17 | شركة جانسين فارماسوتيكا ان. في | Derived 4-alkyl-and-4-canoelperidine derivatives and their use as anti-neroquin |
| ATE469159T1 (de) | 2005-03-03 | 2010-06-15 | Janssen Pharmaceutica Nv | Substituierte oxadiazaspiro-ä5.5ü- undecanonderivate und ihre verwendung als neurokininantagonisten |
| WO2006094948A1 (en) | 2005-03-08 | 2006-09-14 | Janssen Pharmaceutica N.V. | Diaza-spiro-[4.4]-nonane derivatives as neurokinin (nk1) antagonists |
| EP2187890A4 (de) * | 2007-07-19 | 2011-09-07 | Adelaide Res & Innovation Pty | Verfahren zur verringerung des schädelinnendrucks |
| UA105182C2 (ru) | 2008-07-03 | 2014-04-25 | Ньюрексон, Інк. | Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность |
| EP2729147B1 (de) | 2011-07-04 | 2017-09-06 | IRBM - Science Park S.p.A. | Nk-1 rezeptorantagonisten zur behandlung der hornhautrevaskularisierung |
| JP2021514976A (ja) | 2018-02-26 | 2021-06-17 | オスペダーレ・サン・ラッファエーレ・エッセエッレエッレ | 眼痛の治療における使用のためのｎｋ−１拮抗薬 |
| EP4117673A1 (de) | 2020-03-11 | 2023-01-18 | Ospedale San Raffaele S.r.l. | Behandlung von stammzellenmangel |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4329353A (en) | 1980-10-22 | 1982-05-11 | Janssen Pharmaceutica, N.V. | 1-(4-Aryl-cyclohexyl)piperidine derivatives, method of use thereof and pharmaceutical compositions thereof |
| AU8902591A (en) * | 1990-10-10 | 1992-05-20 | Schering Corporation | Substituted imidazobenzazepines and imidazopyridoazepines |
| IL101851A (en) * | 1991-06-13 | 1996-05-14 | Janssen Pharmaceutica Nv | History 01 -) 4 - Pipridinyl - and Pipridinylidene (- Imidazo] A-1,2 [Pirolo, Thiano or Purano (] 3,2 [Azpin, their preparation and pharmaceutical preparations containing them and composition |
| IL101850A (en) * | 1991-06-13 | 1996-01-31 | Janssen Pharmaceutica Nv | History 11-) 4-Pipridinyl (-Imidazo] B-1, 2 [] 3 [Benzazepine, their preparation and pharmaceutical preparations containing them |
| US5674866A (en) * | 1993-07-13 | 1997-10-07 | Janssen Pharmaceutica N.V. | Antiallergic imidazoazepines |
| US5814636A (en) | 1994-07-15 | 1998-09-29 | Meiji Seika Kabushiki Kaisha | Compounds with platelet aggregation inhibitor activity |
| NZ321575A (en) | 1995-10-30 | 1999-05-28 | Janssen Pharmaceutica Nv | 1-(1,2-disubstituted piperidinyl)-4- substituted piperazine derivatives |
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1996
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- 1996-12-20 NZ NZ325845A patent/NZ325845A/xx not_active IP Right Cessation
- 1996-12-20 EP EP96944693A patent/EP0843679B1/de not_active Expired - Lifetime
- 1996-12-20 CA CA002238817A patent/CA2238817C/en not_active Expired - Fee Related
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- 1996-12-20 SK SK830-98A patent/SK283540B6/sk unknown
- 1996-12-20 HU HU9903948 patent/HU229766B1/hu not_active IP Right Cessation
- 1996-12-20 KR KR10-1998-0704830A patent/KR100485147B1/ko not_active IP Right Cessation
- 1996-12-20 PL PL96327136A patent/PL183767B1/pl unknown
- 1996-12-20 CZ CZ19981865A patent/CZ295861B6/cs not_active IP Right Cessation
- 1996-12-20 IL IL12464196A patent/IL124641A/en not_active IP Right Cessation
- 1996-12-20 SI SI9630419T patent/SI0843679T1/xx unknown
- 1996-12-20 BR BR9612307A patent/BR9612307A/pt not_active IP Right Cessation
- 1996-12-20 TR TR1998/01210T patent/TR199801210T2/xx unknown
- 1996-12-20 AT AT96944693T patent/ATE208392T1/de active
- 1996-12-20 PT PT96944693T patent/PT843679E/pt unknown
- 1996-12-20 EA EA199800603A patent/EA001374B1/ru not_active IP Right Cessation
- 1996-12-20 DK DK96944693T patent/DK0843679T3/da active
- 1996-12-20 DE DE69616802T patent/DE69616802T2/de not_active Expired - Lifetime
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- 1996-12-20 JP JP52403397A patent/JP4097043B2/ja not_active Expired - Fee Related
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- 1996-12-20 ES ES96944693T patent/ES2167619T3/es not_active Expired - Lifetime
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- 1996-12-27 MY MYPI96005516A patent/MY117680A/en unknown
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1998
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- 1998-06-22 US US09/102,136 patent/US6251894B1/en not_active Expired - Lifetime
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2002
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2005
- 2005-12-16 AR ARP050105316A patent/AR051817A2/es active IP Right Grant
Also Published As
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